RAPID RESPONSES

Think of Rapid Responses as electronic letters to the editor.

To RESPOND to a particular article: Click on the link 'Respond to this article' in the box at the top left hand corner of the article.

To READ responses to a particular article: Click on the link 'Read responses to this article' in the box at the top left hand corner of the article.

All responses published in the past 14 days are shown below. You can also read responses published in the past 2, 3, 4, 5, 6, 7, 14, or 21 days.


Rapid Responses published in the past 14 days:

201 Rapid Responses published for 103 different articles.

Articles    Rapid Responses
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EDITORIALS:
Boxing and the risk of chronic brain injury
McCrory (4 October 2007) [Full text]
Jump to Rapid Response BMA needs evidence based policy
Andrew J Ashworth   (6 October 2007)
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RESEARCH:
Effectiveness of paramedic practitioners in attending 999 calls from elderly people in the community: cluster randomised controlled trial
Mason et al. (4 October 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Older people who fall are more likely to fall again
Philippa A Logan, et al.   (11 October 2007)
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RESEARCH:
Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies
Loosemore et al. (4 October 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Amateur boxing
Simon M. Kemp   (12 October 2007)
Jump to Rapid Response How did you get that black eye?
Dawn A Sim   (10 October 2007)
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VIEWS & REVIEWS:
Why the culture of medicine has to change
Hayward (13 October 2007) [Full text] [PDF]
Jump to Rapid Response Re: Change yes......but incrementally!
Sam Lewis   (13 October 2007)
Jump to Rapid Response Change yes......but incrementally!
peter j mahaffey   (13 October 2007)
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PRACTICE:
An unusual cause of jaundice
Owen et al. (13 October 2007) [Full text] [PDF]
Jump to Rapid Response A Manifestation of Gilbert's Syndrome?
Ossie F Uzoigwe   (13 October 2007)
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RESEARCH:
Preventing childhood obesity: two year follow-up results from the Christchurch obesity prevention programme in schools (CHOPPS)
James et al. (13 October 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Too early to ditch the fizz campaign
J. Lennert Veerman, et al.   (11 October 2007)
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RESEARCH:
Comparison of hospital episode statistics and central cardiac audit database in public reporting of congenital heart surgery mortality
Westaby et al. (13 October 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Public reporting of Outcomes in Surgery: Time to reflect on Bristol?
Ashok I Handa   (11 October 2007)
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FEATURE:
From small things
Reynolds (13 October 2007) [Full text] [PDF]
Jump to Rapid Response Chemical toxicity and mitochondria
Heikki Savolainen   (12 October 2007)
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NEWS:
Mother asks surgeons to perform hysterectomy on daughter with cerebral palsy
Dyer (13 October 2007) [Full text]
Jump to Rapid Response Hysterectomy/Sterilisation
Vaidyanathan Gowri   (12 October 2007)
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NEWS:
Tooke inquiry calls for major overhaul of specialist training
Eaton (13 October 2007) [Full text] [PDF]
Jump to Rapid Response Post-CCT "Specialist" !
Stuart H McClelland   (13 October 2007)
Jump to Rapid Response Re: Tooke report
D B Double   (12 October 2007)
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EDITORIALS:
Modernising Medical Careers laid bare
Delamothe (13 October 2007) [Full text] [PDF]
Jump to Rapid Response ST Depression or ST Elevation?
Chika Uzoigwe, et al.   (12 October 2007)
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EDITORIALS:
Screening for abdominal aortic aneurysm
Greenhalgh and Powell (13 October 2007) [Full text] [PDF]
Jump to Rapid Response Screening for abdominal aortic aneurysm
Hisato Takagi, et al.   (13 October 2007)
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EDITORIALS:
Participation in mammography screening
Schwartz and Woloshin (13 October 2007) [Full text] [PDF]
Jump to Rapid Response False positives don´t result in overdiagnosis
Christian Weymayr   (13 October 2007)
Jump to Rapid Response And Women Over 70, over 80?
Joseph More   (12 October 2007)
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EDITOR'S CHOICE:
The way of the world
Delamothe (13 October 2007) [Full text]
Jump to Rapid Response What doctors should tell their patients about CAM
Roger A Fisken   (12 October 2007)
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VIEWS & REVIEWS:
Fluoride: a whiter than white reputation?
Griffiths (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Fluoride: a whiter than white reputation?
John Graham   (8 October 2007)
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RESEARCH:
Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review
Pewsner et al. (6 October 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Left ventricular hypertrophy and QT dispersion in hypertensive patients
Antoni Sisó Almirall, et al.   (11 October 2007)
Jump to Rapid Response Correction to response posted on October 07 by Vanezis and Bhopal
Andrew Peter Vanezis, et al.   (10 October 2007)
Jump to Rapid Response Ethnic variations in the ECG
Andrew P Vanezis, et al.   (7 October 2007)
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RESEARCH:
Effectiveness of interventions to promote physical activity in children and adolescents: systematic review of controlled trials
van Sluijs et al. (6 October 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Promoting active life styles in our children
Ediriweera Desapriya, et al.   (10 October 2007)
Jump to Rapid Response Physical activity in childhood and adolescence
Joav Merrick, et al.   (5 October 2007)
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ANALYSIS:
Adding fluoride to water supplies
Cheng et al. (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Fluoridation and aluminium
Christopher Exley   (13 October 2007)
Jump to Rapid Response A question of the common good
C Albert Yeung   (12 October 2007)
Jump to Rapid Response Water fluoridation and bladder cancer
Raymond J Lowry   (10 October 2007)
Jump to Rapid Response By all means, fluoridate. I’ll just refuse to drink it. - Oct 2007
Phillip J Colquitt   (10 October 2007)
Jump to Rapid Response It's time for a moratorium on fluoridation
Barry A Groves   (10 October 2007)
Jump to Rapid Response Adding fluoride to water supplies
Dr Barry Cockcroft   (9 October 2007)
Jump to Rapid Response Ethics of water fluoridation
John F Beal   (7 October 2007)
Jump to Rapid Response Dental benefits of water fluoridation
Michael A Lennon   (5 October 2007)
Jump to Rapid Response Medication with intent – the case against water fluoridation.
Douglas W Cross   (5 October 2007)
Jump to Rapid Response Adding fluoride to water supplies
Colwyn M Jones   (5 October 2007)
Jump to Rapid Response Fluoride Consumption – Much Higher than We Are Told
Peter J Mansfield, et al.   (5 October 2007)
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OBSERVATIONS:
An age old problem
Richards (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Self Management :An age old solution to an age old problem
Arun K Chopra   (13 October 2007)
Jump to Rapid Response Right to die?
Peter Bruggen   (12 October 2007)
Jump to Rapid Response Apologies to Tomji Tanabe
Tessa J Richards   (8 October 2007)
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FEATURE:
Should general practitioners resume 24 hour responsibility for their patients? No
Herbert (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Needs and Wants
Andrew P Moltu, et al.   (6 October 2007)
Jump to Rapid Response The Elephant in the (waiting) room
Duncan M Williams, et al.   (6 October 2007)
Jump to Rapid Response GP out of hours
Julian C Law   (5 October 2007)
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FEATURE:
Should general practitioners resume 24 hour responsibility for their patients? Yes
Jones (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Not either or...
Steven Ford   (13 October 2007)
Jump to Rapid Response GP Land
Dr. Raja Baber Sheraz   (13 October 2007)
Jump to Rapid Response In support of the GP Co-op
john m caine   (12 October 2007)
Jump to Rapid Response 24hour responsibility
ravinder Norman   (11 October 2007)
Jump to Rapid Response depends on format
Duran Kandhai   (11 October 2007)
Jump to Rapid Response 24 hours
Gregory M Read   (11 October 2007)
Jump to Rapid Response Not keen!
Rosemary B Martin   (11 October 2007)
Jump to Rapid Response The Good Old Days
David Howard   (10 October 2007)
Jump to Rapid Response gp 24hr resposibility
tariq m hama   (10 October 2007)
Jump to Rapid Response in the long run - giving up out of hours has been a bad thing
edmund willis   (10 October 2007)
Jump to Rapid Response In reply to Mr Wintertton above...
David P Jones   (9 October 2007)
Jump to Rapid Response yes responsibility is for doctors to bear
robert derek wintertton   (8 October 2007)
Jump to Rapid Response OOH, General Practice and Sanity
David P Jones   (8 October 2007)
Jump to Rapid Response Family Physicians
Milind A Patil   (8 October 2007)
Jump to Rapid Response No need for extended hours
chris jenkins   (7 October 2007)
Jump to Rapid Response TORONTO: After Hours medicine.
Alexander FRANKLIN   (7 October 2007)
Jump to Rapid Response Should general practitioners resume 24 hour responsibility for their patients? Yes
Imran Arfeen   (6 October 2007)
Jump to Rapid Response FINGS AINT WHAT THEY USED TO BE..
Graeme Mackenzie   (6 October 2007)
Jump to Rapid Response Whos falt is this anyway and why make it any worse than it already is ?
Alex G. Robertson   (5 October 2007)
Jump to Rapid Response General practitioners still do provide out-of-hours care
Robert L. Morley   (5 October 2007)
Jump to Rapid Response Out of hours GPs are well qualified , good doctors
Caroline A Mitchell   (5 October 2007)
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FEATURE:
Industry funded patient information and the slippery slope to New Zealand
Toop and Mangin (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Anecdotal instance of positive effects of drug advertising
Charles L. Rogerson   (13 October 2007)
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NEWS:
Australian efforts to tackle abuse of Aboriginal children raise alarm
Sweet (6 October 2007) [Full text] [PDF]
Jump to Rapid Response NT Aboriginal health care
Deane Dight   (7 October 2007)
Jump to Rapid Response Address basic care for Aboriginal people
DAVID G SAMUEL   (5 October 2007)
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NEWS:
UK does well on giving information to patients but poorly on access to new treatments
Watson (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Bismark v. Beveridge
Iain S Fraser   (11 October 2007)
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NEWS:
Africans die in pain because of fears of opiate addiction
Logie and Leng (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Opiates for pain in dying patients and in those with sickle cell disease
Felix ID Konotey-Ahulu   (11 October 2007)
Jump to Rapid Response The fear of Opiate addiction – not unique to Africa
Jecko Thachil   (8 October 2007)
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LETTERS:
A cheap soundbite
Magos et al. (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Cold hands warm heart
Karen J Hebert   (12 October 2007)
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EDITORIALS:
Reform of the coroner system and death certification
Luce (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Unintended consequences
Laurie R Davis   (12 October 2007)
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EDITORIALS:
Mental health in disaster settings
Jones et al. (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Community psychiatry - a building approach
Pandey Vibha   (1 October 2007)
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EDITORIALS:
Encouraging children and adolescents to be more active
Giles-Corti and Salmon (6 October 2007) [Full text] [PDF]
Jump to Rapid Response Working harder together to tackle obesity
Shalini Pooransingh   (12 October 2007)
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EDITOR'S CHOICE:
Tooth and nail
Godlee (6 October 2007) [Full text]
Jump to Rapid Response Fluoridation - Bad To The Bone
Maureen C. Jones   (9 October 2007)
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OBITUARIES:
Bjørn Ibsen
Richmond (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Obituary Notice re Bjørn Ibsen
Ronald V Trubuhovich   (10 October 2007)
Jump to Rapid Response Dunce's hat
Caroline Richmond   (3 October 2007)
Jump to Rapid Response Bjorn Ibsen: Founding father of intensive care
Roger H. Armour   (1 October 2007)
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VIEWS & REVIEWS:
The alcohol industry: taking on the public health critics
Farrell (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Health cost of alcohol unregulated market
Ronaldo R Laranjeira   (2 October 2007)
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VIEWS & REVIEWS:
Ethicist on the ward round
Sokol (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Ethicist on the ward round?
Cathriona Russell, et al.   (3 October 2007)
Jump to Rapid Response Recognising the ethical problem
Jonathan Howell   (3 October 2007)
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PRACTICE:
Care of healthy women and their babies during childbirth: summary of NICE guidance
Kenyon et al. (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Unnecessary controversy
Rishu Tandon   (5 October 2007)
Jump to Rapid Response Prevention: a practical approach
Vibha Pandey   (3 October 2007)
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FILLERS:
Relative risk
Hanna (29 September 2007) [Full text]
Jump to Rapid Response An ethical problem
Mounir (Munir) E Nassar, M.D., FACP   (7 October 2007)
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CLINICAL REVIEW:
Managing anovulatory infertility and polycystic ovary syndrome
Balen and Rutherford (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Management of anovulatory infertility and polycystic ovary syndrome should include diagnosis and treatment of essential nutrient deficiencies.
Ellen C G Grant   (1 October 2007)
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RESEARCH:
Effectiveness and safety of chest pain assessment to prevent emergency admissions: ESCAPE cluster randomised trial
Goodacre et al. (29 September 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Acute chest pain units. What's in a name?
S Richard Underwood   (1 October 2007)
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RESEARCH:
Preventive strategies for group B streptococcal and other bacterial infections in early infancy: cost effectiveness and value of information analyses
Colbourn et al. (29 September 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response The Dangers of Misinterpretation of Economic Analysis
Jude N Chukwuma, et al.   (30 September 2007)
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ANALYSIS:
Use of process measures to monitor the quality of clinical practice
Lilford et al. (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Outcomes Remain The Gold Standard
Robert Matz   (3 October 2007)
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OBSERVATIONS:
Wham, bam, thank you CAM
Kamerow (29 September 2007) [Full text] [PDF]
Jump to Rapid Response The most important work I do.
Dr Edmond V O`Flaherty   (6 October 2007)
Jump to Rapid Response It's good to talk
Susan E Farwell   (3 October 2007)
Jump to Rapid Response What to do about CAM
David Colquhoun   (2 October 2007)
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FEATURE:
Is there enough evidence to judge midwife led units safe? Yes
Page (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Ongoing research on planned place of birth and safety
David M Puddicombe, et al.   (4 October 2007)
Jump to Rapid Response 5 year survey in Isles of Scilly
Toby Dalton   (4 October 2007)
Jump to Rapid Response Midwifery down the drain
Anne Savage   (4 October 2007)
Jump to Rapid Response Are midwife-led maternity units safe?
Dr Mike Bull   (3 October 2007)
Jump to Rapid Response No
Ian A L Treharne   (3 October 2007)
Jump to Rapid Response Author's Response
Lesley Page   (3 October 2007)
Jump to Rapid Response midwifery led-units: choice and safety
Fatima A Husain, et al.   (3 October 2007)
Jump to Rapid Response Risk to babies with home delivery and midwife led units
Philip Murray   (3 October 2007)
Jump to Rapid Response Midwife led unit’s needs more evidence prior to independent practice
Chelliah R Selvasekar   (2 October 2007)
Jump to Rapid Response 'From cradle to grave'
Anna E Livingstone   (2 October 2007)
Jump to Rapid Response Places of birth- Satisfaction or Safety?
Bode Williams   (2 October 2007)
Jump to Rapid Response Place of Birth
Melvyn F Docker   (2 October 2007)
Jump to Rapid Response NO, midwifery-led care is a risky business.
Olakunle Fajemirokun-Odudeyi   (1 October 2007)
Jump to Rapid Response Damaged babies
Lydia M Stevens   (30 September 2007)
Jump to Rapid Response Safety and Quality of care really matter
Sally K Tracy   (30 September 2007)
Jump to Rapid Response Single measure of safety
A Sajayan   (30 September 2007)
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NEWS:
Advice to pregnant women to avoid eating peanuts should be withdrawn, says Lords committee
Kmietowicz (29 September 2007) [Full text] [PDF]
Jump to Rapid Response At last: some common sense
Stuart H McClelland   (1 October 2007)
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NEWS:
Doctors rank myocardial infarction as most "prestigious" disease and fibromyalgia as least
Dobson (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Doctors rank myocardial infarction as most "prestigious" disease and fibromyalgia as least
Maureen Norton   (1 October 2007)
Jump to Rapid Response How "prestigious" do the public view disease
Martin Whitehead   (30 September 2007)
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LETTERS:
Uniquely disadvantaged
Livesey (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Double-edge swords: challenges faced by ill physicians
Robert L. Klitzman   (1 October 2007)
Jump to Rapid Response Advantages and disadvantages perhaps culturally based.
Andre des Etages   (30 September 2007)
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LETTERS:
Profound ethical issues were smoothed over
Blumsohn (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Re: Conflicts of Interest
Aubrey Blumsohn   (1 October 2007)
Jump to Rapid Response Conflicts of Interest
David R Coghill   (30 September 2007)
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LETTERS:
Capitalism is a force for good
Charlton (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Achieving health equity with more liberty, wealth, and ethics.
Anonymous Cuban professional   (5 October 2007)
Jump to Rapid Response Population and Poverty: Malawi
James G Danaher   (2 October 2007)
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LETTERS:
None so blind
Wake (29 September 2007) [Full text] [PDF]
Jump to Rapid Response None so blind...looking for the evidence
Rowland L Cottingham   (10 October 2007)
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LETTERS:
Summary of responses
Twisselmann (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Performance related pay
Peter S L Barling   (5 October 2007)
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EDITORIALS:
Physician assisted death in vulnerable populations
Quill (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Mentally ill given short shrift
Madelyn H. Hicks   (10 October 2007)
Jump to Rapid Response Concerns not dispelled
Desmond O'Neill   (3 October 2007)
Jump to Rapid Response Don't be fooled into accepting doctor-assisted dying
Stephen MW Hutchison   (1 October 2007)
Jump to Rapid Response There is more to vulnerability
Andrew Thorns   (1 October 2007)
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EDITORIALS:
The Declaration of Helsinki
Goodyear et al. (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Re: The Delaration of Helsinki is DEAD
udo schuklenk   (8 October 2007)
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EDITORIALS:
Risk of cancer and the oral contraceptive pill
Meirik and Farley (29 September 2007) [Full text] [PDF]
Jump to Rapid Response Pituitary adenomas are not cancers
Richard Quinton, et al.   (3 October 2007)
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VIEWS & REVIEWS:
MTAS or a tale of evidence heedless medicine
Nachev (22 September 2007) [Full text] [PDF]
Jump to Rapid Response Selection methodology: more fiction than fact, and a worrying future
A Thomson   (12 October 2007)
Jump to Rapid Response Unsatisfactory response by Ms Patterson
Peter von Kaehne   (12 October 2007)
Jump to Rapid Response No defence
ben dean   (11 October 2007)
Jump to Rapid Response Evidence heedless medicine
John Sanderson   (11 October 2007)
Jump to Rapid Response Re: Selection methodology; fact, fiction and the future
Alison L Gill   (11 October 2007)
Jump to Rapid Response Re: Selection methodology; fact, fiction and the future
Matthew J Daniels   (11 October 2007)
Jump to Rapid Response Re: MTAS or a tale of evidence heedless medicine
Alison S Carr   (11 October 2007)
Jump to Rapid Response More light less heat
Frank R Smith   (11 October 2007)
Jump to Rapid Response Selection methodology; fact, fiction and the future
Fiona Patterson   (4 October 2007)
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PRACTICE:
Ramadan fasting and diabetes
Sheikh and Wallia (22 September 2007) [Full text] [PDF]
Jump to Rapid Response Post prandial hyperglycemia
Ali K Kamona   (5 October 2007)
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PRACTICE:
Do all fractures need full immobilisation?
Glasziou (22 September 2007) [Full text] [PDF]
Jump to Rapid Response Appropriate, no universal, referal please
Paul P Glasziou   (11 October 2007)
Jump to Rapid Response The use of Evidence Based Medicine in clinical practice
Emma Stapleton   (8 October 2007)
Jump to Rapid Response evidence
ben dean   (8 October 2007)
Jump to Rapid Response The case for specialist treatment
Margaret M McQueen   (3 October 2007)
Jump to Rapid Response Expertise and evidence must learn to work together
Paul Glasziou   (1 October 2007)
Jump to Rapid Response dumbing down?
ben dean   (30 September 2007)
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RESEARCH:
Mental health consequences of overstretch in the UK armed forces: first phase of a cohort study
Rona et al. (22 September 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Mental health consequences of overstretch – what about hospital emergency departments?
Martin Wiese   (7 October 2007)
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RESEARCH:
Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis
Wald et al. (22 September 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Screening for familial hypercholesterolemia
Peter J. Lansberg, et al.   (5 October 2007)
Jump to Rapid Response Familial hypercholesterolaemia: time for further action, not further debate
Ian Hamilton-Craig   (5 October 2007)
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ANALYSIS:
Medical immigration: the elephant in the room
Winyard (22 September 2007) [Full text] [PDF]
Jump to Rapid Response some overseas medical schools are inferior
edmund willis   (10 October 2007)
Jump to Rapid Response Re: We got to find an amicable solution
Jay Ilangaratne   (2 October 2007)
Jump to Rapid Response Competition is good for patients
Martin Zinkler   (2 October 2007)
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EDITOR'S CHOICE:
Training our doctors
Godlee (22 September 2007) [Full text]
Jump to Rapid Response Training and careers of French doctors
herve Maisonneuve, et al.   (5 October 2007)
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VIEWS & REVIEWS:
No patient is an island
Sokol (15 September 2007) [Full text] [PDF]
Jump to Rapid Response Response to Willett's cartoon
Ron Pigott   (1 October 2007)
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PRACTICE:
A painful hip
O'Connor (15 September 2007) [Full text] [PDF]
Jump to Rapid Response Pain Hip Pitfalls
Chika E Uzoigwe, et al.   (10 October 2007)
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OBSERVATIONS:
Alzheimer's Society replies to Iain Chalmers
Hunt (15 September 2007) [Full text] [PDF]
Jump to Rapid Response Alzheimer Society of Canada responds to Linda Furlini ‘Why I am no longer a member of the Alzheimer Society’
Scott Dudgeon   (3 October 2007)
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EDITORIALS:
Dealing with scientific misconduct
Bosch (15 September 2007) [Full text] [PDF]
Jump to Rapid Response Re: Scientific misconduct occurs at all levels
Alejandro A. Bevaqua   (1 October 2007)
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PRACTICE:
Using a combination inhaler (budesonide plus formoterol) as rescue therapy improves asthma control
Barnes (8 September 2007) [Full text] [PDF]
Jump to Rapid Response A SMART choice for primary care asthma therapy ?
Brian J Lipworth, et al.   (13 October 2007)
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ANALYSIS:
Families of patients with premature coronary heart disease: an obvious but neglected target for primary prevention
Chow et al. (8 September 2007) [Full text] [PDF]
Jump to Rapid Response Targeting at risk families for cardiovascular primary prevention
Martha J Wrigley, et al.   (7 October 2007)
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FEATURE:
The market in primary care
Pollock et al. (8 September 2007) [Full text] [PDF]
Jump to Rapid Response More questions than answers.
Hendrik J Beerstecher   (8 October 2007)
Jump to Rapid Response Market Forces Health Improvement
Richard Alan Mendelsohn, et al.   (3 October 2007)
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NEWS:
Agency warns about dosing error for amphotericin after patients with cancer die
Hawkes (8 September 2007) [Full text] [PDF]
Jump to Rapid Response Correction: Amphotericin product names
Frances MacIntosh   (8 October 2007)
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LETTERS:
Author's reply
Watson (8 September 2007) [Full text] [PDF]
Jump to Rapid Response Re: NICE guidelines on childhood UTI
J Valmai Cook   (1 October 2007)
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PRACTICE:
Ehlers-Danlos syndrome
Gawthrop et al. (1 September 2007) [Full text] [PDF]
Jump to Rapid Response Question re possible association with Attention Deficit Hyperactivity Disorder
Bruce W Urquhart   (5 October 2007)
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FILLERS:
A depressed gorilla
Pop (1 September 2007) [Full text]
Jump to Rapid Response Neglect of Psyhosocial Interventions in a Depressed Gorilla
Dave W H Baillie   (3 October 2007)
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RESEARCH:
Acupuncture as an adjunct to exercise based physiotherapy for osteoarthritis of the knee: randomised controlled trial
Foster et al. (1 September 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Clearly suboptimal acupuncture
Andrew Hoe   (1 October 2007)
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LETTERS:
Time to get our acts together
Reid and Menon (1 September 2007) [Full text] [PDF]
Jump to Rapid Response There is a need for greater awareness of and training on the Mental Capacity Act (MCA) 2005 within the National Health Service (NHS).
Jude N Chukwuma, et al.   (5 October 2007)
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EDITORIALS:
Chronic fatigue syndrome or myalgic encephalomyelitis
White et al. (1 September 2007) [Full text] [PDF]
Jump to Rapid Response Miscommunications and Misunderstandings
Douglas T Fraser   (5 October 2007)
Jump to Rapid Response ME as an inclusion of CFS
Les O SIMPSON   (3 October 2007)
Jump to Rapid Response PSYCHIATRISTS SAY: CBT for ME does NOT work
Tessa Vinicius   (2 October 2007)
Jump to Rapid Response Actometers or pedometers should be used in rehabilitation studies in the field to check whether the interventions are actually leading to (substantial) increases in activity levels
Tom Kindlon   (30 September 2007)
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CLINICAL REVIEW:
Acute respiratory distress syndrome
Leaver and Evans (25 August 2007) [Full text] [PDF]
Jump to Rapid Response Should we use low tidal volume in all our ARDS patients?
Eduardo M Svoren, et al.   (12 October 2007)
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RESEARCH:
Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial
Montini et al. (25 August 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Response to Montini Article
Alejandro Hoberman, et al.   (12 October 2007)
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RESEARCH:
Accuracy of diagnosing atrial fibrillation on electrocardiogram by primary care practitioners and interpretative diagnostic software: analysis of data from screening for atrial fibrillation in the elderly (SAFE) trial
Mant et al. (25 August 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Response from both Hospital and GP angles
Ashish B Patel   (10 October 2007)
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FEATURE:
Hyperactivity in children: the Gillberg affair
Gornall (25 August 2007) [Full text] [PDF]
Jump to Rapid Response Assessment for the Swedish Research Council
Denny H Vågerö   (12 October 2007)
Jump to Rapid Response Industry of Death?
Vanna Beckman   (12 October 2007)
Jump to Rapid Response Apology for a slur required
Steven P R Rose   (3 October 2007)
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EDITOR'S CHOICE:
Nice feedback
Godlee (25 August 2007) [Full text]
Jump to Rapid Response Searching a PDF
Pawan Randev   (1 October 2007)
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RESEARCH:
Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations
Canani et al. (18 August 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Probiotics for treatment of acute diarrhoea in children
María G. Joyanes   (6 October 2007)
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RESEARCH:
Use of intensive case management to reduce time in hospital in people with severe mental illness: systematic review and meta-regression
Burns et al. (18 August 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Assertive Community Treatment: The South East CMHT, Barnet, Experience
Azad A Cadinouche, et al.   (8 October 2007)
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ANALYSIS:
Potential of electronic personal health records
Pagliari et al. (18 August 2007) [Full text] [PDF]
Jump to Rapid Response Prespectives on Personal Health Record
Rahul Shetty, et al.   (6 October 2007)
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ANALYSIS:
Preventive health care in elderly people needs rethinking
Mangin et al. (11 August 2007) [Full text] [PDF]
Jump to Rapid Response Essential geriatric care
Tamilmani A J   (1 October 2007)
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RESEARCH:
Body mass index cut offs to define thinness in children and adolescents: international survey
Cole et al. (28 July 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Re: Thinness,BMI and Body Size
Tim J Cole   (6 October 2007)
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FEATURE:
Should we consider a boycott of Israeli academic institutions? No
Baum (21 July 2007) [Full text] [PDF]
Jump to Rapid Response Professor Baum still not answering and handing over to IMA
Christopher J Burns-Cox, et al.   (12 October 2007)
Jump to Rapid Response Professor Baum, as a Doctor: please treat the cause not the symptom
Mamdouh EL-Adl   (12 October 2007)
Jump to Rapid Response The threatened academic boycott of Israel and the accusation that the Israel Medical association (IMA) is complicit in the torture of prisoners.
Michael Baum   (4 October 2007)
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FEATURE:
Should we consider a boycott of Israeli academic institutions? Yes
Hickey (21 July 2007) [Full text] [PDF]
Jump to Rapid Response Go and see the truth for yourself. I did.
Asad Khan   (7 October 2007)
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EDITORIALS:
Depression in adolescents
Hazell (21 July 2007) [Full text] [PDF]
Jump to Rapid Response Invega advertising
Selwyn Learner   (1 October 2007)
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RESEARCH:
Implementing the NHS information technology programme: qualitative study of progress in acute trusts
Hendy et al. (30 June 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Unexpected benefit of Choose and Book
Paul E Shannon   (11 October 2007)
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CLINICAL REVIEW:
Diagnosis and treatment of sciatica
Koes et al. (23 June 2007) [Full text] [PDF]
Jump to Rapid Response Treatment of Sciatica
Charles S Galasko   (8 October 2007)
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ANALYSIS:
Selection for specialist training: what can we learn from other countries?
Jefferis (23 June 2007) [Full text] [PDF]
Jump to Rapid Response Selection for specialist Training- A fair approach
Vaibhav Tyagi, et al.   (1 October 2007)
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EDITORIALS:
Diabetic ketoacidosis
Dhatariya (23 June 2007) [Full text] [PDF]
Jump to Rapid Response Would Normal Saline be licensed today?
Nicholas Levy, et al.   (11 October 2007)
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RESEARCH:
Interventions to promote walking: systematic review
Ogilvie et al. (9 June 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Inactivity in Secondary Care Doctors
Amy L Chue, et al.   (10 October 2007)
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RESEARCH:
Alarm symptoms in early diagnosis of cancer in primary care: cohort study using General Practice Research Database
Jones et al. (19 May 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Alarm symptoms in primary care: Further evidence
Knut A Holtedahl   (1 October 2007)
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ANALYSIS:
Functional foods: the case for closer evaluation
de Jong et al. (19 May 2007) [Full text] [PDF]
Jump to Rapid Response Functional Foods: Already a feature of every-day practice
Ian R Wallace   (3 October 2007)
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VIEWS & REVIEWS:
Addiction in America: in search of a fix
Veltman (31 March 2007) [Full text] [PDF]
Jump to Rapid Response Addiction: Imaginary Gains and Real Losses
Hugh Mann   (3 October 2007)
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RESEARCH:
Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials
Walter et al. (10 March 2007) [Abstract] [Full text] [PDF]
Jump to Rapid Response Importance of calculation of absorbed dose in radioiodine treatment in patients pre-treated with antithyroid drugs
Gertrud Berg   (12 October 2007)
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RESEARCH:
Effectiveness of community physiotherapy and enhanced pharmacy review for knee pain in people aged over 55 presenting to primary care: pragmatic randomised trial
Hay et al. (11 November 2006) [Abstract] [Full text] [PDF]
Jump to Rapid Response Re: Rotational Field Quantum Magnetic Resonance
Sukhbindar S Sibia   (6 October 2007)
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REVIEWS:
Why are so many people dying on Everest?
Sutherland (26 August 2006) [Full text]
Jump to Rapid Response Damned if you treat, damned if you don’t.
Sean T Hudson   (3 October 2007)
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ANALYSIS AND COMMENT:
Do enforced bicycle helmet laws improve public health?
(25 March 2006) [Full text] [PDF]
Jump to Rapid Response What about motorcycle helmets?
Marcel Girodian   (3 October 2007)
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ON THE CASE:
The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute
Lim et al. (24 December 2005) [Abstract] [Full text] [PDF]
Jump to Rapid Response Practical solution
Jennifer A Stillman, et al.   (6 October 2007)
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NEWS ROUNDUP:
GMC drops charges against paediatrician in Climbie case
Dyer (18 September 2004) [Full text]
Jump to Rapid Response Mellor's dilemma
Jonathan Gornall   (8 October 2007)
Jump to Rapid Response Kawasaki Disease - Misdiagnosed.
Michael D Innis   (2 October 2007)
Jump to Rapid Response Re: Or was she raygunned?
Penny Mellor   (2 October 2007)
Jump to Rapid Response Kawasaki Disease and Victoria Climbie
Nellie T Adjaye   (1 October 2007)
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EDITORIALS:
What's a good doctor, and how can you make one?
Hurwitz and Vass (28 September 2002) [Full text] [PDF]
Jump to Rapid Response Re: its multifactorial
Hammad Akram   (6 October 2007)
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NEWS:
Withdrawal from paroxetine can be severe, warns FDA
Tonks (2 February 2002) [Full text] [PDF]
Jump to Rapid Response Re: Paroxetine
E Lynn Alexander, et al.   (7 October 2007)
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SOUNDINGS:
The value of life
Farrell (12 September 1998) [Full text] [PDF]
Jump to Rapid Response I believe in insulin
Neil \ Kirk\, et al.   (30 September 2007)
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PAPERS:
Genetic influences on osteoarthritis in women: a twin study
Spector et al. (13 April 1996) [Abstract] [Full text]
Jump to Rapid Response Possible Incorrect Citation
Madeline C Walsh   (3 October 2007)
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EDITORIALS:
Boxing and the risk of chronic brain injury
McCrory (4 October 2007) [Full text]
Boxing and the risk of chronic brain injury
BMA needs evidence based policy
6 October 2007
 Next Rapid Response Top
Andrew J Ashworth,
General Practitioner
Davidson's Mains Medical Centre, 5 Quality Street, EDINBURGH, EH4 5BP

Send response to journal:
Re: BMA needs evidence based policy

In the period that the BMA has opposed boxing, there has been a decline in the amateur sport. Gang membership and street violence have increased (perhaps in part replacing regulated amateur boxing tournaments) as outlets for testosterone fuelled youth.

A recent update from the BMA Board of Science(1) claims that the BMA is against boxing because of (a) serious health risks involved (b) non- boxing events are commercialised (this really is put forward as an argument against regulated boxing!) (c) Nothing has changed since 1982 when the BMA first made its mind up.

Argument (a) is inconsistent with the evidence, argument (b) is patent nonsense and argument (c) appears outdated.

The BMA should revisit is policy on the basis of evidence, mindful of the potential negative impacts of its influential views on the public health.

1.http://www.bma.org.uk/ap.nsf/Content/boxing?OpenDocument&Highlight;=2,boxing

Competing interests: Following a direct order as a Royal Navy Medical Officer. I officiated at an amateur boxing bout and saw the sense of belonging and self esteem this sport can give to those without the priviledges of those who seek to ban the sport.

RESEARCH:
Effectiveness of paramedic practitioners in attending 999 calls from elderly people in the community: cluster randomised controlled trial
Mason et al. (4 October 2007) [Abstract] [Full text] [PDF]
Effectiveness of paramedic practitioners in attending 999 calls from elderly people...
Older people who fall are more likely to fall again
11 October 2007
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Philippa A Logan,
Research Occupational Therapist
University of Nottingham, NG7 2UH,
John RF. Gladman, Kate Robertson

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Re: Older people who fall are more likely to fall again

Whilst we welcome the development of services that improve satisfaction and which reduce unnecessary visits to Emergency Departments (ED), if falls are common, and falls prevention is possible, then being seen by a paramedic instead of ED or being referred to falls prevention teams means that these fallers may not get into evidence based services, such as demonstrated in the PROFET (Close et al., 1999) study, which picked up fallers from the ED. Thus, patients may be satisfied, the ED may be cleared, but preventable falls may still continue to occur and the old people affected may be unaware that there are effective interventions they are being denied. In collaboration with our local rehabilitation and ambulance services, we are evaluating in a RCT the application of falls prevention to this group of patients who fall, call an ambulance but who are not transported to hospital.

Close, J., Ellis, M., Hooper, R., Glucksman, E., Jackson, S., & Swift, C. (1999). Prevention of falls in the elderly trial (PROFET): a randomised controlled trial. The Lancet, 353(9147), 93-97.

Competing interests: None declared

RESEARCH:
Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies
Loosemore et al. (4 October 2007) [Abstract] [Full text] [PDF]
Amateur boxing and risk of chronic traumatic brain injury: systematic review of...
Amateur boxing
12 October 2007
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Simon M. Kemp,
Sports Coach
PO10 7TX

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Re: Amateur boxing

Between 1990 - 1994 it was my pleasure and privilege to coach the England Universities' Amateur Boxing squad. The team I took up to Scotland for an International match in November 1993 contained two Medical Students and was Captained by Alex Mehta MA (Oxon) who was then reading for a PhD in Environmental Law at Oriel College, Oxford University.

The British Medical Association has argued that young people under the "Age of Consent" should not be allowed to Box because they may be too young to understand the risks involved in participation in this tough combat sport.

Presumably the BMA would accept that someone studying Medicine at Cambridge or Oxford was old enough, and sufficiently well informed, to understand the risks involved in Boxing? Dr. Alex Mehta, winner of four Oxford University Boxing "Blues", is now a successful Barrister-at-Law. Hard to reconcile that record of intellectual achievement with the BMA's claims that "Boxing is bad for the brain."

Competing interests: Qualified Amateur Boxing Association Coach

Amateur boxing and risk of chronic traumatic brain injury: systematic review of...
How did you get that black eye?
10 October 2007
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Dawn A Sim,
Specialist Registrar in Ophthalmology
Moorfields Eye Hospital, 162 City Road, London EC1V2PD

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Re: How did you get that black eye?

I read with interest that Loosemore et al1 found no evidence for a strong association between amateur boxing and chronic traumatic brain injury.

Conversely, chronic injury does occur with ocular structures, which like the brain, has a limited ability to renew itself. Eyes face blunt impact directly,and can sustain severe lesions resultant from boxing. These can range from minor anatomical aberrations to severe, visual threatening lesions. Examples include lid lacerations and avulsions, tearing of the sphincter pupillae, peripheral iris or ciliary body, traumatic uveitis, cataract, hyphaema, secondary glaucoma from angle recession, retinal tears and detachments, visual field defects secondary to injuries to the visual pathways.

Significant differences have been found between boxers and controls for the number of ocular injuries.2,3 Furthermore, there are significant correlations between the total number of bouts and the total number of losses, and the presence of retinal tears.3

Boxers can have up to ten times the incidence of serious ocular lesions.4 It is important to note that most publications recommend regular evaluations by an ophthalmologist, with emphasis on examination of the peripheral fundus.

1. Loosemore MP, Knowles CH, Whyte GP. Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies. BMJ 2007 doi: 10.1136/bmj.39342.690220.55

2. Wedrich A, Velikay M, Binder S, Radax U, Stolba U, Datlinger P. Ocular findings in asymptomatic amateur boxers. Retina 1993;13(2):114-9.

3. Giovinazzo VJ, Yannuzzi LA, Sorenson JA, Delrowe DJ, Cambell EA. The ocular complications of boxing. Ophthalmology 1987 Jun;94(6):587-96

4. P F Vinger commentary on, M Bianco, A S Vaiano, F Colella, F Coccimiglio, M Moscetti, V Palmieri, F Focosi, P Zeppilli. Ocular complications of boxing. Br J Sports Med 2005;39:70–74.

Competing interests: None declared

VIEWS & REVIEWS:
Why the culture of medicine has to change
Hayward (13 October 2007) [Full text] [PDF]
Why the culture of medicine has to change
Re: Change yes......but incrementally!
13 October 2007
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Sam Lewis,
GP
Surgery, Newport, Pembrokeshire, SA42 0TJ

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Re: Re: Change yes......but incrementally!

I am busy writing a short piece for my 'Policy Analysis' course, contrasting the 'rationalistic' with the 'incrementalist' approach to decision-making... and then you come along , Richard, with a proposal that takes my breath away with its rational and incremental simplicity :-

[ask the clinicians] "Look, what do you need to get your waiting lists down to a managable length?" - they would have done it, and at a cost of one hundredth of what has been spent

Wow !! Didn't Gerry Robinson ask exactly that ? and didn't he hit a wall ??

so tell me Richard, how is it done ??

Competing interests: a doctor and a taxpayer

Why the culture of medicine has to change
Change yes......but incrementally!
13 October 2007
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peter j mahaffey,
consultant plastic & reconstructive surgeon
bedford hospital

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Re: Change yes......but incrementally!

Any analysis of the present woes of the UK medical profession from a working clinician (rather than medical or government politician) is a breath of fresh air in an environment where most of us seem to have been cowed into submission. And Richard Hayward is absolutely right to focus on what it is that spurs a doctor to enjoy his or her daily work....to solve a problem by using one's skills, with beneficial fall-out for patient, doctor and health service.

But after that, his analysis breaks down. The stimulus for the massive changes in our NHS were 'local' (getting down waiting lists etc) and 'big-picture', ie grappling with the spiralling health costs which have afflicted all nations. But the problem was not 'the culture of medicine' which, as Hayward defined, is about the self-gratification involved in diagnosis and treatment. Rather, it was the government of the day's error in inflicting repeated, wholesale, brutal changes to a complex ecosystem which had evolved over 60 yrs since 1947. No system could ever have withstood such an upheaval. All that was really needed was for wise government to make progressive nudges to the tiller. For better or worse, clinicians are far and away the best educated section of the NHS workforce. If someone had simply come to them and said "Look, what do you need to get your waiting lists down to a managable length?" they would have done it, and at a cost of one hundredth of what has been spent in the past 10 years. Moreover, doctors mostly also enjoy efficiency, and a similar direct appeal to them to 'help us get our budgets down for the good of us all' would very likely also have appealed to those self-same qualities.

But now the damage wrought by those seeking to weaken the profession is too great. And we are almost in the end-game where the politicians need only to wrest the last powerful card from our hand, the doctor-patient relationship. Infection crises, generic referrals, clinical guidelines, repeated 'fat-cat' allegations.... and soon we will be fully fledged state employees just as in Scandinavia! And then perhaps the state will realise that it wasn't the 'culture of medicine' that lost it the priceless asset of an independent profession.

Competing interests: None declared

PRACTICE:
An unusual cause of jaundice
Owen et al. (13 October 2007) [Full text] [PDF]
An unusual cause of jaundice
A Manifestation of Gilbert's Syndrome?
13 October 2007
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Ossie F Uzoigwe,
Student
University of Leeds

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Re: A Manifestation of Gilbert's Syndrome?

Dear Editor,

Icterus in the context of thyrotoxicosis is an interesting phenomenon. Given that jaundice is such a rare feature of hyperthyroidism it is unlikely that there exists a direct causal link. It is more probable that there is an underlying hepatic dysfunction which is unmasked and potentially exacerbated by the thyrotoxic state1. The most likely cause is Gilbert’s syndrome. Its prevalence may be as high as 12.4% in Caucasian men2. The disease is generally latent but becomes evident during times of illness. In the present case it is worth considering this possibility.

If the true mechanism was thyroxine-induced oxidative damage, one would suspect considerable hepatocellular injury with a significant irreversible element if the bilirubin rose to levels of 581umol/l, as in the instant case. Indeed 300umol/l is the threshold for liver transplantation in cases of paracetamol overdose. This is notable given that oxidative stress is also the mechanism of paracetamol’s hepatotoxicity3. Such injury would not be consistent with such a radical recovery. The rapid resolution of symptoms, seen in this case, once euthyroidism was established would be classical of the Gilbert’s syndrome.

1. Greenberger NJ, Milligan FD, Degroot LJ, Isselbacher KJ. Jaundice and thyrotoxicosis in the absence of congestive cardiac failure. Am J Med. 1964; 36:840-6.

2. Sieg A, Arab L, Schlierf G, Stiehl A, Kommerell B. Prevalence of Gilbert's syndrome in Germany. Dtsch Med Wochenschr. 1987 31;112:1206-8.

3. Jaeschke H, Knight TR, Bajt ML. The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett. 2003; 144:279-88.

Competing interests: None declared

RESEARCH:
Preventing childhood obesity: two year follow-up results from the Christchurch obesity prevention programme in schools (CHOPPS)
James et al. (13 October 2007) [Abstract] [Full text] [PDF]
Preventing childhood obesity: two year follow-up results from the Christchurch obesity...
Too early to ditch the fizz campaign
11 October 2007
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J. Lennert Veerman,
Research Fellow
UQ School of Population Health, Herston Road, Herston, QLD 4030, Australia,
Jan J. Barendregt

Send response to journal:
Re: Too early to ditch the fizz campaign

Dear Sir,

James et al report that a school-based intervention that reduced children’s consumption of carbonated drinks and the prevalence of overweight was no longer effective two years after completion of the intervention (1). We believe that this conclusion is not warranted, for two reasons.

The first reason is that the authors base their conclusions solely on the proportion of children with overweight. Indeed, this is was statistically significantly different between the intervention and the control groups at 12 months, and not at 3 years.

However, we would argue that average values of BMI, Z-score and waist circumference are better outcome values to use for a population-targeted intervention such as the CHOPPS. Geoffrey Rose pointed out that numbers of overweight or obese individuals are merely those that fall above an arbitrary cut-off point (2). The distribution of BMI in populations can be reasonably well described by a lognormal curve, of which the average shifts to higher values as the obesity ‘epidemic’ progresses (3). Similarly, for Z-scores and waist circumference population distributions can be assumed.

Table 1 makes clear that the changes in BMI, Z-score and waist circumference moved quite a bit towards significance: from p=0.36 to p=0.12, 0.60 to 0.06 and 0.81 to 0.25, respectively. Our conclusion would therefore be that the intervention did not have a significant effect on overweight after 12 months but that it is moving in the right direction.

This is not surprising. Body mass accumulates. Suppose the children learnt to consume less carbonated drinks as a result of the intervention, and that they continue to apply this knowledge as the years pass. This would result in them putting on less weight every year, which after a number of years would become visible in their body mass. We would therefore advise James and colleagues to measure the children again in another couple of years – they may well find the desired statistically significant results.

The second reason we think James et al’s conclusion is not warranted is because of trial characteristics. The trial was originally powered to detect differences in consumption of carbonated drinks, not proportion of overweight. Due to considerable loss-to-follow-up at three year power has further declined. In addition there were large differences at baseline: though not statistically significantly so, the intervention group had an average BMI, Z-score and waist circumference that was lower than that in the control group. Despite the randomisation process, we remain worried that, by chance or by selection, the intervention group might be less prone to overweight. In that case, any observed difference in the prevalence of overweight would not be (fully) attributable to the intervention.

Childhood obesity and what to do about it is a huge problem, with so far very few solutions. In our opinion, James et al dismiss what looks like a promising result, based on an inappropriate outcome measure from an insufficiently powered and poorly randomised trial.

References

(1) James J, Thomas P, Kerr D. Preventing childhood obesity: two year follow-up results from the Christchurch obesity prevention programme in schools (CHOPPS). Bmj 2007.

(2) Rose G. The Strategy of Preventive Medicine. Oxford: Oxford University Press, 1992.

(3) Veerman JL, Barendregt JJ, van Beeck EF, Seidell JC, Mackenbach JP. Stemming the obesity epidemic: a tantalizing prospect. Obesity (Silver Spring) 2007;15(9):2365-70.

Competing interests: None declared

RESEARCH:
Comparison of hospital episode statistics and central cardiac audit database in public reporting of congenital heart surgery mortality
Westaby et al. (13 October 2007) [Abstract] [Full text] [PDF]
Comparison of hospital episode statistics and central cardiac audit database in...
Public reporting of Outcomes in Surgery: Time to reflect on Bristol?
11 October 2007
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Ashok I Handa,
Consultant Vascular Surgeon
Nuffield Department of Surgery, John Radcliffe Hospital, Oxford OX3 9DU

Send response to journal:
Re: Public reporting of Outcomes in Surgery: Time to reflect on Bristol?

I read with interest the report by Westaby and colleagues comparing administrative collected hospital episode statistics (HES) reported by Ayling and the clinically collected central cardiac audit database (CCAD).

This highlights the inaccuracies between HES data collected by poorly paid hospital coders working from poorly kept, and often illegible, case records and clinically collected data by dedicated data managers in the 13 cardiac centres with annual external validation.

I agree with Black (Rapid Response) that all surgical units should prospectively collect activity and outcome data. Clinicians should insist on and hospital managers should provide adequate administrative support for this to be a matter of routine. This would be good for patients as it would allow accurate public reporting of each units performance and avoid future such controversy.

On reflection on Bristol one wonders if clinically robust data such as CCAD had been available at the time, whether the GMC rulings on Dhasmana and Wisheart would have been the same. Having worked for them as an SHO in Bristol in the late 1980's, I did not doubt their commitment and dedication to their patients.

The cardiac surgical community to their credit have responded to Bristol with routine collection of clinically acquired Data for national reporting. Vascular surgeons are now also responding with the National Vascular Database organised by the Vascular Society. Unfortunately this is largely unfunded and unsupported by NHS managers.

Competing interests: None declared

FEATURE:
From small things
Reynolds (13 October 2007) [Full text] [PDF]
From small things
Chemical toxicity and mitochondria
12 October 2007
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Heikki Savolainen,
Professor
Dept. of Occup. Safety & Hlth., FIN-33101 Tampere, Finland

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Re: Chemical toxicity and mitochondria

Dear Editor,

This excellent feature on mitochondria contains much of the current concepts. I would like to add that the organelle, and especially its repiratory chain, is an important target of toxic compounds.

The classic examples include inhibitors of the cytochrome oxidase at the terminal of the chain. It catalyzes the formation of water and is inhibited e.g. by cyanide, hydrogen sulfide, azide or formic acid (1).

Other toxicologically important inhibitors target the succinate dehydrogenase activity at the complex II of the chain. They include e.g. malonate, 3-nitropropionic acid or alkoxyacetic acids, the end metabolites of ethylene glycol ethers (2). The latter is particularly interesting as it leads to an accumulation of succinate which interferes with the degradation of hypoxia inducible factor 1-alpha (HIF-1) which plays a role in malignant transformation (3).

Thus, mitochondrial physiology and biology are important current topics in many fields of study.

1. Savolainen H. Biological monitoring of hydrogen sulfide exposure. Biol Monit, 1991; 1: 27-33.

2. Liesivuori J, Laitinen J, Savolainen H. Rat model for renal effects of 2-alkoxyalcohols and their acetates. Arch Toxicol, 1999; 73: 229-232.

3. Brière JJ, Favier J, Benit P. Mitochondrial succinate is instrumental for HIF 1 lapha translocation in SDHA-mutant fibroblasts under normoxicconditions. Hum Mol Genet, 2005; 14: 3263-3269.

Competing interests: None declared

NEWS:
Mother asks surgeons to perform hysterectomy on daughter with cerebral palsy
Dyer (13 October 2007) [Full text]
Mother asks surgeons to perform hysterectomy on daughter with cerebral palsy
Hysterectomy/Sterilisation
12 October 2007
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Vaidyanathan Gowri,
assistant professor
Sultan Qaboos University, Oman, Muscat 123

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Re: Hysterectomy/Sterilisation

The "news" article on hysterectomy in a cerebral palsy child was very interesting. I have come across similar requests in my practice a few times.

The main issues are the IQ of the child to take care of herself regading menstruation and also from pregnancies (intended or unintended). Social support depends on the country they live and full time family support is not always available. It may be necessary in many circumstances to consider the maternal reqeust either for strilisation or hysterectomy and it should be based on the child's IQ and how much time the mother can devote to give attention to the child at home as well.

Competing interests: None declared

NEWS:
Tooke inquiry calls for major overhaul of specialist training
Eaton (13 October 2007) [Full text] [PDF]
Tooke inquiry calls for major overhaul of specialist training
Post-CCT "Specialist" !
13 October 2007
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Stuart H McClelland,
SpR anaesthetics
Queen's Medical Centre, Nottingham, NG7 2UH

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Re: Post-CCT "Specialist" !

Has no one else noticed that in recommendation 37 of the MMC report, in a diagram of the proposed structure of postgraduate training, after the award of CCT is a box titled "Specialist"? Before advancing to the "Consultant" box there is a further hurdle: "Optional higher specialist exams". Will this be the final step in our journey towards a post-CCT sub- consultant post?

Competing interests: None declared

Tooke inquiry calls for major overhaul of specialist training
Re: Tooke report
12 October 2007
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D B Double,
Consultant Psychiatrist
Nofolk & Waveney Mental Health Partnership NHS Trust, Peddars Centre, Norwich NR6 5BE

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Re: Re: Tooke report

Oh no, not another major overhaul of specialist training!

Competing interests: None declared

EDITORIALS:
Modernising Medical Careers laid bare
Delamothe (13 October 2007) [Full text] [PDF]
Modernising Medical Careers laid bare
ST Depression or ST Elevation?
12 October 2007
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Chika Uzoigwe,
Dept Orthopaedics
Milton Keynes General Hospital,
Mark Bishay

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Re: ST Depression or ST Elevation?

The Tooke report, as it exposes MTAS-gate, scrutinises a time when almost the entirety of the medical community was afflicted with ST depression or ST elevation. Despite the preliminary sound bites from the report, it must not be overlooked that there were both winners and losers. After the evolution of round 1.5, most concede that generally, excellent candidates were awarded ST posts. However, unfortunately, there remained still the "tribe" of equally excellent candidates who were not such rewarded for their distinction. The report promises transparency. This is vital and will hopefully allow the excellent and not-so-excellent losers to learn why they were overlooked as well as finding fault with the system.

There is consensus that the cream should rise to the top. However after this, there should a natural and gradual sedimentation of quality rather a polarised dichotomy of have's and have-nots; excellent and unexcellent or ST depression and ST elevation. A training programme with a single point of access would jeopardise this principle.

The report promises to make uncomfortable reading for doctors and politicians alike but this catharsis is required. Now there appears to be greater collaboration between the government and medical profession, hopefully the Tooke report will take out the depression from ST training.

Competing interests: None declared

EDITORIALS:
Screening for abdominal aortic aneurysm
Greenhalgh and Powell (13 October 2007) [Full text] [PDF]
Screening for abdominal aortic aneurysm
Screening for abdominal aortic aneurysm
13 October 2007
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Hisato Takagi,
Consultant cardiovascular surgeon
Shizuoka Medical Centre, Shizuoka 411-8611, Japan,
Norikazu Kawai and Takuya Umemoto

Send response to journal:
Re: Screening for abdominal aortic aneurysm

In their Editorials, Greenhalgh and Powell(1) cited a recent Cochrane review(2) which reported that screening asymptomatic people for abdominal aortic aneurysm (AAA) significantly reduced not all-cause but AAA-related mortality in men aged 65-79 years. The review,(2) however, excluded the more recent over 15-year follow-up in the Chichester study,(3) median 9.6-year follow- up in the Viborg Country study,(4) and mean 7.1-year follow-up in the Multicentre Aneurysm Screening Study (MASS).(5) Therefore, we(6) performed a meta-analysis of currently available longest follow-up results (both AAA - related and all-cause mortality) of randomized controlled studies of screening for AAA in men.

Our comprehensive search identified four reports: the Chichester study (over 15-year follow-up),(3) the Viborg Country study (median 9.6-year follow- up), (4) the Western Australia study (median 3.6-year follow-up),(7) and the MASS (mean 7.1-year follow-up).(5) Pooled analysis of the four reports demonstrated a statistically significant reduction in both AAA-related (risk difference, ?|0.25%; 95% CI, ?|0.46% to ?|0.04%) and all-cause (risk difference, ?| 1.06%; 95% CI, ?|1.81% to ?|0.31%) mortality with screening relative to control in a random-effects model.(6)

In conclusion, our meta-analysis,(6) an update of the Cochrane review,(2) demonstrated that screening for AAA significantly reduced not merely AAA- related but also all-cause mortality in men aged ?†65 years.

1 Greenhalgh R, Powell J. Screening for abdominal aortic aneurysm. BMJ 2007; 335:732-3.

2 Cosford PA, Leng GC. Screening for abdominal aortic aneurysm. Cochrane Database Syst Rev 2007;(2):CD002945.

3 Ashton HA, Gao L, Kim LG, Druce PS, Thompson SG, Scott RA. Fifteen - year follow-up of a randomized clinical trial of ultrasonographic screening for abdominal aortic aneurysms. Br J Surg 2007;94:696-701.

4 Lindholt JS, Juul S, Fasting H, Henneberg EW. Preliminary ten year results from a randomised single centre mass screening trial for abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2006;32:608-14.

5 Kim LG, P Scott RA, Ashton HA, Thompson SG; Multicentre Aneurysm Screening Study Group. A sustained mortality benefit from screening for abdominal aortic aneurysm. Ann Intern Med 2007;146:699-706.

6 Takagi H, Tanabashi T, Kawai N, Umemoto T. Screening for abdominal aortic aneurysm reduces both aneurysm-related and all-cause mortality. J Vasc Surg (in press).

7 Norman PE, Jamrozik K, Lawrence-Brown MM, Le MT, Spencer CA, Tuohy RJ, et al. Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysm. BMJ 2004;329:1259.

Competing interests: None declared

EDITORIALS:
Participation in mammography screening
Schwartz and Woloshin (13 October 2007) [Full text] [PDF]
Participation in mammography screening
False positives don´t result in overdiagnosis
13 October 2007
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Christian Weymayr,
medical journalist, author of Mythos Krebsvorsorge
44623 Herne, Germany

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Re: False positives don´t result in overdiagnosis

Sir, I loved to read the editorial by Schwartz and Woloshin. But one thing is not quite correct, I think: In the table one can find the sentence "Patient has at least one false positive screening examination that results in unnecessary diagnosis and treatment for breast cancer". Overdiagnosis results from in situ- cancer and invasive cancer, that means they result not from false but from true positives. This differentiation is important because even cancer experts sometimes regard false positives and overdiagnosis as the same.

Competing interests: None declared

Participation in mammography screening
And Women Over 70, over 80?
12 October 2007
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Joseph More,
Retired
Retired

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Re: And Women Over 70, over 80?

Is there an age beyond which one should no longer have screening mammography, or colonoscopy?

It seems that few studies are being conducted on the benefit or otherwise of screening for cancer in older people. I guess that this is due to fear of being labeled an "ageist".

It would seem that there is no benefit in very early detection of a cancer that, on average, would take a significant number of years years to become clinically manifest, in a person whose life expectancy is shorter that. But I have not been able to find any data on this question.

Competing interests: None declared

EDITOR'S CHOICE:
The way of the world
Delamothe (13 October 2007) [Full text]
The way of the world
What doctors should tell their patients about CAM
12 October 2007
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Roger A Fisken,
Consultant physician
Friarage Hospital, Northallerton, DL6 1JG

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Re: What doctors should tell their patients about CAM

You are quite right to highlight the problem of excessive tolerance of CAM and your comments are particularly timely in the light of Prof Ernst's recent publication and the criticisms of CAM from the U.S.A. Is it not now time for the BMJ to commission a themed issue entitled "Why doctors should warn their patients to be sceptical of CAM"? Perhaps Prof Ernst might be invited to be guest editor.

Competing interests: None declared

VIEWS & REVIEWS:
Fluoride: a whiter than white reputation?
Griffiths (6 October 2007) [Full text] [PDF]
Fluoride: a whiter than white reputation?
Fluoride: a whiter than white reputation?
8 October 2007
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John Graham,
Executive Member
National Pure Water Association

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Re: Fluoride: a whiter than white reputation?

Dr Griffiths’ opening paragraph is not original. The following appeared in Dr George Waldbott’s book ‘Struggle With Titans’ in 1965.

“A widely used promotional story has been circulated about Akron, O.; San Francisco, Calif.; Newburgh and El-mira, N.Y.; Charlotte, N.C.; E. Lansing, Mich.; Brantford, Ont., and many other places. It goes like this: Citizens swamped city hall with complaints of illness due to drinking fluoridated water when, to everyone's dismay, it was discovered that somehow fluoridation had not, as yet, been put into operation.

Since the same events are alleged to have occurred in many cities and since, according to the story, after introduction of fluoridation in the above-named cities no further complaints were registered, the veracity of the story is doubtful.” (1)

Dr Griffiths’, claim, to have, 30 years later, looked for evidence of harm from fluoridation, cannot be taken seriously. Not least because, as a pro-fluoridationist, he had an interest in not finding evidence of harm. Investigations into possible harms from fluoridation must be independent and seen to be so.

Dr Yiamouyiannis was right to draw Dr Griffiths’ attention to the concept of confounding factors of which tea consumption is just one when considering total fluoride intake and any possible benefit to dental health. Perhaps the most significant confounding factor ignored since the 1960s is dental health expenditure. Fluoridation is claimed to be cost-effective, but this claim is not based on actual reductions in dental health expenditure as a result of fluoridation (2)(3), but on a questionable assumption that caries are reduced by 25-50% (4)(5).

Dr Griffiths needn’t look to comedians to inform him about the incidence of dental fluorosis. The York Review found that 48% of those who receive fluoridated water will suffer dental fluorosis, and 12.5% will suffer dental fluorosis so severe it will be of aesthetic concern. This equates to 750,000 UK people suffering psychological stress due to damage inflicted upon them by water companies who believe they are obliged by current legislation to administer fluorosilicic acid to their customers.

Natural fluoride is commonly calcium fluoride, a fact overlooked by Dr Griffiths. Calcium is essential for human health, and fluorine is not (6). Linking better dental health to the fluorine content in water whilst ignoring the role played by calcium was heavily influenced by fluoride-polluting US industry in the thirties. This set the scene for over 60 years of controversy, which will continue until Dr Griffiths and the fluoridation lobby accept the truth that fluoridation is medication without individual consent, and does more harm than good.

References

1. A Struggle With Titans, George L Waldbott, MD, Carlton Press, New York, 1965, pg 195.

2. NHSBSA Dental Services Division (formerly Dental Practice Board) data.

3. Preventative Dental Treatments and Dental Health Expenditure in Wolverhampton 1997 – 2002, NPWA, June 2006.

4. Water Fluoridation – an Economic Perspective, D Sanderson, YHEC, 1998

5. BASCD Surveys.

6. Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the Tolerable Upper Intake Level of Fluoride (Request N° EFSA-Q-2003-018) (adopted on 22 February 2005).

Competing interests: None declared

RESEARCH:
Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review
Pewsner et al. (6 October 2007) [Abstract] [Full text] [PDF]
Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in...
Left ventricular hypertrophy and QT dispersion in hypertensive patients
11 October 2007
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Antoni Sisó Almirall,
Associate Professor of Medicine. University of Barcelona
Les Corts and Gòtic Primary Care Centers. Barcelona. Spain,
Antoni Dalfó Baqué.

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Re: Left ventricular hypertrophy and QT dispersion in hypertensive patients

Electrocardiography (ECG) is the usual method for identifying left ventricular hypertrophy (LVH) on standard hypertensive evaluation in primary care. Usually, diagnostic criteria for LVH by 12-lead ECG use a recognized criteria such as Sokolow-Lyon, Casale/Devereux, Cornell product, Cornell voltage, or a combination of variables such as QRS voltages, QRS duration and time-voltage QRS area (1). QT dispersion (QTd), as a measure of interlead variations of QT interval duration in the ECG, may serve as a measure of variability in ventricular recovery time. QT dispersion (QTd) is a recognised predictor of sudden death in patients with hypertrophic cardiomyopathy and congestive heart failure (2). The incidence of sudden death is also increased in hypertensive population with LVH (3).

We investigated the relationship between increased left ventricular mass index (LVMI) in hypertensive patients and QT dispersion of standard electrocardiograms, and calculated the sensitivity and specificity of a QTd value for determine LVH. We analized 125 patients (41 males and 84 females) with essential hypertension. Patients with bundle branch block, coronary heart disease or patients that had receiving an antiarrhythmic drugs were excluded from the study. Standard 12-leaded electrocardiograms were measured in sinus rhythm in all 12 leads by a single blinded observer. QT intervals measurements were obtained from a image-digitalized system (Snap-Scan AGFA). QT interval was taken from the beginning of QRS complex to the end of the T wave (return to isoelectric baseline). If U wave was present, QT interval was measured to the nadir of the curve between T and U waves. QTd was defined as the difference between the maximum (QTmax) and the minimum QT interval. A rate-corrected QT dispersion (QTdc) was calculated by Bazett's formula. Echocardiografic examination was evaluated in all patients according to the recommendation of the American Society of Echocardiography. M-mode echocardiographic left ventricular mass was analysed: criterion of LVH was LVMI above 134 gm/m2 in men and above 110 gm/m2 in women (4). Results are expressed as mean (SD) and statistical analysis was done by using the SPSS software package. Linear regression analysis was performed between all measured variables. QTd accurancy was analized using receiver operating characteristic (ROC) curves analysis.

There were 78 patients (62.4%) with LVH. The mean age were 64.3 (9.6 years), range 29 to 82. The Pearson’s correlation coefficient (r) between QTd and LVMI, QTdc and LVMI and QTmax and LVMI were 0.54 (p < 0.0001), 0.50 (p < 0.0001) and 0.34 (p < 0.0001), respectively. Test performance of QTd for identification of LVH was better in women than in men, with higher areas under the ROC curves in women (0.82 in women and 0.80 in men). In men, a QTd of 48.0 miliseconds provided a sensitivity of 89.5% (66.9-98.7) and specificity of 59.1% (36.4-79.3); otherwise, in women a QTd of 43.6 miliseconds provided a sensitivity of 83.05% (71-91.6) and a specificity of 64% (42.5-82).

These findings suggest that QTd is a useful noninvasive parameter for LVH detection in hypertensive patients, and may play an important role for improve identification of LVH by 12- lead ECG compared with other electrocardiographic criterias.

References.

1. Okin PM, Roman MJ, Devereux RB, Pickering TG, Borer JS, Kligfield P. Time-voltage QRS Area of the 12-lead electrocardiogram. Detection of left ventricular hypertrophy. Hypertension 1998;31:937-942.

2. Barr CS, Naas A, Freeman M, Lang CC, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. The Lancet 1994; 343:327-9.

3. Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Int Med 1991; 114:345-52.

4. Devereux RB, Reicheck N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of a method. Circulation 1977; 55:613-18.

Competing interests: None declared

Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in...
Correction to response posted on October 07 by Vanezis and Bhopal
10 October 2007
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Andrew Peter Vanezis,
Foundation Doctor
Colchester General Hospital, CO4 5JL,
Raj Bhopal

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Re: Correction to response posted on October 07 by Vanezis and Bhopal

Rapid response article to Pewsner et al.1

Ethnicity is relevant to judging ECG criteria for left ventricular hypertrophy

Pewsner et al highlight the danger of using the ECG for detecting left ventricular hypertrophy (LVH), particularly as the sensitivity of the tests is poor. They conclude that no criteria are superior to the Sokolow -Lyon criteria.2 Our recent review supports the first, but not the second conclusion.

Bourdillon et al pointed to the need to take into account age, gender and ethnicity.3 We identified five suitable studies in systematic review in the literature, which compared the sensitivity and specificity of the ECG (using the Sokolow-Lyon and Cornell criteria) for detecting LVH in African origin and White population groups.4-8

Specificity was high using two sets of criteria in the White groups (Cornell: 87.4%; Sokolow-Lyon: 88.9%) but was much lower in the African origin group using the Sokolow-Lyon criteria (72.1%). Specificity was higher for the African origin group using the Cornell criteria (86.2%). There was also some evidence that Cornell criteria were better for African origin populations than Sokolow-Lyon for sensitivity.

Our evidence favours the Cornell criteria over the Sokolow-Lyon criteria. While we agree with Pewsner et al that the ECG is not sufficient for diagnosing LVH we emphasise that it does not have equivalent validity across ethnic groups, which is important in our modern, multi-ethnic and globalised society .

1. Pewsner D, Jüni P, Egger M, Battaglia M, Sundström J, Bachmann LM. Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. doi:10.1136/bmj.39276.636354.AE2.

2. Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J 1949;37:161-863.

3. Peter J Bourdillon. QRS voltage criteria for LVH can be useful. Response to Pewsner D, Jüni P, Egger M, Battaglia M, Sundström J, Bachmann LM. Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. doi:10.1136/bmj.39276.636354.AE

4. Okin PM, Wright JT, Nieminen MS, Jern S, Taylor AL, Phillips R, et al. Ethnic differences in electrocardiographic criteria for left ventricular hypertrophy: the LIFE study. American Journal of Hypertension 2002;15(8):663-671.

5. Chapman JN, Mayet J, Chang CL, Foale RA, Thom SAM, Poulter NR. Ethnic differences in the identification of left ventricular hypertrophy in the hypertensive patient. American Journal of Hypertension 1999;12(5):437.

6. Rautaharju PM MT, Siscovick D, Zhou SH, Gardin JM, Kronmal R, Furberg CD, Borhani NO, Newman AB. The CHS Collaborative Research Group. Classification accuracy of electrocardiographic criteria for left ventricular hypertrophy in normal weight and overweight older adults. Annals of Noninvasive Electrocardiology 1996;1:121-132.

7. Crow RS, Prineas RJ, Rautaharju P, Hannan P, Liebson PR. Relation Between Electrocardiography and Echocardiography for Left Ventricular Mass in Mild Systemic Hypertension (Results from Treatment of Mild Hypertension study). The American Journal of Cardiology 1995;75(17):1233.

8. Lee DK, Marantz PR, Devereux RB, Kligfield P, Alderman MH. Left ventricular hypertrophy in black and white hypertensives. Standard electrocardiographic criteria overestimate racial differences in prevalence. JAMA 1992;267(24):3294-3299.

Competing interests: None declared

Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in...
Ethnic variations in the ECG
7 October 2007
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Andrew P Vanezis,
Foundation Doctor
Colchester General Hospital, CO4 5JL,
Raj Bhopal

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Re: Ethnic variations in the ECG

Rapid response article to Pewsner et al.(1)

This article does a good job at highlighting the danger of using the ECG as a sole diagnostic tool for detecting left ventricular hypertrophy (LVH) and subsequent cardiovascular risk status. Its main conclusions are that the current commonly used ECG criteria should not be used to rule out LVH i.e. the sensitivity of the tests are poor. Furthermore the paper shows that none of the more modern criteria are superior to the Sokolow- Lyon criteria which was devised almost 60 years ago and defines LVH as a total voltage in SV1 + RV5/6 of greater than 3.5 mV.(2)

However we agree with Bourdillon et al assessments that this article has not stratified the data to take into account age, gender and ethnicity.(3) Referring specifically to ethnicity, the literature shows that ethnic variation influences the accuracy of ECG criteria used to detect LVH is significant.

A recent review undertaken by the authors identified five suitable studies in the literature which looked at ethnicity (specifically African origin and White population groups) and how this factor affects the sensitivity and specificity of the ECG (using the Sokolow-Lyon and Cornell criteria) for detecting LVH.(4-8)

The main finding of our review was that the Sokolow-Lyon criteria are less specific for LVH in African origin people than in White people. When the results are taken as a whole they mirror the results obtained by Pewsner et al i.e. the specificity for these tests are good but the sensitivity is poor. However there were slightly higher sensitivity values for the African origin group (Cornell: 31.2%; Sokolow-Lyon: 32.9%) compared to the White group (Cornell: 26.5%; Sokolow-Lyon: 18.2%).

Specificity was high using both criteria in the White groups (Cornell: 87.4%; Sokolow-Lyon: 88.9%) but was much lower in the African origin group using the Sokolow-Lyon criteria (72.1%). Specificity was high however for the African origin group using the Cornell criteria (86.2%).

Pewsner et al shows that the Sokolow-Lyon index remain the best ECG criteria for the detection of LVH in hypertensive patients when taken as a whole. When contrasting the diagnostic accuracy of the Cornell and Sokolow -Lyon criteria across different ethnic groups, our evidence favours the Cornell criteria over the Sokolow-Lyon criteria in research and service contexts. However overall we agree with Pewsner et al that the ECG is not sufficient and would like to add to that the fact that it does not have equivalent validity across ethnic groups, which is important in the modern world where the mixing of different ethnic population groups calls for clarity in this issue.

1. Pewsner D, Jüni P, Egger M, Battaglia M, Sundström J, Bachmann LM. Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. doi:10.1136/bmj.39276.636354.AE2.

2. Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J 1949;37:161-863.

3. Peter J Bourdillon. QRS voltage criteria for LVH can be useful. Response to Pewsner D, Jüni P, Egger M, Battaglia M, Sundström J, Bachmann LM. Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. doi:10.1136/bmj.39276.636354.AE

4. Okin PM, Wright JT, Nieminen MS, Jern S, Taylor AL, Phillips R, et al. Ethnic differences in electrocardiographic criteria for left ventricular hypertrophy: the LIFE study. American Journal of Hypertension 2002;15(8):663-671.

5. Chapman JN, Mayet J, Chang CL, Foale RA, Thom SAM, Poulter NR. Ethnic differences in the identification of left ventricular hypertrophy in the hypertensive patient. American Journal of Hypertension 1999;12(5):437.

6. Rautaharju PM MT, Siscovick D, Zhou SH, Gardin JM, Kronmal R, Furberg CD, Borhani NO, Newman AB. The CHS Collaborative Research Group. Classification accuracy of electrocardiographic criteria for left ventricular hypertrophy in normal weight and overweight older adults. Annals of Noninvasive Electrocardiology 1996;1:121-132.

7. Crow RS, Prineas RJ, Rautaharju P, Hannan P, Liebson PR. Relation Between Electrocardiography and Echocardiography for Left Ventricular Mass in Mild Systemic Hypertension (Results from Treatment of Mild Hypertension study). The American Journal of Cardiology 1995;75(17):1233.

8. Lee DK, Marantz PR, Devereux RB, Kligfield P, Alderman MH. Left ventricular hypertrophy in black and white hypertensives. Standard electrocardiographic criteria overestimate racial differences in prevalence. JAMA 1992;267(24):3294-3299.

Competing interests: None declared

RESEARCH:
Effectiveness of interventions to promote physical activity in children and adolescents: systematic review of controlled trials
van Sluijs et al. (6 October 2007) [Abstract] [Full text] [PDF]
Effectiveness of interventions to promote physical activity in children and adolescents:...
Promoting active life styles in our children
10 October 2007
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Ediriweera Desapriya,
Research Associate
Department of Pediatrics, Centre for Community Child Health Research 4480 Oak Street V6H 3V4,
G.Scime,S.Subzwari and I. Pike

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Re: Promoting active life styles in our children

We read with interest this week’s BMJ systematic review on physical activity promotion interventions of children and youths (1) but the review lack of deserves attention for several potentially important physical activity behaviors. (2) Encouraging active transport is one way to increase overall levels of physical activity. (2) Walking and cycling are two forms of physical activity that meet the metabolic criteria for achieving health benefits from exercise. (3)

Walking or cycling can be fitting more easily into everyday life and life’s tasks than the addition of recreational exercise with its extra time and cost commitments. Walking has the further benefit of being available to most people regardless of income, location or age. (4) Therefore walking is basic forms of transportation that are accessible to virtually all humans in the world.

However, children's independent mobility is greatly influenced by traffic and parents' real and perceived concerns about safety. (2) The epidemic of childhood obesity has been attributed largely to sedentary life styles. Therefore it is critical to identify the barriers and potential effective strategies for surmounting the problems that hinder walking and cycling. (5, 6) One recent study in US explored the question why children don’t walk to school more often. Parents reported multiple barriers that inhibit walking and biking to school as follows: long distances (55%), traffic danger (40%), weather (24%), crime (18%), and school policy (7%). Similarly, in UK a recent study shows that 85% of parents were worried about traffic danger on the journey to school. (5) Parents discouraging their children from walking and cycling to school because they are worried about the dangers from traffic (7)

Cost-benefit analysis of using safe bike/pedestrian trails in Lincoln, Nebraska, to reduce health care costs associated with inactivity was conducted. The cost-benefit ratio was 2.94, which means that every $1 investment in trails for physical activity led to $2.94 in direct medical benefit. Therefore, building trails is cost beneficial from a public health perspective. (8)

Contemporary health promotion places considerable emphasis on creating supportive environments (9). Consistent with this trend, there have been calls for greater consideration of the physical environment in physical activity research and practice (10).

REFERENCES:

(1) Van Sluijs E.M.F., McMinn A.M., Griffin S.J. Effectiveness of interventions to promote physical activity in children and adolescents: systematic review of controlled trials. BMJ 2007 doi: 10.1136/bmj.39320.843947.BE

(2). Giles-Corti, B., Salmon, J. Encouraging children and adolescents to be more active. BMJ 2007; 335: 677-678

(3) Desapriya E, Pike I, Babul S., Health benefits of physical activity. CMAJ. 2006; 26; 175(7):776

(4) Mason, C. Transport and health: en route to a healthier Australia. Medical Journal of Australia 2000; 172:230-232

(5) Rowland D., DiGuiseppi C., Gross M., Afolabi E., Roberts I. Randomized controlled trial of site specific advice on school travel patterns. Arch Dis Child 2003; 88: 8-11

(6). Desapriya E.B., Pike I., Basic A., Subzwari S. Deterrent to healthy lifestyles in our communities. Pediatrics. 2007;119(5):1040-2

(7) British Medical Association Board of Science and Education. Injury prevention. London: BMA, 2001.

(8). Wang G, Macera CA, Scudder-Soucie B, Schmid T, Pratt M, Buchner D. A cost-benefit analysis of physical activity using bike/pedestrian trails. Health Promot Pract. 2005; 6(2):174-9.

(9). World Health Organization (WHO).The Ottawa Charter for health promotion. Health Promotion International, 1986;1, 3–5.

(10). Sallis, J.F., Owen, N., 1990. Ecological models. In: Glanz, K., Lewis, F.M. and Rimer, B.K. Editors, 1990. Health behavior and health education: Theory, research, and practice (2nd ed.)Jossey-Bass, San Francisco, pp. 403–424.

Competing interests: None declared

Effectiveness of interventions to promote physical activity in children and adolescents:...
Physical activity in childhood and adolescence
5 October 2007
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Joav Merrick,
Medical director
National Institute of Child Health and Human Development, Jerusalem, Israel,
Isack Kandel, Meir Lotan, and Hatim A Omar

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Re: Physical activity in childhood and adolescence

EDITOR---Physical fitness and exercise are important aspects of health and well-being of persons of all ages. Earlier there has been a focus on intensive and vigorous exercise, but regular walking and other moderate physical activities have also been beneficial (1). A recent systematic review (2) from the Institute of Metabolic Science in Cambridge looked at 57 studies to determine the effectiveness of interventions to promote physical activity in children and adolescents. They found that multi-component interventions, which included both school, family or community had the greatest potential for being effective.

PHYSICAL ACTIVITY OVER TIME

Tracking physical fitness and activity over time will make our understanding better concerning when children settle into their long-term exercise and fitness patterns. It will also provide information as to when to initiate programs focusing on preventing sedentary adults behaviors. One study (3) tracked physical fitness and physical activity over a five year period with children and adolescents in Muscatine, Iowa, USA. They examined 126 pre- or early-pubescent children (mean age boys 10.8 yr and girls 10.3 yr). Physical fitness was measured using direct determination of oxygen uptake and maximal voluntary isometric contraction, while physical activity was assessed via questionnaire. Boys classified as sedentary based on initial measurements of TV viewing and video game playing were 2.2 times more likely than their peers to also be classified as sedentary at follow-up. Tracking of most physical fitness and physical activity variables was moderate to high, indicating some predictability of early measurements for later values. Sedentary behavior tracked better in boys, whereas vigorous activity tended to track better in girls. These observations suggested that preventive efforts focused on maintaining physical fitness and physical activity through puberty will have favorable health benefits in later years.

A longitudinal study from Belgium of Flemish males from 18 to 40 years of age followed 130 males from age 13 to age 18 years with remeasure at the ages of 30, 35, and 40 years (4). Physical fitness showed the highest stability in flexibility (r = 0.91 between 18 and 30 years, r = 0.96 for both the 30-35 and 35-40 ages intervals), while physical activity showed the highest stability during work (r between 0.70 and 0.98 for the 5-year intervals). Results indicated that for some fitness characteristics the high-active subjects were more fit than their low-active peers. Although possible confounding factors were present (e.g., heredity), a higher level of physical activity during work and leisure time on a regular basis benefited physical fitness considerably.

Another study from Michigan (5) examined whether organized sports participation during childhood and adolescence was related to participation in sports and physical fitness activities in young adulthood. The analyses included more than 600 respondents from three waves of data (age 12, age 17, and age 25). Childhood and adolescent sports participation was found to be a significant predictor of young adult participation in sports and physical fitness activities.

A study from New Jersey (6) looked at the outcomes of an exercise program directed towards Black and Hispanic college-age women. Forty-four women (36 Black, seven Hispanic and one Black/Hispanic) attended exercise classes three times per week for 16 weeks. Compared to low attendees, the high attendees had significantly higher exercise self-efficacy (p <.001), perceived benefits and barriers (p =.004), aerobic fitness, flexibility, muscle strength and percentage of body fat (all p <.001). Daily activity levels improved significantly in the high attendance group following the program (p <.001) and at eight weeks post-program completion (p =.01).

ADOLESCENT PHYSICAL FITNESS IN ISRAEL

In a study of 13 year olds during 1984-1985 from five Jerusalem public schools physical ability was defined in the biological dimension by the running time for 1000 meters and in the psychological dimension by sport motivation (7). The intervention program involved a periodic and progressive increase of physical effort of children in 16 gym lessons during the regular curriculum. The test group improved their running time and had better sport motivation than the control group with differences between boys and girls and an influence of sexual maturation on running time in girls.

As a participant in the World Health Organization (WHO) cross national study on health behaviors in school aged children (HBAC) initiated in 1982 data has also been available for Israel on exercise (8,9). The last results from 1997/98 (9) showed that 76% of 15 year olds males in Israel (in the US: 74%) and 48% of females (US: 54%) exercised twice a week or more.

CONCLUSIONS

Body composition, cardiovascular fitness, strength and fexibility will all benefit from physical exercise and fitness. Intervention and prevention programs should ensure that fitness in adolescence be continued in adult and later life to maximize well-being and health (10).

AFFILIATIONS

Joav Merrick, MD, MMedSci, DMSc, is professor of pediatrics, child health and human development affiliated with Kentucky Children’s Hospital, University of Kentucky, Lexington, United States and the Zusman Child Development Center, Division of Pediatrics, Soroka University Medical Center, Ben Gurion University, Beer-Sheva, Israel, the medical director of the Division for Mental Retardation, Ministry of Social Affairs, Jerusalem, the founder and director of the National Institute of Child Health and Human Development. Numerous publications in the field of pediatrics, child health and human development, rehabilitation, intellectual disability, disability, health, welfare, abuse, advocacy, quality of life and prevention. Received the Peter Sabroe Child Award for outstanding work on behalf of Danish Children in 1985 and the International LEGO-Prize (“The Children’s Nobel Prize”) for an extraordinary contribution towards improvement in child welfare and well- being in 1987. E-Mail: jmerrick@internet-zahav.net. Website: www.nichd- israel.com

Isack Kandel, MA, PhD, is senior lecturer/assistant professor at the Faculty of Social Sciences, Department of Behavioral Sciences, Ariel University Center at Samaria, Ariel. During the period 1985-93 he served as the director of the Division for Mental Retardation, Ministry of Social Affairs, Jerusalem, Israel. Several books and numerous other publications in the areas of rehabilitation, disability, health and intellectual disability. E-mail: kandelii@zahav.net.il

Meir Lotan, BPT, MScPT, is a physiotherapist working as lecturer at the School of Health Sciences, Department of Physical Therapy, Ariel University Center of Samaria, Ariel, affilated with the Israeli National Rett Syndrome evaluation team and director of the Therapeutic Department, Zvi Quittman Residential Center, Millie Shime Campus, Elwyn, Jerusalem. He has a special interest in physiotherapy and persons with intellectual disability, Snoezelen and physical activity for children and adults with intellectual disability with an emphasis on individuals with Rett syndrome. Awarded in 2000 by the IRSA (Int Rett Syndr Ass) for his service to individuals with Rett syndrome. Numerous publications in international peer-reviewed journals in his areas of interest. E-mail: ml_pt_rs@netvision.net.il

Hatim A Omar, MD, Professor of Pediatrics and Obstetrics and Gynecology and Director of the Section of Adolescent Medicine, Department of Pediatrics, University of Kentucky, Lexington. Dr. Omar has completed residency training in obstetrics and gynecology as well as Pediatrics. He has also completed fellowships in vascular physiology and adolescent medicine. He is the recipient of the Commonwealth of Kentucky Governor’s Award for Community Service and Volunteerism and is well known internationally with numerous publications in child health, pediatrics, adolescent medicine, pediatric and adolescent gynecology. Email: haomar2@uky.edu Website: http://www.ukhealthcare.uky.edu/kch/physicians/omar.htm

REFERENCES

1. US Department of Health and Human services. Physical activity and health: A report of the Surgeon General. Atlanta, GA: Centers for Disease Control and Prevention (CDC), Nat Center Chr Disease Prev Hlth Prev, 1996.

2. van Sluijs EMF, McMinn AM, Griffin SJ. Effectiveness of interventions to promote physical activity in children and adolescents: Systematic review of controlled trials. BMJ 2007335:703-15.

3. Janz KF, Dawson JD, Mahoney LT. Tracking physical fitness and physical activity from childhood to adolescence: the muscatine study. Med Sci Sports Exerc 2000;32(7):1250-7.

4. Lefevre J, Philippaerts RM, Delvaux K, Thomis M, Vanreusel B, Eynde BV, Claessens AL, Lysens R, Renson R, Beunen G. Daily physical activity and physical fitness from adolescence to adulthood: A longitudinal study. Am J Hum Biol 2000;12(4):487-97.

5. Perkins DF, Jacobs JE, Barber BL, Eccles JS. Childhood and adolescent sports participation as predictors of participation in sports and physical fitness activities during young adulthood. Youth Society 2004;35(4):495-520.

6. D'Alonzo KT, Stevenson JS, Davis SE. Outcomes of a program to enhance exercise self-efficacy and improve fitness in Black and Hispanic college-age women. Res Nurs Health 2004;27(5):357-69.

7. Halfon ST, Bronner S. The influence of a physical ability intervention program on improved running time and increased sport motivation among Jerusalem schoolchildren. Adolescence 1988;23(90):405-16.

8. Harel Y, Kani D, Rahav G. Health behaviors in school-aged children (HBSC): A World Health Organization cross national study. Jerusalem: JDC- Brookdale Institute, 1997.

9. Currie C, Hurrelmann K, Settertobulte W, Smith R, Todd J, eds. Health and health behaviour among young people. WHO Policy Series: Health policy for children and adolescents Issue 1, WHO Regional Office for Europe, Copenhagen, 2000.

10. Lotan M, Merrick J, Carmeli E. Physical activity in adolescence. A review with clinical suggestions. Int J Adolesc Med Health 2005;17(1):13 -21.

Competing interests: None declared

ANALYSIS:
Adding fluoride to water supplies
Cheng et al. (6 October 2007) [Full text] [PDF]
Adding fluoride to water supplies
Fluoridation and aluminium
13 October 2007
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Christopher Exley,
Reader
Keele University ST5 5BG

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Re: Fluoridation and aluminium

I was surprised that no mention was made of the role that fluoride plays in increasing human exposure to aluminium via gastrointestinal absorption? Aluminium binds fluoride with great avidity and fluoride in drinking water will both facilitate the gastrointestinal absorption of aluminium which is coincidentally present in drinking water but more importantly it will increase the absorption of aluminium from ingested foodstuffs and other beverages. Fluoridation of the potable water supply will lead to higher human body burdens of aluminium. Whether a higher body burden of aluminium should be avoided is, of course, another debate.

Competing interests: None declared

Adding fluoride to water supplies
A question of the common good
12 October 2007
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C Albert Yeung,
Consultant in Dental Public Health
Lanarkshire NHS Board, Hamilton ML3 0TA

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Re: A question of the common good

Cheng et al questioned the ethical issue of water fluoridation surrounding informed consent and human rights. [1] However, there is another side of the coin.

Clearly there is scope for different points of view on the ethics of any major issue of public policy, including water fluoridation. Anyone who takes up the position that the individual has the right to decide the precise composition of water supply is unlikely to accept water fluoridation as anything less than an intrusion. Does that mean he or she can prevent the chlorination of water simply because of a personal aversion to chlorine? [2]

Drinking fluoride-free water is not a basic human right but a question of individual preference. In a society where people come together for mutual benefit, it is a question of balancing such personal preferences against the common good arising from the lower levels of tooth decay which water fluoridation brings.

Individuals cannot make decisions about the composition of the public water supply. These decisions must be made at the community level. The minority who have an ideological objection to water fluoridation do not have a right to impose excess risk on the majority, just because of their personal preference. It could be argued that where there is majority community support, it is unethical not to fluoridate water supply.

1 Cheng KK, Chalmers I, Sheldon TA. Adding fluoride to water supplies. BMJ 2007; 335: 699-702. (6 October.)

2 British Fluoridation Society. One in a Million – the facts about water fluoridation. Manchester: British Fluoridation Society, 2004.

Competing interests: None declared

Adding fluoride to water supplies
Water fluoridation and bladder cancer
10 October 2007
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Raymond J Lowry,
Senior Lecturer in Dental Public Health
University of Newcastle NE2 4BW

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Re: Water fluoridation and bladder cancer

Cheng and his colleagues argue that fluoridation might possibly pose a cancer risk and cite a study from Taiwan by Yang et al(1) to support their contention. The Taiwan study compared ten municipalities with a mean natural fluoride level in the water supply of 0.24mg/litre with ten matched municipalities with a fluoride level of <0.01mg/litre. (There are no artificially fluoridated supplies in Taiwan.) Yang et al made twenty-six site-specific comparisons, and in one of these comparisons showed in females a statistically significant (P <0.05 ) increase in bladder cancer.

Yang et al suggested that it was biologically implausible for water fluoridation to cause bladder cancer in females and not in males, and that with multiple comparisons one significant difference might have been due to chance. The authors concluded that overall their study, supporting the views of many others “does not provide evidence that fluoridation of the water supplies is associated with an increase in cancer mortality in Taiwan”.

Ray Lowry BDS MBChB FFPH

References

1. Yang CY, Cheng MF, Tsai SS, Hung CF. Fluoride in drinking water and cancer mortality in Taiwan. Environ. Res. 2000;82(3):189-193.

Competing interests: None declared

Adding fluoride to water supplies
By all means, fluoridate. I’ll just refuse to drink it. - Oct 2007
10 October 2007
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Phillip J Colquitt,
Technicain/RN
Independent Comment

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Re: By all means, fluoridate. I’ll just refuse to drink it. - Oct 2007

As a well filled customer of various GP dentists here in Australia, I can say that it is the dentist himself who is currently the main threat to my teeth. Not, as this discussion might suppose, the non-fluoridated state of the water here in Brisbane. Given that having water at all is a far greater concern in this sunburnt country.

Taking myself to three different GP dentists, I got three different opinions. It’s truly amazing the offhand way that one said “that tooth probably needs to come out”, while the other two said no such thing about a perfectly well tooth. A specialist prosthodontist was utterly dismissive of the GP dentist’s extraction plan, leaving me with an impression of GP dentists as “wanting work”.

Many young folk I’ve met here in Brisbane have perfect teeth, so I feel the pro-fluoride lobby are focused on the negative outcome – those with cavities. The discussion would be far more interesting if it revealed the non-cavitated individual’s fluoridation supplementation technique, if any occurred at all. Further, it cannot be assumed that fluoride in water ends up in people, since water is often filtered, as is my own supply. I don’t know anyone who drinks tap water.

Dentists have been separate from medicine’s mainstream, in “dental” schools, when they might reasonably be called “minor orthopaedic surgeons”(of the mouth). Tooth is bone. Possibly due to this “dental” isolation, many readers may not know of the old dental practice of “extension for prevention[1]” – this basically means that you get a filling where you don’t need one, because the dentist is allowed to do that. The theory is/was that the filling material is more impervious to cavitation than natural tooth. And now you’re getting fluoride you don’t need, because the government is allowed to do that(proposed).

By all means, fluoridate. I’ll just refuse to drink it.

1: Rossomando EF. Minimally invasive dentistry and the dental enterprise. Compend Contin Educ Dent. 2007 Mar;28(3):166, 168. PMID: 17385399 [PubMed - indexed for MEDLINE]

Competing interests: None declared

Adding fluoride to water supplies
It's time for a moratorium on fluoridation
10 October 2007
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Barry A Groves,
Independent Researcher, maintains www.second-opinions.co.uk
OX7 6LP

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Re: It's time for a moratorium on fluoridation

Recently the BMJ debated ‘informed consent’. Not long ago, we were also instructed on ‘the precautionary principle’ and advised to err on the side of caution. Both of these principles are highly relevant in the present climate of pharmaceutical companies’ and other commercial influences over medical practice, and medical practitioners.

Cheng et al’s paper on the enduring controversy surrounding water fluoridation is a case in which both of the principles above should be considered.

There are thousands of studies into the benefits and adverse side effects of fluoridation. As Cheng et al say, these studies are not of the best quality. But this, in itself, should make us reconsider a practice aimed at whole populations.

Many adverse effects of fluoridation have been cited. Let us just explore one: cancer.

In the 1970s, a comparison between the ten largest fluoridated cities and the ten largest non-fluoridated cities of the USA showed that, while cancer rates had been similar initially, after twenty years the fluoridated cities had 10% more cancer deaths than the non-fluoridated ones.[1] These figures were checked and confirmed in 1976 by the US National Cancer Institute.

The incidence of registered cancers in communities in USA (WHO, 1987) and the Fluoridation Census 1985 by the US Department of Health and Human Services enabled scientists to conduct an epidemiological analysis of the correlation between the two in the United States. They found significant correlations in both sexes between water fluoridation and numbers of cancers of the digestive system (tongue, mouth, pharynx, oesophagus, stomach, colon, rectum and pancreas), the respiratory system (larynx, bronchi and lungs), and the renal system

In the sexual organs, contradictions were seen. In women, cancers of the breast, cervix and ovary were increased in fluoridated areas whereas in males those of the prostate, testis and penis were apparently inhibited. The authors considered that the different fluoride effects suggest a possible mode of action of fluoride as an environmental hormone. The dose-response relationship between the numbers of bone cancers in male teenagers and the amount of fluoridation was statistically significant. These significant relationships indicated that fluoride may not be an initiator but a promoter of cancer.[2]

Because of concerns that fluoride might cause cancer, in 1977 the US Congress ordered the US Public Health Service to conduct the National Toxicology Program animal study. The results were published in 1990.[3] The study showed that sodium fluoride caused osteosclerosis, oral tumours, osteosarcoma and hepatocholangiocarcinoma at cumulative doses comparable to those ingested by humans over a number of years.

In the light of the NTP study on rodents and epidemiolog­ic evidence of an increase in osteosarcoma in boys and young men, especially in fluoridated areas, Dr. Perry Cohn of the New Jersey Department of Health surveyed its incidence in seven counties of New Jersey relative to water fluoridation. He found that in the fluoridated areas, the incidence of osteosar­coma in boys was up to 4.6 times higher than in the unfluorid­ated areas.[4] In a similar study of three New Jersey municipalities, the figures were up to nearly seven times as high in the fluoridated areas. Cohn also found that the general population in those areas was also five times as likely to suffer a cancer.

Cohn’s findings were confirmed in 2001 when Harvard student Elise Bassin was awarded her PhD. Her thesis was based on some brilliant work which showed that young boys being exposed to fluoride in their 6th, 7th and 8th years had a 7-fold increase in osteosarcoma. This important discovery should have been made available immediately. However, it wasn’t until 4 years later that it came to light.[5] It was suspected that this delay might be because of an attempted cover-up of her findings by her professor, Chester Douglass. Chester Douglass has connections with Colgate.[6]

In 1996 a Japanese study linked fluoride with uterine cancer.[7] This was hotly disputed, but there is no denying that when fluoridation ceased, the numbers of cases of uterine cancer went down.

Surely there is sufficient here to invoke the precautionary principle, to mandate a halt to current fluoridation and to postpone any proposed future fluoridation schemes at least until such time as it can be shown without any doubt that fluoridation is safe.

And as the BFS and others continue to deny any adverse effects from fluoridation, how are health advisers and medical practitioners to adopt a precautionary, and how can members of the public, who are to be consulted before any new fluoridation schemes are agreed, to be able to give informed consent.

References

1. Yiamouyiannis JA, Burk D. Fluoridation of public water systems and the cancer death rate in humans. Presented at the 67th Annual Meeting of the American Society of Biologists and Chemists and the American Society of Experimental Biologists. June 1976.

2. K. Takahashi K, Akiniwa K, Narita K. Cancer-promoting power of fluoridation. Paper by presented at the 1998 Bellingham Conference of the International Society for Fluoride Research.

3. Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice. National Toxicology Program Technical Report TR 393: NIH, U.S. Department of Health and Human Services, 1990.

4. Cohn PD. A brief report on the association of drinking water fluoridation and the incidence of osteosarcoma among young males. N J Dept of Hlth, Trenton, New Jersey. Nov 8, 1992.

5. Bassin EB, Wypij D, Davis RB, Mittleman MA. Age-specific fluoride exposure in drinking water and osteosarcoma (United States). Cancer Causes Control 2006; 17: 421-8.

6. "Professor at Harvard Is Being Investigated: Fluoride-Cancer Link May Have Been Hidden". Washington Post, Wednesday, July 13, 2005; Page A03 http://www.washingtonpost.com/wp-dyn/content/article/2005/07/12/AR2005071201277.html

7. Tohyama E. Relationship between fluoride concentration in drinking water and mortality rate from uterine cancer in Okinawa prefecture, Japan. J Epidemiol 1996; 6: 184-191.

Competing interests: Author of "Fluoride: Drinking oourselves to death?"

Adding fluoride to water supplies
Adding fluoride to water supplies
9 October 2007
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Dr Barry Cockcroft,
Chief Dental Officer for England
Department of Health, New Kings Beam House, 22 Upper Ground, London, Se1 9BW

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Re: Adding fluoride to water supplies

Dear Dr Godlee

‘Adding Fluoride to Water Supplies’ (Cheng KK. et al. BMJ, 6 October)

We welcome the opportunity presented by the paper Adding Fluoride to Water Supplies (Cheng, Chalmers and Sheldon, 2007) to restate our view that fluoridation has already made a major contribution to reducing the burden of dental disease and offers the potential for addressing persistent inequalities in oral health. We recognise that, as with other health measures, safety should continue to be monitored and the ethical dimension discussed.

Naturally, we wish first to address the doubts expressed in the paper about the Department of Health’s objectivity. It was of course the Department of Health, which, in 1999, commissioned the University of York to undertake a systematic review of fluoridation. We responded to the report with a commitment to sponsor further research strengthening the evidence base on fluoridation. In 2001, we asked the Medical Research Council to identify and prioritise the research required to inform public policy on fluoridation. Then, in 2003, in accordance with the MRC recommendations, we commissioned the University of Newcastle to investigate the bioavailability of fluoride from artificial and natural sources.

The Newcastle study contributed to better understanding of the health effects of water fluoridation. In some parts of the country, drinking water is naturally fluoridated at the level used in artificial fluoridation schemes and generations have been drinking this water without any evidence of systemic ill effects. The report of the Newcastle study (1) concluded that there were no statistically significant differences in bioavailability between artificially and naturally fluoridated water. As a result, we may continue to have confidence in the safety of fluoridation. In planning further research, we have agreed to take account of suggestions that the study be repeated with a larger sample size - within the inevitable constraints of the funding available.

We do however make no apologies for promoting the benefits of fluoridation on oral health. We have seen significant improvements in oral health in the last 30 years, but many people still suffer unnecessarily from pain and discomfort from dental disease and there are still inequalities across the country. The most serious consequence is the extraction of teeth under general anaesthetic which carries a small risk of serious injury or, very occasionally, death.

There is a strong association between oral health and social class. The probability of having decay experience in primary teeth is about 50% higher in the lowest social group compared with the highest(2). Fluoridation mitigates this association. In Sandwell, the water supply was fluoridated in 1986. Subsequently, the amount of tooth decay in children has more than halved. During the same period, Bolton, with a comparable population mix, saw little change in its children's oral health(3). This contrast is due to the beneficial effects of fluoridation as evidenced by the Systematic Review undertaken by the University of York which found that water fluoridation increases the number of children without tooth decay by 15 per cent and that on average, children in fluoridated areas have 2.25 fewer teeth affected by decay (4). This has been calculated as being equivalent to a 40% reduction in dmft/DMFT(5). There is also increasing evidence of a longer-term beneficial effect of water fluoridation on the dental health of adults with a recent meta-analysis showing a preventive reduction of 27% in dental caries in adults living in fluoridated areas(6).

All water supplies contain some fluoride, and it was from observing different patterns of dental decay in areas of differing levels of naturally fluoridated water, that the benefits of fluoride were first observed. We acknowledge that good results can be obtained from regular brushing with fluoride toothpaste. However, tooth brushing alone will not reduce inequalities in oral health because, as the paper acknowledges, use of toothpaste is dependent upon individual behaviour. Targeted fluoridation schemes based on local decision-making - we are not advocating the fluoridation of the whole country - offer greater potential because they are a population-based public health intervention.

The York report undoubtedly comprises the most comprehensive review of research on fluoridation to date. We were encouraged by the positive findings on the benefits to oral health and the absence of any demonstrable association with systemic illness but we have taken the criticisms of the quality of research very seriously. We agree that the evidence base on the effects of fluoridation on health needs strengthening. That is why, following the publication of the York review, the Department asked the Medical Research Council to assess priorities for future research in the light of the York work. The MRC reported in 2002 (7) and we are committed to a programme of further research based on that MRC advice. Nevertheless, the fact remains that the York team considered 735 research studies which met the Review’s relevance criteria and could find no evidence of an association between fluoridation and systemic illness.

Apart from the protective benefits, the only demonstrable side effect of fluoridating water is dental fluorosis. This is a cosmetic defect of tooth enamel which may range from mild flecking, often undetectable except by a dental expert, to more noticeable marking which may give a small minority of people concern about the appearance of their teeth.

With reference to the ecological study from Taiwan (8) cited in the paper, we would like to quote the conclusions reached by the study’s authors: “Our study found an excess rate of bladder cancer that was restricted to females. It seems biologically implausible for fluoride to affect cancer rates for one sex only.” This view is consistent with the Medical Research Council’s report 6 which recommended that research priorities should be determined by plausibility of effect.

The question of whether the fluorides added to water should be licensed depends upon whether they should be categorised as medicines. The Medicines and Healthcare Products Regulatory Agency consider that drinking water (whether fluoridated or not) clearly falls within the definition of 'food' for regulatory purposes and is not subject to the licensing requirements for medicines.

As the authors indicate, in purely legal terms, the ethical justification for fluoridation depends upon the extent of the benefits to public health. We are satisfied that the persistence of inequalities in oral health provides this justification. Parliament has accepted this argument. Moreover, the circumstances in which fluoridation schemes are introduced was debated in Parliament as recently as 2005 (9) when new requirements for consultations were approved by a large majority in both Houses. Strategic Health Authorities may only make arrangements with a water undertaker to fluoridate an area where they have conducted open, wide-ranging consultations.

It is right for those who carry the local responsibility for preventing disease and promoting health to consider the option of water fluoridation as an effective means of reducing the burden of dental decay especially in communities where decay levels remain unacceptably high. The benefits, safety and ethics have rightly been key issues in previous consultations on water fluoridation and will no doubt continue to be at the heart of future consultations.

Yours sincerely

Dr Barry Cockcroft
Chief Dental Officer for England

Professor Sir Liam Donaldson
Chief Medical Officer for England

References:

(1)Maguire A, Moynihan PJ, Zohouri V (2004). Bioavailability of fluoride in drinking water – a human experimental study. Report for the Department of Health, University of Newcastle

(2)Steele & Lader (2004): Social factors and oral health in children, Children’s Dental Health in the UK 2003, Office for National Statistics, London .

(3) Pitts,N.B.,et al(2005):The dental caries experience of year old children in England and Wales (2003/04) Community Dental Health 22:46-56

(4) McDonagh et al .A Systematic Review of Water Fluoridation, NHS Centre for Reviews and Dissemination, University of York 2000.

(5) Worthington,H.V. and Clarkson J. (2003) The evidence base for topical fluorides (editorial) Community Dental Health 20:74-76

(6) Griffin et al (2007): Effectiveness of Fluoride in Preventing Caries in Adults, J dent Res 86(5): 410-415

(7) Water fluoridation and Health: Report of a Medical Research Council Working Group. Medical Research Council. 2002. London

(8) Yang CY, Cheng MF, Tsia SS, Hung CF (2000). Fluoride in drinking water and cancer mortality in Taiwan. Environ Res; 82(3):189-193

(9) House of Commons Official Report. Third Standing Committee on Delegated Legislation, 25 Mrach 2005 Col 1-11.

Competing interests: None declared

Adding fluoride to water supplies
Ethics of water fluoridation
7 October 2007
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John F Beal,
Consultant in dental public health
Leeds PCT, LS16 6QG

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Re: Ethics of water fluoridation

The ethics of water fluoridation have been widely debated by experts in ethics(1 2 3), by the Courts (4 5 6), by citizens’ panels (7), and in the media. Varying, and sometimes conflicting, views have been expressed. Different people will undoubtedly take different views on ethical issues. The fact remains that fluoride confers substantial benefit to communities that receive it.

Whether water fluoridation is medication is irrelevant as the Medicines Act clearly does not apply to fluoridation which is covered in separate legislation, namely the Water Act 2003. The issue was debated in Parliament, in both Houses, and subject to a free vote. Parliament determined that decisions about the implementation of fluoridation should be made by Strategic Health Authorities after careful and widespread public consultation which could, of course, include further debate about the ethics of fluoridation.

1. Fottrell F (Chairman). Forum on Fluoridation Ireland. Dublin: Stationery Office, 2002 http://www.dohc.ie/publications/fluoridation_forum.html. 2. Harris J. The ethics of fluoridation. Liverpool: British Fluoridation Society, 1989 http://www.bfsweb.org/facts/ethics/ethicsharris.htm. 3 Holt R, Beal J and Breach J Ethical considerations in water fluoridation in Bradley P and Burls A Ethics in public and community health, Routledge, London, 2000 4. Kenny MJ. FLUORIDATION. Judgement delivered by Mr Justice Kenny in the High Court, Dublin, 1963. Dublin: Department of Health, 1963. 5. Chief Justice O'Dalaigh. FLUORIDATION. Judgement of the Supreme Court of Ireland delivered by Chief Justice O'Dalaigh 3rd July, 1964. Dublin: Department of Health, 1964. 6. Jauncey L. Opinion of Lord Jauncey {Iin causa} Mrs Catherine McColl (A.P.) against Strathclyde Regional Council. Edinburgh: The Court of Session, 1983. 7. NICE Citizens Council. Mandatory Public Health Measures. London: NICE, 2005 http://www.nice.org.uk/page.aspx?o=274599.

Competing interests: None declared

Adding fluoride to water supplies
Dental benefits of water fluoridation
5 October 2007
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Michael A Lennon,
Professor and Honorary Consultant in Dental Public Health
University of Sheffield

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Re: Dental benefits of water fluoridation

The recent paper by Cheng et al(1) questions the benefits of water fluoridation. The systematic review conducted by York CRD(2) used two outcome measures of dental benefit. Evidence rated below level B (moderate quality; moderate risk of bias) was excluded from this aspect of the review; twenty-six studies were included (all level B).

First, York showed that the proportion of caries-free children increased by 14.6% in fluoridated districts. Worthington and Clarkson(3), Co-ordinating Editor and Editor respectively of the Cochrane Oral Health Group, have described such a change in the proportion of caries- free children as “a huge reduction in caries”.

In their second calculation York CRD showed that water fluoridation reduced the extent of dental caries by a mean of 2.25 decayed, missing and filled teeth. Worthington and Clarkson(3) calculate this as equivalent to a “preventive fraction” of 40%. This is close to the figure calculated from a different data set and widely circulated by the British Fluoridation Society(4) and others since 1994.

The national caries data cited by Cheng et al hide significant regional variations, and no one to my knowledge has, over the past twenty years, proposed a “national” fluoridation programme for the UK. If we extended water fluoridation from the current 10% to around 30% of the population, there would be substantial benefits for the many disadvantaged young children living in deprived areas in the UK with the highest levels of dental caries.

Professor M. A. Lennon OBE. Chair, British Fluoridation Society

References

1. Cheng KK, Chalmers I, Sheldon TA. Adding fluoride to water supplies. British Medical Journal 2007;335:699-702. 2. McDonagh MSPF, Whiting, et al. Systematic review of water fluoridation. British Medical Journal 2000;321: 855-859. 3. Worthington HV, Clarkson J. The evidence base for topical fluorides (editorial). Community Dental Health 2003;20:74-76. 4. British Fluoridation Society. One in a Million - the facts about water fluoridation. Manchester: British Fluoridation Society, 2004 http://www.bfsweb.org/onemillion/onemillion.htm.

Competing interests: Chair (unpaid) British Fluoridation Society

Adding fluoride to water supplies
Medication with intent – the case against water fluoridation.
5 October 2007
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Douglas W Cross,
Independent Consultant in Environmental Analysis
Croft End, Lowick Bridge, Cumbria LA12 8EE

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Re: Medication with intent – the case against water fluoridation.

The medicinal nature of the product fluoridated water is not in doubt, since it conforms to both definitions of a medicinal product provided in Article 1.2 (a) and (b) of the latest version of the European Communities medicines directive [1]. It is unquestionably medicinal by presentation and by function. A number of European Court of Justice (ECJ) rulings confirm that the intent to medicate, or even deliberately giving the public the impression that a substance has medicinal properties, is the criterion defining a substance or product as ‘medicinal’:

‘If a product is represented to the public so that any averagely well-informed person gains the impression that the substance might have a beneficial effect on some medical condition, then that substance is a medicine under the terms of this Directive.’ [2]

In the Ter Voort decision the ECJ ruled that:

'A product that is recommended or described as having preventive or curative properties is a medicinal product . . . even if it is generally considered as a foodstuff and even if it has no known therapeutic effect in the present state of scientific knowledge',

The nature of a product as medicinal is established by legal definition, whereas the award of a marketing authorization by the Medicines and Healthcare Products Regulatory Authority (MHRA) is an administrative decision subject to political influence. A medicinal product is, and remains, medicinal regardless of whether or not the MHRA has awarded it a licence. The designation of fluorosilicates as source materials for fluoride in water under the Water Act 2003 does not constitute legal authority for their use as medicinal substances. Dilution is not an issue – even water for injection requires, and has, a medicinal product marketing authorisation, since it is used with the intent to medicate.

The argument that fluoridated water is a food is tenable only if it is not a medicinal product. Any food, including water, that contains a medicinal substance is regulated under the medicines directive. If fluoridated water were to be classed as a food then it would be subject to the directives regulating food supplements and/or food additives. Supplements, and the materials from which they may be derived, are strictly controlled:

'(Preamble 9) – Controversy as the identity of those nutrients that could potentially arise should be avoided. Therefore it is appropriate to establish a positive list of those vitamins and minerals.’ [3]

Annex I of the directive sets out in this positive list; the permissible sources of Annex I substances are specified in Annex II. Only the source substances identified in Annex II may be used as supplementary sources of the named vitamins and minerals. Sodium and potassium fluoride are the only authorised source materials for the ‘mineral’ fluoride. The fluorosilicates used in water fluoridation are not ‘substantially equivalent’ to ‘natural’ or any other fluorides, and are absent from Annex II.

All food supplements must be delivered to the consumer in concentrated pre-packed form. Their promotion as having medicinal properties is prohibited:

'Article 6. No food supplement – including any mineral – may be presented to the public as having medicinal properties.’

It is therefore improper to refer to fluoridated water as providing a ‘supplementary’ source of fluoride for consumers, since this implies that it is a permitted food supplement. The practice of ‘fortifying’ the fluoride content of drinking water to reach the ‘optimal’ concentration recommended for dental health protection is improper – the objective of the European Community’s water quality standards is to ensure that the quality of water is the highest possible, not the worst permissible.

When added to a food, including water, then vitamins and minerals (and certain other technical substances essential for the processing of foods) are classed as additives. The directive regulating the addition of vitamins and minerals and certain other substances to foods [4] lists all permissible food additives in Annex I. No fluoride or fluorosilicate is included in this list; their addition to any food is therefore prohibited, and this would also apply to fluoridated milk targeted at children.

Since fluoridated water is either an unlicensed medicinal product or a food containing an unauthorised additive (or, indeed, both), placing it upon the market is prohibited, and any form of advertising that the product has medicinal properties is banned. As the directives are transposed into UK (and Irish) domestic law, advertising fluoridated water as having medicinal properties is an offence. For example, Clause 3 of the UK Medicines (Advertising) Regulations 1994 [5] states:

‘No person shall issue an advertisement relating to a relevant medicinal product in respect of which no product license is in force.’

This clearly acknowledges that unlicensed medicinal products do exist, and that the absence of a product licence granted by the MHRA does not prevent such a product from being classed as medicinal in law. Similarly, rules on the labelling, presentation and advertising of foods [6] prohibit attributing any ‘preventing, treating or curing properties’ to foods. This has been interpreted by the ECJ as banning all health claims relating to human diseases. [7]

‘Publishing’ and ‘advertising’ are interpreted in extremely wide terms [8], which include issuing verbal recommendations for the adoption of fluoridation for the prevention of dental caries to health professionals, executive agencies and the general public. The ethical implications of doing so, especially for health care professionals, are serious, since offenders may be vulnerable to actions in law by any person claiming to have been damaged by the practice. The provision of ‘consultation’ processes on implementing new fluoridation schemes is also contrary to law, since there can be no debate on whether or not to commit a criminal assault upon the public. The provision of any form of professional or corporate indemnity for such liability, including that offered by the British Government to water companies[9], is at risk – there can be no indemnity for a criminal act.

References.

1. 2004/27/EC on medicines for human use (OJ L 136, 30.4.2004 p.34)

2. Case C-60/89, 21 March 1991, re Manteil and Samanni, European Court Reports 1991;I:1547; Case C219-91, 28 October 1992, re Ter Voort, European Court Reports 1992;I:5485; Case C368-88, 21 March 1991 re Delattre, European Court Reports 1991;I:1487; Case C227-82, 30 November 1983, re van Bennekom, European Court Reports 1983;3883

3. 2002/46/EC on Food Supplements (OJ L 183. 12.7.2002, p51

4. 2006/52/EC amending Directive 95/2/EC on food additives other than colours and sweeteners and Directive 94/35/EC on sweeteners for use in foodstuffs (OJ L 204, 27.7.2006 p 1-13)

5. Medicines (Advertising) Regulations 1994 (SI 1994 No. 1932)

6. 2000/13/EC on labelling, presentation and advertising of foods (OJ L 109, 6.5.2000, p 29)

7. Case C221-00, Judgement of 23/1/2003, Commission/Autriche (Rec. 2003, p.I-1007)

8. 65/65/EEC on medicinal products (OJ No 22 of 9.2.1965, p 369/65)

9. The Water Supply (Fluoridation Indemnities)(England) Regulations 2005 (SI 2005 No. 920)

Competing interests: None declared

Adding fluoride to water supplies
Adding fluoride to water supplies
5 October 2007
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Colwyn M Jones,
Consultant in Dental Public Health
Edinburgh EH8 9RS

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Re: Adding fluoride to water supplies

The systematic review of water fluoridation by the York centre for reviews and dissemination (York CRD) concluded that water fluoridation works. It found that an extra 14.6% of children would be completely free of tooth decay with the misery it engenders, and a later estimate of the preventive fraction is a 40% overall reduction in decay (Worthington, 2003). So we can all agree water fluoridation works.

The glaring omission from the article by Cheung et al is mention of the pain, disfigurement, embarrassment and cost that preventable dental decay causes. Although rare, death under general anaesthesia does tragically happen and tooth extraction is the commonest clinical indication for general anaesthesia for children in Scotland.

Water fluoridation works as it does not rely on behaviour change and a number of Cochrane reviews confirm that fluoride in many forms (toothpaste, mouthrinses, etc.) is complementary to water fluoridation.

Cheng et al develop their section on safety by selectively quoting from the literature in citing an ecological study. The study conducted multiple statistical comparisons and only one was significant at the 5% level, a probability you would expect by chance. Rather alarmingly Cheung et al then use this data to calculate excess bladder cancer rates in the UK. However, the original authors state, “Our study found an excess rate of bladder cancer that was restricted to females...... there is no reason to expect sex differences in bladder cancer..... Therefore, the possibility that this is a chance result should be considered....” Equally spurious would have been to calculate the reduction in other types of cancer and suggest water fluoridation has a protective effect.

Most systematic reviews conclude that the evidence base is poor. Cheung et al are correct on the necessity for future research on water fluoridation, and with an estimated 40% reduction in disease it should be a priority. How can we do this? We must introduce a number of large water fluoridation schemes and thoroughly evaluate this population based, public health measure using modern research methods to demonstrate it works, confirm safety and see if early indications are correct that it reduces socio-economic inequalities in dental health. The sooner we get started the better.

References

Worthington HV and Clarkson J. The evidence base for topical fluorides. Community Dental Health (2003)20:74-76.

Competing interests: Dentist Member of the British Fluoridation Society

Adding fluoride to water supplies
Fluoride Consumption – Much Higher than We Are Told
5 October 2007
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Peter J Mansfield,
Independent Health Adviser
Good Healthkeeping,,
Garrod House, Manby, LOUTH LN11 8UT

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Re: Fluoride Consumption – Much Higher than We Are Told

During the systematic review of water fluoridation which spanned 1999-2000 (1), the dearth and poor quality of scientific evidence was a major concern. In particular, no acceptable measurements were yet available of fluoride consumption from all sources in any random sample of the British population. The National Diet and Nutrition Survey published in 2003 (2) the first such data, from 24-hour urinary fluoride assays from most survey subjects. Urinary values were dealt with in Volume Three of the report . The authors inferred that 1% of men and 3% of women had intakes of fluoride above the officially defined safe level of 0.05mg/kg/day. Whilst reviewing the raw survey data for another research purpose I checked this statement. A serious error came to light in the authors’ calculation. The authors seem to have assumed that all fluoride consumed from any source is excreted promptly in the urine. In fact, 90% of ingested fluoride is assimilated into the blood stream (3), and half of that is sequestered in calcified tissues. Only the remaining half, 45% of the ingested fluoride, is excreted via the urine (4). On this basis daily fluoride consumption is higher than daily excretion by a factor of 2.2. When this correction is made, a much larger proportion of the sample is shown to have consumed fluoride at or above the nationally defined safe level. The correct figures range from 8.2% among 19-24 year old females to 25.5% for males aged 50-64.The mean for the entire sample (1429) is 20.2%. This sample does not distinguish subjects receiving fluoridated water from those who do not. Some 24-hour urines were incomplete, so these findings under-estimate the truth. The result suggests that a substantial proportion of the British population are consuming fluoride in amounts that could be responsible for undiagnosed symptoms. Persons accidentally consuming fluoride in excessive amounts deserve to be identified and helped. It is time to raise medical and dental awareness of this. Might not a square to detect fluoride concentration be added alongside glucose to the urine testing dipstick? The authors of the Survey Report and the relevant civil servant have been advised of this apparent error, and have not refuted it. The Food Standards Agency is considering its response.

References

1 McDonagh M, Whiting P, Bradley M et al. A systematic review of water fluoridation. NHS Centre for Reviews and Dissemination: University of York, 2000.

2 Henderson L, Irving K, Gregory J. The national diet and nutrition survey: adults aged 19 to 64 years. HM Stationery Office, 2003;3:129-135.

3 World Health Organisation Monograph Series No 59. Fluorides and Human Health. Geneva: World Health Organisation, 1970:75-89.

4 National Research Council (US). Health effects of ingested fluoride. Washington: National Academy Press,1993:128-133.

Competing interests: None declared

OBSERVATIONS:
An age old problem
Richards (6 October 2007) [Full text] [PDF]
An age old problem
Self Management :An age old solution to an age old problem
13 October 2007
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Arun K Chopra,
Special Lecturer,Nottingham University
QMC,Derby Road,Nottingham,NG7 2UH

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Re: Self Management :An age old solution to an age old problem

Dear editor,

There is no doubt that the demographic changes which we are currently living through will have a major impact on health and social policy in the years to come. An increasingly older population will be more likely to suffer from one or more chronic diseases. Coupled with this, is the rise of depression which is projected to be the largest cause of morbidity by 2020 and which has recently been shown to cause the greatest decrement in health as compared to other chronic diseases, asthma, angina,arthritis and diabetes. The combination of depression with any of these illnesses leads to a greater health decrement than any other combination amongst these illnesses (Moussavi et al,2007). One possible solution to this increasingly complicated scenario is strenghtening the position of self management of chronic illness through models of healthcare delivery such as the collaborative care model. (www.improvingchroniccare.org-accessed 11/10/07)This model has demonstrated effectiveness in both physical and mental ill-health, although its application outside of research trials remains limited. More recently, concerns have been expressed over the value of self monitoring in Diabetes, with researchers reporting no significant gains from such practice(Farmer et al, 2007). In order to bring this possible solution to bear, professionals need to be supportive of patients who collaboratively self manage, there needs to an improved response to problems identified through self management and research is needed to elucidate the patient pathways to self management in order to ensure that the appropriate self management package is provided to a patient at the right stage of their illness course and tailored to the degree of psychological readiness they have to tackle the challenges of living with a chronic illness.

References

Farmer,A. et al (2007)Impact of self monitoring of blood glucose in the management of patients with non-insulin treated diabetes: open parallel group randomised trial.BMJ ;335: 132 Moussavi,S. et al (2007)Depression, chronic diseases, and decrements in health: results from the World Health Surveys.The Lancet;370:851-858

Competing interests: None declared

An age old problem
Right to die?
12 October 2007
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Peter Bruggen,
retired psychiatrist
21 Mackeson Road NW3 2LU

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Re: Right to die?

Yes, as far as you go, but I am sorry that you duck consideration of a right to die.

I am pleased at your concern for dignity and rights of the elderly, but what if our wishes are to die? We talk of rights to freedom to health care, to justice, to being treated with respect and not abused. But, what if, at the end I simply want to die?

I do not mean if I am suffering from a treatable depressive disorder. Treat that and I might try again.

I mean if, at the end, with ‘all said and done’, all treatments tried, I am still in more pain, more discomfort, or with more memory loss than I want or want those caring for me to endure; and if I am not able physically to kill myself (no illegality there). Then what about helping me? I know it is not legal in this country, but it is in some. Is not denying me that help an ‘indignity’, a ‘neglect’ or indeed even a ‘cruelty’.

It does sound as if a supported suicide bill or a euthanasia bill would have public support. It does sound as if the feared-for abuses have not occurred in Oregon, Holland or Switzerland. At least let’s talk about it.

Peter Bruggen
Retired psychiatrist

Competing interests: None declared

An age old problem
Apologies to Tomji Tanabe
8 October 2007
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Tessa J Richards,
Assistant Editor
BMJ, WC1H 9JR

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Re: Apologies to Tomji Tanabe

Counting the number of rapid responses an article generates is one of the yardsticks by which the BMJ assesses its impact - for better or worse. In this instance, however,I am not seeking to generate debate but simply to say sorry to Tomji Tanabe, and you gentle reader, for a misquote. As a result of an editorial gremlin, views I express later in the article about how a society treats its elderly people, are incorrectly attributed to him in the opening sentence. We apologise for this and wish him well.

Competing interests: None declared

FEATURE:
Should general practitioners resume 24 hour responsibility for their patients? No
Herbert (6 October 2007) [Full text] [PDF]
Should general practitioners resume 24 hour responsibility for their patients? No
Needs and Wants
6 October 2007
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Andrew P Moltu,
GP
Limes Medical Centre, Narborough, Leicestershire LE19 2DU,
Helen Herbert

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Re: Needs and Wants

As a full time working GP I have to ask myself do I need to work at night and do I want to? For me and most of my colleagues the answer is an emphatic no!

Let's not delude ourselves most of the night, weekend & evening consultations had little to do with urgent medical need were more about patient convenience than anything else. The few truly urgent cases were a welcome relief!

As a society we need to deliver appropriate urgent health care to those in need. The current system seems to be failing to do that to the satisfaction of many. The old system may have delivered a better quality of care however it was historically underfunded as well as placing unacceptable demands on those obliged to deliver it.

As taxpayers we should also ask whether we truly need to pay for the convenience of those who are impatient, ignorant or simply find it preferable to expect taxpayers to fund their consultaion as 3pm on Sunday rather than 9 am on Monday when it will cost them time from work.

Employers organisations may well be in favour of us providing round the clock services so that they don't loose an employee for an hour or so. Pehaps those employers should employ a company doctor if they find employees attending GP appointments too onerous. Naturally this would not be cost effective.

Those who don't pay tax but still favour a return to more comprehensive services should also consider if they would trade this for lower benefits or smaller pensions?

Those politicians should carefully consider the true costs of what they are suggesting?

Competing interests: I am a working GP

Should general practitioners resume 24 hour responsibility for their patients? No
The Elephant in the (waiting) room
6 October 2007
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Duncan M Williams,
GP
Graig Rd Surgery,
SA18 1EG

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Re: The Elephant in the (waiting) room

Out of hours care is, like in hours care and medical practice in general, rewarding stimulating and professionally fulfilling - isnt that what we set out to do when entering med school - to emulate Jenner and Fleming, (even Dr Findlay!) 'work with poeple' 'to cure the sick' to 'discover the next penicillin', add to that the endlessly fascinating presentations of patients' symptoms and the clinical conundrum of diagnosis with its overtures of Sherlock Homesian detective and deductive effort - are your lips quivering as you read this? Are you champing at the bit to re-engage with Gordon's agenda to have you tramping the city streets and country lanes all hours Gord sends? Not on your nelly!! And why? Because Nelly the Elephant of Consumer Demand is sitting quietly in my waiting room, in A&E; waiting rooms, in her own sitting room, in the OOH centre waiting room and in the waiting room for the next general election with a glint in her eye that says - if you dont want to see me I'm not really here and if you continue to ignore me I'll use this lovely curly trunk and tusks to root out and suck up every new resource - time, money, professional expertise - Oh yes! and particularly tasty is the enthusiasm drive and ambition of all those new recruits put in my feeding trough daily, she does of course have to spit out the occasional indigestible old cynic who sees through the cloak of invisibility and has the audacity to challenge Nellies right to exist! Did I mention the label on the feeding trough - NHS. Nellie of course is a mistress of disguise, camouflage and evolution, she evolves to survive in the environment of the patient, she wears many different colours and appears both in and out of 'hours', those of us who think we see her often fail to challenge her presence as we somehow anticipate the howls of derision emanating from her eggers on in the monkey compound of press, media and complaints industry and the sharp jet of water propelling us towards our defense organisations. The solution to Nellie is the opposite of that for the Emporer who had the problem with his new clothes - he needed a naive child to spot the problem and then he hung his tailors, she needs a few carrots a sharp stick and a keeper (called Gordon, Ming or Dave) to lead her away from the trough because believe it or not it was never meant for Nellie in the first place.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? No
GP out of hours
5 October 2007
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Julian C Law,
GP Kyle of Lochalsh
IV44 8RF

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Re: GP out of hours

I do not relish the the prospect of resuming out of hours responsibility for my patients in the way that it was previously organised. Having spent fifteen years doing on-call for the various rural practices in England and Scotland I can say that the past three years of doing no on-call has been a liberation for me and my family. Furthermore it has benefitted my patients. Cumulative tiredness resulted in me making mistakes that harmed patients. Moreover I do not feel knackered and resentful after having having repeated disturbed nights. I would not object to covering my patients at night if I could have the following day off. This was never an option in the past because of the demands of day to day practice. The result of the new contract was that GPs were actively encouraged to give up out of hours care despite many wishing to continue with some involvement in providing of out of hours care. Perhaps if the provision of out of hours cover had been negogiated at a local level rather than nationally a more coherent and personal service that reflected local needs could have been established.

Competing interests: None declared

FEATURE:
Should general practitioners resume 24 hour responsibility for their patients? Yes
Jones (6 October 2007) [Full text] [PDF]
Should general practitioners resume 24 hour responsibility for their patients? Yes
Not either or...
13 October 2007
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Steven Ford,
GP
Haydon & Allen Valleys Medical Practice

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Re: Not either or...

Editor

There need be no contest here, merely the flexibility to adopt the approach that best suits the patients, doctors and geography.

My own practice did its own OOH until confronted by 'force majeur' and I only stopped doing OOH altogether when it degenerated into a call centre operation.

A diversity of provision arrangements is the right approach.

Yours sincerely

Steve Ford

Competing interests: I am a GP

Should general practitioners resume 24 hour responsibility for their patients? Yes
GP Land
13 October 2007
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Dr. Raja Baber Sheraz,
GP ST2
Staff hostel, West cumberland hospital, Whitehaven, CA28 8JG.

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Re: GP Land

Gp treats the whole patient, not "chest pain", "ankle fracture" or "another neck of femur". Thats what we call as "Holistic approach" in our GP land. Even if the GP works from 0800 to 1700 it does not mean that he/she is not owning the patient. GP gets the feedback from the patient very next day that is not the case in minimum three monthly hospital consultation. At the moment the balance is right between the primary & secondary care. Yes i do support the transition of some specialist work into community, closer to patients own home provided by their own doctor. GPWSI Cardiology is an example! To maintain & improve the quality of general practice we need to give our GP`s a suitable work life balance by giving them the choices of opting in or out of out of hours work. General practice has become a emerging popular choice among our post foundation programme doctors. Bringing out of hour work into primary care "24 hours responsibility" may affect the future career choices! In the current setting General practitioners are doing a great job in providing excellent healthcare to the local community. Suggestion: Why not make small primary care zones & GP`s can do out of hour work in their own practice zones. The benefit would be that patient requiring home visit won`t see a new face! I am sure with this healthy debate we might find an acceptable solution to all which continues to provide the best primary care to our local communities. The important bit would be to include hospital Consultants, GP`s, Current out of hour providers, media & most importantly our own patients!

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
In support of the GP Co-op
12 October 2007
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john m caine,
GP
parbold, lancs, wn8 7nb

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Re: In support of the GP Co-op

Prof. Roger's arguments for the return of 24 hr 7/7 responsibility seem to be that it would improve GP training, reduce admissions and improve patient use of the service and their safety. Oh and that patients would like it and it might be cost effective.

His evidence for these assertions is what exactly?. He states that Heath's (1) opinion was that 'OOH was becoming a shambles' -yet her article is actually calling for an end of the cheaper skill-mixing attempts of some OOH services to introduce non-GP first contact clinicians into OOH and promots the GP Co-ops who have managed to stay in business by opting -in.

He claims that Wanless (2) blamed the steep rise in A&E; attendances to changes in OOH arrangements - but Wanless actually blames the A&E; obsession with 4 hr waiting times along with the OOH changes and gives no evidence for either - In fact the steepest year on year rise in new contacts occurred between 2002/3 and 2003/4 (15% increase) before the new contract came into effect c/w 9% between 2003/4 and 2004/5, and 6% and 2% in the last 2 years.

He claims that OOH is provided by 'less experienced clinicians'. Where is his evidence for this assumption?. Does he have a breakdown of the OOH workforce, that no one else has, or is he still peddling the media prejudice?

My prejudice is that the vast majority of complaints in the MPS report he quoted will be in those organisations whose main aim is to provide a service based on cost rather than quality, i.e. the private companies and the in- house PCT run organisations- by the way how does the rise in OOH complaints compare with the number of complaints about the NHS in general? Is there a general increase in complaints across the NHS or just in those who are getting the worst press?

It is difficult to see what points he is trying to make from his international comparisons. Australia have a private health care system where GPs get paid for each contact and where GPs can reckon on only a third of their registered patients seeing them regularly -the others popping into whichever GP takes their fancy. Roger espouses their stringent guidelines for communication but doesn't elaborate on these. My personal experience of working OOH and in hours in Australia is that continuity of care is a shambles. The OOH quality standards in this country (3) insist on all OOH contact records being faxed/ emailed to the patient's GP by 8am the next morning- If only information regarding our patients’ attendance at A&E; or Walk-in centres came as quickly ( I’ll leave to one side the scandalous time it takes to get outpatient letters or discharge summaries)

In Canada they apparently have a system of extended rotas, which he claims is what Heath also calls for. This sounds fine to me but we haven’t we been there already? Oh yes I remember they are called GP co-ops!

Where these have been allowed to carry on- either by opting in and doing their own thing a la Heath, or by opting out yet being unmolested by PCTs- they continue to provide a high quality service, staffed by local experienced GPs, with excellent lines of communication, and support for younger doctors and training for registrars- does that tick all your boxes?

1.Heath I. Out of hour’s primary care—a shambles? BMJ 2007; 334:341. 2.Wanless D, Appleby J, Morrison A, Patel D. Our future health secured? A review of NHS funding and performance. London: King's Fund, 2007. 3. national quality requirements in the delivery of Out of Hours services: 2006

Competing interests: full time GP and OOH Director

Should general practitioners resume 24 hour responsibility for their patients? Yes
24hour responsibility
11 October 2007
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ravinder Norman,
GP
YATELEY GU46 7LS

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Re: 24hour responsibility

NO to OOH-our daily practice demonstrates that the more availability we have the greater uptake .NHS Direct A&E; walk in clinics do not necessarily prove that there is a need.[A vacuum is filled]Other than true emergencies -of which there are few-most of health care needs can be dealt with during normal working hours. A trial of GP's in A&E; only demonstrates how perceived needs by the public and desire to be seen when, where etc, fuelled by the Governments desire to give everyone what they want rather than sensible use of services -this is not rationing-creates a need where there wasn't any.

The best way as was just beginning to be shown by fund holding then by local GP co-ops is that given funding and support and the trust by MPs .GP's can deliver very good, comprehensive services.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
depends on format
11 October 2007
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Duran Kandhai,
GP-Principal
Newport, NP19 8XR

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Re: depends on format

GPs are independent contractors and I feel that any action even by stealth to impose working unsociable hours(out of hours; 24/7 care) is certainly not acceptable and should forcefully with full support by all stakeholders be rejected. Nonetheless I agree that many GPs would be willing to work OOH(Out Of Hours; 24/7 care)and indeed should have the opportunity to do so in a suitably priced contract, i.e. that reflects the risks, time investment and sacrifice of family/social life. Furthermore some arrangement should be possible whereby the GP who worked the evening or night before should have at least the next morning off. This would be the only way forward to achieve 24/7 care that is acceptable to both patients and doctors. Let's not forget that patients nowadays regard a tired and overworked doctor as "non acceptable" or "risky".

Competing interests: I'm a GP Principal

Should general practitioners resume 24 hour responsibility for their patients? Yes
24 hours
11 October 2007
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Gregory M Read,
GP
Fressingfeld Medical Centre IP21 5PJ

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Re: 24 hours

I would love to go back to the good old days of 24hr responsibility (it was actually one of the reasons I chose general practice as a career), if there was the necessary support for carrying it out, in both financial terms and in generating an attitude from the patients that it was not an extension of our daytime work - an attitude persistently encouraged by the present Government with its obsession with access. Unfortunately, neither of these pre-requisites will happen.

The Government has blatantly encouraged patients to expect a service at weekends and out of hours that is unacceptable to most hardworking general practitioners - this attitude is based on the Tesco's model of "get what you want when you want it" even if it is 3 o'clock in the morning. The difference is that Tesco's know that they can afford to do it making a fabulous profit to boot and also employ their staff on a shift- based system. The person on the cash till at 3 o'clock in the early hours won't be there holding the fort at 9 o'clock later the same morning! The deliveries arrive and the shelves are stocked to accomplish a seamless shopping experience even though it is at a time when most people are asleep. I doubt whether hospitals and other areas of the NHS will be able to provide an equivalent routine service during these times to make our efforts worthwhile when we are providing the required routine OOH service that will be expected of us. If one looks at the way most PCT's organise their finances in order to pay off the massive debts that were there when they came into being, they exert a huge downward pressure on practices to do everything as cheaply as possible or stop commissioning certain services because they are too expensive. How on earth are they going to afford a 24hr service manned by doctors when they are finding it so difficult to provide one on the cheap at present with nurse practitioners and paramedics and bases spread so thin that our patients sometimes have to travel 50 miles to see a doctor or other healthcare practitioner. I worked out that when I did my OOH work and Saturday mornings for the first 10 years in practice, I earned about a pound an hour! I also missed my young daughter growing up in her early years because of the times that I wasn't there. This is something that I would not accept again, especially as I am much older and I wouldn't expect my younger colleagues to be put in the same position. Even when we set up an innovative General Practice Co-operative in our area, it was apparent, as time went by, that the service was starting to be abused by an increasing number of unnecessary calls and the added stress that came with them. And of course to provide this service we had to pay back our membership by working the requisite number of shifts.

Professor Jones, I'm afraid, is typical of the type of GP, who, despite of his excellent skills as a GP, has found other things to do in the world of academia - and this is not denigrating that what he does isn't important for British General Practice. If I am wrong then I apologise, but I doubt whether he spends every week of his working life from 8-6.30, on the coalface, seeing patients and, thus, in his own way, he has already opted out.

I hope that I am not a dinosaur and that there maybe many GPs who feel the same as me. If it comes to the crunch then I will consider my options and retire early, even though it will affect my financial future. I don't think anyone would disagree with the fact that a doctor based OOH system and thus, a return to 24hr responsibility would be the gold standard for general practice OOH but, it requires a sea change in attitude, particularly from this and future Governments - they cannot rely on doctors goodwill to work unsociable hours for no additional income because it's perceived to be a duty that comes with the job. I think that this was why so many of us decided that enough was enough in 2004 and opted out. The only way that a return to 24hr responsibility will work, is if the number of GPs working in the NHS increases dramatically in order to allow a practice-based shift system to work effectively and safely, as well as there being a secure and protected financial package for those who carry it out.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
Not keen!
11 October 2007
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Rosemary B Martin,
GP principal
M14 6 XU

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Re: Not keen!

The day job has undoubtedly got harder under the new contract. The patients who consult by day have every bit as much right to a good service and the two jobs cannot safely be done by the same person.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
The Good Old Days
10 October 2007
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David Howard,
GP and Trainer
Stonehaven, AB39 2TR

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Re: The Good Old Days

Why would anybody want to go back? We can still work out of hours if we want to for raesonable remuneration. Those who prefer a good night`s sleep can go to work refreshed. Recruitment has improved. What were the chances of seeing your own patient previously out of hours unless you worked very onerous rotas? Those who advocate a return to the good old days are aiding our masters in an effort to cut the cost of OOH care pure and simple.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
gp 24hr resposibility
10 October 2007
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tariq m hama,
gp principal
kimberley ng16 2nb

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Re: gp 24hr resposibility

gps too have families which require valuable protected time

why should they be denied this

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
in the long run - giving up out of hours has been a bad thing
10 October 2007
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edmund willis,
gp
bridge street surgery, brigg, north lincs, dn20 8nt

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Re: in the long run - giving up out of hours has been a bad thing

GP's are perceived as overpaid and lazy, and we are being punished by the government for it. If we had kept control of out of hours - we would have a much better standing as a profession, and have a lot more support from the public. The government would have been much less likely to use us a general whipping boy.

My regular patients are amazed when they see me working for one of the remaining outof hours coops. They beleive the media which tells them that gp's dont do out of hours.

The perception that we all were doing out of hours before and now none are is particularly absurd as very few GP's were formerly unable to use deputising services.

The double whammy we are in now is that PCT's now realise how much it costs to organise an effective service and are providing a token service - for example 1 doctor on at night for the city of hull and a huge surrounding area! The resulting service is terrible for patients.. and who gets the blame?? why us of course who provided a mostly good service cheaply for years.

We need to offer to take this job back - there are now lots of doctors who are prepared to work out of hours. If we did this we would improve our reputation, and that would work to our advantage in the long run. We would also resist the the tide of Emergency care practitioners, nurse prescribers, specialist nurses, counsellors, who threaten to take over 'Primary Care'.

Competing interests: i am a gp who does out of hours work

Should general practitioners resume 24 hour responsibility for their patients? Yes
In reply to Mr Wintertton above...
9 October 2007
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David P Jones,
GP - full time
Bangor, Gwynedd

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Re: In reply to Mr Wintertton above...

Part time - I wish.

I work full time - 5 days a week - mostly 11-12 hour days with a "working lunch" and afternoon coffee, if I am lucky, whilst I scramble through mountains of paperwork.

I take 6 weeks holiday a year, as my partners do, which means when they are away (which effectively is half a year) their work needs covering.

I would like to know what other entitlements you allude to as it is clear to me you have no idea of the primary care set up. You, as a paramedic, will work a shift system. You will have time off to compensate and your hours are governed by the European Working Time initiative, unlike mine that do not come under this legislation.

Individual GP's cannot cover their patients 24 hours a day and remain in safe control and you would not want me to be taking critical decisions for your patients (or indeed your family should they be unfortunate enough to need care) at 3am when I have been working without a break for 20 hours.

Think about it that way then think again ................

Competing interests: Full time working GP

Should general practitioners resume 24 hour responsibility for their patients? Yes
yes responsibility is for doctors to bear
8 October 2007
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robert derek wintertton,
paramedic
medical centre nw6 3jr

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Re: yes responsibility is for doctors to bear

yes doctors should bear responsibility for their patients 24 hrs. there are holidays and other entitlements to enjoy. part time apart from health and family reasons should not be out of right. patients suffer form the current system with increase of hospital referals and improper control of hypertension, diabetes, anticoagulant therapy. patients require help and if you are not dedicated enough do not come to medicine. it is not shop keeping. sincerely WINTERTTON(MR)

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
OOH, General Practice and Sanity
8 October 2007
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David P Jones,
GP - full time
Bangor, Gwynedd

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Re: OOH, General Practice and Sanity

Like many of the previous responders, I worked in the "old system". We covered our own patients, 24/7/365. We did ridiculous numbers of unnecessary day time home visits, we rarely did any primary prevention and our surgery work essentially involved acute illness, diagnosis and referral of more serious conditions, the occasional terminal care, and repeat prescribing. House calls for minor problems were common and we soon realised that for every 1 call, approximately 7 patients could be seen in surgery. As time went by, we took on increasing amounts of primary prevention, so much so that by the time the 2004 contract was in place, I would imagine most practices, like ours, were up-to-scratch. At about the same time, in our part of the UK, a difficult semi-rural / rural area, a Co-operative was formed. Instead of 4 doctors being on-call covering 20,000 patients in one area, 3 covered a vast area covering 100,000 patients. And guess what? The expected warnings that things would be unmanageable did not materilise.

The reason why this was so was because it was set up using data from other areas, we listened to others who had done it before us, and we learned. Now, 2004 contract. Why has this not been such a breeze? In my opinion, Government and advisers did not listen. They were told the likely problems. They were told GP's were already up to scratch with preventive care, they were told the budget for OOH was woefully inadequate (I personally informed the Welsh Assembly this in my discussions as the Chair of the local OOH in a meeting between us, NHS Direct, who triaged for us and the Assembly) - but all along they knew best and now they are looking for scapegoats.

No GP is going to go back and work at the rate they were previously paid, and the introduction of market forces to primary care is a cross that this Government and their advisers are going to have to carry. My current work load, with all that it entails, does not allow time for OOH to be done. I would not be safe and I would therefore be doing my patients, and those of my colleagues, no service. It is time for the DOH advisers (whoever these faceless people may be) and the Government to wake up and smell what they have have landed the profession in, start to take advice from the ground workers (sorry professor but being in an academic unit and a surgeon does not qualify you to pontificate on my professional working life) who have been involved in the best Primary Care Service IN THE WORLD. And no, my hand did not slip and press caps lock by mistake - it was a shout!

Competing interests: GP principal

Should general practitioners resume 24 hour responsibility for their patients? Yes
Family Physicians
8 October 2007
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Milind A Patil,
Medical Advisor, Pharma Company
410206

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Re: Family Physicians

In fact, we in India, had this custom of calling GPs as family physicians. I remember my childhood days; the family physician was considered as not only a doctor but also a friend, philosopher and guide. He was not treated as a supplier of some services for a cost!! Unfortunatly, today this is not the case.

Yes, GPs should take 24 hour responsibility for their patients.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
No need for extended hours
7 October 2007
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chris jenkins,
gp
sw9 9tj

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Re: No need for extended hours

As a GP most of the patients that I see are either retired, have chronic illesses and cannot work, are under 5, or at school, are non- working refugees or asylum seekers, single parents, and working people off sick looking for certification. Most of these, especially the elderly do not want surgeries open after dark in the evening. Surely it would be easier and cheaper to let woking people see a second gp near where they work to sort out their mainly self imiting conditions. We already have a mechanism for doing that, its called 'Immediately Necessary Treatment', or for more detialed problems temporary registration for up to three months. What services are going to have to be sacrificed for paying for largely unnecessary extended hours

Competing interests: I am a GP

Should general practitioners resume 24 hour responsibility for their patients? Yes
TORONTO: After Hours medicine.
7 October 2007
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Alexander FRANKLIN,
Physician
Private Practice

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Re: TORONTO: After Hours medicine.

Dr.JONES mentions Canada. Am MBBS(Lond.1959);here since 1970.Can only speak for TORONTO where situation is mixed.

The most personal service is given by GPs who charge up to $3,500 a year to register with their practice. They will usually answer a reserved telephone line at any time. GPs can also forward calls to a House Call service which arranges for a Home visit by a doctor in a particular area. The House call doctor bills the Ontario Health Insurance Plan(OHIP) directly, fee depends on time of visit-usually about $100, and pays a commission,(usually 30%),to the firm. GP groups will often take calls until 9 p.m. for which they are paid extra by OHIP. Afterwards a taped message usually advises patients to go to their nearest emergency department. There is also a Government-paid 24 hour Nurse telephone advisory service. By the way,Criminal Lawyers are available at any time; their fees about $500-700 an hour. From personal experience in UK & Toronto, House Calls are rarely Medically Necessary .Usually an excuse to save petrol and transportation costs plus the advantage of not having to wait in a GP's surgery during working hours. A convenience, just like home delivery by the baker,grocer and milkperson

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
Should general practitioners resume 24 hour responsibility for their patients? Yes
6 October 2007
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Imran Arfeen,
VTS Trainee ST2
Scunthorpe General hospital, dn 15 7bh

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Re: Should general practitioners resume 24 hour responsibility for their patients? Yes

I agree as a Gp registrar while working in OOH I realize the patient care is effected because of continuity of care, I am not sure about financial issues, My view is solely on Patient point of View.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
FINGS AINT WHAT THEY USED TO BE..
6 October 2007
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Graeme Mackenzie,
OUT OF HOURS GP
NORTH CUMBRIA

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Re: FINGS AINT WHAT THEY USED TO BE..

I am probably well qualified to comment on this issue having done 20 years as a GP principal and am now employed as a full time salaried GP in out of hours(OOH). My comments are as follows; Emergency OOH is an increasingly specialist role or should be. I was surprised how I had to skill up when I took by present job. Now that I am focussed on emegency primary care I realise that as a principal before co- operatives I wasn't doing that good a job. Rather that turn the clock back we need to move forward with specialists in primary care OOH. We possibly even need a separate defined speciality with recognised qualifications and bespoke/mandatory training. These doctors will in turn be able to extend their role and work much more with secondary care, not only to reduce admissions but to receive early discharges as well as defining best practice. Best practice is not necessarily reducing admissions, it is doing the best or the potential best for the patient. It is about avoiding, avoidable morbidity. There are many reasons why GP principals and daytime GPs cannot return wholesale to OOH. Geography is one, as many GPs no longer live in their practice areas. Many good co-operatives now have teams of OOH specialists. Replacing those with GPs who have not done signficant OOH for a while would be a risky business. Many co-operatives are now very professional with excellent call handling procedures, nurse practitioners, triage nurses and well developped links to district nursing and palliative care services. Is it suggested that we return to GPs sitting at home writing the calls down on the back of a cornflake packet? Does he suggest that instead of one point of contact, patients across an area take pot luck with whatever system practices have in place to handle their OOH commitment? Large co-operatives have well stocked emergency centres and vehicles with systems to maintain drugs and equipment. Many patients now benefit from immediate access to oxygen, pulse oximetry, IV lines, defibs, nebilisers, palliative care drugs and equipment and more. Large co-operative teams can back each other up if busy. Is it suggested that we return to the days of one GP struggling to cover a large practice with relatively limited amounts of equipment and drugs and absolutely no back up. Are GPs going to start visiting everyone as they did before? If not, you will need centres. Is every practice going to open all hours? If you centralise the treatment centres you are just recreating what we have now! OOH organisations and co-operatives provided a focus for complaints and comments on OOH care. Before them, there was nowhere for complaints to go because they would be against a practice or individual GP. Patients were less likely to complain in these circumstances and the complaints would not be recognised as relating to OOH care. The quality of care I provided as a GP principal working for a co- operative and now provide as a salaried GP is far superior to what I managed before when I had responsibility for regular on call. I resent the implication that OOH GPs are inferior in quality doing the more focused job of OOH. If you are just doing OOH, is the hypothesis not that you will be better. In the perfect world we would all want the doctor we knew seeing us at whatever time we wanted. That doctor would be fully conversant with all out medical history and when called would be polite and helpful to every patient he saw as well as very competent on OOH care. We all know that world never existed, that many GPs chronically resented the on call in a way which must have affected the quality of care, that with the amount of information on patients record nowadays it is safer to assume nothing: something the OOH GP automatically does. The future of OOH care may well be with highly trained, reflective OOH primary care specialists who are motivated to provide best and appropriate care under an umbrella of extended training and large supportive organisations.

Competing interests: OUT OF HOURS SALARIED GP

Should general practitioners resume 24 hour responsibility for their patients? Yes
Whos falt is this anyway and why make it any worse than it already is ?
5 October 2007
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Alex G. Robertson,
GP principle
western avenue medical centre, chester, ch1 5pa

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Re: Whos falt is this anyway and why make it any worse than it already is ?

Imposing a return to 24 hour responsibility will only exacerbate the predicted recruitment crisis. Those GP’s that are due to retire in the near future will see this as a reason to retire early ( as has happened with most major contract changes in the past). These people have seen to many changes in the last 30 years with out being subjected to this. The whole hearted welcome given to the opt out and its’ over whelming uptake surely points to the truth of this. The demands of out of hours care are no longer part of our duties and we should not be looking at taking them on again. However if we are forced to comply with this we should not make the same mistake as the government. We should ensure that we are appropriately remunerated for the task. We can not be held responsible for the idiocy displayed by this government in the past. It was obvious to all what was going to happen. I seem to recall that there were even questions on the Today program on radio 4 about this very issue. A survey carried out by the BBC at the time showed that the vast majority of us would opt out given the opportunity, something denied by the health minister as I recall. Now look at what has happened, as predicted we walked, and I for one can see no compelling reason to walk back. Out of hours is not our responsibility. It belongs to the PCT’s and ultimately the department of health. Where the system is failing they should sort it out. You wouldn’t take a second hand car back to its’ previous owner after 5 years hard use to complain that the tyres are bald. So why do we feel responsible for the current state of out of hours prevision in those areas where it is obviously failing.

Competing interests: I am a GP and I also work in out of hours

Should general practitioners resume 24 hour responsibility for their patients? Yes
General practitioners still do provide out-of-hours care
5 October 2007
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Robert L. Morley,
General Practitioner
Erdington Medical Centre 103 Wood End Road Erdington Birmingham West Midlands B24 BNT

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Re: General practitioners still do provide out-of-hours care

Both Professor Jones and Dr. Herbert appear to make the same mistake in confusing the provision of out- of -hours GP care with the responsibility for organising it.When the profession voted to accept the new contract it did not make "the difficult decision to withdraw provision of out- of- hours", rather it chose to accept a contract which gave practices the option of whether or not to continue to organise as well as to provide twenty-four hour cover.

Two facts need to be clearly understood.Firstly,many practices,particulary those with excellent GP co-operatives, chose to retain responsibility for twenty-four hour care.They continue to do this at financial cost to themselves because they recognise the value of this service compared to the PCO-commissioned alternative.Secondly,general practitioners still provide the out-of-hours medical care required for the patients of "opted-out" practices. GPs in these practices may have opted out of twenty-four hour responsibility;they clearly have not opted out of providing out-of-hours care and continue to provide it for the patients on their lists and those of other practices.

Profesor Jones' article also implies that GPs in training and in the early years of practice gain no out-of-hours experience, and that they no longer do home visits.I am at a loss to explain this misconception.

Competing interests: None declared

Should general practitioners resume 24 hour responsibility for their patients? Yes
Out of hours GPs are well qualified , good doctors
5 October 2007
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Caroline A Mitchell,
GP/ Senior Lecturer
Woodhouse Medical Centre, S13 7LY

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Re: Out of hours GPs are well qualified , good doctors

This article initially implies that patients are only safe in the hands of experienced GPs but concludes with the suggestion that younger GPs could take a greater share of the ‘red eye’ shifts. Out of hours providers recruit fully qualified GPs to their rotas and all GP registrars have supervised out of hours training. This article unfairly implies that they are an inferior and under-qualified cohort. NHS complaints have increased- both in and out of hours. Commercial out of hours providers thrive but many providers were also established as true local GP co- operatives, where local GPs ‘opt in’ to shifts which most fit their working and home lives. All commercial and private out of hours providers have accountable clinical governance systems, where patient safety and good communication are paramount, and from personal experience, operate in a highly supportive and safe environment. Faced by an unsustainable increase in out of hours demand, and significant difficulties recruiting new partners, local GPs formed a city-wide co-operative which provided modern, safe premises, drivers & transport to bring patients to the primary care centre. Over 18 months there was a dramatic reduction in calls; to some (not the disabled and terminally ill), the attraction of an out of hours contact was a convenient but inappropriate home visit. The ability to opt into or out of shifts, in large efficient rotas, transformed my professional and personal life. In 1993 I was a single parent with a young baby. I would have lost my job had supportive partners not covered the 6 to 8.30 am for my 1:4 rota and without the support of friends who looked after my son until after at 11pm, evenings and weekends (an expensive deputising service covered 7 hours).

Competing interests: None declared

FEATURE:
Industry funded patient information and the slippery slope to New Zealand
Toop and Mangin (6 October 2007) [Full text] [PDF]
Industry funded patient information and the slippery slope to New Zealand
Anecdotal instance of positive effects of drug advertising
13 October 2007
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Charles L. Rogerson,
Clinical Data Architect
slough sl1 1th

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Re: Anecdotal instance of positive effects of drug advertising

I think this article doesn't give enough weight to the intelligence of patients and their interest in getting information about their medications.

Anecdotally, an older acquaintance of mine in the States who was a very active hiker developed fairly rapid onset of bilateral leg weakness which increased over a year to the point where he could only walk very short distances. He consulted his GP and several specialists and was finally referred for spine surgery, which he declined.

He then saw an ad for a statin he was taking on television, in which the narrator at the end listed the side-effects, which included muscle weakness. He immediately went to his GP, who DC'd the statin.

The leg weakness immediately improved, though unfortunately not completely. Somehow his physicians had missed this rather obvious possibility.

I believe this may demonstrate that in a clinical environment where clinicians do not communicate fully to their patients the mechanisms and side-effects of prescribed medications, televised medication advertisements similar to those published in medical publications can play a positive role in educating patients.

Competing interests: None declared

NEWS:
Australian efforts to tackle abuse of Aboriginal children raise alarm
Sweet (6 October 2007) [Full text] [PDF]
Australian efforts to tackle abuse of Aboriginal children raise alarm
NT Aboriginal health care
7 October 2007
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Deane Dight,
Senior Lecturer in Pharmacy
University of Canberra ACT AUSTRALIA 2601

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Re: NT Aboriginal health care

Having worked in Alice Springs and Tennant Creek in the Northern Teritory from 1978-80 and 1984-88, one cannot help but be cynical about the Federal emergency response occurring within months of a general election (after 10 years in office). It could be likened to the arrival of the cavalry - sweeping aside and ignoring those healthcare workers who have laboured away for years. Communities in central Australia have, to the best of my knowledge, been dry since my time there. I, like many a colleague valued my time in the Territory and was prompted to go on and study Public Health. Settlement conditions are like those of the third world in our arid continent, lacking in basic clean water. Rural work is extremely rewarding yet there is always a recruitment and retention problem which will not go away, leaving shortages across the full healthcare spectrum. The effect of the Federal 'bandaid' response to far deeper issues than health care alone is yet to be seen. Deane.Dight@canberra.edu.au.

Competing interests: None declared

Australian efforts to tackle abuse of Aboriginal children raise alarm
Address basic care for Aboriginal people
5 October 2007
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DAVID G SAMUEL,
Medical student
Cardiff University

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Re: Address basic care for Aboriginal people

I am a final year medical student currently stydying skin cancer as part of my elective study in Sydney. I ahve read with interest numerous articles highlighting the poor health of aboriginal chldren and communities during my time in Australia, in addition to the new controvertial "child protection NT proposals".

Children from these communities suffer worse dental hygine than other groups, 90% of these children suffer from chornic ear infections and hearing problems before the age of 6 months, chronic disease is a massive problem within aboriginal populations and excissive drinking is sometimes endemic.

I feel that far from creating a more hostile relationshop between the government and these grups of patients, more fundign should be provided to improbing and enhancing their healthcare facilities. Discrimiating and isolating communities is likely to increase the health gap and even encourage more risky behaviours such as excessive alcohol use, expecially if it outlwawed. Educating communitites about sexual health, healthy living and modern medicine is far more worthwhile.

I hope that all aboriginal people are prvodided with healthcare close to their homes by professionals who are senitive to their cultural beliefs and traditions. They should not be isolated and treated differently but integrated into society.

Competing interests: None declared

NEWS:
UK does well on giving information to patients but poorly on access to new treatments
Watson (6 October 2007) [Full text] [PDF]
UK does well on giving information to patients but poorly on access to new treatments
Bismark v. Beveridge
11 October 2007
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Iain S Fraser,
GP
Manchester, M12 5LH

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Re: Bismark v. Beveridge

The Euro Health Consumer Index, 2007 is being cited as evidence that the Bismark system 'delivers better value' than the Beveridge system. One might however pause to consider some other health statistics from the WHO:

Per capita total expenditure (US$) Germany 3521.4 UK 2899.7
Hospital beds per 100000           Germany 844.49 UK 389.79
Physicians per 100000              Germany 340.20 UK 389.79

Surely it is premature to draw conclusions on the merits of one system over another when the playing field is far from level.

Competing interests: None declared

NEWS:
Africans die in pain because of fears of opiate addiction
Logie and Leng (6 October 2007) [Full text] [PDF]
Africans die in pain because of fears of opiate addiction
Opiates for pain in dying patients and in those with sickle cell disease
11 October 2007
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Felix ID Konotey-Ahulu,
Kwegyir Aggrey Distinguished Professor of Human Genetics, University of Cape Coast, Ghana
Consultant Physician Genetic Counsellor, Ten Harley Street, London W1N 1AA

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Re: Opiates for pain in dying patients and in those with sickle cell disease

Opiates for pain in dying patients and in those with sickle cell disease

Dorothy Logie and Mhoira Leng’s report of 6 October describes a conference in Nairobi which highlighted opiophobia – the fear of using morphine therapeutically – “as a big obstacle facing palliative care services in the (African) continent” [1]. The conference was concerned with dying patients. In his rapid response, however, Jecko Thachil concentrated on the use of opiates in sickle cell disease patients. He states that while “very high amounts of opiates (often in hundreds of milligrams) are often required for the patients who suffer from recurrent sickle crises” [2], the expected analgesic effect leaves much to be desired, not to mention side-effects. Dealing with terminally ill patients is one thing; opiate administration to sickle cell disease patients is something else entirely.

Dr Thachil feels an “increased need for additional education regarding sickle cell disease…” Has he examined the experiences of two physicians who personally supervised thousands of people with sickle cell disease on both sides of the Atlantic continuously for years? [3, 4] Treating sickle cell disease is not the same as managing the sickle cell disease patient [5]; the difference in the two approaches tending to separate haematologists on the one hand, from physicians and family practitioners on the other. When a white British consultant physician in a London teaching hospital complained that “the haematologists here have created a cohort of addicts” [6] a white consultant haematologist in another London teaching hospital tore strips off him, accusing him of being a racist for depriving suffering black patients of pain relief, an attack which made me respond thus: “White physicians who, at the risk of being misunderstood by (that haematologist), voice their displeasure at what they see happening on their wards deserve commendation, not condemnation” [7].

Not far from where Dr Jacko Thachil works, also on Merseyside, “during a ward round in a provincial teaching hospital with consultant haematologists on March 6, 1997, I was shown a woman who had been on continuous opiate infusion since September, 1996” [7]. I went on to say in my Lancet communication: “Far from the consultants taking umbrage because I pointed out that the patient could not have been in sickle cell crisis for 6 months, they were happy to discuss with me the way forward” [7]. Dr Thachil feels “an increased need for additional education regarding …addiction to pain medication…and treatment of pain” and he concludes “but who and where these should be focussed on is a matter for debate” [2].

Not a matter for debate at all in my opinion: May I suggest to him certain facts he might wish to probe in his quest for education?

(a) “In Jamaican experience ..morphia or its derivatives are rarely used or necessary” [8] How did Graham Serjeant achieve this?

(b) “Most painful crises may be treated in a day-care centre, the patient returning home in the evening” [9] How is this possible if hooked up on morphine or diamorphine pump “as in the recommended UK protocol”? [6]

(c) “We are convinced that the chest syndrome in the UK and the USA is not entirely unrelated to the routine use of opiates in those countries for sickle cell crises”. [10] Some nurses I am in touch with can write an MSc thesis on this.

(d) Goodman from the USA (where diamorphine is banned for patients) found the use of ketorolac in painful sickle cell crises as efficient as morphine but without the latter’s respiratory depression [11]. So why do British haematologists prefer to use morphine and diamorphine? Answer: “Ketorolac has no product licence in the UK for this indication” [12]

(e) Two questions that I have asked British Haematologists several times but which have never been answered, and which Dr Thachil may now ask the National Institute of Clinical Excellence (NICE) for help in answering:

(i) “Why do West African and West Indian patients with sickle cell disease who did without morphine in their countries have to be given morphine pumps during sickle cell crises when they come to the United Kingdom?” [6, 13]

(ii) If pain from whatever cause deserved the most potent analgesic, and dysmenorrhoea has been known to be intolerably painful, would a British haematologist “not consider it unwise for a hospital to administer diamorphine as routine management of young women?” [7]

Four encouraging signs have emerged in the UK since I have been voicing my displeasure at the use of diamorphine and morphine pumps for patients with sickle cell crises: (1) Some haematologists in the UK and the European continent have abandoned the practice in spite of what the ‘approved protocol’ displays in the emergency rooms. (2) Some sickle cell disease patients have become more vocal in their displeasure of the practice. To them ‘opiophobia’ is not to be condemned [1], but commended. (3) Some family practitioners are looking after their patients at home, using intravenous fluids and other than powerfully addictive opiates to help these patients instead of submitting them to hospital care. (4) A clearer grasp of the causes of crisis has put more emphasis on public health measures (fluids, warmth, treatment of infections, dressing properly, anticipating hazards, immunisations, avoiding tobacco and alcohol), enabling patients prevent crises and helping them use the excellent non-sickling genes they have inherited from their parents to achieve as much of their full potential intellectually as possible [10].

It is therefore not surprising to find that the sickle cell disease patients who have become lawyers, teachers, businessmen and women, nurses & midwives, pharmacists, and even doctors are those whose haematologists have abandoned the opiate culture. Occasionally, however, one found even professors of haematology who would defend the prescribing of diamorphine for a sickle cell disease patient with severe difficulty in breathing. “Chest syndrome” was always there to blame, if the patient died [6].

When in my genetic counselling and family size limitation (GCFSL) drive in Ghana and in the Ghanaian community here in the UK I sense that the urgency of my message is being glossed over I tell my fellow countrymen and women in plain language that if they continue to procreate at the rate they are doing, and more sickle cell disease (ACHE/ACHE) patients are born, the chances are that in the UK they may end up on a heroin drip. This concentrates the mind, and they listen to me. “One in three of you is a NORM/ACHE. Do you want to end up with ACHE/ACHE children who will be given heroin for pain?” [http://www.konotey- ahulu.com/diagram.asp]

Felix I D Konotey-Ahulu MD(Lond) DSc (UCC) FRCP DTMH FGA FGCPS FAAS FTWAS
Kwegyir Aggrey Distinguished Professor of Human Genetics, University of Cape Coast, Ghana and Consultant Physician Genetic Counsellor, Ten Harley Street, London W1N 1AA, England.

Conflict of interest: None declared

1 Logie D, Leng M. Africans die in pain because of fears of opiate addiction. BMJ 2007; 335: 685

2 Thachil J. The fear of opiate addiction – not unique to Africa. Rapid response BMJ 2007, 8 October.

3 Serjeant GR. Sickle cell disease. Oxford: Oxford university Press, 1992 (Second Edition)

4 Konotey-Ahulu FID. The sickle cell disease patient. London: Macmillan 1991; Waftord: Tetteh-A’Domeno Co, 1996.

5 Konotey-Ahulu FID. Sickle cell disease and the patient. Lancet 2005; 365: 382-383.

6 Konotey-Ahulu FID. Opiates for sickle cell crisis? Lancet 1998; 351: 1438.

7 Konotey-Ahulu FID. Opiates for sickle cell crisis. Lancet 1998; 352: 651-652.

8 Serjeant GR. Sickle cell disease. Oxford. Oxford University Press, 1985, page 204.

9 Serjeant GR. Sickle cell disease. Lancet 1997; 350: 725-730.

10 Ringelhann B, Konotey-Ahulu FID. Hemoglobinopathies and thalassaemias in Mediterranean areas and West Africa: historical and other perspectives 1910 to 1997. Atti dell’Accademia delle Scienze di Ferrara 1998; 74: 267-307.

11 Goodman E. Use of ketorolac in sickle cell disease and vaso- occlusive crisis. Lancet 1991; 338: 641-642.

12 Liesner RJ, Vandenberghe EA, Davies SC. Analgesics in sickle cell disease. Lancet 1993; 341: 188.

13 Konotey-Ahulu FID. Morphine for painful crises in sickle cell disease. BMJ 1991; 302: 1604.

Competing interests: None declared

Africans die in pain because of fears of opiate addiction
The fear of Opiate addiction – not unique to Africa
8 October 2007
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Jecko Thachil,
Haematology Specialist Registrar
Royal Liverpool University Hospital, Prescot Road, Liverpool, L7 8XP

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Re: The fear of Opiate addiction – not unique to Africa

I read with interest the article by Logie and Leng dealing with inadequate pain control for patients in Africa. However, the issue of fear of opiate addiction is not uncommon in the Western world especially in the care of sickle cell patients. Though, the reasons are different from the countries in Africa where shortage of health care professionals and excessive bureaucracy may be responsible, physicians' attitudes may be considered as one of the key factors in the developed countries [1]. This is despite the fact that very high amounts of opiates (often in hundreds of milligrams) are often required for the patients who suffer from recurrent sickle crises. Tolerance to opioids can also cause progressive reduction of their analgesic effect, thus explaining the need for increasing doses to achieve the same pharmacological effect [2]. Due to several reasons some of them unfounded, under treatment of sickle cell pain is still common especially in hospitals which are not accustomed to dealing with sickle cell emergencies. In these institutions, the need for unusually high amounts of opiates raises doubts in the minds of doctors who suspect addiction among the patients and the nurses who worry the “doctor’s competence” if they prescribe the high doses. Maintaining a pain requirement chart is a practical way of managing this situation where the usual requirement of pain control could be documented in a folder (or pocket card) with the contact details of physician or the hospital that is in charge of the usual care of the patient.

Another less understood phenomenon related to opiate use in general is the concept of “hyperalgesia”. Hyperalgesia is the exaggerated nociceptive response to noxious stimulation which occurs after repeated opioid administrations probably related to the breakdown of the equilibrium between opioid-dependent analgesic systems and NMDA-dependent pronociceptive systems [3, 4]. This heightened painful state resolves usually with the reduction of opioid dosage which is a difficult decision to make in the setting of increased pain. A second syndrome of hyperalgesia can be observed when serum levels of chronically given opioids are decreased especially after purposeful or inadvertent discontinuation of opioids [5]. These situations require input from a pain specialist for the correct management.

Thus there is an increased need for additional education regarding sickle cell disease, addiction to pain medication, the pharmacology of opioids, and the assessment and treatment of pain but who and where these should be focussed on is a matter of debate [1].

References

1. Shapiro BS, Benjamin LJ, Payne R, Heidrich G. Sickle cell-related pain: perceptions of medical practitioners.J Pain Symptom Manage. 1997; 14:168-74.

2. Laulin JP, Célèrier E, Larcher A, Le Moal M, Simonnet G. Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity. Neuroscience 1999; 89: 631–6.

3. Mao J, Price DD, Mayer DJ. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 1995; 62: 259–74./

4. Célèrier E, Rivat C, Jun Y, Laulin JP, Larcher A, Reynier P, Simonnet G. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000; 92:465-472.

5. Lipman JJ, Blumenkopf B. Comparison of subjective and objective analgesic effects of intravenous and intrathecal morphine in chronic pain patients by heat beam dolorimetry. Pain 1989; 39: 249–56

Competing interests: None declared

LETTERS:
A cheap soundbite
Magos et al. (6 October 2007) [Full text] [PDF]
A cheap soundbite
Cold hands warm heart
12 October 2007
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Karen J Hebert,
F2 Doctor
UBHT, Bristol, BS65SW

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Re: Cold hands warm heart

I have been following the 'bare below the elbows' debate with interest. White coats have been a thing of the past since I was a student and we are now informed that we should not be wearing watches on the wards. Indeed one of my university friends who works at a different trust has to go through special "decontamination procedures" because she works on the C-Difficile bay in her hospital.

The issue I would like to raise may seem a minor one to doctors but is one of reasonable significance to the patients we examine. I have very cold hands - something which is only moderately alleviated by ensuring I dress warmly. I nonetheless still find that my hands are cold enough to make patients remark. Of course I always warn them in advance - to which most of them respond ,"Don't worry dear...cold hands warm heart!"

This is not something that is unique to me...and I believe with the new dress policies that seem to be coming we will either need to bump up the heating (good breeding ground for bacteria?) or have an awful lot of patients suffering!

Perhaps we will be offered hypoallogenic, antimicrobial mittens as a solution...

Competing interests: None declared

EDITORIALS:
Reform of the coroner system and death certification
Luce (6 October 2007) [Full text] [PDF]
Reform of the coroner system and death certification
Unintended consequences
12 October 2007
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Laurie R Davis,
GP
South Hermitage Surgery , South Hermitage, Shrewsbury sy3 7js

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Re: Unintended consequences

Dear Sir ,

One aspect of the changes described by Luce might be the loss of incentive for involvement by the removal of payment to the doctors involved in signing the cremation form.Payment for such a service is ethically questionable ,but currently creates an incentive for GPs to engage in the process.If this is removed ,I predict a loss of interest in this traditional role.Our current terms of service imply that our Duty of Care ceases with the death of the patient.Fitting in a trip to the undertaker or the medical examiner service becomes another unpaid chore and I suspect will tempt doctors to refer more deaths to the coroner on the uncontestable grounds of medical uncertainty, especially if we move further into a culture of blame.Presumably this will result in more postmortems.Or is this the intended consequence?

Yours Sincerely,

Laurie Davis

Competing interests: Future recipient of death certification. Current recipient of occasional cremation fees.

EDITORIALS:
Mental health in disaster settings
Jones et al. (6 October 2007) [Full text] [PDF]
Mental health in disaster settings
Community psychiatry - a building approach
1 October 2007
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Pandey Vibha,
Research Assistant, M.Phil (psychiatric social work)
Central Institute of Psychiatry

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Re: Community psychiatry - a building approach

I Congratulate the Inter-Agency Standing Committee (IASC) for taking such a responsible step towards promoting mental health and preventing mental illness in community at large (Lynne J. et al, 2007). I presume that apart from emergency intervention for psychiatric patients, it will also help in eradicating stigma for mental illness, because in developing and under developing countries, stigma has definite role to play in outcome and prognosis of the illnesses (Hector et al. 2003).

Apart from this, such a step will also pave the way for understanding the role of paraprofessionals in promoting mental health and preventing mental illness. In country like India there is a vast gap between the ratio of psychiatric patients and mental health professionals (Srinivasa MR 1987), so National Mental Health Programme launched in India in the year 1987, has made one among the provisions of identifying community leaders, NGOs, Social welfare sectors, lay volunteers, traditional healers, parents and relatives of the patients, for providing training to these group in early identification of illness and referral services (Agarwal AK. 1998). Such agency like Inter-Agency Standing Committee (IASC) is definitely a need of developing and under developing countries and I hope other government would also come forward to take action in this direction and it would not just simply remain in the file.

REFERENCES

1. Agarwal AK. The forgotten millions. Indian Journal of Psychiatry 1998;40:103-119.

2. Hector W.H. Tsang and Phidias K.C. Tam (2003). The Hong Kong Polytechnic University Fong Chan University of Wisconsin–Madison W.M. Cheung University of Hong Kong. Stigmatizing Attitudes Towards Individual With Mental Illness In Hong Kong: Implications For Their Recovery. Journal Of Community Psychology Vol. 31, No. 4, 383–396.

3. Lynne Jones, Joseph Asare, Mustafa Elmasri, Andrew Mohanraj. Mental health in disaster settings, British Medical Journal, 2007.

4. Srinivasa Murthy,R. Intigration of Mental Health with Primary Health Care. Paper presented at the IV Indo-Symposium on Community Mental Health, NIMHANS, Bangalore,1987

Competing interests: None declared

EDITORIALS:
Encouraging children and adolescents to be more active
Giles-Corti and Salmon (6 October 2007) [Full text] [PDF]
Encouraging children and adolescents to be more active
Working harder together to tackle obesity
12 October 2007
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Shalini Pooransingh,
Locum Consultant in Public Health Medicine
Walsall Teaching PCT, Jubilee House, Bloxwich Lane, Walsall WS2 7JL

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Re: Working harder together to tackle obesity

Editors,

We agree with Giles- Corti and Salmon(1) about a multi component interventions approach to tackling exercise levels in children and adolescents, particularly its emphasis on involving parents and families.

In fact this is the basis of health promotion strategies (2)which recognize the need for healthy public policy, supportive environments, strong community action, personal skill development and a reorienting of health services which may all be necessary to effect change.

Our interest in this editorial stems from the fact that in Walsall we engaged in measuring children on a pilot basis in 2006 (3) before Department of Health (DoH) stipulated that these measurements ought to be done routinely. 1904 children were measured in reception year and years 6, 7 and 10. This equated to 11% of all school children in those years. There were 6% opt outs and those who were absent or withdrew were from higher years and were found to be obese from previous measurements.

We would like to share the findings from this pilot. Six out of eight schools returned evaluation forms and five of these (83%) reported that they clearly understood the aims of the project.

Forty-eight younger children (26% response rate) returned evaluation questionnaires and of these, 58% didn’t know how they felt about being measured and 30% didn’t know why they were being measured.

Many of the year 7s and 10s said they would have liked more information about the measurement process. Although DoH doesn’t recommend sharing results several children wanted to know their measurements and we support this because how can you engage people to take responsibility for their health without providing full information.

Feedback recommended that there should be a coherent approach to tackling obesity across all agencies as it appears that the link between the healthy schools initiative and the measurement process was not being made by some participants.

We therefore need to work harder together because despite all initiatives over the years it appears that children still don’t understand why they were being measured. We have identified another key group of persons – parents as they are the ones who make decisions about foods available in the household and give permission and money for sporting and exercise related activities. Indeed Blair et al (4) report that maternal factors including maternal activity and television watching are associated with percentage body fat in children at 7 years of age.

Dr Sam Ramaiah
Director of Public Health

Dr Shalini Pooransingh
Locum Consultant in Public Health Medicine

Walsall teaching PCT

References

(1)Giles- Corti B, Salmon J Encouraging children and adolescents to be more active Well evaluated complex interventions are still neededEditorial BMJ 2007; 335:677-8.

(2)Donaldson LJ Donaldson PJ Essential Public Health Medicine Libra Pharm Limited 2000.

(3)Evaluation of a Pilot Study to Monitor Childhood Obesity in Walsall Walsall tPCT August 2006.

(4) Blair N, Thompson J, Black P et al Risk factors for obesity in 7 – year – old European children: the Auckland Birthweight Collaborative Study Arch Dis Child 2007; 92:866-871.

Competing interests: None declared

EDITOR'S CHOICE:
Tooth and nail
Godlee (6 October 2007) [Full text]
Tooth and nail
Fluoridation - Bad To The Bone
9 October 2007
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Maureen C. Jones,
Archivist, Citizens for Safe Drinking Water
Retired

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Re: Fluoridation - Bad To The Bone

Regarding the health effects of ingested fluoride and the debate over reliability of various study designs, not mentioned is the elephant in the middle of the room; age-specific exposure.

It is well documented that fluoride is incorporated more readily into mineralizing new bone than into existing bone. Substitution of fluoride for hydroxyl ion in the crystal lattice makes bone more brittle and by predominately decreasing tensile strength, mechanical failure and fracture propagation are strongly influenced. (Review of Fluoride Benefits and Risks, U.S. Dept of Health and Human Services, Feb. 1991.

It is also known that the pharmacokinetics of fluoride in infants reveal a completely different pattern compared to that found in adults. Infants retain 87% of fluoride dosage compared to about 50% for adults (Adv Dent Res June 1994).

Taking her cue from KJ Rothman (Am J Epidemiol 1981, 114:253-259), who warned that age-specific effects must be evaluated: “failure to identify the appropriate time window for exposure may result in misclassification which can adversely affect the ability to detect an association,” Elise Bassin limited her analysis of osteosarcoma to cases less than 20 years old and found a “robust” link between fluoridation and osteosarcoma (Cancer Causes Control 2006, 17:421-428).

Hip fracture is likewise an age-specific effect. Exposure to 1 ppm fluoridated water for 20 years prior to menopause, a period of increased bone remodeling, resulted in a 100% increase in hip fracture for women at age 75 (J Am Med Asso. Vol 268 No 2, 1992, Fig. I). Had these women grown up on fluoridated water the results may have been even more significant.

Therefore, a hip fracture study that selects women age 55 and older, an osteosarcoma study that includes adult subjects, or a meta-analysis that conceals the age-specific factor by blending all data together, will never reveal the true nature of fluoride’s toxicity to bone.

And any government entity that propagates and defends such transparently shoddy science while refusing to fund studies based on age-specific exposure is clearly in the business of shunning the well being of a nation’s citizens in order to defend a failed and libelous public health policy.

Sincerely, Maureen Jones, Archivist Citizens for Safe Drinking Water 1205 Sierra Ave. San Jose, CA 95126 408 297-8487

Competing interests: None declared

OBITUARIES:
Bjørn Ibsen
Richmond (29 September 2007) [Full text] [PDF]
Bjørn Ibsen
Obituary Notice re Bjørn Ibsen
10 October 2007
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Ronald V Trubuhovich,
Honorary Specialist Intensivist
Auckland City Hospital, Pvt Bag 92-024, Auckland New Zealand, 1023.

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Re: Obituary Notice re Bjørn Ibsen

Letter to the Editor, British Medical Journal

It was fitting to see your journal publishing an obituary for the “Founding father of intensive care” (Caroline Richmond, 29Sep07). But without any wish to be making carping criticism may I offer a few corrections, solely for historical accuracy?

1. Hans Christian Larssen should be (Prof.) HCA Lassen, as he appears to have favoured being reported[1]; while the HCA stands for Henry Cai Alexander[2] (not all Danes are named Hans Christian!).

2. Dr Mogens Bjømboe was Dr Mogens Bjørneboe (Microsoft-Word’s “r”+“n” too readily look like “m”).

3. The physicians at the Blegdam Hospital attributed initial high mortality in the epidemic (87% of 31 patients ventilated by “negative” pressure respirators) not to “kidney failure” but to polio virus’s brain- destructive effects. (This issue has recently been re-visited[3]).

4. ENT surgeon Dr Falbe-Hansen, not Ibsen, performed the tracheotomy.*

5. The word “Kommunehospitalet” already incorporates a “the”.

6. Bjørn Ibsen opened his Intensive Therapy [IT] Unit, a conversion from the post-surgical recovery room, on August 1; but the first IT patient was not admitted until 21 December, and was the only one for 1953 (the next year brought 13 patients).[4]

7. Acta Anaesthesiologica Scandinavica was founded in 1957 not 1961; Ibsen was a co-editor on its editorial board.*

8. Ibsen did not write two textbooks, in Danish, on anaesthesia and intensive care in 1950 or 1959;* but in 1969 published in Danish his book “Intensiv Shockterapi.”*

9. Importantly, Ingrid Ibsen, the first Mrs Ibsen, died in 1984. Bjørn Ibsen is survived by his family and his partner.

(Also, reversing the second and third clauses in “inserted a cuffed tube, attaching a to and fro absorption system, which gave good suction” reduces ambiguity?).

As someone who has already committed a major “blue” in this area by, initially, not sorting out the confusion of August 1952 dates from HCA Lassen and others as to which date identified “Bjørn Ibsen’s Day”[5] (the 27th, not the 26th[3]), I have only sympathy for her.

Ronald V Trubuhovich.
Auckland, NZ.

*Acknowledgement I am grateful to Dr Preben Berthelsen for this information.

References.

1. Lassen HCA. Preliminary report on the 1952 epidemic of poliomyelitis in Copenhagen with special reference to the treatment of acute respiratory insufficiency. Lancet 1: 37-41.

2. Wackers GL. Modern anaesthesiological principles for bulbar polio: manual IPPR in the 1952 polio-epidemic in Copenhagen. Acta Anaesthesiol Scand 1994; 38: 420-431.

3.Trubuhovich RV. Further commentary on Denmark’s 1952-53 poliomyelitis epidemic, especially regarding mortality; with a correction. Acta Anaesthesiol Scand 2004: 48: 1310-5.

4. Berthelsen PG Cronqvist M. The first intensive care unit in the world. Acta Anaesthesiol Scand 2003;47: 1190-5.

5. Trubuhovich RV. August 26th 1952 at Copenhagen: ‘Bjørn Ibsen’s Day’; a significant event for anaesthesia. Acta Anaesthesiol Scand 2004: 48:272-7.

Competing interests: Competing Interest. In Press: Trubuhovich RV. BJØRN IBSEN: COMMEMORATING HIS LIFE, 1915 –2007. Crit Care Resus 2007(Dec); 9(4).

Bjørn Ibsen
Dunce's hat
3 October 2007
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Caroline Richmond,
Obituary writer
SW£ 5AQ

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Re: Dunce's hat

Ibsen's colleagues' names were Bjørnboe (not Bjømboe) and Lassen (not Larssen). Mea culpa.

Competing interests: Author of this obituary

Bjørn Ibsen
Bjorn Ibsen: Founding father of intensive care
1 October 2007
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Roger H. Armour,
Retired Consultant Surgeon
Honorary Consultant Surgeon, Lister Hospital, Stevenage SG1 4AB

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Re: Bjorn Ibsen: Founding father of intensive care

Caroline Richmond's moving obituary and tribute to Bjorn Ibsen deserves to be framed and a copy put on the wall of every intensive care unit in the world. On ATLS (Advanced Trauma Life Support) and ALS (Advanced Life Support) courses the airway and ventilation are given first place in the management, but the lessons are sometimes forgotten and patients die. I am sure that medical students, and doctors looking after ill patients, would benefit by reading about Dr. Ibsen's life work in helping those whose breathing was failing.

Competing interests: None declared

VIEWS & REVIEWS:
The alcohol industry: taking on the public health critics
Farrell (29 September 2007) [Full text] [PDF]
The alcohol industry: taking on the public health critics
Health cost of alcohol unregulated market
2 October 2007
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Ronaldo R Laranjeira,
Senior Lecturer on Addictive Behaviour
Federal University of São Paulo - Rua Borges Lagoa, 564 - São Paulo 04023-000

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Re: Health cost of alcohol unregulated market

The paper of Farrell touched upon a very important issue that is the alcohol industry strategies in the developing world. Brazil is a good example of these strategies. We have 1 million selling points for alcohol in a population of 180 millions. These points can sell alcohol at any time of the day, to anybody, including minors. We have a very agressive advertising strategy on television that reaches millions of children. In recent research on a random sample of drivers, 30% of them had alcohol in their blood. Brazil is by any account an unregulated market of alcohol, and the alcohol industry is trying their best to keep that way. This lack of regulation contributes to the increase of consumption at the rate of 10% a year.

If all that was not enough, the alcohol industry is also approaching health professionals for a partnershhip in order to defend that harm reduction approach is the best option to Brazil.

Farrell´s paper is a good warning of the health implications of this unwelcome partnership.

Competing interests: None declared

VIEWS & REVIEWS:
Ethicist on the ward round
Sokol (29 September 2007) [Full text] [PDF]
Ethicist on the ward round
Ethicist on the ward round?
3 October 2007
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Cathriona Russell,
Lecturer in ethics,
School of Religions and Theology, Trinity College Dublin, Dublin 2,
Desmond O'Neill

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Re: Ethicist on the ward round?

Ward rounds are challenging environments for complex communication, even for clinicians (1). For the uninitiated the ward round is a kind of ‘rabbit-in- the-headlights’ experience. It is not, we contend, the ideal place to hone the skills of the non-medical ethicist, in a kind of do-or-die approach. It is surely not just a whimsy of medical culture that students first encounter the human circulation system in the relatively bloodless arena of cadaver dissection rather than on the cutting table of the surgical theatre. Although it does seem legitimate to claim that the lecture hall can only therefore be a very poor approximation of the messiness of ‘doing ethics’ on the ward, that is only part of the picture. Rather than turning the ethicist onto the ward, it might be safer to introduce her to a clinical specialist who can see through the ‘shroud of science’ and has never lost sight of the ‘patient as person’.

Clinical ethics is not the ‘antithesis of science’, but rather an integrating discipline (2). The experience of the medical specialist immersed in the ‘messy’ complexity of the everyday is precisely what it needs, alongside the ‘abstract’ discipline of ‘detachment’ and ‘critique’ of conceptual approaches (neither of which may be exclusive to ethicist or clinician). Student encounters with ethics have to reflect both perspectives, otherwise, as Sokol experienced, ethical concepts seem to get lost in the scientific jargon. Medical ethics teaching needs to move from the jingoism of philosophical principlism and the focus on sensationalist cases to a concerted engagement with the everyday. Otherwise we may well seem to encourage the flouting of principles rather than their legitimate contextualisation (3).

Clearly the professional context looms large for the trainee and practised alike. The point is to institutionalise good practises and engender good ethics role-models. This involves ‘socialising’ students to a view of patient care that society and patients would recognise and endorse (4). What we would propose is that clinical teaching should extend back and forth from the ward to the lecture room in a socialising process, rather than dispatching the non-medical ethicist unprepared to the ward.

1. Grahame-Smith DG. An encounter with Beethoven's cleaning lady. Lancet. 1993;342:1315.

2. Russell C, O'Neill D. Ethicists and clinicians: the case for collaboration in the teaching of medical ethics. Ir Med J. 2006;99:25-7.

3. Pillon, S. Desirability and Practicality, Response BMJ 21.12.2006

4. Koch, T. Sokol’s corrective? Response BMJ 14.12.2006

Competing interests: None declared

Ethicist on the ward round
Recognising the ethical problem
3 October 2007
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Jonathan Howell,
Consultant in Public Health
West Midlands Specialised Commissioning Team, Edwin House DE14 2WF

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Re: Recognising the ethical problem

Perhaps the bedside feels too difficult a place to reconcile the sort of dilemmas where we need to use an ethics framework( 1). It seems to me as I get older that I tend to use ethics in a more formal way than I ever did when struggling with the uncertainties of patient care in the surgery or on the ward. Perhaps that's a combination of experience and the fact that public health practitioners don't have the patient in front of them.

What might be termed the fourth ethics criteria is an aspect of public health that many clinicians may not conciously address. We should all look for benefit for the patient whilst minimising harm and respecting their autonomy. However the needs of the individual patient also need to be balanced against those of the population in the sense of need being about the ability to benefit from an intervention. This can be difficult for healthcare professionals as the opportunity costs of a clinical decision usually relate to patients who cannot be identified as individuals.

Ethics seems to help most when decisions might go in a number of different ways all of which can have some justifying arguments. Those who have been involved with Primary Care Trust (PCT) panels trying to decide on funding requests for exceptional cases should all be aware of the use of ethics. These situations clearly illustrate Sokol's point that an ethical problem cannot easily be resolved if it has not been spotted and worked through in a structured way.

Without the formal teaching and awareness of ethics then we may not have the understanding to make reasonable decisions in difficult circumstances. That is to make decisions that other reasonable people might have made in similiar circumstance had they understood the detail of the issues. If we are not seen to understand the use of ethics then the respect for our complex decisions will ultimately affect the respect for professionals in the health service.

(1) Sokol DK. Ethicist on the ward round. BMJ 2007; 335: 670 (29 September).

Competing interests: JH has advised on decisions about funding treatments for individuals and for populations.

PRACTICE:
Care of healthy women and their babies during childbirth: summary of NICE guidance
Kenyon et al. (29 September 2007) [Full text] [PDF]
Care of healthy women and their babies during childbirth: summary of NICE guidance
Unnecessary controversy
5 October 2007
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Rishu Tandon,
Registrar
Prince Charles Hospital ,Merthyr Tydfil CF47 9DT

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Re: Unnecessary controversy

Dear Sir,

I feel that idea of delivering either in midwifery led unit or a obstetric unit leading to a debate of place of birth is catching a controversial pitch . I just wonder how could one spend time debating on such issues when we know there are millions of women who die in labour due to nonavailability of proper health care services. The social geographical and cultural circumstances in every continent of world are different .

The concept of midwifery led care is excellent provided we pay attention to make it a universial feasibility in every part of world where there is lack of infrastructure for proper health services rather than trying to equate them with obstetricians . The place for both of them is unique and it is a privilege for women in developed nations when they can have the choice of options for place of birth provided they fully understand the risks versus benefits. Only time will generate the evidence needed to support or refute the concept of ideal care model for women in labour. But I feel it will be far useful if we try to generate research based evidence on trying to reduce maternal mortality universally rather than trying to focus on debate for midwifery versus medicalised care.There is no absolute truth as circumstances may be different. Even a well informed women's reponse may be biased from experinces in her previous births or her mental makeup for risk taking behaviour. Motherhood is something which is to be enjoyed since the time of conception till safe delivery. The advances in medical knowldge have to an extent medicalised the process of labour but when cannot ignore the factor of safety which should be the parameter to be judged in whatever research is undertaken to manage low risk labours. Whether or not it is worth leaving women in labour nonsubjected to medical intervention should only be analysed if we have a database of universal maternal mortality cases interpreting the causes and possible interventions. Women bear pain to bring a new life to this world and this should be seen as a sign of strength which makes them no different in any part of the world.

Competing interests: None declared

Care of healthy women and their babies during childbirth: summary of NICE guidance
Prevention: a practical approach
3 October 2007
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Vibha Pandey,
Research Assistant (M.Phil in Psychiatric Social Work)
Central Institute of Psychiatry

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Re: Prevention: a practical approach

Maternal care during child birth is no doubt one of the most pertinent issues for physical and mental health of the baby as well as for mother. There are many studies which confirm the relation between mental retardation and poor maternal health during delivery (King BH et al 2000).

The guidelines by the National Institute for Health and Clinical Excellence (NICE) for healthcare professionals caring for women during labour and birth is an important step towards the prevention of number of mental and physical disorder in infant. But the question is that some of the provisions like labouring in water etc ., mentioned in the guideline does not seems to be practically feasible in developing countries like India and other nations of south east Asia and Africa, reason for which author has already mentioned (Kenyon S, et al., 2007)

In developing countries, the prevalence of mental retardation is no more less than any other countries because of so many other associated factors like lack of nutritional food, poor hygiene, illiteracy, poverty etc. There is lack of awareness among the population residing in this region.

Guideline should have formulated keeping these factors in consideration and should have also included the pre-natal and post-natal prevention for better prognosis.

According to the guideline mentioned in the article (Kenyon S, et al., 2007) health professionals are required to provide these information to the mother and thus, it will restrict to those women who are visiting the nursing home and even if midwives are providing the information, they will required enough skills to identify those risks which is quite not faceable in developing countries because of poor quality of training of midwives. It is suggested that there should be some provision of identifying members from the community like NGOs, lay volunteers etc and providing them training for identifying high risk factors and referring them to nearby health center for further prevention or care of mother during pregnancy.

Apart from this, one major hindrance in the successful implementation of this programmed would be personal interest of physician who at times go for caesarean section or instrumental vaginal birth because of its high probability of earning money. Under this circumstances how sure are would we that they will provide correct information to their patients? The solution for this problem would be inclusion of family members for providing detail information by some non profitable groups or organization. Overall maternal health care is not important only during delivery but it starts when a girl opens her eye in the world.

REFERENCES

1. Kenyon S; Ullman R; Mori R; Whittle M (2007) Care of healthy women and their babies during childbirth: summary of NICE guidance BMJ ;335:667- 668. doi:10.1136/bmj.39322.703380.AD.

2. King BH, Hodapp RM, Dykens EM, Mental retardation. In: Sadock BJ,Sadock VA,eds. Kaplan & Sadock’s Comprehensive Textbook of Psychiatry: 7th ed. Vol 2. Baltimore: Lippincott Williams & Wilkins: 2000:2587.

Competing interests: None declared

FILLERS:
Relative risk
Hanna (29 September 2007) [Full text]
Relative risk
An ethical problem
7 October 2007
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Mounir (Munir) E Nassar, M.D., FACP,
Retired. No affiliation with medical school
Pittsford, NY 14534 USA

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Re: An ethical problem

In responding to "When is hospital the right place to be" by Dr. Hanna, BMJ 2007 335:666 (September 29), it is my opinion, that the bottom line is an ethical problem. In a free society, the patient provided he or she is competent, has the final choice of where his chest pain complaint is to be evaluated. It is his prerogative.

I am not certain that it solves the problem (though it may help) educating the public about the importance of symptoms of chest pain, and the course of action to take : Chew a tablet of aspirin, stop all activity and rest, take sublingual nitrite if available (ideally baring complications) times three 5-7 minutes apart if symptoms persist, and call ambulance for transport to hospital for immediate evaluation, but in the final analysis it is the patient's decision whether to go or not.

In the instance of the general practitioner, the patient refused to go to a center for chest pain evaluation, the practitioner should have a short conference with patient and immediate next of kin explaining the dire consequences, including demise, and with documentation.

On a final note chest pain maybe expeditiously evaluated using the underutilized timed 2-d echocardiogram in the emergency department.

Sincerely,

Mounir(Munir) E Nassar, M.D.,FACP

Competing interests: None declared

CLINICAL REVIEW:
Managing anovulatory infertility and polycystic ovary syndrome
Balen and Rutherford (29 September 2007) [Full text] [PDF]
Managing anovulatory infertility and polycystic ovary syndrome
Management of anovulatory infertility and polycystic ovary syndrome should include diagnosis and treatment of essential nutrient deficiencies.
1 October 2007
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Ellen C G Grant,
physician and medical gynaecologist
Kingston-upon-Thames, KT2 7JU

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Re: Management of anovulatory infertility and polycystic ovary syndrome should include diagnosis and treatment of essential nutrient deficiencies.

Professor Adam Balen’s review of the management of polycystic ovary syndrome (PCOS) is informative. 40-50% of women with PCOS are overweight and insulin resistance is seen in 20-40% of obese women and 10-15% of slim women. Clomifene and gonadotrophins can cause superovulation and a potentially life threatening hyperstimulation syndrome. Trials of the insulin sensitizing agent metaformin disappointed with a high miscarriage rate. Menstrual cycles in obese women were more safely restored by weight loss.1 What, however, are the fundamental causes of PCOS?

An important clue is the association with eating disorders (anorexia or obesity) which suggests nutritional deficiencies or imbalances. 20 - 25% of white women have PCOS in the UK, a country where most women have taken contraceptive pills before pregnancy. Past users had a significantly increased risk of ovarian cysts and increasing trend with longer use in one large study.2 Women with PCOS have a high incidence of insulin resistance, glucose intolerance, obesity, hypertension, diabetes mellitus and cardiovascular disease - conditions known to be increased by contraceptive pills. Progesterone and oestrogen use can cause zinc and magnesium deficiencies, raise copper levels and reduce copper stores.3,4

South Asian immigrants to the UK have a prevalence of PCOS up to 52%. Vitamin D deficiency is known to be a factor in the causation of PCOS along with calcium dysregulation.5,6 It has been repeatedly shown that a low serum ionized magnesium and a high ionized calcium to magnesium ratio is often associated with insulin resistance, cardiovascular problems, diabetes mellitus and hypertension. A significantly lower serum Mg2+ and total magnesium and a significantly higher serum Ca2+/Mg2+ ratio has been found in PCOS patients compared with controls.7 Also a decreased total antioxidant status and increased oxidative stress in women with PCOS may contribute to the risk of cardiovascular disease.8

There are numerous references in PubMed to essential nutrients and “insulin resistance” - magnesium 190, zinc 66, copper 25, chromium 87, selenium 18, manganese 11, vitamin D 90, vitamin B 264, folic acid 44, and also references to insulin resistance and fish oils. There may have been a worrying increase in deficiencies of essential fatty acids in recent years.9

Professor Balen and I agree that there is a need to optimize health of all women before fertility treatment to prevent adverse effects for mothers and children. Unfortunately, in my experience of assessing the nutritional status of preconception couples over 30 years, many couples have endured repeated and unsuccessful fertility treatments before their deficiencies have been diagnosed. Repletion may enable couples to conceive naturally and make drug treatment unnecessary. I think that it is unethical to stimulate ovaries in nutritionally deficient women, whether slim or obese. It is possible to measure micronutrient mineral levels accurately to parts per billion. This is not minutiae but “Big Print Medicine”.

1 Balen AH, Rutherford AJ. Managing anovulatory infertility and polycystic ovary syndrome. BMJ 2007; 335:608-11.

2 Ramcharan S, Pellegrin FA, Ray R, Hsu J-P. TheWalnut Creek Contraceptive Drug Study. A prospective study of the side effects of oral contraceptives. Center for Population Research Monograph Vol 111, Maryland, USA 1981, pp 162.

3 Grant ECG. The pill, hormone replacement therapy, vascular and mood over-reactivity and mineral imbalance. J Nutr Environ Med 1998; 8:105 -116.

4 Grant ECG. Nutritional supplements to prevent pregnancy complications. http://bmj.com/cgi/eletters/329/7458/152#67502, 16 Jul 2004

5 Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, Kimmig R, Mann K, Janssen OE. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006;114 :577-83.

6 Thys-Jacobs S, Donovan D, Papadopoulos A, Sarrel P, Bilezikian JP. Vitamin D and calcium dysregulation in the polycystic ovarian syndrome. Steroids 1999; 64:430-5.

7 Muneyyirci-Delale O, Nacharaju VL, Dalloul M, Jalou S, Rahman M, Altura BM, Altura BT. Divalent cations in women with PCOS: implications for cardiovascular disease. Gynecol Endocrinol 2001;5:198-201.

8 Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006;440:944- 8.

9 Grant ECG. Re: Measuring Fatty Acids - Possible increases in omega -3 and omega-6 deficiencies among women. http://bmj.com/cgi/eletters/330/7498/991#108033, 27 May 2005

Competing interests: None declared

RESEARCH:
Effectiveness and safety of chest pain assessment to prevent emergency admissions: ESCAPE cluster randomised trial
Goodacre et al. (29 September 2007) [Abstract] [Full text] [PDF]
Effectiveness and safety of chest pain assessment to prevent emergency admissions:...
Acute chest pain units. What's in a name?
1 October 2007
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S Richard Underwood,
Professor of Cardiac Imaging
Imperial College London, Royal Brompton Hospital, London SW3 6NP

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Re: Acute chest pain units. What's in a name?

Goodacre and colleagues have shown in a cluster randomised trial that the dedicated acute chest pain units in their trial did not reduce the proportion of patients admitted, and may have led to an overall increase in emergency medical admissions (1). The study addresses an important question although it is unclear to what extent the findings can be generalised. It is tempting to suggest that the trial may have been of the sign on the door through which patients passed rather than the care and investigations received once through it.

Patients seen in hospitals with a dedicated acute chest pain unit were observed for 2 to 6 hours and underwent biochemical testing and an exercise ECG. Hospitals without dedicated units were asked not to introduce such specific elements of care but we are not told what care or investigations were used. Since biochemical testing and the resting ECG are essential components of the investigation of patients presenting with acute chest pain (2,3), it is inconceivable that the control group did not receive these, and the main difference between the groups is likely to have been the immediate availability of an exercise ECG. The relatively low specificity of the exercise ECG may itself have triggered admission from the acute chest pain unit and led to the findings.

In contrast to these traditional methods of assessing patients with acute chest pain, there is now substantial evidence from randomised trials that imaging techniques such as myocardial perfusion scintigraphy (MPS), echocardiography and X-ray computed tomography (CT) have a role. In the ERASE trial, patients presenting to a acute chest pain unit with a non- diagnostic resting ECG, were randomised to care similar to that in the ESCAPE trial and to early resting MPS with subsequent stress functional imaging if acute infarction was excluded (4). The imaging strategy reduced the number of admissions of patients who did not have an acute coronary syndrome without reducing admission of those who did. Similar findings have been shown in other studies of MPS and of CT, emphasising the cost-effectiveness of imaging strategies in the setting of acute chest pain (5,6).

While it is true that few emergency departments or acute chest pain units in the UK have the facilities for 24 hour resting MPS or CT, their implementation would not present impossible challenges and the investment might even be self-financing. The evidence is sufficiently strong that the outcome of the ESCAPE trial may have been different had either the acute chest pain units or the emergency departments used an imaging based protocol. Let us be less concerned with the sign on the door than with the activities beyond it.

References 1 Goodacre S, Cross E, Lewis C, Nicholl J, Capewell S. Effectiveness and safety of chest pain assessment to prevent emergency admissions: ESCAPE cluster randomised trial. Br Med J 2007; 335: 659-62.

2 van der Werf F, Ardissino D, Betriu A, et al. Management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2003; 24: 28-66.

3 European Society of Cardiology. Myocardial infarction redefined - a consensus document of the joint European Society of Cardiology / American College of Cardiology committee for the redefinition of myocardial infarction. Eur Heart J 2000; 21: 1502-13.

4 Udelson JE, Beshansky JR, Ballin DS, et al. Myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia. JAMA 2002; 288: 2693-700.

5 Stowers SA, Eisenstein EL, Wackers FJT, et al. An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but non-diagnostic electrocardiograms: results from a randomized trial. Ann Emerg Med 2000; 35: 17-25.

6 Goldstein JA, Gallagher MJ, O'Neill WW, Ross MA, O'Neil BJ, Raff GL. A randomized controlled trial of multi-slice coronary computed tomography for evaluation of acute chest pain. J Am Coll Cardiol 2007; 49: 863-71.

Competing interests: None declared

RESEARCH:
Preventive strategies for group B streptococcal and other bacterial infections in early infancy: cost effectiveness and value of information analyses
Colbourn et al. (29 September 2007) [Abstract] [Full text] [PDF]
Preventive strategies for group B streptococcal and other bacterial infections in...
The Dangers of Misinterpretation of Economic Analysis
30 September 2007
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Jude N Chukwuma,
Honorary Clinical Research Fellow
School of Medicine, Swansea University,
Chisolum I. Chukwuma, General Practitioner

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Re: The Dangers of Misinterpretation of Economic Analysis

The findings by Colbourn et al(1) are very important and most welcome. However, it does bring to mind the dangers of political translations, interpretations and misinterpretations of such robust economic analyses.

It will be wrong for politicians to harbour any notion that the National Health Service (NHS) is primarily a money making or money saving machine; the quality of life and associated productivity of a healthy population should always be borne in mind.

Reference: 1. Colbourn TE, Asseburg C, Bojke L, Philips Z, Welton NJ, Claxton K, Ades AE, Gilbert RE. Preventive strategies for group B streptococcal and other bacterial infections in early infancy: cost effectiveness and value of information analyses. BMJ 2007; 335: 655-658

Competing interests: None declared

ANALYSIS:
Use of process measures to monitor the quality of clinical practice
Lilford et al. (29 September 2007) [Full text] [PDF]
Use of process measures to monitor the quality of clinical practice
Outcomes Remain The Gold Standard
3 October 2007
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Robert Matz,
Medical Director of Quality Assurance
Mount Sinai Hospital, New York, NY10029/USA

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Re: Outcomes Remain The Gold Standard

To the Editor:

Since each process measure is directed at a specific outcome,it is the outcome measure which should count.If not then the process may not be valuable[despite "expert" opinion]or the process needs further review and/or correction.If a process measure is used to measure quality and the outcome can not be detected to be improved as a result of the process then the process requires adjustment/needs to be responded to as to why it is showing no measurable effect/changed depending on the specific outcome being measured /or abandonded.No matter how you slice and dice it it is an outcome not the process that matters.

Measuring a process maybe easier and quicker but it should result in a clinically meaningful improvement in a significant outcome.Mortality,for most processes,is as Lilfor,et.al.[1] suggest is too blunt an instrument- after all we all will die.But there are multiple clinically meaningful outcomes that can be measured, short of death, that can be tied to processes and should be the measurement of choice.The fact that "other" factors play arole in the outcomes of interest and value does not negate the outcome measurement if the process is clinically and statisticallyimportant in the real world.

Ref.Liliford RJ,Brown CA,Nicholl J.Use of process measures to monitor the quality of clinical practice.BMJ 2007;335:648-650

Sincerely,

Robert Matz,M.D.

Competing interests: None declared

OBSERVATIONS:
Wham, bam, thank you CAM
Kamerow (29 September 2007) [Full text] [PDF]
Wham, bam, thank you CAM
The most important work I do.
6 October 2007
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Dr Edmond V O`Flaherty,
GP
Gleneagle,Greygates,Mount Merrion,Co. Dublin

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Re: The most important work I do.

When I became a GP I had no knowledge of any therapy other than what we were taught ih hospital. We kept patients in bed for quite a while after an infarct as we did with patients who had severe back pain.We used drugs which later proved to be highly dangerous. Many years later I developed an interest in nutrition in mental health,using vitamins,minerals,amino acids and essential fatty acids as complemetary treatment and now I use these nutrients for many patients with much satisfaction.If a patient who has seen a cardiologist comes to me and says he heard I could improve his disease I would laugh at the idea. However if a patient who had seen a psychiatrist comes there is a better than 50:50 chance that I can significantly improve his condition.Much work has been done in this field by the late Dr David Horrobin,Professor Malcolm Peet of Sheffield University and Professor Andrew Stoll of Harvard but much more needs to be done,especially in publishing results. Drug companies will not pay anything to advance this type of treatment. Doctors generally have no knowledge and no interest in the subject.I think that is outrageous. This month for example I have 2 patients who have been diagnosed with schizophenia starting at university and all I have done is to try to normalise their biochemistry while leaving their medication to the psychiatrist.This is the most important work I do and the most satisfying.For those interested I have a website at www.omega3.20megsfree.com

Competing interests: None declared

Wham, bam, thank you CAM
It's good to talk
3 October 2007
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Susan E Farwell,
Registered osteoapth
72 Heavitree Road, Exeter, EX1 2LP

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Re: It's good to talk

Douglas Kamerow observes correctly that complementary and alternative medicine is not scientifically proven, yet patients seem to be voting for it with their wallets. He suggests that a sensible approach for the medical profession is

1. To talk to patients about their treatments
2. To talk to one another about possible treatments
3. To assess the literature, such as it is

May I suggest talking directly to complementary practitioners as well? Most of us are moderately sensible types. Many of us find it almost impossible to catch the attention of a doctor in order to explain what we are doing to their patients and why we are doing it. I can only speak for osteopaths but know that many of my colleagues would value a response to our attempts to communicate.

Susan Farwell
Registered Osteopath, Exeter

Competing interests: I am a registered osteopath

Wham, bam, thank you CAM
What to do about CAM
2 October 2007
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David Colquhoun,
Professor of Pharmacology
UCL WC1E 6BT

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Re: What to do about CAM

Douglas Kamerow seems to me to be excessively tolerant of people who make a lot of money out of unproven and disproved treatments.

I have to say that I prefer the straight talking of his compatriot, Gerald Weissman

"If the trend persists, perhaps MIT or Cal Tech will march in step with the medical schools and offer prizes for integrative alchemy or alternative engineering."

Or Wallace Simpson

"It is time for Congress to defund the National Center for Complementary and Alternative Medicine (NCCAM). After ten years of existence and over $200 million in expenditures, it has not proved effectiveness for any "alternative" method. It has added evidence of ineffectiveness of some methods that we knew did not work before NCCAM was formed."

That is something that could be done. (The expenditure on NCCAM is now close to a billion dollars.)

In the UK NHS, Primary Care Trusts are, quite rightly, withdrawing funding from homeopathy. One homeopathic hospital will close and another is in great danger. Something has been done, at last.

Competing interests: None declared

FEATURE:
Is there enough evidence to judge midwife led units safe? Yes
Page (29 September 2007) [Full text] [PDF]
Is there enough evidence to judge midwife led units safe? Yes
Ongoing research on planned place of birth and safety
4 October 2007
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David M Puddicombe,
Research Assistant
National Perinatal Epidemiology Unit, University of Oxford OX4 1AG,
Mary Stewart and Rachel Rowe

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Re: Ongoing research on planned place of birth and safety

In the most recent issue of the BMJ the Head to Head feature focused on whether or not there is enough evidence to judge midwife led maternity units safe (BMJ 2007;335;642 & 643). This article was of particular interest to us at the National Perinatal Epidemiology Unit (NPEU) because we are currently conducting the Birthplace in England Research Programme (Birthplace) http://www.npeu.ox.ac.uk/birthplace, which incorporates the Evaluation of Maternity Units in England (EMU) cited by Professor Drife. Birthplace is funded by the National Institute for Health Research (NIHR) and the Department of Health (DH) and comprises a series of related studies to compare the safety and cost effectiveness of planned place of birth and describe how provision of maternity services affects women’s experiences.

This whole research programme is predicated on the fact that there is currently insufficient evidence to say whether there is a difference in outcomes according to planned place of birth for women at low risk of complications during labour and birth.

Birthplace includes a large national prospective cohort study which will compare the safety and cost effectiveness of births planned at home, in midwifery units and in obstetric units irrespective of the actual place of birth. A feasibility study to determine whether births planned at home can be included is ongoing. If it is not possible to include planned birth at home, the national study, which will begin in January 2008, will compare births planned in midwifery units and births planned in obstetric units. Results from the national cohort study will be available by the end of 2009.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
5 year survey in Isles of Scilly
4 October 2007
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Toby Dalton,
General Practitioner
The Health Centre, St.Mary's, Isles of Scilly TR21 OHE

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Re: 5 year survey in Isles of Scilly

We have recently conducted a five year survey of our midwifery service. And ALTHOUGH we do transfer roughly half of those initially determined as low risk, the satisfaction of the mothers surveyed and the outcomes for all have been good. We, as GPs, do the ALSO course ( advanced life support in obstetrics), and attend every delivery in support of our midwifery service. I am very much in favour of Midwife led care. Toby Dalton. Data AVAILABLE at your request.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Midwifery down the drain
4 October 2007
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Anne Savage,
retired
N/A

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Re: Midwifery down the drain

Professor Drife's defence of 'hospital is best'will not be well received in this area where our local hospital has been severely censured and a legal case is threatened over an intrapartum death and, last year, a hospital up the road was put under 'special measures' following an unacceptably high number of maternal deaths.

I was a GP Obstetrician back in the last century. Four of us in the area provided obstetric care for any woman in the area who was suitable for delivery in a Maternity Hospital, a Mother and Baby Home, where the 'normal' girls were delivered on site ,and for a number of home deliveries. We had all conducted twenty normal deliveries and seen ten 'abnormals' as students and had had post-graduate training. We worked with a team of six midwives, were always available and frequently present during the second stage but never took over the delivery. It was a team effort and included the local hospital where we received excellent back- up and we also could call on two flying squads. An additional safeguard was a system of 'Midwives' Aid' whereby any midwife could summon any doctor on the obstetric list in times of crisis. We had no neonatal deaths, though one very premature baby died in hospital following a prolapsed cord.

This excellent service was largely disbanded when consultant obstetricians became frightened that they would be responsible for doctors they could not directly control. Some year later, when I was working part of the time in Africa I used to do short locums to 'keep my hand in'. I was shocked at the attitude of midwives in too many places, bored, discontented and unresponsive to women's needs. I sympathised with them, up to a point. Their skills were downgraded, the most junior doctor to arrive in the labour ward could and often did, ignore their advice. In the end it was the women who suffered.Our local paper has been flooded with letters complaining of the poor treatment they experienced and many are now booking with Independent Midwives.

This seems to be the worst of both worlds. It is Professor Drife and his colleagues who are responsible for this sad state of affairs but I worry about the government telling women they can have home deliveries but not reestablishing the safeguards. One thing that could be done is to put the midwives in charge of the labour ward, allow them direct contact to the consultant and why not teach the senior staff to intubate and do simple repairs?

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Are midwife-led maternity units safe?
3 October 2007
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Dr Mike Bull,
Retired GP
Oxford

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Re: Are midwife-led maternity units safe?

I was a GP obstetrician in Oxford from 1956 to 1992 and during that time cared for about 2,000 pregnant women. When I commenced practice some 40% low risk women were booked for home confinement. I was rapidly convinced that no case could be classified as normal until the baby was crying in the cot and the placenta was safely in the bucket. As a consequence I initiated the Oxford GP Maternity Unit, at first situated alongside the Churchill Hospital Consultant Obstetric unit but later fully integrated into the John Radcliffe Hospital. I carefully audited results from this unit for 25 years and, although all cases were selected on the basis of low risk, some 30% required to be transferred to consultant care during pregnancy and another 15% due to complications arising during labour. Whilst we were able to offer a relaxed and supportive style of care to individuals, we were situated physically so that complications could be dealt with promptly due to the proximity of consultant staff and equipment. I have no doubt that maternity care should now in all cases be offered in such a situation.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
No
3 October 2007
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Ian A L Treharne,
Consultant Obstetrician
QE 2 hospital al74hq

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Re: No

I agree with Prof. DRIFE, that there is no evidence to support Midwifery led units. Working in a unit where there is a proposed merger of two units 13 miles apart I have reservations

If cases of major post partum haemorrhage in home births have to travel extra miles for treatment the outcome may not be as good as in cases in hospital. Safety of mother and baby should come before financial restraints.

Competing interests: Consultant Obstetrician

Is there enough evidence to judge midwife led units safe? Yes
Author's Response
3 October 2007
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Lesley Page,
Professor in Midwifery
King's College London SE19NH

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Re: Author's Response

Dr Bury suggests that women should give birth in hospital in case unpredictable complications such as post-partum haemorrhage occur. The point that I made was that the focus on single indicators of safety has taken our attention away from the real problems facing modern maternity services. These include a steadily rising intervention rate (i.e.caesarean section), and the failure of modern maternity services to close the gap in both perinatal and maternal mortality rates between rich and poor, and between different ethnic groups. Nearly a quarter of women in the UK are delivered of their babies by caesarean section. This high caesarean section rate is associated with significant morbidity for the mother, a higher maternal mortality rate and an increased risk, including the risk of stillbirth, in subsequent pregnancies. The intervention rate should not be considered as a secondary outcome measure, it is a primary outcome measure.

The conclusion that planned home birth is no less safe than hospital birth for women without complications was based on the systematic review and meta-analysis referenced in the article. The reviewed studies included all outcomes of both groups including those women and babies who had been transferred to hospital. The analysis revealed no statistical difference in mortality between planned home and planned hospital birth: the confidence interval was not compatible with extreme risks in any of the groups (odds ratio (OR) =0.87, 95%confidence interval (CI)=0.54-1.41). Furthermore there was a lower frequency of low Apgar scores (OR =0.55; 0.41-0.74) in the home birth group. The meta-analysis also showed that fewer interventions occurred in the home birth group. (1). The lower intervention rate may be one of the reasons to choose home birth. Of course the evidence on home birth must be interpreted with caution. In the absence of a large enough randomized controlled trial, despite the matching of groups and controlling for confounding variables in observational studies, there is a possibility of bias. The most likely source of bias being that women who have elected to have their babies at home are motivated to avoid interventions.

Women making the choice between home and hospital birth need to know the risks and benefits of all settings, and of any uncertainty in the evidence base. As Olsen commented ‘it cannot be claimed that planned hospital birth is safe for all babies, nor can it be claimed that planned home birth is safe for all babies’. (1) The National Institute for Health and Clinical Excellence (NICE)guidelines for intrapartum care of healthy women and their babies during childbirth state that ‘women should be offered the choice of planning birth at home, in a midwife-led unit or in an obstetric unit’. (2)

1. Olsen O. Meta-analysis of the safety of home birth. Birth 1997; 24:4-13.

2. National Collaborating Centre for Women’s Health.Intrapartum care of healthy women and their babies during childbirth. [Nice Clinical Guidelines]. London: RCOG Press; September 2007.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
midwifery led-units: choice and safety
3 October 2007
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Fatima A Husain,
Consultant Obstetrician & Gynaecologist
Heatherwood & Wexham Park Hospitals NHS Foundation Trust, SL2 4HL,
Phillip W. Reginald

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Re: midwifery led-units: choice and safety

Dear Editor,

We read with interest the views of both authors and wish to make the following points:-

Childbirth is not risk free. Although the process is a natural one, it is not declared safe until the baby is delivered and the third stage is complete. Risk categorisation of a pregnancy is possible, but complications are usually unpredictable needing urgent attention. When this happens in an isolated midwifery led unit (MLMU), transferring the patient to hospital is the only option. Outcome is then variable and depends on the nature of the complication and transfer facilities available. Each patient intending to deliver in a MLMU should be given explicit information emphasizing that this is the only option in the event of a complication. This could reduce the number of deliveries in, and question the viability of, isolated MLMUs.

Positive birth experience and safety are important but should not be confused or allowed to compromise each other. Efforts must be made to provide a positive experience in the safety of a hospital maternity unit and possibly in an integrated MLMU.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Risk to babies with home delivery and midwife led units
3 October 2007
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Philip Murray,
Clinical Research Fellow
Endocrine Sciences Research Group, Core technology Facility, University of Manchester, M13 9NT

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Re: Risk to babies with home delivery and midwife led units

To suggest that there is likely to be no increased risk to a baby from a planned home/midwife centre delivery does not make sense. For those developing signs of fetal distress they will have to be transferred to a consultant led unit. This will inevitably add some time delay prior to delivery and for a very small number of babies this time delay will be significant leading to possible brain damage and death.

There will also be babies born unexpectandly flat. Although midwives are well trained in neonatal resuscitaion their skills are not likely to be as good as a middle grade paediatrician present in hospital.

I accept that the number of these babies is likely to be very small and that there are high intervention rates in consultant led units but I do feel that all mothes opting for home/midwife led units should be warned of the likely increased risk to their babies.

These comments apply only to midwife led units not on the same site as a consultant led unit.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Midwife led unit’s needs more evidence prior to independent practice
2 October 2007
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Chelliah R Selvasekar,
Specialist Registrar in Colorectal Surgery
Christie Hospital, Manchester M20 4BX

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Re: Midwife led unit’s needs more evidence prior to independent practice

I read with interest the debate on midwife led obstetric care.1 There is currently not much evidence for an independent midwife led unit.2 The aim for this government initiative appears to reduce the cost which will compromise quality.

I can comment from my personal experience when my wife was admitted for childbirth in an NHS hospital where I was working and found an appalling practice when my wife was in labour for nearly three days without being seen by a consultant and managed by midwifes without much continuity of care. Finally when my son was born he developed severe sepsis which I believe is due to prolonged labour and was cared by neonatologists at the local hospital and then transferred to a tertiary unit, where it was a consultant led practice. I was able to appreciate the difference in the care, the communication among the health professionals and to the patients was exemplary in the consultant led set up compared to the midwife practice. When I made an official complaint about the lack of adequate obstetric care and lack of communication to improve the quality of the midwife service at the local hospital, the explanation was suboptimal and to my surprise I have noted similar traumatic experience in other midwife led units since then from colleagues and friends. Hence I think before the government introduces the midwife led service, it should assess the available evidence and have an optimal safety plans to ensure midwife care is adequate and not compromise the mother and baby. It is not only important to know the positive side of the mid wife led service, but we as the end users of healthcare should be aware of the negative aspects, near misses, assess the way to prevent mishaps and avoid the ego and tunnelled vision among the midwifes and encourage them to work as a team, audit their work and be more open to ensure welfare of mother and baby. At the end of the day we should understand that the obstetrician has a global approach to patient care as they have gone through a standard medical training whereas the midwife training is limited to a specialty and their overall approach is minimal, hence need to be supervised by an obstetrician for the welfare of the society.

Reference List

1. Page, L. Do we have enough evidence to judge midwife led maternity units safe? BMJ 335, 642-643. 29-9-2007.

2. Hodnett ED, Downe S, Edwards N, Walsh D. Home-like versus conventional institutional settings for birth. Cochrane Database Syst Rev 2005; CD000012.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
'From cradle to grave'
2 October 2007
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Anna E Livingstone,
General practice principal
The Limehouse Practice Gill Street Health Centre London E14 8HQ

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Re: 'From cradle to grave'

Yes, I agree, birthing centres and home are places of low risk for birth, for women for whom normal deliveries can be expected, and for their babies and I've followed the evidence and arguments across three decades. Here we see Page, midwife, female, with references discretely hidden on the web, pitted against Drife, male, obstetrician, with ostentatious confidence intervals bold on his pages 'not significant but significant'. The age old battle for control of women's bodies continues between midwives and surgeons. However the latter have to bear the responsibility of clinically unjustifiable rises in Caesarian rates,with concomitant maternal complications, and lower breast feeding rates, while in wealthier countries skills have been lost across the board in safely conducting vaginal deliveries that are in the least complex. If you want a safer vaginal breech delivery you need to go to a poor country.

But, what of the women ? They don't exist in isolation at a brief period of time spanning pregnancy and the puerperium, but as part of families and a local community, with other influences and aspects to their lives and health which knit in with the childbearing experience. It is shocking that Page doesn't mention general practice at all, and worse than that O'Drife seems to have know idea of the substantial role in maternity care played by many general practitioners and general practices. General practice, can and does bring together local people as patients and families, health visitors, GPs and receptionists who know them all and can identify and support through medical and psychosocial risks. We have been part of such a team in our practice since the early eighties and are not special in this. Local community based services where delivery support is part of ongoing care is what most of the women we see want, whether that delivery be at hospital or outside, and there is great interest in the soon to open birthing centre nearby.

Competing interests: I am an NHS GP working in a practice antenatal clinic with midwives and health visitors

Is there enough evidence to judge midwife led units safe? Yes
Places of birth- Satisfaction or Safety?
2 October 2007
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Bode Williams,
Consultant Obstetrician and Gynaecologist
Frimley Park Hospital NHS Trust, Surrey, GU16 7UJ

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Re: Places of birth- Satisfaction or Safety?

I read with the interest the ongoing debate about the comparative safety of different places of birth for ‘low-risk’ pregnancies. This is based on the misleading notion that pregnant women can be divided into low or high risk groups at the beginning of their pregnancies according to prior history and offered appropriate level of care. Everyone knows that risk assessment is a continuing and dynamic process throughout pregnancy and childbirth. Regrettably, clinical risk scoring systems do not work well in pregnancy. Hence, the vast majority of women who develop life- threatening complications during labour and childbirth including shoulder dystocia and postpartum haemorrhage are so-called ‘low-risk’ pregnancies.

The stark reality is that midwives and doctors cannot predict these childbirth complications in advance in any individual pregnancy and current obstetrics management is based on timely intervention when they occur.

It seems that the real choice for pregnant women and their supporters is to decide whether to take a chance hoping that nothing will happen and give birth in the ‘plush home from home’ surroundings of the stand-alone midwifery led units in the quest for satisfaction. The alternative is to choose ‘well-resourced’ hospital labour wards with proven safety track records in dealing with relatively uncommon but life threatening childbirth complications.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Place of Birth
2 October 2007
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Melvyn F Docker,
Retired Medical Physicist
ex B'ham Women's Hospital B15

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Re: Place of Birth

Is there enough evidence to judge the safety of midwife led units? I believe that the birth experience is probably better in these. BUT the safety of mother and child must of greater importance. The midwife led unit must be a small one attached to a hospital with full obstetric and theatre facilities! Melvyn Docker

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
NO, midwifery-led care is a risky business.
1 October 2007
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Olakunle Fajemirokun-Odudeyi,
SPR Gynaecological Oncology Leeds
St James's University Hospital Leeds LS9 7TF

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Re: NO, midwifery-led care is a risky business.

There is no evidence that midwifery-led care is safer compared to consultant-led care and it can in fact have negative impacts on birthing experience.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Damaged babies
30 September 2007
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Lydia M Stevens,
GP
TW8 8DS

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Re: Damaged babies

The articles are short on details regarding perinatal morbidity rather than mortality, which I'm sure reflects the lack of evidence. A case that sticks in my mind from my training was that of a transfer from a midwifery unit some miles away. This child of a "low risk" mother was unexpectedly born "flat." Apparently, there had been no attempt at resuscitation until 20 minutes after birth, when the only anaesthetist in the hospital arrived, having previously been in theatre with a patient he couldn't leave. My understanding is that midwives who only work in low risk units get very little practice in resuscitation, its not the same on a dummy how ever often their "skills" are updated, because nearly all their babies are born screaming. Perinatal mortality is a tragedy but brain damaged babies who could potentially have been saved by timely paediatrician is even more so, and a huge cost in litigation and lifetime care of a quadraplegic child with severe cerebral palsy (as resulted in this case). Every baby is essentially "untested" until born so even "low risk deliveries" sometimes result in unexpectedly sick infants that need expert care immediately. By all means let women come in last minute and go home very soon, but for the unexpected calamity I am sure where I would want to be. Whatever happened to "Domino" deliveries where community midwives helped the labour at home, came in with the mother for the last phase, and quick discharge if all well. Most women were in only 6 hours - perfect compromise?

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Safety and Quality of care really matter
30 September 2007
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Sally K Tracy,
Professor Women's Health and Midwifery
University of Technology, Sydney, NSW, AUSTRALIA

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Re: Safety and Quality of care really matter

“Head to Head” this week clearly illustrates the chasm that continues to divide maternity service policy both in the UK and elsewhere. Page correctly identifies that the problem lies in ‘the move to have all women give birth in hospital’ as ‘one of the biggest uncontrolled medical and social experiments of the 20th century’. Drife, on the other hand makes claims that a confidence interval that is ‘only just’ not significant is relevant in the discussion about evidence. (Hopefully the rationale to accept or reject research guiding the newly announced NICE guidelines for intrapartum care was not based on similar opinion!) Clearly the opportunity was missed to judge the effectiveness of hospital birth before all women were advised it was the safest place; however there are important quality signals which we should not continue to ignore. These include for example the amount of pain and suffering associated with increased surgical intervention in birth. Maternal mortality has not improved with rising rates of caesarean section and the increased incidence of life saving hysterectomy following catastrophic post partum haemorrhages is alarming. Every professional concerned with the health of mothers and infants should be eager to find solutions to improve these events. Drife’s claim that ‘safety is never absolute’ signals an opportunity to centre practice changes on sound principles of risk management combined with simultaneous and continuous evaluation of processes of care. Adhering to processes of clinical improvement alongside the introduction of birth centres and midwifery group practices should guarantee the safest possible future maternity care. Advising a woman on the safety of birth in hospital or at home relies on so many more aspects than we have been prepared to acknowledge previously. As Page asserts the domination of a medical view of birth and sole reliance on perinatal mortality measures has blinded us to other equally important factors that drive safety in maternity care.

Competing interests: None declared

Is there enough evidence to judge midwife led units safe? Yes
Single measure of safety
30 September 2007
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A Sajayan,
Anaesthetist
Hertfordshire

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Re: Single measure of safety

The argument that Prof.Page give in favour of midwife lead centres in my opinion is just a reflection of the age old frustration among the midwives against the 'intervening' doctors(includes obstetricians and anaesthetists). She complaints that all the discussions are centred around a single measure of saftey ie,perinatal mortality.Which is the most important end point in a stressful process like pregnancy other than being rewarded with a healthy baby?So it is quite understandable and acceptable that the whole process will be discussed on this outcome and how to make that safer.

In her article the doctors are pictured as the monsters who interfere unnencessarily in a natural process waiting for an opportunity to pull the patient in to the theatre for a caesarean section.

The cat comes out of the bag in the sentence ''midwifery had been taken from its community base ...and lost its professional autonomy and influence''.I think this fear of losing influence is a basic problem with most if not all midwives and that reflect in their attitude towards doctors.

While she rightly suggest that we need both approaches in balance,her definition of the roles of midwives and obstetricians and the lack of positive experience and personal approach in the latter group lacks quality evidence,just like the cochrane studies she quoted.

As an anaesthetist who has seen many 'straightforward' pregancies ending up in major complications without much notice,I believe a lot needs to be done in terms of infrastucture like transportation,obstetric unit availabilty at reasonable distance,patient screening mechanisms,understanding of limitations and above all a mutual respect between the two (three including us anaesthetists)professions to make the outcome of the whole exercise better.

Given a choice between a holistic,total apporoach with no guarantee of timely 'intervention' and a so called 'fragmented' care with a guaranteed intervention if needed,I know which one I will choose.

Competing interests: None declared

NEWS:
Advice to pregnant women to avoid eating peanuts should be withdrawn, says Lords committee
Kmietowicz (29 September 2007) [Full text] [PDF]
Advice to pregnant women to avoid eating peanuts should be withdrawn, says Lords...
At last: some common sense
1 October 2007
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Stuart H McClelland,
Anaesthetic Research Fellow
Queen's Medical Centre, Nottingham, NG7 2UH

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Re: At last: some common sense

The House of Lords committee’s forthright comments about advice to avoid peanut during pregnancy and infancy is a welcome injection of common sense and scientific rigor into this area. Whilst not having an expert knowledge of immunology, it has always seemed totally illogical to me how avoiding an antigen during immune system development might avoid future allergy to that antigen. A key process within the immune system is the differentiation of ‘self’ from ‘foreign’ material. Avoiding peanut during immunological maturation would seem likely to place it firmly in the ‘foreign’ category once exposure eventually takes place.

Advice given to pregnant women and new parents often seems to languish disproportionately in the realm of pseudo-science and conjecture. Most expectant or new parents will have the welfare of their offspring as their first concern and wish to err on the side of caution. However the committee’s finding that peanut avoidance may be fuelling the rise in peanut allergy is a timely reminder of our responsibility to “first do no harm”.

Our strive for a pathogen, toxin and risk free existence is not achievable, and the consequent guilt contributes to the stress of modern life. That this strive may not even be desirable must now lead to a dispassionate and reasoned review of the advice we give during pregnancy and early parenthood. All recommendations should be supplied with an honest statement about the evidence for them. The risk of failing in this is that all official advice be seen as questionable, and that important public health messages are lost.

Competing interests: None declared

NEWS:
Doctors rank myocardial infarction as most "prestigious" disease and fibromyalgia as least
Dobson (29 September 2007) [Full text] [PDF]
Doctors rank myocardial infarction as most "prestigious" disease and fibromyalgia...
Doctors rank myocardial infarction as most "prestigious" disease and fibromyalgia as least
1 October 2007
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Maureen Norton,
Medically retired
WN3 6DF

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Re: Doctors rank myocardial infarction as most "prestigious" disease and fibromyalgia as least

Having had fibromyalgia for the last 15 years (I am 53) I find it so disheartening to think that this illness is in this day and age not taken seriously enough. OK so it is not life-threatening, but it is quality of life threatening. This illness has caused me to lose my job, my social life not to mention other aspects of my life that I use to enjoy. As far as it being linked to emotional problems; I am happily married, have no worries, well no more or less than the average person. I force myself each day to do things even though they cause me great pain, I push myself so as not to have to rely on others. I hardly ever go to see my GP, not that she is not understanding, she is, but what is the point, there is no cure. However Pregabalin this last 2 years has given me a better quality of life, from being virtually lay horizontal most of the day, I am able to do more things, but it is not a cure. SO PLEASE MEDICAL PROFESSION do not treat your patients with fibromyalgia with less importance than say somebody who is in pain with arthritis, we are human beings in pain.

Competing interests: None declared

Doctors rank myocardial infarction as most "prestigious" disease and fibromyalgia...
How "prestigious" do the public view disease
30 September 2007
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Martin Whitehead,
Specialist Registrar in Geriatric, Stroke and General Internal Medicine
Southern General Hospital, Glasgow, G51 4TF

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Re: How "prestigious" do the public view disease

The researchers in Oslo present very interesting, and potentially worrying data. I'm sure all medical practitioners have "favourites" when it comes to managing the vast spectrum of medical and surgical issues with which we are presented on a daily basis. This may of course impact on our ability and possibly even our desire to provide optimal management in each unique scenario. I think it would be of additional interest, however, to assess whether the public also ranks these disease states in a similar manner. The finding that final year medical students have similar views to senior doctors suggests that this may be a reflection of the prestige held by society in general, rather than medical professionals - or alternatively it could be that medical school education is very effective in perpetuating the beliefs of the establishment.

Competing interests: None declared

LETTERS:
Uniquely disadvantaged
Livesey (29 September 2007) [Full text] [PDF]
Uniquely disadvantaged
Double-edge swords: challenges faced by ill physicians
1 October 2007
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Robert L. Klitzman,
Assoc. Prof. of Clinical Psychiatry
Columbia University/1051 RSD/NY NY USA 10032

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Re: Double-edge swords: challenges faced by ill physicians

In response to my article on “Pleasing doctors: When it gets in the way” (1), Mann (2), in highlighting doctors’ limitations, and Livesey (3), in suggesting the range of struggles sick doctors face, raise important issues.

In fact, physician illness is a uniquely double-edged sword. Ill doctors are forced to learn and unlearn much; and face a variety of these and other complex, inter-connected tensions. They face many challenges (e.g., stigma, and denial of symptoms), but often now come to see, in ways they had not before, how they and colleagues can communicate and interact with patients better. Some alter their own clinical practices, after seeing, e.g., their own doctors sitting down, rather than standing up when speaking at the bedside, and framing bad news in ways that still provide hope and reassurance (even if based not on science, but on a ‘placebo effect’). Many sick doctors become more aware of the importance of spirituality and non-medical aspects of care in patient care. The challenges they face make many more empathetic to the obstacles their patients, too, confront.

Whether directly or indirectly, these struggles frequently lead doctors to arrive at insights that can help others. Providers can readily dismiss patients’ complaints, but the experiences of ill physicians, having been on both sides of the stethoscope, can potentially be more poignant and effective in compelling colleagues to improve interactions with interactions. As I describe, far more fully and detailed, in a book just published, When Doctors Become Patients (4), the experiences of wounded healers illuminate multiple critical areas of medicine, and can inspire physicians – as providers and/or as patients -- to be ever more effective.

1. Klitzman, R., Pleasing Doctors; when it gets in the way, BMJ 2007 335:514.

2. Mann, H., Why is my doctor too busy to talk to me? BMJ, Rapid response, 12 Sept. 2007

3. Levesey, A., Uniquely disadvantaged. BMJ 2007; 335:630.

4. Klitzman, R., When doctors become patients. New York and London: Oxford University Press, 2007.

Competing interests: None declared

Uniquely disadvantaged
Advantages and disadvantages perhaps culturally based.
30 September 2007
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Andre des Etages,
SpR
Southampton General Hospital

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Re: Advantages and disadvantages perhaps culturally based.

I think that the views expressed by Dr Livesey are valid within the context of those individuals who have had the privelige of being treated by their colleagues.As a foreign medical graduate, I have experienced the professional courtesy that was extended to me personally as well as to my family abroad.This filled me with a sense of vocation, humility and gratitude.

My experience in the United Kingdom, however has been different.Few GPs gave the perception of taking any personal or family illness as seriously as I would have expected. This however varied largely with the personality of the GP concerned and my own cultural bias.There are times when I was given the distinct impression that I should know how to deal with family complaints(though,outside of my area of expertise) and indeed should have done so, rather than visit a busy surgery. As a medical student,I was taught that a doctor who treats himself (or family),has a fool for a patient. This is a motto I stick by.The majority of my patients are well educated and like them,I visit my GP when I need to.

It is perhaps worth remembering that we were not born doctors and that like any individual we are not immune to illness. When approached in a therapeutic capacity by a colleague,we should put our "get over it" and "school of hard knocks" culture aside and look with compassion at the patient beyond the stethescope.

Competing interests: None declared

LETTERS:
Profound ethical issues were smoothed over
Blumsohn (29 September 2007) [Full text] [PDF]
Profound ethical issues were smoothed over
Re: Conflicts of Interest
1 October 2007
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Aubrey Blumsohn,
Consultant
Sheffield Teaching Hospitals NHS Trust

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Re: Re: Conflicts of Interest

This is a fascinating new definition of a conflict of interest Dr Coghill. Essentially what we are saying is that previous expression of a view constitutes a conflict of interest if that same view is later expressed. I will try to oscillate my views and ethical standards to avoid this in future.

Pervasive mistrust of our profession seems to be the rule rather than the exception, and I believe we need a rather better standard of debate.

"Conflict" of interest: Have previously written about the Gillberg affair [1,2,3].

References

1. http://scientific-misconduct.blogspot.com/2007/09/who-is-beast-merger-of-medical-journals.html

2. http://scientific-misconduct.blogspot.com/2007/07/intimidation-by-patient-advocacy-groups.html

3. http://scientific-misconduct.blogspot.com/2007/07/gillberg-affair-and-fall-of-scientific.html

Aubrey Blumsohn

Competing interests: Fascinated observer

Profound ethical issues were smoothed over
Conflicts of Interest
30 September 2007
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David R Coghill,
Senior Lecturer in Child and Adolescent Psychiatry
University of Dundee, Ninewells Hospital, Dundee, DD3 6HH

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Re: Conflicts of Interest

Whether I agree or disagree with Blumsohn regarding the BMJ's treatment of the "Gillberg affair" is unimportant. However I must question Blumsohn's definition of "no competing interets". I believe that his own experiences with research misconduct, which have prompted him to run a blog entitled "Scientific Misconduct Blog, About all manner of corporate pharmaceutical scientific misconduct. If you're not outraged, you're not paying attention.", represent a significant competing interest and should, in the interest of transparancy, have been made clear.

Competing interests: Researcher in ADHD acquaintance of Christopher Gillberg. Has received research funding from industry.

LETTERS:
Capitalism is a force for good
Charlton (29 September 2007) [Full text] [PDF]
Capitalism is a force for good
Achieving health equity with more liberty, wealth, and ethics.
5 October 2007
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Anonymous Cuban professional

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Re: Achieving health equity with more liberty, wealth, and ethics.

I thank the BMJ Editors for publishing the Maryon-Davis’ editorial (linking the WHO Commission on Social Determinants of Health’s Interim Statement), and the Charlton and Danaher’s comments,[1-4], which I shall comment as follows.

The WHO commission statement,[1-2] is very comprehensive, rigorous, and positive, but it did not discuss some of the causes of the causes of ill-health. For example: Terror and lack of ethics as poverty are bad for health; and liberties, wealth, and ethics are the things that can cure the remainder terror, poverty, social and health inequities, ill life and health in the developing world.

It could be discussed the need of the observance, verified by the correspondent United Nations (UN) Commission, of all the human individual economic, civil and political liberties and rights, as crucial factors of remaining social and health inequities and ill life and health in poor countries. It could be also debated also the historical role of capitalist wealth growth reducing the great feudal inequities between few rich and huge poor classes through a gradual increasing equity toward the overall wealth mean within the middle class. Formerly, most of the world’s people of middle and rich classes now were poor with inequities.

Had a free and moderate China retained its two million political exiles, which have moved to Taiwan since 1949, it might now be as integrally advanced with free information technology (IT) as Hong Kong or Japan. Similarly, a free and peaceful Russia, and free and united Korea and Cuba, would have been as developed with free IT as the US, as South Korea or Singapore, and as Iceland (table) or South Florida, respectively.

Socialist China’s state capitalism from 1978, without individual liberties for all, more in the North West and Central regions, is achieving much wealth, but it is not curing its terrified civil society, misery, equity at the bottom, health inequities, and ill life and health.

If Malawi and other poorest countries could implement a modern capitalism system improving their institutional legal, economic, social and political chaos, as happened in Ireland and other affluent countries since 1750, the high birth rate Malawi has would freely decrease by the spontaneous planning of the families by themselves.

Whether this is so clear, why near a hundred of poor countries still are retarded in different degrees of primitive feudalism, non capitalist and capitalist stagnation?

In the last century, while the UK, US and most developed countries were working hard and spreading spontaneously economic wealth, social prosperity, technology, science, trade, and political democracy worldwide, Russia and their satellites were, and some still are, recruiting developing countries, conspiring, imposing an inverse globalization, re-tyrannizing and re-impoverishing the world with social fallacies.[5]

The world has advanced thanks to democratic capitalism, liberating humanity in more than 50% from despotic governments and in more than 60% from the generalized famines, poverty, epidemics and inequities still in the mid-1700s.[6-8] These achievements could be better known by the world’s poor if are discussed there too.

The trial of the Soviet totalitarian-terrifying socialism has failed everywhere to satisfy the basic individual liberties, rights, needs, levels and quality of life and health, according to the UN and WHO integral definitions. Social democrat and socialist programs in the developed Europe, Canada and Asia-Oceania, respecting individual rights and socially distributing plentiful wealth are very different things, although is uncertain, if the growth rhythms in the long-term could be able to maintain them.

Cuba, once advanced,[9] since 1959 has 99% of natives living, working and aging equal in a watched over and terrified civil society, as ‘cattle’ with low infant and infectious mortalities and high longevity, due to its specially preserved capitalist trends for propaganda purposes. Natives are captive in re-impoverished cities and villages, hungry, indoctrinated, psychopathic and corrupted (‘owned and spurred on’ by aristocrat ‘red’ families and cronies monopolizing all liberties, wealth, first-class living and health standards as the foreigners), suffering a worse equity at the bottom than the Cuba of 1750.

The only way to decrease the great social and health inequities that remain in the poor non capitalist countries is through a capitalist human development, because the socialist human involution compels to the great feudal inequities again. In Sub-Saharan Africa, it was proven decades ago that socialist involution needed a basic capitalist growth and infrastructure, and enormous subsidies that any country had.

All the UN agencies and their 200 country members and teams have had very difficultly to resist the Russian, Chinese, Cuban and allies massive ideological subversion, misinformation, and pressures.[5] It is the hour that the UN agencies and countries face and assume a clear position before the ideological division and chaos that these retrograde countries still promote in their assemblies and commissions.

The ancient hopes of the great religious leaders, and thinkers as Plato, Moro and others, to calmly reduce the social and health inequities, in spite of the hate and violence instigated by the Marx and Lenin’s doctrine of envy, enforced by bellicose followers to seize the wealth of our countries, have been gradually materialized with more liberty, wealth, and ethics perfecting the free market economy in the last 250 years.

This author has enough intra-national and international evidences analyzed to scientifically and statistically support a broader exposition of these comments, if necessary.

Thank you.

References:

1. Maryon-Davis A. Editorials. Achieving health equity for all. BMJ 2007;335:522-523. (accessed 3 Oct 2007). http://www.bmj.com/cgi/content/full/335/7619/522

2. Commission on Social Determinants of Health. Interim statement. Achieving health equity: from root causes to fair outcomes. 2007. (accessed 3 Oct 2007). http://www.who.int/social_determinants/resources/csdh_media/csdh_interim_statement_07.pdf

3. Charlton BC. Capitalism is a force for good. BMJ 2007;335: 628-629. (accessed 3 Oct 2007). http://www.bmj.com/cgi/content/full/335/7621/628-b

4. Danaher JG. Rapid Response. Population and Poverty: Malawi. BMJ 2007 (2 October 2007). (accessed 3 Oct 2007). http://www.bmj.com/cgi/eletters/335/7621/628-b#177491

5. Anonymous Cuban Professional. Rapid Response. UN and WHO Leaders could Welcome a Bioeconomic-Psychosocial Paradigm. BMJ 2006 (15 November 2006). (accessed 3 Oct 2007). http://www.bmj.com/cgi/eletters/333/7576/1015#149265

6. Landes DS. The Wealth and Poverty of Nations: Why Some Are So Rich and Some So Poor? 1st Ed. New York: W.W. Norton Co. & Inc., 1999.

7. Fogel RW. The escape from hunger and premature death, 1700–2100: Europe, America, and the third world, 1st Ed. New York: Cambridge University Press, 2004.

8. Sachs JD. The End of Poverty. Economic Possibilities for Our Time. 1st Ed. New York: The Penguin Press, 2005.

9. Anon. Cuba's delayed transition needs. Lancet 2006;368:1323. (accessed 3 Oct 2007). http://www.thelancet.com/journals/lancet/article/PIIS0140673606695445/fulltext

Table

Relation of freedoms with economic and IT growth in some countries

  Index-Year  /  Countries                           

GNI per capita      [1990 US$  converted GK PPP] 1                      

Economic freedom [ranking position 157-1] 2            

Mobile cell phone [x1000 inh]  3 

Internet users [x1000 inh]  3 

Political & civil rights & liberties [ratings 2-14]  4

Countries

1900

1957

2005

2005

2004

2004

2005

Cuba 

1400

2406

2691

156

7

13

14

Iceland  

2000

6323

24501

15

998

772

2

North Korea       

900

1087

1027

157

2

5

14

South Korea  

800

1206

17259

36

761

657

3

Singapore 

1000

2318

24571

2

910

571

9

China  

545

631

5519

119

258

73

13

Taiwan 

700

1314

19163

26

968

580

2

Hong Kong 

700

2825

27709

1

1184

506

7

Japan

1180

3136

22119

18

716

587

3

Russia (USSR) 

1237

3576

7304

120

517

101

11

United States

4091

10920

30519

4

617

630

2

Sources:

1. Groningen Growth Development Center. Total economy database; Angus Madisson historical statistics database, 2007. (accessed 3 Oct 2007). http://www.ggdc.net/ 

2. Heritage Foundation. Indexes of economic freedom. WCAS, 2007.  (accessed 3 Oct 2007). http://www.heritage.org/research/features/index/countries.cfm

3. United Nations Development Program. Human development index tables, 2007.  (accessed 3 Oct 2007). http://hdr.undp.org/hdr2006/pdfs/report/HDR_2006_Tables.pdf

4. Freedom House. Freedom in the world 2006. Annual global survey of political-rights and civil-liberties, 2006.  (accessed 3 Oct 2007). http://www.freedomhouse.org/uploads/pdf/charts2006.pdf 

 

 

Competing interests: None declared

Capitalism is a force for good
Population and Poverty: Malawi
2 October 2007
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James G Danaher,
Retired NHS GP
33 Ashby Road Ravenstone Leicestershire LE67 2AA

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Re: Population and Poverty: Malawi

Population and Poverty: Malawi

“In Malawi the standard of living (daily calorie consumption) is perhaps the lowest that ever existed in human history. This is a consequence of medical advances which allow population to increase even during chronic famine.”1

The population increase in Malawi in consequence of these medical advances is dramatic, as can be seen when we compare the demography of Malawi and Ireland.

The land area of Malawi is not all that greater than that of Ireland (94,080sqKm to 68,890sqKm)2 and in 1950 their populations were about the same. The United Nations low estimates3 for their populations are:

Ireland 2.9 million in 1950; 3.8 million in 2000; and an estimated 5.3 million in 2050. Malawi 2.8 million in 1950; 11 million in 2000; and an estimated 27 million by 2050.

Ireland is prosperous. Malawi is poverty-stricken and semi-starved, and will remain so for the foreseeable future. Many factor contribute to these differences, but a major factor must be that the population increase in Ireland is small, and the population increase in Malawi is huge and unmanageable. Sadly, over the last fifty years, almost no one has wanted to be involved in the difficult task of providing Malawians with effective family planning.

1.Charlton, Bruce G Capitalism is a force for good. BMJ 2007;335:628 2.CIA World Fact Book 3.www.unpopulation.org

Gerald Danaher 33 Ashby Road Ravenstone Leicestershire LE67 2AA jgd@gerrydanaher.com

Competing interests: None declared

LETTERS:
None so blind
Wake (29 September 2007) [Full text] [PDF]
None so blind
None so blind...looking for the evidence
10 October 2007
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Rowland L Cottingham,
Consultant in Emergency Medicne
Brighton and Sussex Universities NHS Trust

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Re: None so blind...looking for the evidence

Wake asserts that "over 50% of people attending accident and emergency departments would receive better care from Primary Care Practitioners." He has not referenced his claim.

The evidence I have seen is a study performed by Dale and colleagues in King's College Hospital in 1995 showing that 40.9%(1)were classified as 'Primary Care' and could be seen by General Practioners (GPs). However, the GPs were 'considerably' more likely to refer Accident and Emergency (A&E;) patients than A&E; doctors were. I repeated the study in a semi-rural seaside town (2) and found there to be a seasonal variation; 38.7% attended with primary care problems in winter and 43.8% in the summer by the same criteria as Dale used. I am not aware of any study that has shown a higher figure than this. I would like to ask Wake to provide his evidence.

1. Dale J, Green J, Reid F, Glucksman E. Primary care in the accident and emergency department: I. Prospective identification of patients. BMJ. 1995 Aug 12;311(7002):423-6.

2. Cottingham RL. Primary care problems in patients attending a semi- rural accident and emergency unit: a prospective study. J Accid Emerg Med. 1998 May;15(3):168-9.

Competing interests: I have conducted a study into Primary care attenders at an Emergency Department.

LETTERS:
Summary of responses
Twisselmann (29 September 2007) [Full text] [PDF]
Summary of responses
Performance related pay
5 October 2007
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Peter S L Barling,
GP
Oswestry SY10 7HR

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Re: Performance related pay

This argument may come and go like the tide and yet both performance related pay and straight salaries have their strong points,as well as weak points.A salary may provide a secure financial back ground for a physician leaving his or her energies for their work.However,it also allows the indolent an easy passage through a working life especially when the initial joys of the job have paled with time.

Performance related pay allows incentives which can provide a driving force.It can also provide for political intrusion in attaining aims for policy such as the quality and outcome framework.Performance related pay can also result in over treatment and questionable overperformance.

I have worked in both systems,in Canada and the UK.I remember a patient who had three separate claims for hysterectomy over a few years.Overly zealous surgery,and extended follow up consultations for minor illness.I also can see the sloth that can invade the NHS.Interestingly ,we now have in the NHS some of the overtreatment mechanisms for increasing budgets.The double follow up of otitis externa in A&E; departements springs to mind.

A balance of the two concepts might (or not)be the answer.A performance related pay which increased in an exponential curve could provide a good average pay,a poor pay for the indolent,and a controlled increase for the hard worker.It would also allow for political objectives,as well as giving warning of of overtreatment.Objectives could be changed annually in keeping with ever changing medical opinion.Rigid quality and outcome framework taking no account of changes in geriatric care could be replaced.

Will we ever get it right.

Competing interests: a GP

EDITORIALS:
Physician assisted death in vulnerable populations
Quill (29 September 2007) [Full text] [PDF]
Physician assisted death in vulnerable populations
Mentally ill given short shrift
10 October 2007
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Madelyn H. Hicks,
Honorary Lecturer
Health Service and Population Research Dept, Institute of Psychiatry, de Crespigny Park, London, SE5

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Re: Mentally ill given short shrift

Quill (1) and Battin (2) misleadingly convert the lack of appropriate research on mental illness and euthanasia or physician-assisted suicide (EAS) in Oregon and the Netherlands into ‘evidence’ of no vulnerability. If a law specified ‘advanced age’ as a justification for EAS, the elderly would be recognized as vulnerable. Yet they assert that the Dutch mentally ill are not vulnerable, despite Dutch law allowing EAS for mental disorders without physical illness. They minimize rates of EAS for mental disorders, neglecting to report cases where Dutch psychiatrists are consulted by another physician who carries out EAS for a mental disorder, in addition to the 2-5 directly-assisted deaths by Dutch psychiatrists annually. EAS is allowed for mental disorders without any psychiatric assessment. Psychiatrists are consulted in only 3% of Dutch EAS requests (3). The number receiving EAS for mental disorders among the remaining 97% of patients is unknown, though Dutch GPs report performing EAS for depression (4).

Finally, the studies they cite used clinicians’ impressions of whether patients were depressed, even though it is well-documented that clinicians frequently fail to diagnose depression in the terminally ill (5). The single study that used a standardized depression-screening tool found that depression increased euthanasia requests in Dutch cancer patients by a factor of four (6). Other studies using standardized tools associate depression in the terminally ill with increased requests for hastened death, including physician-assisted suicide and euthanasia (5), yet Oregon and the Netherlands have never used standardized depression screening to determine how often depressed patients request and receive EAS. Mental illness is common and undertreated in the terminally ill, a problem that crosses ethnicity, gender and age. This review shines a feeble 10-watt glow into a mine shaft; insufficient unless you don’t really want to see whether someone is at the bottom.

References:

1. Quill TE. Physician assisted death in vulnerable groups. BMJ 2007;335:625-6.

2. Battin MP, van der Heide A, Ganzini L, van der Wal G, Onwuteaka- Philipsen BD. Legal physician-assisted dying in Oregon and the Netherlands: evidence concerning the impact on patients in "vulnerable" groups. J Med Ethics 2007;33:591-7.

3. Groenewoud JH, van der Maas PJ, van der Wal G, Hengeveld MW, Tholen AJ, Schudel WJ, van der Heide A. Physician-assisted death in psychiatric practice in the Netherlands. NEJM 1997;336:1795-801.

4. Jansen-van der Weide MC, Onwuteaka-Philipsen BD, van der Wal G. Granted, undecided, withdrawn, and refused requests for euthanasia and physician-assisted suicide. Arch Intern Med 2005;165:1698-704.

5. Hicks MH. Physician-assisted suicide: a review of the literature concerning practical and clinical implications for UK doctors. BMC Family Practice 2006; 7 (1):39. http://www.biomedcentral.com/1471-2296/7/39.

6. van der Lee ML, van der Bom JG, Swarte NB, Heintz PM, de Graeff A, van den Bout J: Euthanasia and depression: a prospective cohort study among terminally ill cancer patients. J Clin Oncol 2005; 23:6607-12.

Competing interests: None declared

Physician assisted death in vulnerable populations
Concerns not dispelled
3 October 2007
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Desmond O'Neill,
Director
Centre for Ageing, Neuroscience and the Humanities, Adelaide & Meath Hospital, Dublin 24, Ireland

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Re: Concerns not dispelled

Hyperbole and misplaced emphasis are unhelpful in ethical debate, particularly for contentious issues such as physician-assisted death (PAD). The assertion by Quill (1) that the Battin analysis (2) 'dispels many of the concerns' of the impact of PAD on vulnerable groups is an exaggeration of the security of the findings, given the nature and type of data provided. The data in the study is limited in both quantity and quality, and the time scale for Oregon - 9 years - is short. By focussing only on the over 85's as the "elderly" group misses out on older people from 65 to 84 who are not only more likely to have more frailty than other age groups, but who are also over-represented in the PAD ratios in both countries. It is also somewhat lacking in perspective to dismiss the euthanasia of 3% of those with Alzheimer's disease and advance directives as effectively unimportant in the debate, a point which fuels further concern over the inherent prejudices against disability implicit in advance directives (3).

Of more concern is the narrow definition of vulnerability, and indeed the recognition that vulnerability not only carries corresponding responsibility but also that vulnerability applies to the majority of the population at any one time (4). Perhaps the most illuminating metaphor for our universal extrinsic vulnerability is captured in Sontag's Illness as Metaphor, wherein she talks of the social and philosophical context so colouring the context of healthcare that it is "impossible to take up residence unprejudiced by the lurid metaphors with which it has been landscaped". It is in this context that the leniency of the courts, and the lack of sanction from the medical profession, for involuntary euthanasia of a patient with Alzheimer's disease in the Netherlands raise serious concerns (5). The societal and professional damage and concerns arising from PAD require a broader and less polemical discussion, and may be also be aided by the insights of doctors involved with other forms of physician-assisted death should also be considered (6).

1) Quill TE. Physician assisted death in vulnerable populations. BMJ 2007;335:625-6.

2) Battin MP, van der Heide A, Ganzini L, van der Wal G, Onwuteaka- Philipsen BD. Legal physician-assisted dying in Oregon and the Netherlands: evidence concerning the impact on patients in "vulnerable" groups. J Med Ethics 2007;33:591-7.

3) O'Neill D. Present, rather than, advance directives. Lancet. 2001;358:1921-2

4) Vladeck BC. How useful is 'vulnerable' as a concept? Health Aff (Millwood). 2007;26:1231-4.

5) Sheldon T. Dutch GP found guilty of murder faces no penalty. BMJ 2001;322:509.

6) Gawande A. When law and ethics collide--why physicians participate in executions. N Engl J Med. 2006;354:1221-9.

Competing interests: None declared

Physician assisted death in vulnerable populations
Don't be fooled into accepting doctor-assisted dying
1 October 2007
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Stephen MW Hutchison,
Consultant Physician in Palliative Medicine
Highland Hospice, Inverness, IV3 5SB

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Re: Don't be fooled into accepting doctor-assisted dying

Quill’s editorial raises several issues that must be challenged.

He cites the practice in Oregon and Holland where many patients are involved with hospice care. He says, “Oregon is amongst the nation’s leaders in other markers of good end of life care, including deaths at home, opioid prescribing, hospice enrolment, and public awareness about end of life options”. However it is important to recognise that palliative care in Oregon and Holland are far removed from the service we are privileged to have in the UK. For instance, in Oregon, most hospice care is at home, expenditure per patient is negligible compared to that in the UK, and there are only 2 in-patient units and a total of only 23 beds for the whole state! Hospice care plans are reviewed once every 2 weeks in contrast to every few hours in UK palliative care units (1). We certainly cannot look to Oregonian practice as an optimal standard of palliative care.

Quill states of physician-assisted death in Oregon that “There has been no significant change in frequency over nine years”. This is wrong. In 1998 there were 5.5 physician-assisted suicide deaths per 10000 deaths, and in 2004 the figure was over 12 per 10000. In 1998 a total of 16 people died in this manner, and the figure has risen to 38 in 2005, a 42% increase (2). In Holland, the number of euthanasia deaths fell from 2.6% in 2001 to 1.7% in 2005, but the number of deaths from ‘terminal sedation’ has increased to 8.2% of all deaths (3). In Oregon, ‘deep sedation’ may be used to achieve pain control (1). Such practice is alien to UK palliative care. In my work, resorting to sedation in order to achieve symptom control is vanishingly rare. We do not need to sedate patients into oblivion in order to achieve symptom control. In any case we also seek to enable patients to interact to their maximum potential with their environment, and sedation thwarts that important aspect of care.

Quill almost seems to legitimise the LAWER cases where the lives of approximately 1000 people each year are terminated without their explicit consent. Heaven forbid that we should blithely grow to see such statistics as acceptable!

The figure of one in fifty deaths from covert practice of physician- assisted suicide or euthanasia prior to Oregonian legislation does not reflect UK experience, where there is no evidence of any covert physician- assisted suicide (4) and the incentive to legislate in order to prevent covert practice needs to be questioned.

Finally, Quill acknowledges that the studies he quotes "do little to resolve the moral and religious questions surrounding these practices”. However, let us be very careful that these do not become relegated to the irrelevant. Matters of faith and belief will, for many doctors, legitimately guide their response to these issues, and all of us must guard against subtle erosion our moral standpoint. That does not mean the slide into an unthinking state, but on the contrary, requires that we constantly rehearse the sound moral, religious, ethical and practical reasons for our rejection of doctor-assisted dying in the UK.

1 Lessons from Oregon: the hospice perspective. Presentation by Ann Jackson, Executive Director, Oregon Hospice Association, Help the Hospices, London, June 2007.

2 Eighth Annual Report on Oregon’s Death with Dignity Act. Oregon Department of Human Services, March 2006.

3 van der Heide et al. End-of-Life practices in the Netherlands under the Euthanasia Act. New England Journal of Medicine 2007, 356: 1957-65

4 Seale. National survey of end-of-life decisions made by UK medical practitioners. Palliative Medicine 2006; 20: 3-10

Competing interests: None declared

Physician assisted death in vulnerable populations
There is more to vulnerability
1 October 2007
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Andrew Thorns,
Consultant in Palliative Medicine
Pilgrims Hospice. Margate. Kent. CT9 4AD.

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Re: There is more to vulnerability

Quill’s editorial review of the relationship of vulnerability to physician assisted death (PAD) welcomes recent data suggesting that, in most circumstances, vulnerable groups are no more likely to receive PAD than other non-vulnerable groups (1). He reports 1 in 50 patients in Oregon discuss assisted dying with their doctor – a not surprising figure which is similar to informal surveys of my own practice.

These may not be explicit requests to have PAD but clear expressions that the person felt, at that time, that they would be better off dead. The reasons: poor information and communication skills, lack of effective symptom control, misperceptions of what the last stages of life will be like, fear of being a burden and the impact on families.

These were not vulnerable people as defined by research standards, but made vulnerable by their situation. Vulnerability is a state we can all find ourselves in, especially when facing the end of our lives regardless of background or status. The first step in managing an individual’s vulnerability is to improve the poor areas of practice that cause it.

Andrew Thorns
Consultant and Honorary Senior Lecturer in Palliative Medicine
Chair of the Association for Palliative Medicine Ethics Committee.
Pilgrims Hospice and East Kent NHS Trust. Margate. CT9 4AD.

1. Quill TE. Physician assisted death in vulnerable groups. BMJ 2007;335:625-6

Competing interests: None declared

EDITORIALS:
The Declaration of Helsinki
Goodyear et al. (29 September 2007) [Full text] [PDF]
The Declaration of Helsinki
Re: The Delaration of Helsinki is DEAD
8 October 2007
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udo schuklenk,
Professor and Ontario Research Chair in Bioethics
Queen's University, Watson Hall 308, Kingston, ON, Canada

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Re: Re: The Delaration of Helsinki is DEAD

One observation and one comment:

The observation - Just a few years ago an Editorial such as this would have led to a true avalanche of letters and comments. The absence of pretty much any response suggests that Dr Noble might be right. One wonders whether professionals have decided to move on from the Declaration of Helsinki.

The comment - Perhaps the difficulties in terms of quality, transparency of the deliberative process and other such crucial issues are not only a problem with regard to the Declaration of Helsinki. Other 'ethical' guideline producers such as CIOMS, or UNESCO with its utterly inapt Declaration on Bioethics and Human Rights, have to confront the question of whether halfway intelligible ethics documents can reasonably result from committee based drafting processes. The evidence suggests that that probably is not a good idea to begin with. Perhaps the time has come to discard most 'ethics' guidelines and request their owners label them correctly. Virtually all 'ethical' guidance documents and declarations are barely disguised policy documents hiding under the cloak of 'ethics'. No wonder that the arguments over Helsinki have been as bitter as they were, given that many of those involved were not in the business of drafting an ethics document but a policy document aimed at changing real world practices (preferably in other countries).

Competing interests: None declared

EDITORIALS:
Risk of cancer and the oral contraceptive pill
Meirik and Farley (29 September 2007) [Full text] [PDF]
Risk of cancer and the oral contraceptive pill
Pituitary adenomas are not cancers
3 October 2007
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Richard Quinton,
Consultant & Senior Lecturer in Endocrinology
Royal Victoria Infirmary & University of Newcastle-upon-Tyne, NE1 4LP, UK,
Andrew Advani

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Re: Pituitary adenomas are not cancers

Dear Sir,

In their Editorial discussion of the UKRCGP study results, Meirik & Farley (1) repeatedly make the same factual error as the study authors themselves (2) by referring to "cancers.....of the pituitary".

For the record, pituitary adenomas are benign tumours in that they (a) do not metastasise, (b) do not invade adjacent tissues and (c) are exceptionally slow-growing (3).

The great majority of pituitary tumours are hormonally inactive microadenomas (<1cm diameter), which are of no clinical significance. Although every macroademona must have started off as a "micro", it is estimated that only 10% of microadenomas have the potential to evolve into macroadenomas (4).

Carcinomas of the pituitary gland are so rare that an Endocrinologist could easily practice for an entire lifetime in a specialist pituitary referral centre and never see a single case (4).

Despite not being cancerous, adverse events do occur in relation to benign pituitary adenomas due to (a) local mass effect (typically on the overlying optic chiasm to cause bitemporal visual field loss), (b) systemic effects of secreted products, PRL causing hypogonadism in prolactinomas, GH in acromegaly and ACTH in Cushing's disease, or (c) hypopituitarism resulting from tumour mass itself, or more commonly, its treatment by surgery and/or fractionated external beam radiotherapy (4).

Pitfalls regularly encountered by the non-specialist include (a) performing unnecessary neurosurgery on patients whose pituitary adenomas were PRL-secreting and would therefore best been treated with oral dopamine-agonist therapy and (b) automatically assuming that high PRL levels are diagnostic of a prolactinoma and thereby failing the allow for the possibility of a non-secretory adenoma (causing hyperprolactinaemia via pituitary stalk compression) expanding to compress the optic chiasm despite normalisation of PRL levels on dopamine-agonist therapy.

Outcomes can be improved by ensuring that patients are treated by clinicians with the appropriate expertise in the field, working as part of a multidisciplinary team (Endocrinology, specialist Pituitary Surgery, Neuroradiology and Clinical Oncology) (4).

Yours sincerely,

Andrew Advani & Richard Quinton

Refs:

(1). Meirik & Farley Editorial in BMJ 12/9/07 (2). Hannaford et al, BMJ 12/9/07 (3). Any textbook of pathology or even Wikipedia (4). "Pituitary Tumours: epidemiology, pathogenesis & Management". Edited by Susan Webb, Bioscientifica, Bristol, 1998. ISBn 1 901978 04 4

Competing interests: None declared

VIEWS & REVIEWS:
MTAS or a tale of evidence heedless medicine
Nachev (22 September 2007) [Full text] [PDF]
MTAS or a tale of evidence heedless medicine
Selection methodology: more fiction than fact, and a worrying future
12 October 2007
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A Thomson,
Doctor
London

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Re: Selection methodology: more fiction than fact, and a worrying future

Although Prof Patterson claims that "there is over a century’s literature on selection methodologies," it is disappointing that 7 out of 8 of her references are self-citations.

Prof Patterson fails to address the question "why change?" other than stating that the reasons for change rested on the potentially flawed belief that doctors should be forced to choose a speciality with no prior relevant experience. She neither questions nor attempts to justify the validity of such a significant assumption - how can she then justify any process which is based on it?

Her account of the development process, if true, is very worrying - although she attempts to distance herself from the disaster, she does admit her involvement, with the admission that selection forms for entry above ST1 were hastily cobbled together "from existing application forms", that there is no evidence of their validity outside of GP selection.

Prof Patterson was aware of the flaws, and could have used her authority as an expert in selection methodology to halt this sorry process which wasted so much time. She could have objected, refused to allow her work to be implemented in this way and firmly recommended continuing with current selection procedures. Why did she do none of these things? Why did she press ahead with an enormous human experiment for which no ethical approval had been sought or granted, and to which the subjects had not consented. Her reply addresses none of these questions, and I find it rather sinister that she is already looking to the future without attempting to learn from the terrible mistakes in her recent past.

Competing interests: Dr Thomson was one of the thousands of UK doctors who were sacked and made to reapply for their own jobs using flawed selection methods which Prof Patterson and the Work Psychology Partnership helped to develop.

MTAS or a tale of evidence heedless medicine
Unsatisfactory response by Ms Patterson
12 October 2007
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Peter von Kaehne,
General Practitioner
Scotland

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Re: Unsatisfactory response by Ms Patterson

Although there is over a century’s literature on selection methodologies, [...]


This could suggest that there are heaps and heaps of data available on the subject, that Ms Patterson's role was only one of sifting the abundant and overwhelming evidence and that the medical profession was grossly negligent in its previous blatant disregard of good science on the subject.

And yet, all but one quote in Ms Patterson's response appear to be self references.

What does this tell us?

While I am in no position to judge even remotely how close and how responsible Ms Patterson's outfit was, the response by Ms Patterson leaves me in little doubt that she was too close and had too much responsibility.

So, please leave us alone with your suggestion that you share the anger of the profession. Chances are, that you are a perfectly valid target for the anger of the profession. Your letter at least does not reassure me on that account.

Competing interests: None declared

MTAS or a tale of evidence heedless medicine
No defence
11 October 2007
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ben dean,
sho
oxford

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Re: No defence

Fiona Patterson is clearly attempting to distance herself from the complete and utter failure of MTAS 2007 with her above response that lists many references that are used as so called 'evidence'. The process that she had a large part in creating and forcing upon us was certainly not suitable for the selection of any trainees; irrespective of whether they were Foundation trainees, ST1s, ST9s or monkeys. I have not managed to find a single Foundation trainee who thinks that their selection process over recent years has been anything other than a load of politically correct hogwash.

The MTAS process and the use of white space questions were proven beyond any doubt to be rubbish of the highest order, and certainly not fit for use in any selection process. If Prof Patterson wants evidence, then I think the year 2007 provides an overwhelming quantity of evidence that should should force her to go back to the proverbial drawing board before inflicting any more of this upon unsuspecting juniors.

Undoubtedly Prof Patterson was only one of many of a dysfunctional heirarchy that was to blame, however she is a little naive if she thinks that she can talk her way out of any responsibility so easily. The future is indeed challenging and this is because so many people including Prof Patterson did so much to create a completely useless selection process last year. I suggest if this argument becomes about evidence, then the events of 2007 can provide more concrete evidence than any number of psychoeducationalist trials.

Competing interests: None declared

MTAS or a tale of evidence heedless medicine
Evidence heedless medicine
11 October 2007
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John Sanderson,
Professor of Clinical Cardiology
B16 8AH

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Re: Evidence heedless medicine

Belatedly I have just read Dr Nachev's brilliant analysis of the failure of MTAS. The lack of any experimental evidence is typical of most social or health economics policy. The contrast between the introduction of a new medicine and a new administrative 'therapy' or reorganization could not be greater. It appears that major NHS changes are introduced based on no-more than anecdotal evidence which would not be tolerated in the realm of medical therapeutics. Why are not the same standards applied and a proper controlled trial done of some of the proposed changes? It is not too difficult to envisage two differing policies being tested in two health care regions and the results tested after 5 years like in a clinical trial. The RCT has been one of the greatest steps in medicine and as we all know the results of a large clinical trial are often the exact opposite of the expected, obvious or 'logical' conclusion. Massive social and administrative changes are often introduced on a whim and a feeling that it must be right. The same mistakes are about to be made by Darzi and his collegues in the government with respect to general practice and polyclinics. No doubt millions of pounds more will be wasted on major stuctural changes with zero evidence of any actual benefit.

Competing interests: None declared

MTAS or a tale of evidence heedless medicine
Re: Selection methodology; fact, fiction and the future
11 October 2007
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Alison L Gill,
ST2 Medicine
Harrogate District HospitalHG2

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Re: Re: Selection methodology; fact, fiction and the future

Ms Patterson's points would be far more credible were it not for the fact that seven of her eight references were self-citations!

She accepts that pre-existing "selection practices in medicine have been effective", and that few "understand what a clinician does on a daily basis". What qualifications then does she have to make such recommendations and changes to medical selection and training?

She reports having "learned more from collaborating with the medical profession than from any other" - so why during this shambolic recruitment system, did she not think it necessary to consult with exactly those people that were to be affected by the changes?

Competing interests: MTAS applicant, four interviews, offered two posts, only to find months down the line that I should have been offered all four but due to a "system error" I was listed as having accepted an offer before I was even made aware of it!

MTAS or a tale of evidence heedless medicine
Re: Selection methodology; fact, fiction and the future
11 October 2007
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Matthew J Daniels,
FTSTA ST2 CMT
Addenbrookes Hospital, CB2 0QQ

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Re: Re: Selection methodology; fact, fiction and the future

In Professor Patterson statement is clear that her expectations for the process and the reality of its implementation were quite at odds.

Why then has it taken until October 2007 for these concerns to be voiced?

I recall one of the white box questions in the probity section - "Give a specific example of a time when you became aware that a clinical mistake had been made, either by you or someone else. How did you deal with this situation and how did your actions contribute to the outcome?"

As the Fidelio group have already reminded us; "All that is necessary for the triumph of evil is that good men do nothing."1.

1 Brown M et al The Lancet 2007; 369:967-968

Competing interests: Dr in training disillusioned by the whole process

MTAS or a tale of evidence heedless medicine
Re: MTAS or a tale of evidence heedless medicine
11 October 2007
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Alison S Carr,
Deputy Postgraduate Dean, NHS Education South West (Peninsula Institute)
Plymouth PL6 8DH

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Re: Re: MTAS or a tale of evidence heedless medicine

Dear Editor

I would like to correct some of the details that have been cited by Dr Nachev on the development of resources for recruitment and selection into specialty training in 2007. The author suggests that the criteria and procedure for selection in MTAS were principally designed by a handful of organisational Psychologists from Work Psychology Partnership and that the selection methods developed have never been used to select specialist trainees. Neither of these suggestions are correct.

Professor Fiona Patterson and her colleagues from Work Psychology Partnership have worked alongside the medical profession for over 12 years in helping develop recruitment and selection methodology for recruiting specialist trainees such as General Practitioners, Obstetricians, Paediatricians, and Surgeons. This team specialise in recruitment and selection methodology and have applied their knowledge base to medicine in liaison with specialists from the medical specialties. Work Psychology Partnership have worked with GPs for over ten years in developing the recruitment and selection processes used successfully for recruitment into general practice training. In addition, for several years they have worked developing and evaluating recruitment and selection pilots into surgery with the Royal College of Surgeons. In fact almost all of the research published on recruitment and selection into medical training has been published with Professor Fiona Patterson as one of the authors.

In this article, Dr Nachev remarks that every slide of the material prepared for the Department of Health he had seen was emblazoned with Work Psychology Partnership logo (www.mmc360.com/documents/ recruitment_to_specialist_training.pdf). In fact most of these slides were designed by myself in my role as Honorary Associate Dean for the National Recruitment and Selection Project 2007. In this role, I was one of three doctors who accompanied the methodology team on Deanery roadshows around the United Kingdom providing information for Deanery staff and trainers on the processes of recruitment and selection into specialty training proposed for 2007.

In addition, it must be stressed that the medical input to the recruitment and selection process was provided by doctors and that processes used were introduced with consultation of the Royal Colleges, Work Psychology Partnership acting as Consultants in recruitment and selection methodology. The criteria for recruitment and selection into Specialty Training, from which the methodology was developed, were those as laid down by the PMETB (http://www.pmetb.org.uk/index.php?id=456).

Competing interests: None declared

MTAS or a tale of evidence heedless medicine
More light less heat
11 October 2007
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Frank R Smith,
Primary Care Taskforce Lead
South Central SHA Highcroft Winchester SO22 5DH

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Re: More light less heat

The BMJ of the 22nd September has a number of pieces on medical training. The Editor has 'pondered the BMJ's coverage' but she should re-assess her sanctioning of Nachev's personal view as completely counter-productive to the debate, despite its tabloid appeal in playing to the masses of (deservedly)unhappy junior doctors. Selection science is not an oxymoron, and whilst longitudinal studies still need to be done, there is evidence building of the utility of different selection methods compared to the traditional CV and interview. The Tooke analysis of the events of 2007 is likely to identify some key learning points. The BMJ should aim for more light but not heat in this debate.

Competing interests: Have worked on developing selection for GP with Professor Patterson

MTAS or a tale of evidence heedless medicine
Selection methodology; fact, fiction and the future
4 October 2007
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Fiona Patterson,
Professor of Organisational Psychology and Partner Work Psychology Partnership
City University, London. EC1V 0HB

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Re: Selection methodology; fact, fiction and the future

This response has been amended on legal advice.

Although there is over a century’s literature on selection methodologies, rarely has any process provoked such fierce debate as MTAS.

The problems surrounding selection methodology are multi- faceted and multi-dimensional, well beyond disregarding CVs, relying on ‘white space’ questions and poor IT delivery.

For the distress caused, I share the anger of the profession. The inquiry led by Sir John Tooke details the facts about our role in the process (http://www.mmcinquiry.org.uk). Here, I highlight critical issues to encourage close scrutiny of facts surrounding principles, methodology and context underlying MTAS, so there is learning for the future.

Clearly, in the past, selection practices in medicine have been effective. Although few would deny there is scope for improvement, the CV and interview process has generally worked well. So why change? MTAS was devised alongside the MMC programme introduced by the Department of Health, where the fundamental principles underpinning gateways to progression were changed overnight. Consequently this changed the rules governing selection. Traditionally, medicine has relied on robust CV indicators of attainment such as work experience and College exams for selection decisions. The MMC pathway relied on the belief that doctors could be selected to specialities without any prior experience in that specialty. The selection methodology in MTAS was designed for ST1, not for thousands of doctors already working in specialties. Under MMC principles and in compliance with PMETB (http://www.pmetb.org.uk/index.php?id=456), we were advised that work experience and exams could not be scored, or used to rank applicants. The introduction of run-through ST1 posts was new.

I have worked on selection methodology in medicine for over 12 years. This work informed selection centre development and the introduction of new shortlisting tests in General Practice (GP) 1-3. In 2007, all deaneries worked together through a GP national office, where thousands of doctors are successfully appointed using this process 4. Since 2002, in partnership with doctors we developed selection methodology for many secondary care specialties 5-7 and for graduate entry into medical school 8. Although commonality exists across all specialities and levels, selection criteria for each are distinct, with evidence supporting different priorities between specialties.

Having completed this work, in 2004, I was invited to meet the MMC team to advise on selection methodology into specialty training. I recommended developing a national test for shortlisting (supported by early evidence from GP) and validated selection centres with full College involvement and large-scale consultation. Following this meeting, I received no further correspondence from the MMC team and no pilots were put in place. In May 2006, we won an open competition tender organised by the Department of Health. Our work included advising on selection methodology for Foundation programmes and the GP selection process. For specialty selection, the scope of work states; “The number of applicants expected to apply for entry into Specialty Training is approximately 6,000 and that applications will be via a single electronic national portal entry system (separate project) the working assumption for the closing date will be 5th January 2007.” At the outset we were asked to advise on selection methodology for ST1. We were not asked to deliver selection methodology for doctors in ‘transition’ via ST2, ST3, ST4 and FTSTAs, nor academic posts. We believed these arrangements would be delivered via local processes.

The rules and parameters governing MTAS were defined by MMC, based on PMETB principles and via the COPMeD steering group, represented all stakeholders. Given the time scale (less than 16 weeks) there was no option but to use materials from existing application forms used (over several years) for entry into specialist training. By contrast, in collaboration with the GP national office, my team designed the shortlisting test with GPs, which has shown to work well. For the future, the GP model has been identified as best practice.

However, this model cannot be transferred into all specialties. Medicine is a broad discipline and secondary care is significantly different requiring bespoke selection methodologies. There is added complexity due to different selection ratios for both specialties and locations. ‘One size’ cannot fit all. Some believe selection practices in other professions can be readily transferred but medicine, in the UK, is truly unique. For those deciding policy, few understand what a clinician does on a daily basis. A significant challenge is to translate the needs of the profession to policy makers.

I have advised on selection methodology in all sectors. In the past 12 years I have learned more from collaborating with the medical profession than from any other. Unlike selection approaches used by some organisations, I applaud the focus on psychometric scrutiny, the need for validatory evidence and the demand to treat human beings with respect and dignity in the process. The fact is, MTAS was not designed by psychologists. Without a full understanding of the issues, we cannot hope to navigate the future, which looks yet more challenging.

References

1. Patterson F, Ferguson E, Lane PW, Farrell K, Martlew J, Wells AA. Competency model for general practice: implications for selection, training and development. Br J Gen Pract 2000;50:188-93.

2. Patterson, F., Lane, P., Ferguson, E. & Norfolk, T. A competency based selection system for GP trainees. BMJ 2001 323, 2.

3. Patterson F, Ferguson E, Norfolk T, Lane P. A new selection system to recruit general practice registrars: Preliminary findings from a validation study. BMJ 2005;330:711-4.

4. Plint, S., Gregory, S., Evans, G. (2007). Recruitment to GP specialty training 2007. BMJ Career Focus 335: gp73-gp75

5. Randall R, Davies H, Patterson F, Farrell K. Selecting doctors for postgraduate training in paediatrics using a competency based assessment centre. Arch Dis Child 2006; 91:444-8.

6. Randall R, Stewart P, Farrell K, Patterson F. Using an assessment centre to select doctors for postgraduate training in obstetrics and gynaecology. The Ostetrician and Gynaecologist 2006;8:257-62.

7. Rowley D, Patterson F. The right choice: A pilot selection centre to improve selection of future surgeons. Surgeons News, October 2007.

8. Kidd J, Fuller J, Patterson F, Carter Y. Selection Centres: Initial description of a collaborative pilot project. Proceedings for the Association for Medical Education in Europe (AMEE) Conference, September 2006, Genoa Italy.

Competing interests: I am a Partner in the Work Psychology Partnership who were awarded a contract by the Department of Health to advise in selection methodology in June 2006. We were investigated for competing interests for earlier publications but no accusation was upheld, including that from the BMJ.

PRACTICE:
Ramadan fasting and diabetes
Sheikh and Wallia (22 September 2007) [Full text] [PDF]
Ramadan fasting and diabetes
Post prandial hyperglycemia
5 October 2007
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Ali K Kamona,
Staff Grade physician
Ashford hospital,Middlesex TW15 3AA

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Re: Post prandial hyperglycemia

Patients with diabetes are at a higher risk of complications because of the postprandial hyperglycemia.Many studies have shown that.The DECODE(Diabetic Epidemiology Collaborative analysis of Diagnostic Criteria in Europe)have clearly shown that glucose level 2 hours after an oral challenge of glucose is powerful predictor of cardiovascular risk.Many other studies have shown that. Most fasting people will not tolerate a large meal when they break their fast.Some of them,however,will have a large meal and continue to eat throughout the evening. This issue must be kept in mind and made clear to the diabetic during the consultation.

Competing interests: None declared

PRACTICE:
Do all fractures need full immobilisation?
Glasziou (22 September 2007) [Full text] [PDF]
Do all fractures need full immobilisation?
Appropriate, no universal, referal please
11 October 2007
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Paul P Glasziou,
general practitioner
Oxford, OX3 7LF

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Re: Appropriate, no universal, referal please

I am pleased that no one has questioned the validity of the Liow trial or its applicability to the patient: the trial enrolled Mason 1 and 2 radial head fractures, and my patient had a "suspected" Mason 1 undisplaced fracture. The issues raised appear to concern which patients require referral from primary care, a goal of 100% "success", and the appropriate information resources doctors should use. I would like to discuss these in turn.
How should we decide who is managed in primary care and who in secondary care? One extreme that Dr McQueen seems to suggest is that "all conditions should ideally be reviewed by specialists" and GPs would simply decide which specialist every patient should see. An immediate problem would be the swamping of secondary care, and delays in treatment that would degrade rather than improve care. But even if we could massively increase secondary care capacity to allow referal of all patients, the resulting fragmented care would have undesirable consequences, particularly for patients with multiple conditions and for preventive care. This may partly explain why stronger primary care is related to better health outcomes[1]. Rather than every patient been seen by consultants, we would be best off with appropriate referal guidance. As a junior doctor, though I studied Apley's texts, I liked Patrick Browne's "Basic Facts of Fractures" because of its clear guidance about expertise needed to handle different injuries and fractures (using a * to **** system). Undisplaced radial head fractures, along with undisplaced clavilcular fracture, contused elbow, isolated fibula fracture, etc are one "*" and "... can be managed quite adequately by any doctor at his office with the minimum of equipment".
While I admire the sentiment of 100% success, this is an impossible "target". Primary and secondary care should work together to continually reduce error and poor outcomes, but we will never reach 100%. As the various reports on quality and safety suggest, secondary care is not error free either[2,3], and an overworked and overcrowded secondary care would be more prone to error. Wise use of our medical workforces’ diverse skills is necessary to give us the time to manage well.
Finally, the respondents appear not to be aware of how we currently answer, and don't answer, information needs in practice. Several studies suggest that most doctors information needs go unanswered, and when they are answered it is generally with readily available rather than the best information[4]. And searching clinicians poorly skilled in searching and appraisal can degrade rather than improve decisions[5]. Patients would be better served if clinicians better recognised their own information needs, and had the skills to identify and use the best available research evidence, and discuss this with colleagues in both primary and secondary care.
References
1. Macinko J, Starfield B, Shi L. The contribution of primary care systems to health outcomes within Organization for Economic Cooperation and Development (OECD) countries, 1970-1998. Health Serv Res 2003: 831-65.
2. Experience of wrong site surgery and surgical marking practices among clinicians in the UK. Qual Saf Health Care. 2006 Oct;15(5):363-8.
3. Shaw R, Drever F, Hughes H, Osborn S, Williams S. Adverse events and near miss reporting in the NHS. Qual Saf Health Care. 2005 Aug;14(4):279-83.
4. Green ML, Ciampi MA, Ellis PJ. Residents' medical information needs in clinic: are they being met? Am J Med. 2000 Aug 15;109(3):218-23.
5. McKibbon KA, Fridsma DB. Effectiveness of clinician-selected electronic information resources for answering primary care physicians' information needs. J Am Med Inform Assoc. 2006 Nov-Dec;13(6):653-9.

Competing interests: None declared

Do all fractures need full immobilisation?
The use of Evidence Based Medicine in clinical practice
8 October 2007
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Emma Stapleton,
ST3 otolaryngology
Institute of Neurosciences, Southern General Hospital, Glasgow G51 4TF

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Re: The use of Evidence Based Medicine in clinical practice

I was slightly concerned by Glasziou's admission that he read only abstracts (not full papers) and that his search took only a few minutes, yet he used this information to make a clinical decision regarding a patient about whom he had insufficient information, and who had a condition he was unqualified and inexperienced in managing.

None of us can deny that there's a valid basis for the judicious use of EBM in policy-making and safe protocol-construction, but I'm not sure Glasziou's method was a safe or professional way to do it. As a Professor of Evidence Based Medicine, surely he's aware that making a safe clinical judgement on the basis of published data requires meticulous critical appraisal and a comprehensive systematic review of all data available, and that this cannot safely be carried out as he describes?

I'm relieved to hear that his patient recovered uneventfully, and I think Miss McQueen's rapid response hit the nail on the head. These 'simple' cases may be safely managed by GPs in 80% of cases, but what about the other 20%?

A two-minute Pubmed search (and a skim through the online abstracts of published trials) are no substitute for comprehensive specialist review, nor are they a substitute for non-specialist treatment under strict, safe departmental protocols constructed using Evidence Based Medicine in the form of a comprehensive, critical literature review.

Competing interests: None declared

Do all fractures need full immobilisation?
evidence
8 October 2007
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ben dean,
sho
oxford

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Re: evidence

There are several questions that remain unanswered concerning this case. There is a great difference between being able to competently search the literature and being able to put the results of that literature search into practice safely and competently.

Judging from the opinion of several consultant orthopods who have responded and several I have spoken to, Professor Glasziou is treading on thin ice.

Arguably there are several problems with his argument, for one the radiology report is assumed to be correct, virtually all orthopods will look at the Xray in person as well as the report, risk can only be increased by not viewing the film. Secondly the interpretation of specialist evidence requires clinical experience in that area, and by this I mean clinical experience out of primary care in a more specialist setting.

I am sure that Professor Glasziou would get things right most of the time, but as another respondent points out, what would happen if a fracture was mismanaged, whether down to a dodgy radiology report or down to a misinterpretation of the evidence, or even down to a lack of specialist orthopaedic skills?

I wonder how far a GP could go in managing fractures before they reached a point beyond which their actions would be indefensible if something went wrong? Certainly in today's litiginous landscape GPs would be very brave or stupid to move too far away from their areas of expertise.

One thing that certainly should be encouraged, is for GPs to just ring the local orthopod to double check things, even if they are 99% sure. Prof Glasziou's original article intimated an attitude of not double checking things, am I the only one who thinks that this is probably not the best attitude to encourage?

Competing interests: None declared

Do all fractures need full immobilisation?
The case for specialist treatment
3 October 2007
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Margaret M McQueen,
Consultant Orthopaedic Trauma Surgeon
Edinburgh Orthopaedic Trauma Unit, EH16 4SU

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Re: The case for specialist treatment

I accept that all systems are inherited and that at present 'simple' fractures are seen by a range of staff with varying degrees of expertise. However would Professor Glasziou not agree that in a modern system which should be becoming more sophisticated all conditions should ideally be reviewed by specialists. If GPs treat 'simple' fractures such as the radial head fracture in question then probably about 80% will do well. However a non-specialist will not be able to identify those who are unlikely to do well and for whom early intervention gives better outcomes. Politically 80% success may be considered acceptable but does Professor Glasziou not agree that as clinicians we should be striving for 100% success?

Competing interests: None declared

Do all fractures need full immobilisation?
Expertise and evidence must learn to work together
1 October 2007
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Paul Glasziou,
General Practitioner
OX3 7LF

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Re: Expertise and evidence must learn to work together

Expertise and evidence from research are both needed for best medical practice, but how to integrate these is an ongoing evolution. Like Dr Dean, I too would be concerned if clinicians at any level - junior doctor, experienced GP, or consultant - did "a quick ad hoc internet search" rather than finding high quality research relevant to the patients problems. And clinicians at all levels have information needs in most consultations, but usually ignore these or use readily available or out of date resources to get answers. I would also resist the "dumbing down": expertise is essential. But with over 1,500 new research articles entering MEDLINE each day, finding and applying the best research is an additional expertise for any medical graduate who does not want their "use-by" date to be yesterday.

Expertise is essential for all stages of managing a patient. But expertise can go wrong, and needs continual checking against good research. Mr Kazi is correct that experienced clinicians will find that remanipulation is sometimes needed when paediatric forearm fractures are immobilized with short arm plasters. But experience cannot teach us everything, and hence the recent randomised trial[1] that showed such remanipulation was needed just as frequently with long arm plasters was something of a surprise. Expertise and evidence need to learn to work hand in hand, without either claiming to know all.

I was disappointed that some of the respondents chose to denigrate the expertise of general practitioners and made assumptions about their, or my, clinical experience. I was intrigued to notice the difference in the management of simple fractures in the UK and Australia. In Australia GPs routinely manage a number of minor fractures which avoids unnecessarily clogging the specialty system with injuries that can be readily handled in the community, and reserve precious expertise for cases were it is really needed. My patient was clearly one who could be well managed in the community, and made an uneventful recovery.

1. Bohm ER, Bubbar V, Yong-Hing K, et al. Above and below-the-elbow plaster casts for distal forearm fractures in children. A randomized controlled trial. J Bone Joint Surg Am 2006;88:1–8.

Competing interests: (Author's Response)

Do all fractures need full immobilisation?
dumbing down?
30 September 2007
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ben dean,
sho
oxford

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Re: dumbing down?

I read the article with great interest and this segment stood out for me:

"Of course, I could have called the local orthopaedic registrar, and that is often the wise thing to do. But once I had seen the patient I was sure that this was just a "minor" fracture that could be dealt with in primary care."

If a junior doctor, for example, elected to make clinical decisions in areas in which they were not adequately trained by conducting a quick ad hoc internet search instead of consulting the specialist for an opinion, then I think the junior doctor may find themselves in hot water. Why is it acceptable for a GP to do the same? I think the same principles apply.

As Mr Mahaffey eloquently points out, this kind of attitude is rather symptomatic of the dumbing down present in our declining health service. Many undertrained workers are now being given roles beyond their means, and most worryingly they are starting to believe they are up to the task. Whether it be HCAs doing the job of nurses, or paramedics having a crack at diagnosis, GPSIs doing the work of fully trained specialists or nurse practitioners carrying out the work of fully trained doctors; it seems that this dumbing down is rather dangerous and this is ironically demonstrated by Professor Glasziou's piece.

Competing interests: None declared

RESEARCH:
Mental health consequences of overstretch in the UK armed forces: first phase of a cohort study
Rona et al. (22 September 2007) [Abstract] [Full text] [PDF]
Mental health consequences of overstretch in the UK armed forces: first phase of...
Mental health consequences of overstretch – what about hospital emergency departments?
7 October 2007
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Martin Wiese,
Consultant in emergency medicine
Leicester Royal Infirmary, LE1 5WW

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Re: Mental health consequences of overstretch – what about hospital emergency departments?

Rona and colleagues have suggested that a relationship might exist between the incidence of mental health problems in UK armed forces and the duration of their deployment. [1] These findings might well be relevant to non-military settings in which employees are exposed to the stress of working under emergency conditions for prolonged periods of time. Hospital emergency departments (EDs) are likely to be one of them.

The presence of high levels of psychological distress among ED consultants compared with other groups of doctors has previously been recognized. [2] Several factors have probably led to further increases of stress in health care professionals working in these units. Emergency departments have to comply with government targets introduced under the NHS plan to complete patient management within 4 hours. The recent Wanless review of NHS funding and performance has highlighted that ED attendances across the board have risen by more than 37% between 2002 and 2005, a trend that is still continuing. The report postulates that this has been due to the combined effects of reduced waiting times in emergency departments and the opt-out of general practitioners from out-of-hours care provision. [3] While most trusts have initially invested in increased staff and improved facilities in order to meet the 4-hour target, funding has in many places not kept up with the ever-increasing patient numbers. The resulting pressure on staff to deal with the rising workload has been compounded by the EWTD controls on junior doctors’ working hours and, most recently, by the changes to postgraduate training under the umbrella of ‘Modernising Medical Careers’. ED staff in the UK therefore routinely find themselves to be not only dealing with emergency conditions but working under emergency conditions.

The same mental health consequences affecting consultants are likely to be present in nursing staff and higher emergency medicine trainees similarly exposed to the stress of ‘prolonged deployment’ in the ED. More junior doctors working in emergency departments, such as those in their second foundation year (FY2) or first two specialist training years (ST1 and 2) might be relatively protected thanks to the shorter duration of their ‘exposure’.

Further research providing the evidence base for strategies to improve the working lives of health care professionals dedicated to the delivery of front line emergency hospital care is urgently required.

References

1. Rona RJ, Fear NT, Hull L et al. Mental health consequences of overstretch in the UK armed forces: first phase of a cohort study. BMJ 2007;335:603.

2. Burbeck R, Coomber S, Robinson SM et al. Occupational stress in consultants in accident and emergency medicine: a national survey of levels of stress at work. EMJ 2002;19:234. http://emj.bmj.com/cgi/content/abstract/19/3/234

3. Wanless D, Appleby J, Harrison A, Patel D. Our future health secured? London: King's Fund, 2007. www.kingsfund.org.uk/publications/kings_fund_publications/our_future.html

Competing interests: None declared

RESEARCH:
Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis
Wald et al. (22 September 2007) [Abstract] [Full text] [PDF]
Child-parent screening for familial hypercholesterolaemia: screening strategy based...
Screening for familial hypercholesterolemia
5 October 2007
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Peter J. Lansberg,
Staff member
Dept of Vascular Medicine Academic Medical Center Amsterdam 1100 DD Amsterdam; StOEH Amsterdam 1105,
Maud N. Vissers, Hans J. Avis, Barbara A. Hutten, John J.P. Kastelein

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Re: Screening for familial hypercholesterolemia

Since 1994, cascade screening is the preferred strategy in the Netherlands for the active identification of familial hypercholesterolemia (FH) patients. After an initial pilot phase, the programme was expanded and accelerated in 2003 and is now one of the four national screening programmes that include breast cancer, cervical cancer, and the screening of inborn errors of metabolism at birth. Once an FH mutation is identified in a clinically diagnosed patient, relatives are subsequently tested through cascade screening for the same mutation (1). The success of this programme is reflected by the fact that more than 13.500, over a third, of the estimated 40.000 FH carriers in the Netherlands have already been identified and it is expected that by 2014 the vast majority of FH patients will be known. Also, our screening programme has already been proven to be cost-effective (2).

We were very surprised that Wald and colleagues (3) seemed to be unaware of this established programme and made no reference to it in their manuscript. These colleagues, in fact, proposed an intriguing strategy that would provide a proactive approach to identify FH patients at an early age. They suggest screening all infants for FH at approximately 15 months of age, based on their low-density lipoprotein cholesterol (LDL-c) level. If the clinical diagnosis is established in the child, the parents are then to be screened. Simply, the parent with the highest LDL-c is determined to be the one affected. They hypothesize that it will take approximately 30 years to identify all affected families in the UK. We do not think that this strategy is superior to the one that has been implemented in the Netherlands and we feel that some important caveats of the Wald approach merit discussion.

Tracing index patients solely through infant screening may result in missing a large number of affected individuals. FH carriers with one or two children have a 50% and 25% chance, respectively, of giving birth to non-affected offspring and, like FH carriers without children, might therefore never be identified. Also, Wald et al. suggest that non paternity could only be found in approximately 4% the tested children, but this is probably a very conservative estimate since incidence rates as high as 30% have been reported (4).

Secondly, Wald et al. place very little emphasis on false negative results. In the Dutch screening programme, 18% of the mutation positive FH patients were found to have LDL-c levels below the 90th percentile at the moment of screening; the majority of these patients would not be diagnosed to have FH based on clinical criteria alone. A similar situation will occur when screening infants. Hence, to establish the diagnosis of FH solely based on clinical parameters is, in our opinion, inadequate for national screening. Unfortunately, genetic confirmation is also not always possible because of putative mutations in novel genes associated with FH such as apolipoprotein B, PCSK9 and likely others. Therefore, clinical and genetic methods complement each other and, in our opinion, reduce errors that would limit finding affected family members.

Finally, we would like to underline that the identification of an index patient, by whatever strategy, is only the start of a far more complex process: finding affected family members. To set up and implement an organization that can effectively and efficiently perform this complicated task at a national level is pivotal for the success of an FH screening programme and should not be underestimated. We have shown, however, that with appropriate government support such a programme can be successfully implemented.

We believe that the suggested strategy by Wald et al., although commendable for its proactive approach, has several important flaws that would impede effective screening of FH families.

1. Umans-Eckenhausen MA, Defesche JC, Sijbrands EJ, Scheerder RL, Kastelein JJ. Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands. Lancet 2001;357(9251):165-8. 2. Wonderling D, Umans-Eckenhausen MA, Marks D, Defesche JC, Kastelein JJ, Thorogood M.Cost-effectiveness analysis of the genetic screening program for familial hypercholesterolemia in The Netherlands. Semin Vasc Med 2004;4(1):97-104. 3. Wald DS, Bestwick JP, Wald NJ. Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis. BMJ 2007;335(7620):599. Epub 2007 Sep 13. 4. Anneke Lucassen, Michael Parker. Revealing false paternity: some ethical considerations. Lancet 2001; 357: 1033-1036

Competing interests: None declared

Child-parent screening for familial hypercholesterolaemia: screening strategy based...
Familial hypercholesterolaemia: time for further action, not further debate
5 October 2007
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Ian Hamilton-Craig,
Professor of Preventive Cardiology
Griffith University School of Medicine, Gold Coast, Queensland 4215, Australia

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Re: Familial hypercholesterolaemia: time for further action, not further debate

In spite of major advances in molecular diagnosis and therapy, the detection rate of familial hypercholesterolaemia (FH) remains unacceptably low in most countries where diagnostic criteria for FH are confusing and poorly understood by general practitioners, and public and political awareness of the disorder also almost non-existent (1). Up to 75% of patients may be unrecognized prior to their first coronary event, which is often sudden death. Improving the diagnosis rate at an early stage of disease is therefore critical to improve the outcome of FH management.

Wald et al’s recent article proposing population-wide screening of 1- 9 year old children at the time of immunization is therefore timely, appealing and challenging (2). It is appealing firstly because early detection offers the best hope of controlling otherwise rapidly progressive atherosclerosis by therapy to lower LDL cholesterol levels, as shown for carotid intima-medial thickening in children treated from the age of 10 years (3). Secondly, children frequently return to their GPs for further immunizations, thereby offering the chance to have a ‘second bite of the cherry’. Thirdly, detection of FH in childhood offers the opportunity to counsel against smoking and other adverse lifestyle habits that usually start in childhood. Finally, screening of parents of affected children will make the programme more cost-effective.

The challenge comes in determining whether to choose a community-wide versus a selective screening approach, the age to perform screening, and the diagnostic criteria to use. Diagnosis of FH can be made at any phase of life: in utero (for homozygous FH), at birth (shown to be unreliable because of birthing factors affecting cord blood lipid levels), in the neonatal period (at age 5 days, heel-prick blood is used to diagnose the rarer inherited metabolic disorders), during childhood, adolescence and in adulthood. A variety of parameters can be used for diagnosis, including clinical stigmata of tissue cholesterol deposition (in adults), levels of total cholesterol, LDL cholesterol, ApoB and/or ApoB/A-1 ratio, Lp(a) and apoB, or the detection of an LDL receptor mutation.

In adults, cascade family screening has been performed most successfully in Iceland and the Netherlands, where most cases of FH have already been detected and LDL receptor assays used for diagnosis (4). These countries are small, have a single coordinating centre, are heavily funded by government, and the Netherlands has an effective patient support organization similar to HEART-UK.

In these countries, approximately 8 near relatives are detected with FH for each index case (1). The ratio of cases detected/index case indicates the effectiveness of cascade family screening. In most countries, however, this ratio is considerably lower, partly because of logistical difficulties in performing cascade screening, lack of funding, lack of community and professional awareness, and privacy issues (1). In Australia the Privacy Act prevents doctors from approaching near relatives without their permission – a ‘catch-22’ situation. Index FH patients are left to contact relatives, an unsatisfactory situation with poor results for several reasons. Many relatives are non-contactable, while others refuse screening because they are ignorant of the nature of FH and the benefits of early treatment.

The paper by Wald et al should return screening of parents and children back to the mainstream of preventive strategies for management of FH. It is time for further action, not further debate. Community-wide screening programmes in children at the time of immunization should be initiated now.

References

1. Hamilton-Craig I. Case-finding for familial hypercholesterolemia in the Asia-Pacific region. Seminars in Vascular Med. 2004; 4:87-92.

2. Wald DS, Bestwick JP, Wald NJ. Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis. BMJ. 2007; 335:599

3. Rodenburg J, Vissers MN, Wiegman A et al. Statin treatment in children with familial hypercholesterolemia: the younger, the better. Circulation. 2007 Aug 7;116(6):664-8.

4. Fouchier SW, Defesche JC, Umans-Eckenhausen MW, Kastelein JP. The molecular basis of familial hypercholesterolemia in The Netherlands. Hum Genet. 2001 Dec;109(6):602-15.

Competing interests: None declared

ANALYSIS:
Medical immigration: the elephant in the room
Winyard (22 September 2007) [Full text] [PDF]
Medical immigration: the elephant in the room
some overseas medical schools are inferior
10 October 2007
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edmund willis,
gp and clinical tutor hyms
bridge street surgery, brigg, north lincs, dn20 8nt

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Re: some overseas medical schools are inferior

As well as having an elephant in the room - we also have some ostriches with their heads stuck firmly in the sand ! -if we dont recognise that some overseas medical schools provide a poor education. Some students hardly see a patient before qualifying. Of course there are also some overseas graduates who can match anyone from the uk.

If many uk graduates have to go overseas to find work and the nhs employs doctors who have a less intensive and expensive education, that is overall a poor bargain for the taxpayer. The uncertainty and hopelessness is also terrible for morale among our junior doctors and medical students, and that has a severe effect on patient care.

The HSMP must be stopped and something must also be done about EU graduates. In my dreams the GMC might find something useful to do about a real problem.

Competing interests: None declared

Medical immigration: the elephant in the room
Re: We got to find an amicable solution
2 October 2007
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Jay Ilangaratne,
Founder
www.medical-journals.com

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Re: Re: We got to find an amicable solution

It is suggested by Prabhu that "UK has moral a responsibility to look after the interest of those IMGs who have worked in the NHS and those who have come to UK with the promise of equal opportunity".However, even before the restrictive immigration rules came into force, some IMGs may have suffered in the hands of one NHS Consultant of Indian origin who brazenly stated on an online forum that[1] "Indians can always go back home" and questioned where the local graduates could go while emphasising he would give preference to British graduates at the interview stage.With attitudes like that one wonders as to how the UK could properly discharge any moral obligation(if not a legal one) it has to treat IMGs fairly?

References

[1]Ilangaratne J. Confession of an Asian consultant. BMJ Rapid Responses 5 Dec 2003.(http://bmj.bmjjournals.com/cgi/eletters/327/7427/0-h)

Competing interests: None declared

Medical immigration: the elephant in the room
Competition is good for patients
2 October 2007
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Martin Zinkler,
Consultant Psychiatrist
Newham Centre for Mental Health, E13 8SP

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Re: Competition is good for patients

The temptation to over-regulate medical immigration should be resisted. A certain degree of competition for doctors' jobs in training and beyond is healthy and will help in selecting those doctors who do well with their patients.

Being trained in Germany at a time when postgraduate jobs were quite competitive, I found the system showed quickly which doctors did well and which didn't. After all not everyone successful in medical school will make a good doctor, whether it is about confidence, competence, attitude or organisational skills. Doctors who don't do well in clinical practice have a range of other employment possibilities in research, industry, publishing or indeed starting a new career. But to deal effectively with underperforming doctors employers need to be able to quickly fill vacant posts which only works where there is competition for posts.

From the individual doctor's perspective it creates an incentive to perform above expectations. The idea that everyone who graduates from medical school should complete specialist or GP training is unique to medicine and perhaps to the clergy. A more competitive system with more incentives to do well on the job can increase quality in clinical practice generally and could reduce the need for complex, expensive and probably ineffective mechanisms to regulate medical practice like the ones suggested by the GMC.

Competing interests: None declared

EDITOR'S CHOICE:
Training our doctors
Godlee (22 September 2007) [Full text]
Training our doctors
Training and careers of French doctors
5 October 2007
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herve Maisonneuve,
GAME president and CME manager
Pfizer, 75014 Paris,
Yves Matillon

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Re: Training and careers of French doctors

Editor,

Your editorial quoting articles in the BMJ issue of 22 September 2007 exposed uncertainties and raised questions regarding the training and the careers of UK doctors.1 This situation is not unique to the UK. Other European countries, and particularly France, are struggling with a shortage of junior doctors (more acute in certain specialties) and an uneven distribution of doctors across the country leading to potential issues regarding the immigration of doctors to fill the gaps.2

In the UK, there are published data cited by Ed Borman3 indicating that 36% of doctors registered to practise in the NHS qualified abroad. There are also unpublished data showing that almost half of the MTAS (Medical Training Applications Service) applicants were trained overseas (table 2 on page 594).4 The French system does not currently have sufficient data to drive decisions, and when available, as in the UK, data must be interpreted with caution. In a move to have more data available on the demography of French health care professionals, the ‘Observatoire National de la Démographie des Professions de Santé’, (www.sante.gouv.fr/ondps/) was set up 5 years ago. It’s too early to draw conclusions on its utility.

The UK is not the only country that urgently needs coherence of policies on immigration and medical training to avoid further difficulties in the future. In France, we have 4 issues: Medical student quotas based purely on short term economic constraints, unequal distribution of doctors throughout the country, lack of selection process for doctors qualified outside France, inadequate evaluation of all doctors throughout their career.

The number of students in medical schools and the number of graduate doctors seem to be set on short term economic constraints. Medical schools admitted 8000 students in 1975, 6000 in 1980, 4000 in 1990, 3500 in 2000 and it was urgently decided to train 7100 students in 2007. Once, they pass this selection, medical students are reasonably assured to graduate 10 years later. Thus we are still following short term reasoning, without considering other factors such as the feminisation of the workforce, the decrease in working hours, the increasing gap between graduating and beginning professional activity, early retirement, the quest for a better quality of life, the place of other health care professionals (specifically nurses), and the migration of doctors around the world.

The distribution of doctors across France is also a subject of debate as there are discrepancies between regions, with more doctors per capita in the South than in the North. Many villages in the countryside have no doctors, and too many specialists are competing in large cities.. Managing the balance between incentives and disincentives for doctors (and other health care professionals) to set up practice in order to ensure access to care is a subject of continued political debate. At the end of September 2007, the new government proposed to regulate the distribution of regional doctors by requiring authorisation to open a new surgery In October 2007, medical students and residents are going on ‘strike’ (a French way to signify opposition to government) to fight this proposal..

The current shortage of French doctors was described 15 years ago by the Conseil National de l’Ordre des Médecins (French medical association), and other academic bodies. French community doctors do not work in hospitals, and vacant positions are filled by poorly-paid foreign doctors. In 2007, there are thousands of doctors who qualified abroad and are employed in hospitals without having passed any serious selection process. Having learned medicine in a different cultural context and knowing the basics of the French language are not sufficient when we recognize the importance of communication skills, professionalism and cooperation between professions.

Basically, we need to assess competencies of all doctors throughout their career, irrespective of the country where they qualified. The public in all countries seek to receive the best care from health care professionals. As in many countries, in France, this reflection on competency assessment started in 2002,5 after the Bristol affair. The French colleges of medical specialties should propose an evaluation process for assessing doctors during their career. Foreign and French doctors should be subject to the same process if they wish to work in France. The next step will be the implementation of the process, and decision-makers should be sufficiently informed to make the right decisions.

Communication between decision-makers and the profession is key at country and at the European level. Five groups have their specific responsibilities: trainee doctors, professional organizations (colleges), employers, government and patients. We should all share information (although insufficient, there is discussion at the European community level), produce accurate data and promote research to better regulate the medical professions. We should allocate funds to organise conferences and observe the immigration of doctors. This should avoid making short-term opinion-based decisions, and allow for long-term decisions to be taken based on research data.

Hervé Maisonneuve, MD President of Global Alliance for Medical Education, www.game-cme.org and Continuing Medical Education Director, Pfizer, Paris, France.

Yves Matillon, MD Professor of Clinical Epidemiology, Claude Bernard University, Lyon and Head of the health professions competencies evaluation task force, Health ministry, Paris, France.

No conflict of interest.

We thank Chloe Brown for editing this paper

References

1 Godlee F. Training our doctors. BMJ 2007;335: doi:10.1136/bmj.39343.610613.47

2 Le Breton-Lerouvillois G, Kahn-Bensaude I. L’atlas de la démographie médicale en France (généralités). Situation au 1er janvier 2007. Conseil national de l’ordre des médecins, Paris. Juin 2007, étude n°40. www.conseil-national.medecin.fr

3 Borman Ed. Should postgraduate training places be reserved for UK graduates? No. BMJ 2007;335:591.

4 Winyard G. Medical immigration: the elephant in the room. BMJ 2007;335:593-595.

Competing interests: None declared

VIEWS & REVIEWS:
No patient is an island
Sokol (15 September 2007) [Full text] [PDF]
No patient is an island
Response to Willett's cartoon
1 October 2007
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Ron Pigott,
Retired Plastic Surgeon
Retired

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Re: Response to Willett's cartoon

Dear Editor

Looking at Willett's cartoon with increasing interest, I was intrigued to notice that 2/3 of the committee were left handed, the reverse of the proportion in the general population, I believe.  Do left handers self select or are otherwise selected for the characteristics associated with left handedness ( What they? -  a brief perusal of the longer OED suggests an article for the Christmas number in itself, perhaps). Is there something about ethics committees that require left handedness?

Or is there a practical explanation? Is Willett left handed in the artistic tradition of Leonardo da Vinci and feels that the committee should be of like disposition?

On another tack, it is the spider that is usually at the centre of the web and the committee have been caught, shortly to be balled up ready for serving at Christmas.  The semi crucified pose is just to entice them onto the web believing that it is they who are saviours. The pose incidentally adopted by the far from supplicant figure in Leonardo's 'Vitruvian man' drawing of proportions.

 If the figure in the middle has been saddled with learning  difficulties and a lymphoma, he has already lost most of his hair so might not be so upset about losing the rest as a child, say.

Even as they hope to help, all but the white coated houseman, whose sleeve I am pleased to see is rolled up to avoid inadvertent transfer of MRSA etc., are palm down, telling, pulling his strings while the houseman, palm up, is open minded, asking questions.

Seven unequivocal men and six women.  The nurse figure, with watch pinned to front has either a beard, presumably male, or prognathism m or f.  The theatre cap and mask render the other figure, top right, unisex.  Anyway a politically correct balance there.

Yours sincerely

Ron Pigott
Retired Plastic Surgeon

Competing interests: None declared

PRACTICE:
A painful hip
O'Connor (15 September 2007) [Full text] [PDF]
A painful hip
Pain Hip Pitfalls
10 October 2007
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Chika E Uzoigwe,
Dept of Orthopaedics
Milton Keynes General Hospital,
Vivek Gulati, Mohammed Z. Choudhury

Send response to journal:
Re: Pain Hip Pitfalls

Dear Editor,

I read with interest the article by O’Connor on the painful hip. It is an important lesson for clinicians that the plain radiograph of the hip alone should not have the final word. If the index of suspicion is high further imaging should be sought. However the first step should be to review plain radiographs of the entire pelvis. The most common cause of hip pain after a fall in the elderly is fracture of the pubic rami. In such cases there is rarely a concomitant neck of femur fracture1.

The use of MRI for the diagnosis of the hip fractures in itself remains contentious. Magnetic resonance has redefined fractures. Traditional wisdom taught that the bone integrity was a binary phenomenon; either the bone was fractured or intact. MRI has revealed that there is no such definitive dichotomy. Rather there is a gradation of bone injury from bone bruising to cortical fractures2. The clinical significance of bone bruising in the neck of the femur remains uncertain. There is little evidence to show that it is the harbinger of the frank cortical fracture. Indeed bone marrow oedema seen in traumatic injuries to hip is seen in a number of other conditions including osteoarthritis3.

1. Sharma A; Lakshmanan P; and Lyons K Interesting Relationship Between fracture neck of femur and Pelvic ring fractures in a low velocity injury. JBJS Vol 88-B, Issue SUPP_I, 167.

2. Punwar S, Hall-Craggs M, Haddad FS. Bone bruises: definition, classification and significance. Br J Hosp Med (Lond). 2007 68:148-51

3. Ragab Y, Emad Y, Abou-Zeid A. Bone marrow edema syndromes of the hip: MRI features in different hip disorders. Clin Rheumatol. 2007

Competing interests: None declared

OBSERVATIONS:
Alzheimer's Society replies to Iain Chalmers
Hunt (15 September 2007) [Full text] [PDF]
Alzheimer's Society replies to Iain Chalmers
Alzheimer Society of Canada responds to Linda Furlini ‘Why I am no longer a member of the Alzheimer Society’
3 October 2007
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Scott Dudgeon,
Chief Executive Officer
Alzheimer Society of Canada, 20 Eglinton Ave West, Suite 1200, Toronto, ON M4R 1K8

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Re: Alzheimer Society of Canada responds to Linda Furlini ‘Why I am no longer a member of the Alzheimer Society’

As the CEO of the Alzheimer Society of Canada, I am disturbed that the British Medical Journal would seek to add additional confusion to an already inflamed issue by giving voice to Dr. Linda Furlini, who seeks to call into question the integrity of the Alzheimer’s Society of the UK by recounting her experience with the Alzheimer Society of Canada, a different and completely independent organization on the other side of the Atlantic.

Still, in response to what can only be viewed as a direct attack on the Alzheimer Society in Canada, I feel it necessary to correct Dr. Furlini’s claim that the we are more interested in supporting the agendas of pharmaceutical companies than we are in helping improve the lives of Canadians touched by dementia.

Let me start by saying that the majority of funds raised by Alzheimer Societies across Canada, including the one Dr. Furlini led in Quebec, are directed to help provide information and support to those directly affected by dementia. The Alzheimer Society is, and will continue to be, completely dedicated in its mission to provide help for today to the almost half a million Canadians living with dementia. We do this through extensive education and informational programs, innovative services such as Safely Home™ - Alzheimer Wandering Registry, and through hundreds of caregiver and early stage support groups.

Through its research program, the Alzheimer Society of Canada also supports critically needed research both into the basic biomedical search for a cure, as well as research into the social/psychological aspects of Alzheimer's disease. The latter, which focuses on improving the quality of life of both those with the disease and their caregivers, is a unique program, and one we are very proud of. The Alzheimer Society is not in the business of evaluating the effectiveness of different therapies, but instead advocates that all treatment options deemed safe and effective by Health Canada be available and accessible to all those who might benefit from them. In supporting activities that enhance the quality of life of people with Alzheimer’s disease and of their caregivers, the Alzheimer Society of Canada shares a common cause with our counterparts around the world, including the Alzheimer’s Society in the UK.

As the national voice for Canadians affected by dementia, the Alzheimer Society is also a strong advocate for change within our provincial and federal governments. It is our belief that the Government of Canada must act now and sponsor the development of a Canadian Dementia Management Strategy. The strategy will draw upon the collaborative efforts of policymakers, health-care system managers, clinicians, researchers and health-care providers. It will encompass those aspects that most directly impact the lives of those touched by Alzheimer's or a related dementia, including research, prevention, diagnosis, improved care, care for the caregivers and improved treatment. Our advocacy efforts can be viewed on our website at www.alzheimer.ca.

As to the question of where our funding comes from, the majority is donated to the Society by individuals from across the country. While the Alzheimer Society does receive donations in the form of unrestricted educational grants from pharmaceutical companies, we also receive funding from many other major corporations in every sector of the economy – from banks to restaurant chains. These funds allow the Society to independently develop and support our critical programs and services. Our financial statements can be viewed on our website at www.alzheimer.ca.

Finally, to suggest that the Alzheimer Society is simply a “disguised drug manufacturer mouthpiece” is an extreme injustice to the thousands of dedicated staff, volunteers and donors across the country who work very hard to understand and meet the needs of people whose families have been affected by dementia, and to the researchers attempting to prevent or ameliorate it.

Scott Dudgeon, Chief Executive Officer, Alzheimer Society of Canada

Competing interests: None declared

EDITORIALS:
Dealing with scientific misconduct
Bosch (15 September 2007) [Full text] [PDF]
Dealing with scientific misconduct
Re: Scientific misconduct occurs at all levels
1 October 2007
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Alejandro A. Bevaqua,
Medicine Doctor
Servicio Penitenciario Bonaerense

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Re: Re: Scientific misconduct occurs at all levels

It is really shocking and, of course, absolutely disagreeable to take notice that scientific misconduct -fraud- is in the highest levels of scientific structure.

I really didn´t know that the problem affected the names of Mendel and Pasteur; something i´ve heard about Freud and Newton. Anyway, the words of Dr. Xavier Bosch just confirm my own ones: the problem of scientific misconduct known although perhaps not in such a level. We always have a tendency to believe certain persons are not really humans and so, they don´t transgress rules. But they are persons, and they have our same necessities.

Now, we have another problem: if this cases of fraud commited by renowned scientists are really true, I haven´t voices against these people. Of course, it is true that we can´t change the past; and those already gone persons can´t argue in their defense. So let them to rest in peace. History is just that.

But we don´t have to forget; we can´t forget and we can´t be ignorant of the problem. It exists and, fortunately, we are talking and writing about it. That´s a good beginning.

I really think -I always insist ad nauseam- it is necessary to to teach young people the philosophical basis of right science but, beside this, we have to pursue and punish -as hard as possible- those who commit fraud. Anyhow, i really don´t expect too much good results. I can just invite our colleagues -at least those who spend time in reading this lines, those who really believe we have a problem with scientific misconduct- to do our best to detect, pursue and punish the bad scientists who base their work in fraud and nothing but fraud. I don´t know how to do this, but I certainly know that we have to do something. Academic Professors are, undoubtely, the first step in detecting fraud. I think they have great responsability and they can really help in this way.

Dr. Alejandro A. Bevaqua

Competing interests: None declared

PRACTICE:
Using a combination inhaler (budesonide plus formoterol) as rescue therapy improves asthma control
Barnes (8 September 2007) [Full text] [PDF]
Using a combination inhaler (budesonide plus formoterol) as rescue therapy improves...
A SMART choice for primary care asthma therapy ?
13 October 2007
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Brian J Lipworth,
Consultant Chest Physician
Asthma and Allergy Research Group ,University of Dundee,and Tayside Centre for General Practice,
Catherine Jackson

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Re: A SMART choice for primary care asthma therapy ?

Professor Barnes makes an apparently cogent argument for using SMART single flexible combination inhaler therapy as the preferred treatment for moderate to severe asthma .Unfortunately his arguments are likely to be rather biased due to the inherent flawed selection criteria used for inclusion into these clinical trials. This is because the SMART trials [and indeed other long acting beta2-agonist trials] selectively exclude patients who are non responders to formoterol, because inclusion requires patients to have demonstrable beta-2-adrenoceptor agonist reversibility .

There will always be a heterogeneous response to formoterol due to the predictable development of tolerance ,especially for protection against bronchoconstrictor stimuli ,which may in part be genetically determined [1] .In everyday clinical practice ,especially in primary care ,we do not commonly see such patients who have marked beta-2 agonist reversibility ,as seen in the clinical trials, so it is not possible to extrapolate the results of these studies to what happens out there in the real world .

The blanket prescribing of SMART to patients as advocated by Professor Barnes is a slippery slope ,unless perhaps one restricts using the SMART regimen to those who demonstrate beta-2 agonist reversibility ,which is unlikely to happen on a routine basis in the busy setting of primary care ,where most patients with asthma are treated in the UK . The other concern for primary care prescribing is that the routine use of SMART will inevitably creep back in the guidelines from step 3 to step 2 ,whereas most patients with mild to moderate disease can be adequately controlled on an optimised dose of inhaled steroid alone ,which is considerably cheaper .

References

1.Lipworth BLong-acting beta(2)-adrenoceptor agonists: a smart choice for asthma? Trends Pharmacol Sci. 2007 Jun;28(6):257-62. Epub 2007 Apr 26

Competing interests: BJL and the Asthma and Allergy Research Group has received payments for performing clinical trials ,educactional support ,equipment ,speaking and consulting from : AstraZeneca ,GlaxoSmithKline,Teva,Mundipharma,Nycomed,Cipla,Neolab,Schering ,Plough,Merck,Trinity-Chiesi,Innovata .

ANALYSIS:
Families of patients with premature coronary heart disease: an obvious but neglected target for primary prevention
Chow et al. (8 September 2007) [Full text] [PDF]
Families of patients with premature coronary heart disease: an obvious but neglected...
Targeting at risk families for cardiovascular primary prevention
7 October 2007
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Martha J Wrigley,
Cardiac Research Coordinator
Ashford & St Peter's Hospitals NHS Trust, Chertsey, Surrey KT16 0PZ,
Peter Wilkinson, Consultant Cardiologist

Send response to journal:
Re: Targeting at risk families for cardiovascular primary prevention

In their article discussing the opportunity for targeting families with a history of premature coronary heart disease, Chow and colleagues 1 conclude that research is needed to identify barriers and determine the most effective approach. Over the past three years we have undertaken a single centre case study looking at primary prevention for the first degree relatives of patients diagnosed with premature coronary heart disease (CHD) 2. The study was undertaken in a district general hospital, when their relative, sibling or parent, was initially diagnosed with premature CHD on our coronary care unit. The participants were invited to participate in a two year health promotion programme where a nursing assessment of their lifestyle risk factors was evaluated, discussed and they were encouraged and supported to make behavioural changes. The final results are being analysed, so we are unable at present to comment on the outcome of the study; but can reflect upon certain demographics which provide valuable insight regarding the participants who completed the study.

We used purposive sampling and within a year recruited 28 participants, from 14 families; 21 of these completed the study. We invited first degree relatives of any age and gender to participate in the study, excluding those with a diagnosis of cardiovascular disease. The age range of our population varied from 19 to 58 years; 4 of the participants were less than 25 years, while 7 where between 26 and 35 years of age. A third of our participants, 7, lived within 5 miles of the hospital but 8 travelled over ten miles to attend the study. For 13 of our participants their relative had been diagnosed with CHD in the preceding year; however for 8, the diagnosis had been made between one and 14 years previously.

The points of interest arising from this study is that firstly people of all age ranges are interested in participating. It is important that young people are involved in prevention studies, when the atherosclerotic process can start in childhood 3 and influencing behavioural change is often easier when people are younger and less established in their lifestyle practices. We know that attendance at a cardiac rehabilitation programme is influenced by distance, where the distance that patients travel to the classes can affect adherence to the programme 4. Yet here we show that people were willing to travel to receive comprehensive lifestyle assessment and advice. Even those for whom the diagnosis of their relative occurred over a year ago, again they are still willing to attend five visits, in a hospital setting, over a two year period.

Perhaps instead of looking for barriers to prevention we should be encouraged that people of all ages are actively interested and will travel to participate in a health promotion research study. Reflecting upon our own experience with this cohort we can illustrate that the sustained enthusiasm and interest from these people, to receive professional advice, encouragement and support, may not be as problematic at one might assume. We would regard the model of cardiac rehabilitation classes to be suitable for patients to bring their relatives to receive appropriate assessment, advice and support; where integration of primary, secondary and tertiary prevention can occur.

References

1. Chow CK, Pell ACH, Walker A, O'Dowd C, Dominiczak AF. Families of patients with premature coronary heart disease: an obvious but neglected target for primary prevention. British Medical Journal 2007;335:481-5. 2. Wrigley MJ, Pakrashi T, Maslin-Prothero S, Watkinson G. Primary Prevention for Coronary Heart Disease: past evidence, present measures and future challenges. British Journal of Cardiac Nursing 2006;1(6):294-304. 3. Hayman Laura L, Meininger JC, Daniels Stephen R, McCrindle Brain W, Helden Liz, Ross Joyce, et al. Primary Prevention of Cardiovascular Disease in Nursing Practice: Focus on Children and Youth. Circulation 2007;116:344-57. 4. Campbell N, Grimshaw J, Rawles J, Ritchie L. Cardiac Rehabilitation: the agenda set by post-myocardial-infarction patients. Health Education Journal 1994;53:409-20.

Competing interests: None declared

FEATURE:
The market in primary care
Pollock et al. (8 September 2007) [Full text] [PDF]
The market in primary care
More questions than answers.
8 October 2007
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Hendrik J Beerstecher,
GP principal
111 Canterbury Road, Sittingbourne, Kent, ME10 4JA

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Re: More questions than answers.

Dear editor,

Pollock et al ask ‘how will NHS spending be accounted for in the new primary care market?’

We received this reply to the question in July 2006 when I asked to see the financial details of the contracts with private providers: ‘I can confirm that the Department holds details of the cost of the Walk in Centre and general medical services, however it is not currently prepared to release this information’. (1)

With all the talk of competition, some questions remain. Why are PMS, APMS and private contractors not offered the same capitations as GMS contractors, determined by an allocation formula that is taking account of patient needs? (2) Why did the advisory board for APMS contracting contain several of the private companies that are now providing primary care services? (3)

A final detail, the Barking and Dagenham surgery and walk-in centre (that reputedly received £5 million for a 5 year contract) is not catering for 7,000 patients yet, that is the potential amount of patients registered at the end of the 5-year period.(4) How many patients are registered for primary care services and at what cost remains known exclusively to the Department of Health for the time being.

(1)Response to your Query : - Ref:DE00000117554 - Government- brokered deal - FOI request. 19-07-2006.

(2) Morgan CL, Beerstecher HJ. Primary care funding, contract status, and outcomes. An observational study. British Journal of General Practice 2006; 56: 825-829 http://www.ingentaconnect.com/content/rcgp/bjgp/2006/00000056/00000532/art00004

(3) The NHS confederation. APMS Core Group Meeting 21st July 2004, London. http://www.bmj.com/cgi/content/full/335/7622/DC1

(4) Michael Day. UK government accused of privatising the NHS. BMJ 2006;333:61. http://www.bmj.com/cgi/content/full/333/7558/61

Competing interests: None declared

The market in primary care
Market Forces Health Improvement
3 October 2007
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Richard Alan Mendelsohn,
Acting Director of Chronic Disease Systems
Birmingham East and North PCT, Waterlinks House, Aston, Birmingham B7 4AA,
Peter Thebridge, Andrew Donald and Sophia Christie

Send response to journal:
Re: Market Forces Health Improvement

Pollock and colleagues (1) cite Pfizer Health Solutions as a company with a commercial contract to provide primary and community medical services to the NHS in England – specifically chronic disease management for Birmingham East and North Priamry Care Trust (PCT). They also suggest the provision of these services is through the ownership of health centres or general practices. This is not the case.

Pfizer Health Solutions (a business division of Pfizer Ltd) works in partnership with Birmingham East and North Primary Care Trust and NHS Direct to deliver Birmingham OwnHealth®, a chronic disease management service. The service does not, and was never intended, to replace general medical services, but rather to act in tandem with them to support its members in helping patients to better self-care.

In 2005, the predecessor PCTs went to the emerging Market in Primary Care under the aegis of the then Birmingham and Black Country Health Authority in order to respond to the need for accelerated Health Improvement in a deprived population relatively starved of effective chronic disease management systems. The result is Birmingham Own Health® – an evidenced based, effectively commissioned telehealth project which delivers care management for diabetes mellitus, heart failure and ischaemic heart disease (2) over the telephone to some of the PCT’s most deprived, hard to reach residents.

Results from both routine service monitoring (3) and user evaluations have shown improvements in behavioural and biochemical markers in relation to diabetes and heart disease and high levels of patient satisfaction - indeed these findings form part of a complex evaluation strategy. Such a strategy ensures that the service performs above the norms expected for an NHS service. Furthermore, the Partnership is jointly accountable through its own parent Boards – and the Professional Executive Committee in the case of the PCT thus ensuring that there is local NHS scrutiny of access, costs and quality.

Finally, the provision of this service through NHS Direct ensures that the Care Managers are employed in NHS posts governed by national agreements. We believe that this is an example of the Market in primary care meeting a health improvement need alongside more traditional service models to everyone’s benefit in a controlled manner.

(1)Pollock AM, Price D, Viebrock E, Miller E. The Market in Primary Care. BMJ 2007;335:475-477

(2)Long Term Conditions Team, Department of Health. Self care for people with long term conditions., November 2006. www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_063157

(3)Department of Health. Long Term Conditions – Local Evidence and Guidance. September 2007. http://www.dh.gov.uk/en/Policyandguidance/Healthandsocialcaretopics/Longtermconditions/DH_4128530

Competing interests: None declared

NEWS:
Agency warns about dosing error for amphotericin after patients with cancer die
Hawkes (8 September 2007) [Full text] [PDF]
Agency warns about dosing error for amphotericin after patients with cancer die
Correction: Amphotericin product names
8 October 2007
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Frances MacIntosh,
Executive Medical Director, UK
Bristol-Myers Squibb Pharmaceuticals

Send response to journal:
Re: Correction: Amphotericin product names

I wish to draw your attention to an error in the BMJ article headed “Agency warns about dosing error for amphotericin”, written by Nigel Hawkes, and published in BMJ, dated 8 September 2007, volume 335, page 467.

The article states that “Mr Sunner and Mr Richards died after being prescribed the non-lipid formulation of amphotericin, known as AmBisome, but being treated with Fungizone, the lipid formulation, in error”. In this statement the Product names have been referred to incorrectly.

Please be advised of the following correction:

AmBisome is the liposome encapsulated formulation of amphotericin B (the Summary of Product Characteristics for this product can be found on http://emc.medicines.org.uk/).

Fungizone is the non-lipid formulation of amphotericin B (the Summary of Product Characteristics for this product is attached).

Liposomal encapsulation can substantially affect a drug’s functional properties relative to those of the un-encapsulated drug. Further details can be found in the products’ respective Summary of Product Characteristics.

Competing interests: Employee of Bristol-Myers Squibb Pharmaceuticals

LETTERS:
Author's reply
Watson (8 September 2007) [Full text] [PDF]
Author's reply
Re: NICE guidelines on childhood UTI
1 October 2007
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J Valmai Cook,
Consultant Radiologist
Queen Mary’s Hospital for Children, Epsom and St Helier University NHS Trust, Carshalton SM5 1AA

Send response to journal:
Re: Re: NICE guidelines on childhood UTI

The production of national guidelines, in a controversial subject such as the management of urinary tract infection in childhood, was always going to be difficult. The NICE guideline committee are to be congratulated on their attempt to base the guidelines on publications which stand up to the scrutiny of evidence based medicine and include new understanding of the pathogenesis of the interrelationship of voiding dysfunction, renal scarring, dysplasia and vesicoureteric reflux ( VUR).

However, the new NICE guidelines (1) do represent a fairly major shift in the diagnostic paradigm since the Royal College of Physicians’ guidelines in 1991. Most involved in the management and imaging of children with urinary tract infection have seen a decline in the number of children with renal scarring over the years . This can be considered to be due to the greater awareness of the importance of detecting and investigating urinary tract infections in childhood, the improvements in antenatal scanning and a clearer understanding of the importance of bladder dysfunction as an important contributory factor.

There is concern , by many , that the new NICE guidelines could result in a reversal of this position. There is also controversy regarding the value of prophylactic antibiotics in young children with either reflux or previous renal damage. If it is believed that prophylaxis does not alter the natural history, then it is difficult to advocate investigation to identify patients that need treatment. This is a fundamental premise before one begins to address the controversies that exist in selecting the most appropriate imaging technique (3) which may be of a variable standard.

I completely agree that a randomised placebo controlled trial of prophylactic urinary antibiotics should be undertaken and before the NICE guidelines are universally adopted as it may then be difficult to mount such a treatment trial when fewer children will be identified as potential candidates.

When the draft NICE guidelines were first published, I , with members of my department, retrospectively applied the proposed NICE protocol of investigation to a cohort of 79 infants under the age of 1 year who were fully investigated (ultrasound, micturating contrast cystography and delayed DMSA) over the last 3 years.(2) This under 1 year group of children represented those whose management would be most altered by adopting the NICE guidelines. A brief summary of the results is tabulated below.

Results of Imaging Infants 0-6months with an urinary tract infection

Good response (55)
30 normal Ultrasound ( US)
8 VUR
No DMSA scars

Poor response /complex (14)
4 normal US
4 VUR
1 DMSA scar

Good response (55)
25 abnormal US
11 VUR, 2 duplex and 1 single kidney
3 Vesico ureteric junction obstruction

Poor response /complex (14)
10 abnormal US
6 VUR
2 DMSA scars
Results of Imaging  Infants 6m-1 year with an urinary tract infection

Good response(7)
5 normal US
3 VUR
No DMSA scar

Poor response /complex (3)
1 normal US
I VUR
No DMSA scar

Good response(7)
2 abnormal US
2 VUR
2 DMSA scans

Poor response /complex (3)
2 abnormal US
2 VUR
1 DMSA scar
Comparison of Local and NICE guidelines , MCUG results

0-6 months good response	0-6 months complex	6m-1y good response	6m-1 
year complex
Total	        55	14	7	3
Local invx.	55	14	7	3
Local abnormality 22	10	3	2
NICE invx.	25	14	0	3
NICE abnormality 13	10	0	2
NICE MISSED	8	0	3	0
Comparison of Local and NICE guidelines, DMSA results 

0-6 months good response	0-6 months complex	6m-1y good response	6m-1y
complex
Total	        55	14	7	3
Local invx	55	14	7	3
Local abnormal	1	3	2	1
NICE invx	0	14	0	3
NICE abnormal	0	3	0	1
NICE MISSED	1	0	2	0

Ultrasound abnormalities also included subtle findings such as 
dilatation of the distal ureters beyond 4 mm and presence of any 
urothelial thickening.

The results of this small study suggest that most children in a paediatric centre will be detected by the NICE guidelines but a small number will be missed and the significance of this is uncertain . Most children were found to be in the 0-6 months age group including cases from the neonatal unit. In this study, all children with renal scarring had been demonstrated to have VUR except for one patient who had unilateral VUR and a scar in the contralateral kidney. There were very few with obstructed renal tracts as the vast majority of these had been detected by a careful antenatal hydronephrosis screening programme.

There are many very useful clinical recommendations proposed by NICE . However, in view of the controversies that range it might be a little premature to adopt such a minimalist protocol of imaging as yet. It may be possible for other larger centres to also retrospectively apply the NICE guidelines or alternatively a national prospective trial of centres prepared to follow the previous Royal College of Physicians guidelines or the new NICE protocols could be considered.

J. Valmai Cook
Consultant Radiologist
Queen Mary’s Hospital for Children, Epsom and St Helier University NHS Trust, Carshalton SM5 1AA
valmai.cook@epsom-sthelier.nhs.uk

Competing interests: None declared

PRACTICE:
Ehlers-Danlos syndrome
Gawthrop et al. (1 September 2007) [Full text] [PDF]
Ehlers-Danlos syndrome
Question re possible association with Attention Deficit Hyperactivity Disorder
5 October 2007
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Bruce W Urquhart,
Senior medical Officer Alcohol, Tobacco and other Drugs Service
Toowoomba Australia

Send response to journal:
Re: Question re possible association with Attention Deficit Hyperactivity Disorder

In my previuos work within Child and Youth Mental Health, I saw many children that seemed to be hyperflexible and seemed to have issues related to inattention and distractibility. Has any one noted similar issues?

Competing interests: None declared

FILLERS:
A depressed gorilla
Pop (1 September 2007) [Full text]
A depressed gorilla
Neglect of Psyhosocial Interventions in a Depressed Gorilla
3 October 2007
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Dave W H Baillie,
Specialist Registrar in Adult Psychiatry
East London and the City Mental Health NHS Trust, Anita House, Wilmer Place, London, N16 0LN

Send response to journal:
Re: Neglect of Psyhosocial Interventions in a Depressed Gorilla

Given that the serotonin theory of depression has been dismissed as a pharmaceutical industry propagated myth (Lacasse 2005) and given the efficacy of psychosocial interventions, we were surprised that Pop only considered a pharmacological approach in the treatment of a depressed gorilla.

While even the most enthusiastic evangelists of NICE-recommended CBT might acknowledge the limitations of cognitive restructuring with a gorilla, more pragmatic activity scheduling and behavioural activation both have a good evidence base as stand alone treatments for depression.

Antonio Damasio (1994) conceptualised emotional experience as being embedded within visceral and musculoskeletal states. In depression, reduced efferent activity from the peripheral nervous system can be stimulated by Dance Movement Therapy, another proven therapy for depression (Jeong-Young-Ja, 2005).

Ayurvedic philosophy, and more recently Harrison et al (2005), has indicated a relationship between low mood and overcrowding, such as might be the case in Bristol Zoo, and it might be that a letter in support of rehousing, the ubiquitous default intervention of the helpless psychiatrist, could have been useful.

Dianne Fossey observed the importance of social hierarchy in gorilla groups and it could be that Pop’s patient’s withdrawal from the role of alpha male precipitated an existential crisis characterised by a failure to negotiate Erikson's final task of development: integrity versus despair. Or in the words of the Jungle Book’s King Louie, “I’m (was) the king of the swingers, the Jungle V.I.P. I’ve got to the top and then had to stop and that’s what’s bothering me”.

Pop, IC. A depressed gorilla. BMJ 2007; 335: 445 (1 September).

Lacasse JR, Leo J. Seotonin and Depression: A disconnect between the advertisements and the scientific literature. PloS Med (2005) 2 (12): e392

Harrison J, Barrow S & Creed F. Social deprivation and psychiatric admission rates for different diagnostic groups. BJPsych (1995) 167 (4) 456-62

Jeong-Young-Ja, Hong-Sung-Chan, Lee-Myeong-Soo, Park-Min-Cheol, Kim- Yong-Kyu, Suh-Chae-Moon. Dance movement therapy improves emotional responses and modulates neurohormones in adolescents with mild depression. The International journal of neuroscience (2005) 115 (12) 1711-20

Antonio Damasio (1994) Descartes Error: Emotion, Reason and the Human Brain. Vintage Books, London.

Competing interests: None declared

RESEARCH:
Acupuncture as an adjunct to exercise based physiotherapy for osteoarthritis of the knee: randomised controlled trial
Foster et al. (1 September 2007) [Abstract] [Full text] [PDF]
Acupuncture as an adjunct to exercise based physiotherapy for osteoarthritis of...
Clearly suboptimal acupuncture
1 October 2007
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Andrew Hoe,
Physiotherapist
Oxfordshire Primary care Trust

Send response to journal:
Re: Clearly suboptimal acupuncture

We already have other evidence to support the use of acupuncture in the treatment of osteoarthritis of the knee in the form of systematic review, meta-analysis, safety-profiling and cost-benefit analysis (Acupuncture in Medicine 2006, Vo. 24, Supplement).

However, other controlled trials that have shown positive effects for acupuncture on chronic knee conditions have used considerably longer courses of treatment than that used by Foster et al. (2007) who used “up to six treatments” (Foster et al. 2007, p.5). This is illustrated below:


Authors				[Number of treatments used]
Berman et al. (2004)				[23]
Scharf et al. (2006)			       [10 or 15]
Witt et al. (2006)			       [up to 15]
Vas et al. (2004)				[12]
Sangdee et al. (2002)				[12]
Witt et al. (2005)				[12]
Tukmachi et al. (2004)			        [10]

In their review, White et al. (2007) included a meta-analysis which also demonstrated positive effects for acupuncture in this condition, however, in six out of the eight studies which were of a good-enough quality and similarity to be included electro-acupuncture was used. Among scientific acupuncturists this is commonly believed to be a stronger form of acupuncture treatment.

Therefore Foster et al. (2007) have used the weaker form of acupuncture (manual acupuncture) and they have chosen to use only about 50% of the amount that other research teams have deemed it necessary to use, despite their claims that this meets minimum standards of “adequacy”.

In short, there is a very real possibility that the negative findings in this trial are due to the suboptimal use of acupuncture in terms of number of treatments and type of acupuncture applied.

References

Berman B.M., Lao L., Langenberg P., Lee W.L., Gilpin A.M., Hochberg M.C. (2004) Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized controlled trial. Annals of Internal Medicine 141 (12) 901-10

Foster N.E., Thomas E., Barlas P., Hill J.C., Young J, Mason E., Hay E.M. (2007) Acupuncture as an adjunct to exercise based physiotherapy for osteoarthritis of the knee (15 August 2007). www.bmj.com

Sangdee C., TeeKachunhatean S., Sanapanich K, Sugandhavesa N., Chiewchantanakit S., Pojchamarnwiputh S., Jayasvasti S. (2002) Electroacupuncture versus Diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. Complementary and Alternative Medicine 2

Scharf H-P, Mansmann U., Steitberger K., Witte S., Kramer J., Maier C., Trampisch H-J., Victor N. (2006) Acupuncture and knee osteoarthritis. Annals of Internal Medicine 145 12-20

Tukmachi E., Jubb R., Dempsey E., Jones P. (2004) The effect of acupuncture on the symptoms of knee osteoarthritis – an open randomised controlled study. Acupuncture in Medicine 22 (1) 14-22

Vas J., Mendez C., Perea-Milla E. (2004) Acupuncture as a complementary therapy to the pharmacological treatment of osteoarthritis of the knee: randomised controlled trial. British Medical Journal 329 (7476) 1216-1219

White A., Foster N., Cummings M., Barlas P. (2007) Acupuncture treatment for chronic knee pain: a systematic review. Rheumatology 54

Witt C., Brinkhaus B., Jena S., Linde K., Streng A., Hummelsberger J., Walther H.U., Melchart D., Willich S.N. (2005) Acupuncture in patients with osteoarthritis of the knee: a randomised trial. The Lancet 366 (Jul 9-Jul 15)

Witt C.M., Jena S., Brinkhaus B., Wegscheider K., Willich S.N. (2006) Acupuncture in patients with osteoarthritis of the knee or hip: A randomized controlled trial with an additional nonrandomized arm. Arthritis and Rheumatism 54 (11) 3485-3493.

Competing interests: Practicing physiotherapist using acupuncture.

LETTERS:
Time to get our acts together
Reid and Menon (1 September 2007) [Full text] [PDF]
Time to get our acts together
There is a need for greater awareness of and training on the Mental Capacity Act (MCA) 2005 within the National Health Service (NHS).
5 October 2007
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Jude N Chukwuma,
Honorary Clinical Research Fellow
School of Medicine, Swansea University,
Shuja Reagu, Chisolum I Chukwuma

Send response to journal:
Re: There is a need for greater awareness of and training on the Mental Capacity Act (MCA) 2005 within the National Health Service (NHS).

The MCA 2005 (and its code of Practice) came into full force in England and Wales on October 1st 2007. The Act introduces a new Criminal Offence of ill-treatment or wilful neglect of people who lack capacity. It is crucial for individual staff members to have an appropriate level of understanding of the Act and it principles, and be able to work within its Code of Practice as appropriate. We are surprised by the poor media coverage at this crucial time of full implementation of the Act.

In July 2007, barely three months before the full implementation of the Act, we undertook a survey of the awareness and training needs for the MCA 2005 within a National Health Service Trust in the United Kingdom. The aim of the survey was to gain an insight into staff members’ perceived level of preparedness and confidence for the implementation of the Act and its Code of Practice. Its objectives were to raise awareness, identify information gaps and further training needs.

Our methods included a 12-item self-rated questionnaire which was administered to a stratified sample of staff working in the NHS Trust: the strata included staff working in Rehabilitation, Old age and Learning Disability Psychiatry. This population was selected by the trust’s MCA 2005 Steering Committee on the understanding that they were more likely to encounter the more vulnerable patient population in the course of their daily work. A total of 90 questionnaires were sent out, and 59 responses were received (response rate of 66%)

The results revealed that only 48 of the 59 respondents (81%) reported that they were aware of the MCA 2005; 11 of the 59 respondents (19%) reported lack of awareness.

21 of 59 respondents (37%) were not aware of the date the Act was to come into force. Only 13 of 59 respondents (22%) said that they had undergone training to familiarise themselves with the Act. Common comments from respondents who had attended the available training included that training sessions were “boring” and “not tailored to individual professional needs”.

Overall only 8 of the 59 respondents (13%) felt prepared and confident to implement the Act within their practice. However, more than half of the respondents (58%) had arranged further training.

In terms of acts amounting to a Criminal Offence within the MCA 2005, 25% of respondents said they ‘did not know’ while 10% mentioned wilful neglect, only 25% correctly included ill treatment and wilful neglect.

This survey identified the need for increased awareness, training and follow up training, in order to improve competence, confidence and preparedness of staff for the implementation of the MCA 2005 It also identified a need to tailor training to individual professional needs. It went on to recommend strategies to facilitate these identified needs including that awareness and training information may be attached to payslips, training may be part of new staff induction programme, need for follow up training to improve competence and confidence, need for compulsory attendance at training, and need to tailor training to individual professional needs.

Competing interests: None declared

EDITORIALS:
Chronic fatigue syndrome or myalgic encephalomyelitis
White et al. (1 September 2007) [Full text] [PDF]
Chronic fatigue syndrome or myalgic encephalomyelitis
Miscommunications and Misunderstandings
5 October 2007
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Douglas T Fraser,
n/a
London W6

Send response to journal:
Re: Miscommunications and Misunderstandings

Professor Peter White of St Bartholomew's Hospital rightly points out that "the history of this field has been littered with miscommunications and misunderstandings".

Professor Stephen Stansfeld of St Bartholomew's Hospital communicated in 2004 that (1):

"The interface between physical and mental illness (is) typified by Chronic Fatigue Syndrome. On the interface between physical and mental illness, research continues into chronic fatigue syndrome and the development of treatment trials led by Dr Peter White".

Professor John Garrow, a consultant physician at St Bartholomew's Hospital, communicated in 2005 that (2) "the most valuable message I gained from the second session was the observation by Professor Peter White (Psychological Medicine, St Bartholomew's Hospital) that patients with chronic fatigue syndrome (CFS, or ME) have a worse prognosis if the diagnosis they are given is ME than if it is CFS. He concludes that chronic fatigue implies a physiological state that the patient may overcome by suitable exercises, whereas ME implies a viral disease of the brain and muscles over which the patient has no control."

In their 2007 public communication from the St Bartholomew's Hospital Chronic Fatigue Syndrome/ ME Service website, there is an article entitled: 'Expectations for Outcome' (3).

After removing some slightly extraneous material for the sake of clarity, it basically communicates that:

"We have found that three-quarters of our patients with CFS/ME significantly improve or recover with treatment in our clinic; research has suggested that a quarter recover their health and a further half significantly improve. Some of those who recover don't actually recover, some don't even improve, and some should go elsewhere".

In 2007 Jason and Brown stated that (4): "Relatively few patients with CFS completely recover from the illness, with a recovery rate of 0-6% and increased disability in 10-20% of patients over time", while the CDC state (5) : "Improvement rates varied from 8% to 63% in a 2005 review of published studies, with a median of 40% of patients improving during follow-up. However, full recovery from CFS may be rare, with an average of only 5% to 10% sustaining total remission".

Assuming that the Jason, Brown and CDC figures are not unreasonable, the St Bartholomew's Hospital Chronic Fatigue Syndrome/ ME Service website communication should perhaps then read:

"We have found that three-quarters of our patients with CFS/ME significantly improve or recover with treatment in our clinic; research has suggested that very few recover, some improve and a significant number get worse. Whilst in our service, some of those who recover don't actually recover, some don't even improve, and some should just go elsewhere".

Chia and Chia found that (6) "Enterovirus VP1, RNA and non-cytopathic viruses were detected in the stomach biopsy specimens of CFS patients with chronic abdominal complaints. A significant subset of CFS patients may have a chronic, disseminated, non-cytolytic form of enteroviral infection, which could be diagnosed by stomach biopsy".

Dr Jonathan Kerr commented that (7) "the role of enterovirus infection as a trigger and perpetuating factor in CFS/ME has been recognized for decades...however, several negative studies combined with the rise of the psychiatric 'biopsychosocial model' of CFS/ME have led to a diminished interest in this area...the importance of gastrointestinal symptoms in CFS/ME and the known ability of enteroviruses to cause gastrointestinal infections, led John and Andrew Chia to study the role of enterovirus infection in the stomach of CFS/ME patients...these intriguing data for which there is ample supporting data strongly suggest a new and hitherto unrecognized disease mechanism in CFS/ME patients, which in my opinion, could trigger and perpetuate this disease...The role of EV infection of the stomach in the pathogenesis of irritable bowel syndrome also needs to be clarified in light of these results."

Referring to the 'biopsychosocial model' which has distracted scientific research and funding into the disease, PACE trialist and Professor of Cognitive Behavioural Therpay Trudie Chalder insightfully communicated that (8):

"It is theoretical and it doesn't lead us anywhere".

More precisely, the psychiatrist Dr Niall McLaren wrote (9):

"In practice, if we want to know whether Engel's biopsychosocial model is truly a model, or just a case of wishful thinking, then a simple test will decide the issue. Try making, say, a prediction about a man's psychological state from his biological data, or vice versa. Or perhaps try to predict wholly from sociological data which girls will develop post-partum mental disorders as young women or psychoses in old age. Since nothing like this can be done, Engel's 'model' is not a model in any interesting sense of the term" and (10): "In a word, the officially-endorsed biopsychosocial model is pure humbug, i.e. (some)thing that tricks or deceives; nonsense, rubbish, just because it does not exist."

Hopefully, the recent advent of the internet (11) should help clear up any "miscommunications" and "misunderstandings".

Douglas T Fraser

(1) Department of Psychiatry, Barts and the London UK http://tinyurl.com/2ac2zl

(2) http://www.healthwatch-uk.org/newsletterarchive/nlett58.htm

(3) http://www.bartscfsme.org/expectations.htm St Bartholomew's Hospital Chronic Fatigue Syndrome/ ME Service: ('view source' - "Chronic fatigue syndrome, ME, London, St Bartholomew's Hospital, CBT, Peter White") - "Expectations for Outcome - We have found that three-quarters of our patients with CFS/ME significantly improve or recover with treatment in our clinic; research has suggested that a quarter recover their health and a further half significantly improve. For some people recovery may not necessarily mean a return to their previous lifestyle, if this contributed to them becoming ill in the first place. Some patients may not improve whilst in our service, but we would expect to help them to cope better with their illness and manage symptoms more effectively. Some patients may find other approaches to managing their ill health more helpful than those we provide here".

(4) Functioning in individuals with chronic fatigue syndrome: increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia Molly M Brown and Leonard A Jason Department of Psychology, DePaul University, Center for Community Research, Chicago, IL, USA Dynamic Medicine 2007 http://www.dynamic-med.com/content/6/1/6

(5) http://www.cdc.gov/cfs/cfsbasicfacts.htm

(6) http://press.psprings.co.uk/jcp/september/cp50054.pdf Chronic Fatigue Syndrome is associated with chronic enterovirus infection of the stomach -Journal of Clinical Pathology Sept 13 2007

(7) Enterovirus infection of the stomach in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME) Jonathan R Kerr St George's University of London J Clin Pathol.14 September 2007.http://jcp.bmj.com/cgi/content/abstract/jcp.2007.051342v1

(8) Page 15 - "Biopsychosocial Medicine An integrated approach to understanding illness" Edited by Peter White, Department of Psychological Medicine, St Bartholomew's Hospital, London, UK April 2005 OUP

(9) www.futurepsychiatry.com/rev_thesis/Rev%20Chapter%207.doc

(10)McLaren N. The biopsychosocial model and scientific fraud. Paper presented to annual congress, RANZCP, Christchurch May 2004 available from the author at jockmcl@octa4.net.au

(11) http://en.wikipedia.org/wiki/Internet#Growth

Competing interests: None declared

Chronic fatigue syndrome or myalgic encephalomyelitis
ME as an inclusion of CFS
3 October 2007
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Les O SIMPSON,
retired experimental pathologist
Dunedin, New Zealand 9077

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Re: ME as an inclusion of CFS

None of the many spirited responses to the White et al editorial have drawn attention to the urgent need to dissect ME from the all-embracing concept of CFS.

It seems incomprehensible that there has been a multiplicity of guidelines produced for the management of a disorder for which there is no accepted aetiology or pathophysiology. Possibly, to a major extent, this simply reflects the rejection of earlier concepts.

In the second edition of his book, Ramsay noted that the clinical identity of the ME syndrome was based upon three distinct features.

"1. A unique form of muscle fatigability whereby even after a minor degree of physical effort. three, four or five days, or longer, may elapse before full muscle power is restored. (NB. Strenuous activity changes the shape populations of red cells in both healthy and unwell subjects.)
2. Variability and fluctuations of both symptoms and physical findings in the course of a day. (A blood sample taken during remission showed normal features, but six hours later, after a relapse a blood sample was grossly abnormal.)
3. An alarming tendency to become chronic.

Ramsay discussed the clinical features of ME under three headings.
1. Muscle phenomena. He noted, "...it is important to stress the fact that cases of mild or even moderate severity may have normal muscle power in a remission."

(NB It is rare for remissions to be mentioned let alone discussed and no guideline provides an explanation of their happening. A short paper titled, "The implications of remissions in ME," was quickly rejected by the BMJ.)

2. Circulatory impairment. This was manifested as cold extremities and facial pallor.

3. Cerebral dysfunction. The cardinal features were the impairment of memory and the power of concentration, plus emotional lability.

It seems strange that Ramsay did not consider that the cerebral and muscle dysfunction might be related causally to the circulatory impairment, as it seems that this could be the key factor in the pathophysiology of ME. A major problem relating to acceptance is that the problems concern altered blood rheology - and blood rheology is not taught in medical schools.

My work indicates that ME is a dysfunctional state resulting from inadequate rates of delivery of oxygen and nutrient substrates, due to impaired capillary blood flow, to maintain normal tissue function. Some of the background to this claim is summarised below. In 1986 we reported that ME blood filtered poorly (1) and in the following year reported similar findings with regard to MS blood. In addition MS blood viscosity was increased and changed red cell shapes were observed by scanning electron microscopy.(2) A study which showed that the red cells of healthy animals and humans could be classified into six different shape classes (3) was followed by a report that ME blood contained high levels of cup forms, which would help to understand the poor filterability of ME blood.(4) The results from a further 99 cases were presented at the Cambridge Symposium in 1990. In 1992, New Jersey Medicine published an article relating to idiopathic chronic fatigue in which I pointed out that individuals who by chance had smaller than usual capillaries would be at risk of developing chronic sickness after exposure to an agent which changed the shape populations of red cells.(5)

The implications for ME were discussed in a 1997, invited paper titled, "Myalgic encephalomyelitis (ME):a haemorheological disorder manifested as impaired capillary blood flow."(6) In 2001 we reported the results from red cell shape analysis of more than 2100 blood samples from members of ME groups in four countries.(7)

It should be noted that SPECT scans show the expected effects of shape- changed, poorly deformable red cells in reducing cerebral blood flow in regions which by chance have smaller than usual capillaries.

It has been reported that SPECT scans in three different psychiatric disorders showed reduced blood flow in different regions of the brain, so it could be expected for psychological/psychiatric problems to emerge in some ME people as a part of their dysfunctional state.

References.

1.Simpson LO et al. Pathology 1986;18:190-2.

2.Simpson LO et al. Pathology 1987;19: 51-5.

3.Simpson LO. Br J Haematol 1989;73:561-4.

4.Simpson LO. NZ Med J 1989;102:106-7.

5.Simpson LO. NJ Med 1992;89:211-6.

6.Simpson LO. J Orthomol Med 1997;12:69-76.

7.Simpson LO et al.J Orthomol Med 1997;12:221-6.

Competing interests: None declared

Chronic fatigue syndrome or myalgic encephalomyelitis
PSYCHIATRISTS SAY: CBT for ME does NOT work
2 October 2007
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Tessa Vinicius,
GP
Amsterdam, Netherlands

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Re: PSYCHIATRISTS SAY: CBT for ME does NOT work

NICE says CBT works for ME, and they say that is evidence based. Apart from that many patients have been saying that it doesn't work, there have also been many psychiatrists who have done the same. Dr Stein from Canada has been mentioned, but in a recent article in The World Journal of Biological Psychiatry, April 2007, Dr Sanders and Dr Korf, from a psychiatric department in Groningen, The Netherlands, reported the following: "The psychiatric and psychosocial hypothesis DENIES the existence of CFS as a disease entity." Now this reminds me very much of the NICE guidelines; who don't even mention the WHO listing of ME as a neurological illness. But please read on, because these psychiatrists have a lot more interesting things to say: "In CFS cognitive behavioural therapy is most commonly used. This therapy, however, appears to be INEFFECTIVE in many patients. The suggested causes of CFS and the divergent reactions to therapy may be explained by the LACK of recognition of subgroups. IDENTIFICATION of subtypes may lead to MORE EFFECTIVE therapeutic interventions." I have put these words in capitals, so it is easier to read, and as this appeared in April, NICE should have known about it.

I would think that the best way forward, would be a radical revision of the NICE ME guidelines, and to do what the Canadians did, and what these psychiatrists have now advised to do as well. Separate ME from other illnesses with fatigue, so you can offer those others proper treatment, and you can start looking for a cause and hopefully a cure for ME.

Competing interests: None declared

Chronic fatigue syndrome or myalgic encephalomyelitis
Actometers or pedometers should be used in rehabilitation studies in the field to check whether the interventions are actually leading to (substantial) increases in activity levels
30 September 2007
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Tom Kindlon,
Unavailable for work due to ill-health
Dublin, Rep. of Ireland

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Re: Actometers or pedometers should be used in rehabilitation studies in the field to check whether the interventions are actually leading to (substantial) increases in activity levels

The authors make reference to the PACE trial [1], a major trial in the area. It seems particularly curious that this trial will use actigraphy watches before the patients start the trial, but will not use them again on the patients during or at the end of the trial. This would give information on whether the patients are increasing their total activity levels or simply doing the activity that is part of the trial in the place of other activity they used to do, but which they have cut down on or cut out altogether.

This is important given previous studies in the area. For example, one study [2] "using a 26-session graded activity intervention involved gradual increases in physical activity" found that "from baseline to treatment termination, the patient’s self-reported increase in walk time from 0 to 155 min a week contrasted with a surprising 10.6% decrease in mean weekly step counts."

Another study [3], investigating CBT this time, is regularly quoted as having showing the effectiveness of CBT for CFS. However if one examines the actometer data from this study from the group given CBT, the increases in activity were minimal [4]. For instance, the baseline average was 67.9, which increased to 68.8 after treatment and to 72.2 at follow- up. Approximately 4 points. Not unlike the medical care controls, who went from 64.9 to 68.7 in the same period.

Given the costliness of the trial - over £3m (of UK taxpayers' money) - it is disappointing that the PACE Trial is not using objective outcome measures which were previously recommended in a review of CFS interventions [5]: "Outcomes such as "improvement," in which participants were asked to rate themselves as better or worse than they were before the intervention began, were frequently reported. However, the person may feel better able to cope with daily activities because they have reduced their expectations of what they should achieve, rather than because they have made any recovery as a result of the intervention. A more objective measure of the effect of any intervention would be whether participants have increased their working hours, returned to work or school, or increased their physical activities."

Perhaps it is not too late for this data to be collected from some participants?

[1] White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; on behalf of the PACE trial group. Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy. BMC Neurol 2007;7:6. http://www.biomedcentral.com/1471-2377/7/6

[2]. Friedberg, F. Does graded activity increase activity? A case study of chronic fatigue syndrome. Journal of Behavior Therapy and Experimental Psychiatry, 2002, 33, 3-4, 203-215

[3]. Prins JB, Bleijenberg G, Bazelmans E, et al. Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial. Lancet 2001; 357: 841-47.

[4]. Van Essen, M and de Winter, LJM. Cognitieve gedragstherapie by het vermoeidheidssyndroom (cognitive behaviour therapy for chronic fatigue syndrome). Report from the College voor Zorgverzekeringen. Amstelveen: Holland. June 27th, 2002. Bijlage B. Table 2.

[5] Whiting P, Bagnall A.-M., Sowden AJ, Cornell JE, Mulrow CD, Ramirez G (2001). Interventions for the Treatment and Management of Chronic Fatigue Syndrome: A Systematic Review. JAMA 286: 1360-1368

Competing interests: None declared

CLINICAL REVIEW:
Acute respiratory distress syndrome
Leaver and Evans (25 August 2007) [Full text] [PDF]
Acute respiratory distress syndrome
Should we use low tidal volume in all our ARDS patients?
12 October 2007
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Eduardo M Svoren,
Senior Registrar In Anaesthesia
St Bartholomew Hospital,
Marcela Vizcaychipi

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Re: Should we use low tidal volume in all our ARDS patients?

Dear Editor. We read with great interest the clinical review about Acute Respiratory Distress Syndrome (ARDS) published on 25th Aug 2007(1) and we found remarkably surprising the ventilatory strategy recommended by the authors, quoting the Network Trial as a landmark paper in mechanical ventilation (2). We would like to refresh that the Alliance for Human Research Protection (AHRP) has led the American National Institute of Health to suspend enrolment of patients in the Network Trial on grounds of legally invalid consent (most of the patients of the ARDSnet trial were enrolled without a legally effective consent) and also due to failure to minimize risk (the use of excessive tidal volume in the control group ignore previous trials suggesting that high tidal volumes have been associated with higher death rate) (3). In addition Peter Eichacker suggested in his meta-analysis that the used of low tidal volume is not associated with proven survival benefits (4).

Good experimental and clinical evidence support the concept that the use of high tidal volume in this group of patients may be detrimental by inducing and aggravating lung injury (5). However, we consider there is still not enough and conclusive clinical evidence to accept the use of tidal volume adjusted to 6 ml per kg of predicted body weight in all patients presenting in the intensive Care Unit with ARDS. Furthermore, this unconventional respiratory modality might potentially lead to harm (6,7,8,9). We would like to advocate a more conservative approach limiting plateau pressure between 28 and 32 cm of H20 as a more prudent ventilatory strategy until new evidence settle this controversy.

1- Susannah Leaver, Timothy Evans. Clinical Review .Acute Respiratory Distress Syndrome. BMJ 2007;335:389-94.

2- Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional volumes for acute lung injury and the acute respiratory distress syndrome. N Eng J Med 2000;342:1301-8.

3- Amat o MB. Beneficial effect of the open lung approach with low distending pressure in acute respiratory distress syndrome. A prospective randomised study on mechanical ventilation. Am J of Resp and Crit Care Med 1998;152:1835-1846.

4- P Eichacker. Meta-Analysis of acute lung injury and acute respiratory distress syndrome. Trials testing low tidal volumes.Am J Resp Crit Care Med 2002;166:1510-1514.

5- Slusky AS.Lung injury caused by mechanical ventilation. Chest 1999;116:9s-15s.

6- Brochard L. Tidal volume reduction for ventilatory prevention of ventilatory induced lung injury in acute respiratory distress syndrome. Am J Resp Crit Care Med 1998;158:1831:38.

7- Brower RG. Prospective, randomised, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med1999;17:1492-98.

8- Stewart TE. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. N Eng J Med 1998;338:355-361.

9- Ricard JD. Are we really reducing tidal volume and should we? Am J Resp Crit Med 2003;167:2002-2003.

Competing interests: None declared

RESEARCH:
Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial
Montini et al. (25 August 2007) [Abstract] [Full text] [PDF]
Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled...
Response to Montini Article
12 October 2007
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Alejandro Hoberman,
Professor of Pediatrics
Children's Hospital of Pittsburgh, 15213,
Ellen R. Wald

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Re: Response to Montini Article

We were pleased to read the study by Montini and co-workers which has further substantiated our study regarding the effectiveness of using oral antimicrobials for the management of acute pyelonephritis in children.1 We congratulate them on enrolling this large cohort of children. The difference in proportion of girls vs boys among children in the two studies may well relate to the frequency of circumcision in the two populations. Our population studied in the US included relatively few uncircumcised boys; accordingly, the rate of UTI among boys in general will be reduced. The rate of circumcision in the Italian study is not cited. Conway et al evaluated electronic health record data from a network of 27 primary care practices; 543 (89%) of the 611 children aged 6 years or younger diagnosed with an initial UTI were female.2 The rate of reflux noted in our study (40%) is quite consistent with the results of numerous other investigations.3, 4 The differences in rates of scarring are quite interesting. Because we studied children less than 2 years of age, the threshold for evaluation for the presence of UTI may have been lower resulting in earlier diagnosis and treatment and therefore less scarring. This is perhaps reflected in the shorter time to defervescence and the lower rate of scarring – which is also consistent with more recent studies.5

Additional unanswered questions we have regarding the Montini study include: (1) the timing of entry is not clear: were children enrolled after the first sample of urine or after the second confirmatory urine was obtained?, (2) the assumption that children with initial negative DMSA scans had no reinfections during the ensuing year in order to assume that a negative initial scan results in a negative follow-up scan (88 and 89 children in the oral and parenteral treatment groups, respectively); (3) a relatively large proportion of children (20.3%) lost to follow-up, and (4) with regard to interpretation of DMSA renal scans, (a) whether any interobserver agreement was measured in preparation for or during the trial, (b) whether any standardization of interpretations by regions or extent, other than definitions of acute pyelonephritis and renal scarring were utilized.

References:

1. Montini G, Toffolo A, Zucchetta P, et al. Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial. Br Med J 2007; 335:386.

2. Conway PH, Cnaan A, Zaoutis T, Henry BV, Grundmeier RW, Keren R. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. Jama 2007;298(2):179-86.

3. Downs SM. Technical report: urinary tract infections in febrile infants and young children. The Urinary Tract Subcommittee of the American Academy of Pediatrics Committee on Quality Improvement. Pediatrics 1999;103(4):e54.

4. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection. Pediatrics 1999;103(4 Pt 1):843-52.

5. Garin EH, Olavarria F, Garcia Nieto V, Valenciano B, Campos A, Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics 2006;117(3):626-32.

Competing interests: None declared

RESEARCH:
Accuracy of diagnosing atrial fibrillation on electrocardiogram by primary care practitioners and interpretative diagnostic software: analysis of data from screening for atrial fibrillation in the elderly (SAFE) trial
Mant et al. (25 August 2007) [Abstract] [Full text] [PDF]
Accuracy of diagnosing atrial fibrillation on electrocardiogram by primary care...
Response from both Hospital and GP angles
10 October 2007
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Ashish B Patel,
Specialist Registrar Geriatrics and GP
Leicester General Hospital LE1 5WW

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Re: Response from both Hospital and GP angles

Working as an SpR in Geriatric Medicine as well as being a GP, i am not surprised at the results of this excellent study. I feel that GP's need more training in basic general medicine, not just cardiology. With the ageing population GP's are caring for more and more elderly patients. Perhaps, the QOF system has fallen short in its aims should be rewarding GP's for detecting and diagnosing disease rather than numbers.

Competing interests: None declared

FEATURE:
Hyperactivity in children: the Gillberg affair
Gornall (25 August 2007) [Full text] [PDF]
Hyperactivity in children: the Gillberg affair
Assessment for the Swedish Research Council
12 October 2007
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Denny H Vågerö,
Professor, director
Centre for Health Equity Studies, CHESS, Stockholm University/ Karolinska Institutet

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Re: Assessment for the Swedish Research Council

Jonathan Gordall quotes me in his article. Allow me to clarify.

I was asked by the Swedish Research Council to review some of the critique against Gillberg, specifically the harsh critique against Gillberg's work formulated by Eva Kärfve in her book"Brain Ghosts" (available only in Swedish). My judgment (see below), as well as that of professor Ottoson, concerned what was written by Eva Kärfve and whether her critique of the Gillberg group was unfair and could be said to constitute scientific misconduct. We were not asked, and found no particular reason, to look into whether she was collaborating with the scientology church or not - in fact this is irrelevant to the primary conflict between Kärfve and Gillberg. Neither were we asked to, or did we, look into the events leading up to the destruction of Gillberg’s large data material. Both of these aspects are central in Gordall’s article and in the 22 (so far) rapid responses.

The reviews commissioned by the Swedish Research Council in 2006 have only been available in Swedish. I think they would help the reader of BMJ to understand the roots of the controversy and to move beyond the bitter accusations and counter-accusations. My review and that of professor Jan Otto Ottoson came to similar conclusions. Finally the Swedish Research Council followed our advice that Kärfve’s criticism should not be dismissed as scientific misconduct.

Below is my statement for the Swedish Research Council.

To the Swedish Research Council

I, the undersigned, have been requested by the Swedish Research Council to present my views on the Lund University communication of 26 March 2005 concerning the claim that Eva Kärfve had been guilty of scientific misconduct. A preliminary approach was made to me in the late autumn of 2005, and this was followed by a definite request in February 2006. The Lund University communication raises a number of issues. The Swedish Research Council, however, primarily wanted me to take a position on the question of whether Eva Kärfve’s research could be described as scientifically dishonest on the basis of three passages in her book Hjärnspöken (‘Brain Ghosts’) specified in the university communication.

My opinion on these three points is as follows:

1. Kärfve (page 15) writes that Gillberg and Landgren ignored or dismissed findings that indicated the relevance of social factors, such as social class or housing conditions, for minimal brain dysfunction (MBD). Is this claim misleading or untrue?

Gillberg discussed psychosocial conditions and social class in a number of different places in his doctoral thesis. He finds, for instance (page 103, table III), that social class, poor housing areas and rented flat accommodation are highly correlated to the MBD diagnosis. Similarly, the mother’s stress load is significantly correlated to the MBD diagnosis in the child. He nevertheless concludes (page 112) that “Social disadvantage is in itself not an etiological factor”.

This certainly looks like a dismissal.

The keywords in seeking to understand Gillberg’s conclusion are in itself. On page 112, he explains: “Social class, although in itself highly correlated to the MBD diagnosis, was not in any way a factor directly affecting the background variables studied.” Instead, the etiologically operative background factors to which weight is attached are for instance “prenatal non-optimal factors” and “hereditary non-optimality” etc. Gillberg appears to be arguing that since social class and housing area are not linked to these background factors, they cannot be of etiological interest. But if social class and housing area are highly correlated to MBD, despite not being correlated to variables such as “prenatal non- optimal factors”, a reasonable conclusion would instead seem to be that social class is an (‘upstream’) etiological factor that operates via some other mechanism than the ones discussed above. Thus an important discovery is left hanging in the air, without any interpretation.

Alternatively, social class may nevertheless have affected the factors grouped under the heading “prenatal non-optimal factors” (including for instance low weight at birth and premature birth) without such a link being detected in this particular study, targeting as it does a relatively limited number of persons (= low statistical power). In Sweden, low birth weight and premature birth were more common among working-class mothers and mothers with little education during this period. Gillberg himself notes in his thesis the relevance of low birth weight and “small for gestational age” as etiological factors for MBD (pages 110–111). Thus it would have been reasonable to expect that “prenatal non-optimal factors” would mediate the observed correlation from social class to MBD in Gillberg’s study. Here, too, an unanswered question is left hanging in the air.

The factors grouped under the heading of “hereditary non-optimality” also include some with a social content. Late puberty among older relatives is taken to be suboptimal heredity. But the age of entry into puberty has been shown to be highly differentiated by social class in all countries where the matter has been examined. This background factor, therefore, might equally well be interpreted as a social factor as an hereditary one.

Kärfve may be wrong to argue that Gillberg ignored the impact of social class and housing area on the development of neuropsychiatric diagnosis. She is right, however, to argue that he dismissed them as significant causal factors. Gillberg’s reasons for dismissing them are hardly convincing, at least not in light of our current knowledge in this area. Even if Gillberg had devoted greater attention to this issue, it goes almost without saying that a sociologically trained person would want to analyse this point in greater depth and to partly dispute it. Kärfve’s criticism in this respect cannot therefore be described as illegitimate.

2. Kärfve (pages 49–55) discusses what is termed the Mariestad study by Magnus Landgren, Christopher Gillberg et al. The study is included in Landgren’s thesis. Lund University’s communication asks for comments on what Kärfve says about this study on page 52 in her book. In describing the authors’ work, she talks about them “rummaging through old patient records”, accuses them of cynicism and urges that their work be rejected. Kärfve’s tone is bantering. Is she misleading, scientifically dishonest or propagating an untruth?

Kärfve comments on the fact that five children who were screened as positive and whose parents subsequently declined to take part in the clinicial study were nevertheless included in it. Landgren and his colleagues give the children neuropsychiatric diagnoses with the aid of patient records (“a thorough evaluation of all previous records and of the screening results” [page I:5 in Landgren’s thesis]). The diagnoses are given without the team having met the children. Examination of the records led to five children being given the following diagnoses: motor perception dysfunction, mental retardation, DAMP, ADHD, and in one case a combination of ADHD/DAMP.

This procedure contrasts sharply with the account of how other children in the study were given their diagnoses, namely through “…in- depth neurodevelopmental/neuropsychiatric assessment. This comprised a detailed history, psychiatric and neurodevelopmental examination, neuropsychological assessment and evaluation of speech and language performed by the author (ML), psychologists and speech therapists…. a medical, developmental and behavioural history was taken at interview with the parents, using a standardised interview schedule…etc.” (Page I:3 in Landgren’s thesis.)

Diagnosis setting and diagnosis criteria are one of the most controversial aspects of the Gillberg group’s research. There is good reason to critically discuss the way these five diagnoses were made. The study is a limited one, at least in terms of statistical ‘power’, and it is not clear to what extent the addition of these five diagnosed children to the other 58 diagnosed children has affected various conclusions in the study. The methodological problem is left unsolved. Landgren’s discussion fails to tackle the problem; instead, the mothers’ reluctance to take part in the study is seen as possible confirmation of the neuropsychiatric diagnosis given to the children. Nor is there any discussion of the ethical problem of including the five children in the study against their parents’ wishes.

I am of the opinion that Kärfve’s criticism on this point – despite the severe language it is couched in – is neither dishonest, untrue nor unreasonable.

3. Point 3 in the Lund University communication principally concerns pages 45–55 in Kärfve’s book. These sections mainly deal with how Gillberg’s and Landgren’s theses estimate the prevalence of MBD (Gillberg) and DAMP and other diagnoses (Landgren). Gillberg makes specific estimates of the prevalence in Sweden based on their studies. Kärfve is highly critical of how Gillberg’s prevalence estimate is strongly influenced by two cases that were transferred from the control group to the group with MBD. As a result, MBD prevalence among boys is estimated at almost 10 per cent. This illustrates how small changes in the material can have a major impact on estimates. Kärfve has similar objections to Landgren’s estimates.

Probably a more important problem concerning the estimation of prevalence of such neuropsychiatric diagnoses among children in Sweden is the extent to which the authors’ material is selected. Even if the intention is to base the study on the population as a whole, a step by step process occurs until those who are to take part in the study are finally selected. The selection covers such aspects as the researchers’ choice of study venue, whether the children attend preschool, parental decisions whether or not to take part in a survey, decisions by preschool staff whether or not to distribute the survey questionnaires, parental decisions as to whether their children should be clinically examined or not, and the researchers’ decisions whether to expand groups or move people between groups. It is by no means certain (especially in the case of the Göteborg study) that prevalence estimates are actually based on a sample of children that is representative of the child population in each venue, not to mention Sweden as a whole. A full discussion of possible bias in the estimation is needed. Nor have Landgren and Gillberg included any statistically calculated confidence intervals with their estimates. This is otherwise common practice, especially if working with representative samples. Thus it is difficult to express any opinion at all on the value of Gillberg’s estimation from 1981 that 7.1 per cent of Swedish children have MDB.

Viewed objectively, therefore, Kärfve’s criticism of what she calls Gillberg and Landgren’s neuropsychiatric mathematics is not particularly startling.

Conclusions

Lund University has asked for an assessment of certain passages in Eva Kärfve’s book, ‘Brain Ghosts’. Are they examples of scientific misconduct? Kärfve does not pursue any neuropsychiatric research of her own – in her book she makes no reference to publications of her own in this field – and can therefore hardly be accused of scientific misconduct in the sense of having invented her observations, falsified her findings or showing negligence in the presentation of her data. Original research – the base on which scientific knowledge is built – must of course be the area of activity subjected to the closest scrutiny, whether cheating or dishonesty is suspected or not.

In the present case, the question is whether Kärfve’s critique of research undertaken by others is dishonest. All three points raised in the Lund University communication concern Kärfve’s discussion of the Gillberg group’s research, not her own studies (in the same book) concerning the ideological roots of some of the ideas that both laypersons and professionally trained experts possess/have possessed concerning mental ill-health and its causes. Scientific critique should also be subject to scrutiny, of course, but can the same criteria be applied?

Scientific critique, whether strongly polemical or not, should in my opinion be considered a legitimate activity even when the person levelling the criticism does not primarily belong to the research community being criticised. Advancing one’s criticism outside academia, as part of the public discourse, is also legitimate. Normally, scientific critique helps improve the research in question. Research controversies, even when marred by irrelevancies, often generate new perspectives on old truths or unresolved scientific issues. In that sense, scientific critique is one of the conditions of research and a prerequisite for knowledge growth. Kärfve’s sociological expertise means that she is competent to assess various aspects (but not all) of the Gillberg group’s research. Research methodology and analyses of causal links are (or should be) essentially the same in all disciplines primarily concerned with studying human beings and human society. If they nevertheless differ, there is every reason to express oneself with care and to carefully encourage interdisciplinary understanding.

Kärfve’s book is largely a polemical publication of a general nature – primarily intended, perhaps, to influence the community at large and policymakers, and only as a secondary consideration addressing the specialised circle of people working scientifically with these matters. One might take the view that Kärfve is unnecessarily disputatious in tone, or sometimes goes a bit far, but writing a polemical publication on scientific issues that is partly or largely aimed at a general readership can hardly be equated with scientific misconduct. On the contrary, it is a time-honoured tradition in many scientific fields.

I believe it would be of benefit to the scientific discourse if Eva Kärfve were also to express her views precisely and scientifically in the sociological or medical science press. An unfortunate aspect of the conflict currently surrounding neuropsychiatry is that it risks drawing up unproductive battle lines between social scientists and the medical profession. Ranging the ‘biological’ against the ‘sociological’, or ‘biologism’ against ‘sociologism’, may be popular nowadays, but it is totally fruitless. Most biological processes are affected by people’s relations to one another, i.e. by society. Equally, social processes are affected by biology. If we are to understand how, we need a dialogue between disciplines. If the Swedish Research Council has a part to play in connection with the Kärfve-Gillberg conflict, it should be to promote such a dialogue and to prevent bloc-building and disciplinary trench warfare.

Some unique research material has been destroyed. The development of children’s mental health in modern Swedish society is in many ways a cause for concern. We need to bury the hatchets.

Stockholm, 20 March 2006

Denny Vågerö Professor, Member of the Royal Swedish Academy of Sciences

(Translation by Stephen Croall)

Competing interests: None declared

Hyperactivity in children: the Gillberg affair
Industry of Death?
12 October 2007
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Vanna Beckman,
Free lance journalist and writer
Kungälv, Sweden

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Re: Industry of Death?

Steven Rose uphelds at least two different professional roles – one as a basic neuroscientist and another one that is deeply involved in political and ideological struggles in fields not directly connected with his neuroscientific research. Unfortunately in his writings he often doesn’t keep these roles apart but appears with the authority of the all- knowing scientist also when struggling against the well established diagnosis of ADHD, what he regards as the excessive use of anti- depressants or everything that he includes under the heading of neurogenetic determinism.

Read for instance the chapter Explaining the brain, healing the mind? in his book “The 21st Century Brain. Explaining, mending and Manipulating the Mind” (2005) - and I think most people would join me in appointing Steven Rose a pronounced advocate for the anti-psychiatry camp. He devotes much space to the tragic cul-de-sacs of psychiatric practice like lobotomy and barbiturates, in a condescending tone ridicules the “so-called ‘evidence-based medicine’“ and the “bible of DSM”. Talking of SRRIs he stresses the suicide risk, the big money involved and Peter Breggin’s ideas that many psychiatric disturbances be caused by drugs. His picture of psychiatry is all black and sinister, without mentioning the considerable advances made during the last half century in the quest to alleviate the burden of mental conditions.

After having described what he calls the epidemic of depression and anxiety and the widened criteria for bipolar disease and schizophrenia he asks if it is “as some conspiracy theorists (such as the scientologists) suspect, a medicalising myth through which people are kept in thrall by a sinister psychiatric establishment?” (page 225). After finishing the book it is difficult not to draw the conclusion that his own answer must be in the positive. I have absolutely no suspicion that Steven Rose has direct relations to scientology, but nevertheless many of his themes coincide with the writings of Thomas Szasz, Peter Breggin and others in their rather homogeneous anti-psychiatric ideology whose most aggressive megaphone is the Church of Scientology with its DVD “Psychiatry – Industry of Death”.

Vanna Beckman,

freelance journalist and writer, Kungälv, Sweden

Competing interests: None declared

Competing interests: None declared

Hyperactivity in children: the Gillberg affair
Apology for a slur required
3 October 2007
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Steven P R Rose,
Emeritus Professor of Biology
Open University, Milton Keynes MK7^AA

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Re: Apology for a slur required

I have no axe to grind in this rather heated debate and have played no part in it. However, as the freelance journalist Vanna Beckman arbitrarily drags my name into the discussion by alleging, without evidence, that I 'belong to the camp of anti-psychiatrists' and am close to 'but fear to be connected with' scientologists, it is time to demand an apology. I do not know who Ms Beckman is, have never knowingly corresponded with her, and wish to make it categorically plain that I have abolutely no time for or truck with scientology. Nor, as a bsic neuroscientist, am I an 'anti-psychiatrist', by which I assume she means an adherent to the school of Laing and others from the 60s. What I am and remain, is a sceptic about the nature and scale of the current diagnoses of attention deficit hyperactivity disorder amongst children, the claims that such diagnoses have a reliable base in genetically based disturbances of neurotransmitter metabolism, and the uses of powerful medication to conrol the condition.

Competing interests: None declared

EDITOR'S CHOICE:
Nice feedback
Godlee (25 August 2007) [Full text]
Nice feedback
Searching a PDF
1 October 2007
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Pawan Randev,
GP
Measham Medical Unit

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Re: Searching a PDF

Dear Editor

"Clinicians don't read guidelines—and who can blame them, faced with hundreds of pages and unsearchable pdfs"

As a clinician I agree that large guidelines are difficult to read and assimilate into daily clinical life. However PDF documents are searchable. If you look at the toolbar there is a binocular icon. Choosing this icon opens a search box to the right of the document. This will search the whole document for phrases and words.

As an example, I searched a 150 page PDF file for "GP", "primary care", "RCGP", "community". The whole process, from opening the document to reading and considering the results took ten minutes.

There is also a way of searching large Word documents. Pressing "CTRL" and F, opens up a search box which will go through the document.

It may be worth reflecting that few professionals seem to have had training in these techniques.

Competing interests: I am setting up an IT skills training organisation

RESEARCH:
Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations
Canani et al. (18 August 2007) [Abstract] [Full text] [PDF]
Probiotics for treatment of acute diarrhoea in children: randomised clinical trial...
Probiotics for treatment of acute diarrhoea in children
6 October 2007
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María G. Joyanes,
Researcher
CNA-AESAN Health Ministry of Spain

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Re: Probiotics for treatment of acute diarrhoea in children

Canani et al. in their excellent work of Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations concluded that the efficacy of probiotic preparations for treating of children with acute diarrhoea is related to bacterial strain (1). I agree with this conclusion that the modulation of gastrointestinal microbiota is basically strain dependent. Other factors also need consideration. Children are aged 3-36 months in each group (n=45). The sample size was chosen in order to improve statistical test power. However, probiotic action depends also on microbiota found in the gastrointestinal tract is related to the age of children, environment and food. The broadly aged groups (involves babies and infants 2-3 y) beyond homogeneity, distribution overlap with the groups. Because of this it could be suggested another closer analysis to the specific age in order to obtain a more precise interpretation.

Canani RB, Cirillo P, Terrin G, Cesarano L, Spagnuolo MI, De Vincenzo A, Albano F, Passariello A, De Marco G, Manguso F, Guarino A Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. BMJ 2007;335:340 (18 August), doi:10.1136/bmj.39272.581736.55 (published 9 August 2007)

Competing interests: None declared

RESEARCH:
Use of intensive case management to reduce time in hospital in people with severe mental illness: systematic review and meta-regression
Burns et al. (18 August 2007) [Abstract] [Full text] [PDF]
Use of intensive case management to reduce time in hospital in people with severe...
Assertive Community Treatment: The South East CMHT, Barnet, Experience
8 October 2007
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Azad A Cadinouche,
Staff Grade Psychiatrist
CMHT South East 6th Floor Premier House Edgware HA8 7BJ,
Latha Weston

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Re: Assertive Community Treatment: The South East CMHT, Barnet, Experience

The Assertive Outreach Team for the London Borough of Barnet was disbanded in October 2006. The proviso was the respective CMHTs would integrate assertive community treatment and offer it as part of their package of service provision.

In our current practice we have an identified list of patients, both ex-AOT and new. These patients fulfil most of the Burns & Firn criteria 4(severe enduring mental illness, poor adherence to medication, poor engagement with services, relapse would have severe consequences, fluctuating social functioning) and also they may have had frequent or lengthy acute hospital care 5. This list is scrutinised once weekly at the Multi Disciplinary Team meeting and patients are added or removed accordingly. There is a follow up twice weekly to monitor their progress or absence of.

Our approach is based on the ‘Recovery/Strengths’ model 2. These patients are more likely to have complex needs with a higher use of domiciliary visits. They are offered a range of tailored interventions (ex. Daily living skills, problem solving skills, cognitive behavioural skills, addressing substance misuse, physical health monitoring, voluntary work, family interventions) 5 to promote social inclusion and rehabilitation.

Our CMHT works collaboratively with the Crisis Resolution Home Treatment Team. This allows the extra community support and intensive monitoring, especially out of hours, in the home environment to limit social disruptions for those patients on the brink of hospitalisation.

Due to resources limitations we cannot offer a ‘fidelity model’ of an Assertive Community Treatment Team 1.In our experience, offering community contacts and individualised care by a trained and motivated staff is an effective way of delivering assertive community treatment 3.

Dr Azad Cadinouche, MD, MRCPsych
Staff Grade Psychiatrist

Dr Latha Weston, MRCPsych
Consultant Psychiatrist

CMHT South East, Premier House, Station Road, Edgware HA8 7BJ

1.Burns T, Catty J, Dash M, Roberts C, Lockwood A, Marshall M. Use of intensive case management to reduce time in hospital in people with severe mental illness: systematic review and meta-regression. BMJ 2007; 335:336-40

2.Killaspy H. Assertive community treatment in psychiatry. BMJ 2007; 335:311-2

3.Killaspy H, Bebbington P, Blizard R, Johnson S, Nolan F, Pilling S, king M. The REACT study: randomised evaluation of assertive community treatment in north London. BMJ 2006; 332: 815-20.

4.Kent A, Burns T. Assertive community treatment in UK practice. Advances in psychiatric treatment 2005; 11:388-97

5.Sainsbury Centre for Mental Health. Assertive Outreach Interventions. www.scmh.org.uk.

Competing interests: None declared

ANALYSIS:
Potential of electronic personal health records
Pagliari et al. (18 August 2007) [Full text] [PDF]
Potential of electronic personal health records
Prespectives on Personal Health Record
6 October 2007
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Rahul Shetty,
Physician
Quebec,Canada,G1P 4R1,
Rahul Shetty

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Re: Prespectives on Personal Health Record

Pagliari, Detmer and Singleton's article on the potential of electronic personal health records (EHRs) is timely but this also raises some fundamental questions.First where are the data stored ? and then who actually controls these data? Patients who create and finally control their health data through personal health records either in online or off line method can restrict the viewing of their records to their own physicians and if they have any malicious data,they can erase it completely.Despite the presence of audit trailing, it is not yet a fool proof method to keep track of all changes to the health data.Moreover,physicians who access these records may be overwhelmed by presence of extensive record of personal health data by some patients.To isolate the good,bad and not useful data may be a tedious task for physicians and health care professionals in future.Next question is where are the data stored,is it in a secure server and if so for how long will the data be stored-life time of a patient or beyond?Can these data be used for research purpose or statistical analysis?

Despite these concerns,personal health record have an useful role to play in health care management.Adopting technologies in health care will significantly reduce the cost and improve the effectiveness of health care delivery.Over prescription of medications,duplication of tests and lack of sharing of medical information among health care service providers has resulted in increased cost of health care in the current era.To improve the effectiveness of economic resources in area of health care, there is a need for fundamental changes in health care industry,although these changes cannot be done dramatically over the period of couple of years,but could be accomplished in the future.

Electronic Personal Health Record may be the first step towards enabling change in health care industry.

Competing interests: Rahul Shetty is co-founder of Mezocore Technologies Inc. which develops a personal health record database MedicDrive.

ANALYSIS:
Preventive health care in elderly people needs rethinking
Mangin et al. (11 August 2007) [Full text] [PDF]
Preventive health care in elderly people needs rethinking
Essential geriatric care
1 October 2007
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Tamilmani A J,
Medical Officer, Indian Inst Of Technology- Madras
Chennai-600036

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Re: Essential geriatric care

Dear Sir,

Congrats to the Author first. I have a different opinion about the need for Preventive Geriatric Care for old age related diseases. Most of the chronic illnesses start in middle age between 30 and 50 because of poor knowledge about HEALTH AND PREVENTIVE CARE. Sedentary lifestyle, Inadequate exercise, Improper food habits, frequent travels, late working hours, excessive physical and mental stress and ignorance atlast are the presumptive factors for the late onset geriatric disabilities like Osteoarthritis , Alzeimers and Dementia... I did not include diabetes, Hypertension , IHD , Bronchial Asthma or Tuberculosis as the geriatric diseases since the onset of the above nowadays maximum in middle age. It's highly mandatory to educate the middle aged population about the life style modifications and preventive aspects of Geriatric Diseases.

Thereby we can extend the lifespan of a human without any deadly diseases in his old age too.

With sincere Regards,
Dr(Sqn Ldr) AJ Tamilmani
Institute Hospital, Indian Institute of Technology - Madras, Chennai-600036

Competing interests: None declared

RESEARCH:
Body mass index cut offs to define thinness in children and adolescents: international survey
Cole et al. (28 July 2007) [Abstract] [Full text] [PDF]
Body mass index cut offs to define thinness in children and adolescents: international...
Re: Thinness,BMI and Body Size
6 October 2007
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Tim J Cole,
Professor of medical statistics
UCL Institute of Child Health, London WC1N 1EH, UK

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Re: Re: Thinness,BMI and Body Size

Dr Connolly suggests that our paper is fundamentally flawed in viewing BMI as a measure of thinness or obesity

Dr Connolly suggests that our paper [1] is fundamentally flawed in viewing body mass index (BMI) as a measure of adiposity. Our earlier related paper [2] made clear that BMI is only a proxy for adiposity, which to be identified accurately requires a direct measure of body fat. However BMI is popular as it is moderately correlated with adiposity and has the benefit of being widely applicable, since weight and height measurements are ubiquitous.

 

Dr Connolly goes on to state that ponderal index (PI) is better than BMI, but it all depends on what is meant by "better". PI like BMI is an index of weight and height, and so lacks information about body composition. Thus both indices are poor proxies for adiposity, be it thin or fat.

 

His dimensional argument supporting PI over BMI (i.e. dividing weight by height3 rather than height2) is valid when applied across species (e.g. from mouse to elephant) where the correlation between weight and height is close to 1. But within the species of homo sapiens the weight-height correlation is only about 0.7, so the best predictor of weight (based on log-log regression) is 3 x 0.7 ~ 2. This imperfect correlation, which is biologically inevitable, attenuates the height power and ensures that BMI rather than PI is uncorrelated with height.[3]

 

In practice the optimal height power to predict weight varies with age in children, due to heterogeneity in the rate of maturation; it increases from 2 near birth to 3 in puberty and back to 2 or less in adults.[4] Thus PI is briefly better than BMI in puberty.

 

But this is not the whole story. Obesity itself is positively related to height (fatter children tend to be taller), so the optimal index should be correlated with height. Through most of childhood BMI is positively correlated with height while PI is negatively correlated. Thus BMI is consistently better than PI.[5]

 

Dr Connolly argues that the gradients of the BMI cut- offs are strikingly attenuated compared to the centiles of normal growth charts. This is also quite wrong as the cut-offs are centiles, averaged across surveys, and are very similar in shape to the centiles of the constituent national BMI charts. His argument involves heat exchange in infancy, but the cut-offs only start at age 2 years, well past infancy.

 

Dr Connolly's final point is that an index incorporating weight, height and waist should be better than one using just weight and height. This is almost certainly true, but not for the reasons he gives. Waist circumference is a fairly direct measure of central fat, and so provides the information on adiposity that weight-height indices like BMI and PI lack.

 

1.         Cole TJ, Flegal KM, Nicholls D, Jackson AA. Body mass index cut-offs to define thinness in children and adolescents: international survey. Brit Med J 2007;335:194-7.

2.         Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity: international survey. Brit Med J 2000;320:1240-3.

3.         Cole TJ. Weight-stature indices to measure underweight, overweight and obesity. In: Himes JH, editor. Anthropometric assessment of nutritional status. New York: Wiley-Liss; 1991. p. 83-111.

4.         Cole TJ. Weight/heightp compared to weight/height2 for assessing adiposity in childhood: influence of age and bone age on p during puberty. Ann Hum Biol 1986;13:433-51.

5.         Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. Inter-relationships among childhood BMI, childhood height, and adult obesity: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2004;28:10-6.

 

 

Competing interests: None declared

FEATURE:
Should we consider a boycott of Israeli academic institutions? No
Baum (21 July 2007) [Full text] [PDF]
Should we consider a boycott of Israeli academic institutions? No
Professor Baum still not answering and handing over to IMA
12 October 2007
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Christopher J Burns-Cox,
consultant physician
Southend Farm,,
Wotton-under-Edge GLOS GL12 7PB

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Re: Professor Baum still not answering and handing over to IMA

Yet again (October 4) the Professor has not responded to the facts in the reports from multiple Human Rights Organisations listed by Derek Summerfield.For an academic deliberately to ignore the evidence is strange indeed and suggests an attempt at denial. There is plenty of evidence of the disgrace of Israelis officially, purposefully and deliberately causing pain and suffering to Palestinian detainees - amongst others. The Israeli government has claimed that detainees are 'under constant medical supervision'.

In 2001 the BMA, a close friend of the IMA, published a handbook 'The Medical Profession and Human Rights'. It was written by its Human Rights steering group chaired by Professor Vivienne Nathanson. It includes a description of prolonged torture of a Palestinian detainee (p64) and states that the Israeli authorities use 'forms of pressure which might constitute torture or cruel and degrading treatment'. (Evidence obtained under torture is legally valid in Israel.) The book (p65) states that 'Israeli doctors examined detainees prior to interrogation to ensure they were fit enough to withstand the 'moderate physicial pressure'.

I can see it is very difficult for a Zionist and for the IMA to accept that the Israeli government and Medical Association is involved in torturing and that denial is one, albeit disgraceful, way of coping but the facts are thoroughly out in the public domain.

Seek ye the truth where it may be found, Professsor Baum, but I am not sure the IMA is its sacred repository!

The IMA in its response is still in denial and veers off the point in an oft repeated fabrication that Palestinian ambulances frequently carry bombs and suicide bombers. In fact the Jewish American Medical Project has recently analysed these stories and found only one instance and the truth of that was debatable. The Jerusalem Post agreed with this report! What is undoubtedly true and carefully documented is the slaughter of Palestinian health workers and attacks on ambulances being shot at and many staff injured and killed.

Appended to the IMA response are two letters. The first is to Officials including the Chief Medical Officer and Chief Military Prosecutor of 'the territories'asking for a meeting and reassurance about the state of health of the Palestinians. This interest might be reassuring but why was the letter sent as recently as July 12 2007? Is this merely belated or sent as a tactic in panic? It is tragic that those Israeli doctors who do chose to practice according to internationally acceptable ethical standards are led by an organisation that betrays them so openly. All the Palestinian health organisations and Physicians for Human Rights Israel have called for the IMA to be boycotted and a group of UK doctors agrees. We have waited too long already. It is in the interests of Israelis, their doctors and of the Palestinians that the IMA be boycotted to help it come to its senses. It would be a surprise, but a wonderful one, if the BMA acted according to its official principles and assisted in this.

Competing interests: None declared

Should we consider a boycott of Israeli academic institutions? No
Professor Baum, as a Doctor: please treat the cause not the symptom
12 October 2007
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Mamdouh EL-Adl,
Consultant Psychiatrist
Princess Marina Hospital, Upton, Northampton NN5 6UH

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Re: Professor Baum, as a Doctor: please treat the cause not the symptom

Editor It seems that Professor Baum did not pay any attention to treating the cause & decided to limit his article to looking for a symptomatic treatment!

1.Israel is a democracy! 2.Israel is multicultural! 3.If you want to boycott, do not use USB! 4.Some Jews established a charity in Gaza to treat Palestinian children. 5.Israeli Doctors treat Palestinian & Israeli patients equally! 6.Boycott will harm peace initiative!

1.Israel is a democracy: Does any democracy have the right to occupy the land of another nation? Of course no. Thus being democratic does not give Israel the right to occupy Palestine. However the elected Israeli Prime Minister has a different view. The Israeli plan:- "I believed, and to this day still believe, in our people’s eternal and historic right to this entire land." Ehud Olmert, Israeli Prime Minister, to the US House of Representatives, June 2006 [1} Does Professor Michael Baum support this view?

2.Israel is multicultural! [2] - Israel is the only country that considers religion as the nationality of its citizens i.e. any Jew is entitled to be an Israeli citizen anytime s/he wants. It is important to know that the numbers of Palestinians in Israel (Muslim & Christians) is in progressive decline due to the aggressive Israeli policies supported by the Israeli military machine.

-Israel was established in 1948 based on the claim that the Jews lived in this land 5000 years ago & have the right to return to it. On the other hand the Palestinians who were driven out of their lands by the Zionist armed groups since 1948 are denied the right to return back to their homes. The Israeli government denies the Palestinians the right to return after 50 years, while the Zionists claim the right to occupy Palestine 5000 years later.

-Yuri Avneri, an Israeli peace activist stated in one of his articles: “When tanks overrun cars, destroy houses, topple electricity poles, open water pipes, leave behind them thousands of homeless people and cause children to drink from puddles in the street, it causes terrible hatred. A Palestinian child, who sees all this with his eyes, becomes the suicide-bomber of tomorrow”[3]. Is this what could be considered by Professor Baum multicultural!

3.Professor Baum stated in his article: “If you want to boycott, do not use USB, .. because it is made in Israel!!” [2]. The right question should be: Is their a reason to boycott? If the boycott is for supporting human rights, should we sacrifice supporting human rights to use the Israeli made USB!! 4.Some Jews established a charity in Gaza to treat Palestinian children! Does this justify the Israeli occupation of Palestine & the violation of basic human rights of the Palestinians? Establishing this charity neither justifies the occupation nor reduces the size of the crimes that have been committed & still continued against the Palestinians since the establishment of the Zionist state.

5. Israeli doctors treat Palestinian & Jewish patients equally [2].

- Is equity in care a basic human right or a privilege offered to Palestinian patients by the kind hearted occupying power? Under the IV Geneva Convention, the occupying power is responsible for the people under its occupation. So the healthcare of all Palestinians living under the Israeli occupation is the responsibility of Israel. Lastly, it should be said: Do not treat the Palestinians when ill if treating them justifies to you occupying their land.

Doctors are taught in the medical school to treat the cause & not to limit their care to treating the symptom. However Professor M Baum in his article did not condemn the Israeli occupation of Palestine & its disastrous impact on the life of all Palestinians. Instead Professor Baum was only minded with highlighting the help offered by Israeli doctors to relief some of the Palestinian misery. Michael Baum should have bravely stated that the route cause of the problem is Occupation & should have called for the end of this occupation. However he has chosen not to treat the cause, Why?!.

I wonder: Would Professor Baum pass a medical student in the exam if this medical student focused only on the symptomatic treatment.

6.Boycott will harm peace initiative! Where is peace? Can we have Peace without Justice?!!!!! Dani Filc, chairperson PHR Israel PHR Israel stated: When extreme poverty results from the deliberate destruction of the economic infrastructure, we would expect them to make their stand clear as to the dire results on Palestinians’ health and demand the end of this policy. When faced with a humanitarian crisis, we would expect them to lead a struggle for changing the policy that causes it, at least regarding the health issues [4].

Dr M EL-Adl Consultant Psychiatrist

References

1. Halpin D, Educate How? www.bmj/rapidresponse, accessed on 10.08.07 2. Baum M, Should we consider a boycott of Israeli academic institutions? No. BMJ 2007;335(7611):125 (21 July), doi:10.1136/bmj.39266.509016.AD 3. Avneri Y, wais.stanford.edu/Israel/israel_viewofyury42002.html - 5k, accessed on 10.08.07 4. Dani Filc, Do we take ethics seriously? www.bmj/rapid response, 11.05.07/accessed on 10.08.07

Competing interests: None declared

Should we consider a boycott of Israeli academic institutions? No
The threatened academic boycott of Israel and the accusation that the Israel Medical association (IMA) is complicit in the torture of prisoners.
4 October 2007
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Michael Baum,
Professor of Surgery
University College LondonLondon W1N 6AH

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Re: The threatened academic boycott of Israel and the accusation that the Israel Medical association (IMA) is complicit in the torture of prisoners.

One of the ugliest consequences of the debate on the threatened academic boycott of Israel was to provide another opportunity for Dr Derek Summerfield to repeat his libel that the IMA is complicit in the torture of Palestinian detainees. My initial response and that of the IMA were insufficient to convince a number of your readers and the latest posting (14th September) from a Doctor Brian Robinson stated; “Prof Baum has still not provided independent evidence to justify his exoneration of the Israeli Med Assoc: does it exist?” In addition I have received several hate filled e mails implying that our silence could be interpreted as guilt.

It is of course easy to make accusations but it takes time to collect the evidence to refute these allegations. I alerted the editor of the BMJ that I was working with the IMA to produce a once and for all statement that the IMA is not an arm of the Israeli government or the Israel Defence Force (IDF) and is not complicit in the torture of prisoners. I’m now happy to post it on their behalf. It has to be remembered that it is impossible to prove a negative. For example no one could prove that British doctors, members of the BMA, have never been involved in the torture of IRA prisoners during the Irish troubles or in the present war against the Taliban in Afghanistan.

I have reasonable hope that the open minded and uncommitted of the readership will accept that the IMA is not involved in torture and takes its responsibility for the health and welfare of both Palestinian and Israeli Arabs very seriously. In the end peace can only emerge from the tentative journey from hate and fear, to mutual respect, trust and eventually to reconciliation.

Yours Sincerely,
Michael Baum

Response from the Israel Medical Association (IMA) to Derek Summerfield in the British Medical Journal (BMJ)

We have been asked to refute the allegations and so-called “evidence” produced by Derek Summerfield in his never-ending campaign against Israel. Unfortunately, it is next to impossible to refute baseless allegations.

The burden of proof should be on Summerfield to prove that his “facts” are true, and not on Prof Baum or the IMA to prove that they are not. I am curious to know what evidence Summerfield himself would provide to prove he is not involved in torture if we had accused him of being so.

Nonetheless, as our silence is erroneously interpreted as admission, we will address some of the points raised by Summerfield in his most recent letter to the BMJ (Response and challenge to Professor Baum: what counts as evidence? BMJ 335 (7611) 125).

The first source Summerfield brings is a quote by Amnesty International that Israeli doctors working with the security services “form part of a system in which detainees are tortured, ill-treated and humiliated in ways that place prison medical practice in conflict with medical ethics.” This statement is a blanket allegation without any proof attached. How can one hope to refute such allegations? One can show Dr Summerfield thousands of Israeli doctors whose ethical standards are above impeachment and who are no in no way involved in anything that can be construed as torture. Yet neither he, nor anyone else, has, despite repeated entreaties on our part to do so, provided us with the name of one doctor involved in torture in order that we might properly investigate the allegations.

Summerfield states that Physicians for Human Rights-Israel (PHRI) reported in 2003 that since 1992 they had been attempting to get the IMA to join their opposition to torture, but in vain. I can state with certainty that the IMA has always opposed torture, and, in addition, in the last several years, we have worked hand in hand with PHRI on various issues. In a recent three month period, ten letters went out to various officials and bodies in the army, government etc. after we received potentially problematic information from PHRI. Summerfield further claims that “Amnesty told me in the 1990s that they too had made various approaches to the IMA on this account and had always been rebuffed.” Unfortunately, no one at the IMA has any idea to what approaches he or they are referring.

Summerfield slams Prof. Baum for using the statements of Dr Blachar as evidence against his claim that the IMA is complicit in the ill- treatment of prisoners. And yet he cavalierly asserts that “Torture continues to state policy in Israel” by relying on a Btselem report (an organization that can not be called neutral in their allegiances) that cites testimonies of 73 Palestinian detainees to “confirm that almost all Palestinian detainees suffer physical and mental abuse amounting to torture.”

Summerfield continues to make unequivocal and uncorroborated statements such as “Palestinian health professionals are regularly shot dead or wounded on duty.” He also notes that health workers in ambulances are questioned and searched, people are detained at checkpoints and the security barrier has negatively affected coherence in the primary health system, statements which are likely true. Unfortunately, we are well aware of the difficult living conditions in which the Palestinian population finds itself. As long as terrorists continue to infiltrate from the Palestinian territories, the roadblocks are regrettably a security necessity. Further, ambulances and ill patients have abused the system in attempts to commit terrorist attacks, such as the 2005 case of Wafa al-Bas who took advantage of a humanitarian medical clearance granted to her by Israel to attempt a suicide bombing at Israel’s Soroka Hospital, the very hospital in which she was hospitalized for over a month early this year while doctors worked tirelessly to save her life, after she was severely burned in an accident at home.

In addition, ambulances have been used on more than occasion to transport terrorist or explosives. For instance, on March 26 2002, Ahmed Jibril, a Tanzim operative and ambulance driver for the Palestinian Red Crescent (PRC) was arrested while driving an ambulance belonging to the PRC in which were found an explosives belt and explosives under the stretcher on which lay a sick Palestinian child. Nidal Abd al Fatah Abdallah Nidal, an ambulance driver from Qalqilya employed by UNWRA, admitted to using the ambulance to transport weapons and explosives for Hammas. And Waffa Idris, a PRC employee, perpetrated the suicide bombing on Jaffa Street in Jerusalem in January 2002. She was dispatched by a PRC ambulance driver who is also a Tanzim operative, and she was assisted by another PRC employee. It is also believed she may have traveled in a PRC vehicle, and used PRC documents to go through IDF checkpoints. Unfortunately, these are not isolated incidents.

Summerfield notes that “PHRI accused the IMA of basically being an arm of the political establishment.” However, neither he nor PHRI has provided any reason or evidence to support such an absurd claim.

Unfortunately, I can not address, nor do I want to, all the usual rants made by Derek Summerfield, and his reliance on such known “politically neutral” bodies and figures such as Amnesty International, Btselem, Edward Said and Noam Chomsky to support his positions. Summerfield also takes issue with the fact that the WMA and the BMA have repeatedly refused to condemn the IMA and oppose an academic boycott against Israel. Does he feel that they, too, are an arm of the Israeli political establishment or perhaps there are unbiased, rational people who see things differently from him?

Although, we do not feel the need to defend ourselves against the likes of Dr Summerfield, we will nonetheless cite a few examples of actions taken by the IMA and Israeli doctors in an effort to alleviate the difficult situation of Palestinian civilians:

1. 2,346 Palestinian children with birth defects were treated last year in Israeli hospitals (up from 1,604 in 2005), 29, 919 Palestinian patients were granted permits to undergo medical treatments in hospitals in Israel (up from 24,076 in 2005), and 1,600 Palestinian emergency patients were transferred by ambulance from the PA to hospitals in Israel (up from 800 in 2005).
2. IMA has intervened in cases where a Palestinian patient was to be evicted from an Israeli hospital due to lack of funds. For example, in one instance a patient was to be evicted from a Tel Aviv hospital because no money was forthcoming from the PA; IMA chair of ethics convinced the hospital to waive the charges if money was not received from the PA.
3. IMA has intervened, including petitions to the High Court of Justice, in situations where Palestinian patients, physicians or medical students encountered difficulties at Israeli checkpoints. Two examples: Joint IMA -PHR petition to HCJ regarding patients in need of life saving treatment (a settlement was reached in this case) and another regarding an entry permit for an AIDS patient (in this case, the petition was dismissed when the court found that there was a legitimate security interest in disallowing his entry).
4. The IMA has called for funds to be transferred to the PA in the form of food and medicine so that help could be given where it is truly needed, including a letter to the Minister of Health to see what the government is doing to prevent a shortage of medicine and medical supplies to the Palestinian territories.
5. The IMA has, at several points in the past, attempted to meet with its Palestinian counterparts in an effort to foster mutual cooperation and better understanding, including the release of a joint statement. Almost none of these meetings have taken place, because of refusal on the Palestinian side.
6. IMA has issued ethical statements regarding imprisonment in hospitals and has intervened where necessary.
7. IMA attempted to assist Al-Quds University in East Jerusalem gain recognition by the Council for Higher Education.
8. IMA issued a recent appeal to Israel Railways Authority regarding the unnecessary detention/discrimination by railway authorities of two Arab physicians.
9. IMA established a hotline for Arab physicians wishing to complain of discrimination at airport and action taken on their behalf.

Although we are an apolitical organization, we certainly do speak out on behalf of the assurance of proper health services for the Palestinian population. I attach a sample letter (Appendix A) in this regard. Regarding Gaza in particular, I would remind you that Israel withdrew from the Gaza strip two years ago, in accordance with Palestinian wishes and at great economic and emotional expense to its own population, many of whom find themselves without jobs, homes or stability to this day. It is therefore incumbent upon the Palestinian leadership to ensure the health care services of its population there. Nonetheless, in cases where necessary health care was unavailable in either Gaza or the West Bank, Israel has frequently taken it upon itself to provide these services, often at its own expense.

Regarding the issue of torture: we will once again-hopefully for the final time- unequivocally state that we completely oppose the involvement of physicians in anything that can be construed as torture. The IMA has taken a public stand against torture in various forums, in letters to the BMJ and as a signatory to the Tokyo Declaration. I attach a sample letter (Appendix B) we have recently written on this matter to Mr. Yuval Diskin, head of the Israel Security Agency (ISA). We also recently addressed this issue in the Knesset (Israeli Parliament) where we stated our position that doctors employed by the ISA or security services and involved in the questioning of Palestinian detainees or prisoners are absolutely forbidden to take part or assist in any way in questioning that is accompanied by torture. (July 3, 2007). Finally, we have been working for the last several months to incorporate a translation (done by PHRI) of the Norwegian Medical Association/World Medical Association course on “Doctors working in prisons: human rights and ethical dilemmas”; this course was recently made available to Israeli doctors.

Summerfield interprets the silence of Baum and the IMA as an admission of guilt. In actuality, it derives not from guilt but from an intense weariness of having to respond time and time again to baseless attacks from someone with a very clear agenda. Summerfield expects self-flagellation on our parts for wanting to live in peace, to protect our children from attack, for trying to balance security needs with the very real and pressing need to assure proper health services for all, Israeli and Palestinian. But for that we can not, and will not, apologize.

Malke Borow, JD
Manager, Division of Law and Policy
Israel Medical Association

Appendix A

July 12, 2006

To: Maj.-Gen. Joseph Mishlav, Coordinator of activities in the Territories
Brig.-Gen. Yechezkel Levi, Chief Medical Officer
Brig.-Gen. Avichai Mandelbeit, Chief Military Prosecutor

Re: Invitation to a meeting regarding the health status in the territories-promoting cooperation between the IMA and relevant bodies

The IMA has been repeatedly approached by both local and foreign organizations regarding the status of the civilian population in the West Bank and Gaza.

It goes without saying that we do not address political or security issues; nonetheless, we are sure that you share our belief that we must do everything in our power to preserve an acceptable level of health even during armed conflict and to concern ourselves with the essential humanitarian needs of the civilian population.

The IMA is interested in trying to advance fruitful cooperation with you, in order to improve the channels of communication and activity between us, to understand the scope of inquiries you receive and to see how the IMA can take part in medical and humanitarian aid to the civilian population during this difficult period.

Therefore, we would kindly request a joint meeting.

We will be in touch within the next few days in order to schedule such a meeting and hope you will positively answer our request.

Sincerely,

Dr. Yoram Blachar
President
Israeli Medical Association

(Translated from the Hebrew)

Appendix B

July 12, þ2007

To:
Mr. Yuval Diskin
Head of the Israel Security Agency

Re: Reports of B’tselem and the Center for the Protection of the Individual on the matter of torture and abuse of Palestinian detainees- implications for medical personnel working in interrogation centers

We would appreciate your response to the enclosed letter, which was forwarded to us yesterday.

It appears from the letter that the report in question allegedly raises suspicion that the ISA still uses physical and emotional measures that can be defined as torture.

We would note that the position of the IMA on this matter remains as it always was, namely that it is absolutely forbidden for doctors employed by the ISA or security services and involved in the questioning of Palestinian detainees or prisoners are absolutely forbidden to take part or assist in any way in questioning that is accompanied by torture.

We, too, would like to receive answers to the questions posed in the letter of Physicians for Human Rights, and would appreciate a response at your earliest convenience.

Sincerely,

Dr. Yoram Blachar
President
Israeli Medical Association

(Translated from the Hebrew)

Competing interests: I wrote the opposing piece in the debate

FEATURE:
Should we consider a boycott of Israeli academic institutions? Yes
Hickey (21 July 2007) [Full text] [PDF]
Should we consider a boycott of Israeli academic institutions? Yes
Go and see the truth for yourself. I did.
7 October 2007
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Asad Khan,
Specialist Registrar, Respiratory Medicine
Wythenshawe Hospital, Manchester, M23 9LT

Send response to journal:
Re: Go and see the truth for yourself. I did.

I have been following the debate in these columns with a mixture of interest and incredulity. I wonder how many of those who accuse Tom Hickey and Derek Summerfield of 'anti-Israel bias' and 'anti-Semitism' have actually visited the West Bank or Gaza to see the facts for themselves. I had the good fortune to visit Israel and the West Bank for two weeks in August. What I saw there changed my life forever.

We spent a lot of time at checkpoints in the West Bank. Unfortunately, the word 'checkpoint' sounds so benign that it hardly conveys the horror of the place. Have you seen a cattle shed crammed full of animals? With only one gate to get out, guarded by a farmer with a stick? Well, just replace him with an Israeli soldier with a rifle- and the animals with Palestinians- and you're not far. At Huwwara checkpoint near Nablus, we saw a queue extending for half a kilometre out of the cramped shed and into the merciless sun. One by one, the Palestinians were called forward and their documents inspected. Some got through, others were turned back. Depending on the mood of the soldier. The explanation given for the checkpoints- 'security'- is a lie, as the barriers mostly stand between Palestinian cities and towns, not between Palestine and Israel.

Israel, through its system of 700 checkpoints, roadblocks and earth mounds in the West Bank strangles the Palestinians' freedom of movement. 68 women have been forced to give birth at checkpoints since the year 2000 (www.ifamericansknew.org). Half of the babies involved have died, as have 4 of the women. Many of the babies born have suffered irreversible brain damage. Imagine being the helpless husband or son of a woman forced to endure the pain of labour on the baking earth at a checkpoint- with an armed soldier looking on- and you will begin to understand how suicide bombers are born.

18000 houses have been demolished by Israel since 1967, often over the heads of their inhabitants (Israeli Committee Against House Demolitions- www.icahd.org). The reason given again? The big lie- security. The truth is that even if a Palestinian owns a piece of land, to build or extend an existing dwelling on it, he must put in an application costing $20000. This is almost uniformly rejected, and as his family grows, he is forced to build illegally. Then in come the bulldozers. The Palestinian then has to clear the rubble themselves and pay the Israeli government for the cost of demolishing his house.

There have been several references in these columns to the attempted terrorist attacks by Muslim doctors in Britain. Such people would do well to remember that the first 'doctor terrorist' was Jewish- Baruch Goldstein, who gunned down 29 Palestinians at prayer in the city of Hebron in 1994, injuring 150 others. A shrine to Goldstein has been erected in the fanatical settlement of Kiryat Arba- a plaque there reads: "To the holy Baruch Goldstein, who gave his life for the Jewish people, the Torah and the nation of Israel". It has become a pilgrimage site for those with extreme right-wing views.

In the old city of Hebron, 400 fanatical settlers- protected by Israeli Defence Force soldiers- hold 30000 Palestinians to ransom. They stone and kick the inhabitants, while the Israeli army forbids Palestinians to drive- in some areas, even to walk- on the streets. I saw for myself the concrete blocks, rubbish and human excrement thrown down onto passing Palestinians by the illegal settlers occupying the flats above Arab shops. The racist graffiti is shocking:

- 'Arabs to the gas chambers!' - 'Watch out Fatima, we will rape all Arabs!' - 'Mohammed is a pig'. Below this is a drawing of a pig reading the Quran. - 'If you Arabs had just used a f***ing condom, then none of this would have happened!'

(If anybody finds this unbelievable, give me your email address and I shall be all too happy to send you photographic evidence.)

Walking through old Hebron, you pass row upon row of abandoned shops with their doors welded together and spray-painted with the Star of David. The resonance of the Warsaw ghetto is chilling.

As for the stance that Israel is the 'only democracy in the Middle East' and 'treats all its citizens equally', I invite you to visit the Negev desert in Israel. The Israeli organization Physicians for Human Rights (www.phr.org.il) told us of the plight of Bedouins there. There are 60 villages which have existed before 1948, the existence of which Israel does not recognize. As a result they have no healthcare, electricity or clean water. Their infant mortality rate is 7 times the Israeli average- in the 4th richest country in the world, with possibly the best healthcare system anywhere.

Those who grieve at the potential loss of academic freedom that a boycott of Israel may cause would do well to learn about the violation of Palestinian academic freedom. We visited Birzeit University just outside Ramallah. There we were told by Yasser Darwish, the Public Relations officer for the institution, how during the Second Intifada the Israelis constructed a checkpoint between Ramallah city and Birzeit. This checkpoint was nothing but a series of earth mounds, piles of rubble and huge rocks stretching for a mile and a half- with the sole purpose of obstructing the passage of people. This was not all- people trying to reach the University by walking around the obstacles were often greeted with beatings, rubber bullets and teargas. Sometimes students and teachers would be allowed to go to Birzeit in the morning but the checkpoint would be completely closed in the afternoon when it was time to go home. 5000 students and teachers would then have to take a circuitous route over hills and through valleys to get home- this would take upto 2 hours.

Students- including females- were subjected to humiliating body searches. Soldiers stormed the women's dormitories on several occasions, breaking windows, doors and furniture. Electricity, water and telephone lines in Birzeit and Ramallah were cut off, isolating people from the outside world.

Healthcare is not a 'basic human right' in Palestine. It is incredible that some people have been highlighting the graciousness of Israel in agreeing to treat wounded and ill Palestinians. Under the Geneva conventions, an occupying power has responsibility for the health of the people it occupies.

In Nablus, we visited Rafidia Hospital, the main general hospital. We were met by Dr Sadaqah, the Deputy Director. He told us that each time the Israelis invade Nablus, the first thing they do is to encircle the hospital, preventing the passage of staff and patients and resulting in unnecessary deaths. Sometimes patients need to be transferred to hospitals in Jerusalem or Israel- however the Israeli authorities create hurdles at every opportunity. Often by the time permission is obtained (a minimum of 2 days even for an emergency), the patient dies- this happened to a burns patient two days before our visit.

At the height of the 2002-2003 invasions and curfews, Rafidia received 8-9 cases of serious injuries every day. Staff ended up living in the hospital for 23 days. The Israeli army prevented casualties from the Old City from going to Rafidia- a clinic was set up in a mosque in the Old City to deal with them. Dr Sadaqah told us that this clinic had to perform two emergency amputations without anaesthesia. The Israelis would also prevent bodies from being taken for burial- as a result the hospital morgue overflowed and ice-cream trucks had to be used to store the bodies.

He also told us that the Israelis would regularly enter the hospital, and actually removed 4 patients from their beds. One of these was actually an intensive care patient who had just returned from major surgery. When the doctors and nurses asked for reasons, they were simply pushed aside. We were horrified to learn that when the soldiers removed patients from the hospital, they were accompanied by Israeli doctors who never tried to stop this happening. The soldiers would often remove patients from ambulances while they 'checked' them.

Do you hear the Israeli Medical Association protesting against these gross violations of human rights by Israel?

I had the good fortune to interview two students from Al Quds University Medical School in Jerusalem. To understand the unique situation that al-Quds students- and indeed all Palestinian Jerusalemites- face, it is important to revisit 1967 when Israel occupied the West Bank and Gaza, and illegally annexed East Jerusalem. Israel declared Jerusalem to be 'the unified capital of Israel'; a position not recognized by the international community, including the United States.

The Palestinian residents of Jerusalem were offered Israeli citizenship- however this entailed pledging allegiance to Israel. Unsurprisingly, most of them declined. They were therefore declared 'residents' without citizenship, and are obliged to carry blue Jerusalem ID cards. The space next to 'Nationality' on these cards is blank. The residents of the West Bank, in contrast, carry green ID cards.

Blue ID holders cannot travel to the West Bank, and those with green ID cannot enter Jerusalem. This situation has divided families- including married couples. If a Jerusalem resident marries a West Bank Palestinian, it is forbidden for them to live together either in the West Bank or Jerusalem. As a result, many couples live illegally, in constant fear that one of them will be discovered and expelled. The only precedent to this obscene situation is that of South Africa under apartheid.

The students explained that the campus of the medical school is located in the Jerusalem suburb of Abu Dis. The main teaching hospital- Maqassed- is in the city proper. You used to be unable to tell where Abu Dis ended and Jerusalem started. Not any more. Israel's Separation Wall has separated the two and for all practical purposes, Abu Dis is now in the West Bank.

One of the students told us that of the 40 students in his year, 5 have blue ID and the rest green. You can imagine the consequences. To go to Maqassed for their training, students with green ID need a special permit- which is very difficult to obtain. Even those who manage to get one can never be sure they will make it to the hospital as they are frequently turned away at the checkpoint for no reason. Therefore most green ID students are forced to travel to West Bank hospitals for their clinics- across more checkpoints.

The converse situation is that blue ID students may be able to attend clinics but are often stopped from going to lectures in Abu Dis. And this is no straightforward trip- a journey that should take no more than ten minutes can last an hour and a half due to checkpoints and the circuitous route the students have to take.

When they do manage to qualify, al-Quds doctors are prohibited from working in hospitals in Jerusalem and Israel as their qualification is not recognized by Israel. The West Bank hospitals are only an option for those with green ID. This situation forces many to go abroad.

As for those who claim that Israel, with its violations of human rights, is 'merely defending itself', I would like to bring to your attention the following statistic from the BBC: In 2006, 660 Palestinians were killed by Israeli 'security' forces. These included 141 children. The total number of Israelis killed by Palestinians in 2006? 23. Follow the link below for the story:

http://news.bbc.co.uk/1/hi/world/middle_east/6215769.stm

Now that I am back in the UK- and have opened my mouth in these columns- I know I shall be accused of being anti-Semitic. This is intellectually bankrupt nonsense. I have many Jewish friends in Britain, and now in Israel as well. They are disgusted at what Israel is doing, and are fighting a brave and often dangerous battle, sometimes at the expense of being ostracized by family and friends. The leading critics of Israeli policy- Noam Chomsky, Amira Hass, Ilan Pappe, Norman Finkelstein, the late Tanya Reinhart- are all Jewish.

This is not a centuries-old Jews versus Muslims conflict. (Also remember- 12% of Palestinians are Christians, and this number includes leading figures like Hanan Ashrawi and the late Edward Said.) It is a matter of basic human rights. If one is criticizing house demolitions, checkpoints, extrajudicial executions etc, and one is accused of being anti-Semitic, then the accuser is bizarre indeed. In order for these criticisms to be anti-Semitic, the accuser has to accept those violations of international law as inherent characteristics of Judaism. So who is being anti-Semitic here?

Another question I am likely to be asked is, 'There are so many conflicts in the world today- why are you so obsessed with Palestine?' In case you hadn't guessed by now, justice for Palestine is the key to peace in the Middle East. It is a festering sore in the flesh of every Arab; the longer it goes on, the more resentful of the West they become.

Yes, there are many terrible conflicts like Darfur, Somalia, the Congo, Chechnya and Kashmir. But these are relatively recent, while the oppression of the Palestinians has been going on for 60 years. It is the longest ongoing occupation in the world today- and the only one apart from Iraq. And the only one where the oppressor is being financed and armed to the teeth by the 'civilized' world.

You may wonder what all this has got to do with the debate over a boycott. Well, despite individual dissenting voices, it is clear that Israeli academia and the Israeli Medical Association have failed to come out as a body and condemn the occupation. This is despite repeated calls by Palestinian, Israeli and international human rights organizations. By their silence, they are complicit in human rights abuses- I have no choice but to campaign for a boycott.

The 'exchange of ideas' has led nowhere- despite years of talks at governmental level, a just peace for the Palestinians remains a distant dream. It is time for people in other countries to adopt measures to stigmatize Israel, something which their governments refuse to do. There is a precedent- South Africa. Given the fact that many prominent South Africans- including Nelson Mandela, Ronnie Kasrils and Desmond Tutu- have publicly said that Israel's oppression of the Palestinians is far worse than South Africa under apartheid- why the hesitation to enforce a boycott?

As for those who sympathize with the Palestinians but are against boycotts, I have a simple question- in that case, what are they going to do for the Palestinians- whom the world has boycotted and abandoned for so long? If the academic freedom of Israelis is sacred, should that not apply to Palestinians as well?

For a full account of my trip, please visit

http://chestdocinpalestine.blogspot.com

Competing interests: I am a Muslim who refuses to be labelled an anti-Semite simply for criticizing the oppressive policies of the Israeli state.

EDITORIALS:
Depression in adolescents
Hazell (21 July 2007) [Full text] [PDF]
Depression in adolescents
Invega advertising
1 October 2007
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Selwyn Learner,
Creative Director
Ogilvy Healthworld Advertising, 121-141 Westbourne Terrace london W2 6JR

Send response to journal:
Re: Invega advertising

I would like to respond to Dr M Siddiq's concerns about Invega advertising. Firstly I agree that gratuitous use of imagery liable to offend is unnecessary. But Invega is an antipsychotic licensed to treat schizophrenia, a condition which in many ways, both clinical and metaphorical, traps people within their former selves. The imagery is associated with wording and the whole communicates that within the person you see with schizophrenia is the normal human being aspiring to be free of this terrible disease.

So at the very least I can say that clinical relevance was the intention - though it was also the intention to be elegant, beautiful, visually arresting and intellectually innovative. Research with Drs of all races and creeds did not provoke a negative response, and this form was preferred to a male one. Dr Siddiq's reference to humour in the advertisement suggests perhaps he has not read it or viewed it properly. Perhaps that is understandable if it offends.

I wish to acknowledge that Dr M Siddiq has the right to dislike and complain. But that with the same right comes mine and my client's right to use this sort of imagery. For we have contravened no moral code, nor ethical code, nor boundary of good taste as currently in vogue in this country.

Indeed in reference to Dr Siddiq's comment that "pharmaceutical companies present or advertise...in a dignified, civilised way" I would suggest that this advertisement is probably one of the most dignified and civilised he or his colleagues will have ever seen.

I share Dr Siddiq's concerns over the moral decline, but I refute that this advertisement is in any way part of that. And I refute that Dr Siddiq's view is one held by anything other than a miniscule portion of Britain's multicultural (perhaps we should say 'monoculture of diverse influences'?) and multi- religious society. In our present society the decline of tolerance seems more rapid than the decline of morality or the Judeo-Christian ethic that is the backbone of our British society.

Competing interests: I created the Invega ad

RESEARCH:
Implementing the NHS information technology programme: qualitative study of progress in acute trusts
Hendy et al. (30 June 2007) [Abstract] [Full text] [PDF]
Implementing the NHS information technology programme: qualitative study of progress...
Unexpected benefit of Choose and Book
11 October 2007
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Paul E Shannon,
locum consultant anaesthetist
Doncaster Royal Infirmary, DN2 5LT

Send response to journal:
Re: Unexpected benefit of Choose and Book

As an ex-National Clinical Lead for Choose and Book, I am well aware of the benefits that the system provides for clinicians. One unanticipated benefit is the avoidance of using Royal Mail during strike action! Outpatient appointments and referral letters are made electronically and so are not subject to the vagaries of the postal system. Let's hope that this strike action will encourage colleagues to look afresh at Choose and Book.

Similarly, letters to the editor of the BMJ are unaffected when utilising Rapid Responses. However, who knows if readers will see this before the strike ends?

Competing interests: None declared

CLINICAL REVIEW:
Diagnosis and treatment of sciatica
Koes et al. (23 June 2007) [Full text] [PDF]
Diagnosis and treatment of sciatica
Treatment of Sciatica
8 October 2007
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Charles S Galasko,
Emeritus Professor Orthopaedic Surgery
Retired

Send response to journal:
Re: Treatment of Sciatica

Re: Koes et al. Diagnosis and treatment of sciatica, 23 June 2007 .

The advice given in this clinical review is dangerous. If cauda equina syndrome is suspected or the patient suffers acute severe paresis or progressive paresis the patient must be sent to hospital and preferably a spinal unit immediately. All the evidence suggests that decompression of an impending or developing cauda equina syndrome gives the patient the optimum chance of recovery of bladder function, bowel function, muscle weakness etc. whereas a delay, even of hours, can substantially effect the outcome resulting in permanent bladder dysfunction, bowel dysfunction, impotency in males, loss of vaginal sensation in females, other sensory disturbances and muscle weakness.

Yours faithfully

Professor Charles S B Galasko

Competing interests: None declared

ANALYSIS:
Selection for specialist training: what can we learn from other countries?
Jefferis (23 June 2007) [Full text] [PDF]
Selection for specialist training: what can we learn from other countries?
Selection for specialist Training- A fair approach
1 October 2007
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Vaibhav Tyagi,
Physician Trainee
John Hunter hospital lookout Rd New lambton 2305 NSW Australia,
Deepti Tyagi

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Re: Selection for specialist Training- A fair approach

It has been a long time since subjective evaluation and non objective parameters were followed in selection process of specialist training all over the World. I believe the need of the hour is now to adopt a fair transparent system where nationality,domestic or overseas status would not affect the selection criteria. Instead of relying too heavily on referee reports as is usual in many countries, it would be appropriate to have a MCQ examination with or without a clinical examination in different specialities. The exam would be an objective way to assess a candidate in all aspects rather than a CV , referee reports,or mere 10 minute interview.

I believe this would be an objective approach and would translate lip service about fair and transparent selection into action.

Competing interests: International medical graduate -Basic Physician Trainee in Australia

EDITORIALS:
Diabetic ketoacidosis
Dhatariya (23 June 2007) [Full text] [PDF]
Diabetic ketoacidosis
Would Normal Saline be licensed today?
11 October 2007
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Nicholas Levy,
Consultant in Anaesthesia and Critical Care
West Suffolk Hospital, IP33 2QZ,
Dr Stuart Lowe

Send response to journal:
Re: Would Normal Saline be licensed today?

Dear Sir

We read with interest the recent editorial by Dhaetariya(1). In his editorial, the use of Hartmann’s solution is bought into question and most of the physiological arguments are eloquently rebuked in the ensuring rapid response correspondence.

One of his most contentious comments is that there is unlikely to be a randomised study between normal saline and Hartmann’s solution due to the potential dangers of Hartmann’s solution. This comment is highly provocative as it suggests that those professionals who treat their diabetic patients with Hartmann’s solution are essentially being negligent, and as the ensuring correspondence shows there are a number of intensivists who choose to use Hartmann’s as part of the fluid regime to resuscitate patients with diabetic ketoacidosis (DKA).

Dr Dhaetariya questions the validity of use of Hartmann’s solution, which whilst we agree is not the perfect solution, we do believe is superior to normal saline, and we would like to question whether normal saline would ever be licensed now, if it was to be developed in the 21st century.

The pre-clinical studies would show that it does not maintain electrical or mechanical activity of isolated muscle preparations (2,3). In fact in 1901 in his seminal paper Harvey Cushing called saline ‘poisonous ’(2).

The phase 1 studies would show when normal saline is administered to healthy volunteers they subjectively complain of bloatedness, confusion, stomach cramps and essentially feel unwell. Objectively they develop a severe hyperchloraemic acidosis and retain the excess saline and fluid for a longer period than when compared to Hartmann’s solution.(4,5)

The Phase 2 studies, and there have been 3 randomised controlled studies comparing the administration of normal saline and balanced solution in high risk patients , again would not support the continued development of normal saline (6,7,8). In fact, 2 of the 3 studies were prematurely halted due to the excess morbidity in what was subsequently discovered to be the normal saline cohort.(6,8)

In summary, we reject the concept that it is potentially dangerous to administer Hartmann’s in preference to normal saline in patients with DKA, and we would welcome a study to find the solution to this contentious area (Pun intended).

1. Dhatariya KK. Diabetic Ketoacidosis. BMJ 2007; 334: 1284-5.

2. Cushing H. Concerning the poisonous effect of pure sodium chloride solutions upon the nerve-muscle preparation. Am J Physiol.1901; 6: 77-90

3. Howell W. An analysis of the sodium, potassium, and calcium salts of the blood on the automatic contractions of heart muscle. Am J Physiol.1901; 6: 181-206

4. Williams EL,et al. The effect of intravenous lactated Ringer’s solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers. Anesth Analg 1999;88:999–1003.

5. Reid F, Lobo DN, et al. (Ab)normal saline and physiological Hartmann’s solution: a randomized double-blind crossover study. Clin Sci (Lond) 2003;104:17–24.

6. O’Malley et al. A randomized, double-blind comparison of lactated Ringer's solution and 0.9% NaCl during renal transplantation. Anesth Analg 2005; 100: 1518-24. 7. Waters JH, et al. Normal saline versus lactated Ringer's solution for intraoperative fluid management in patients undergoing abdominal aortic aneurysm repair: an outcome study. Anesth Analg 2001; 93: 817-22.

8. Wilkes NJ, et al. The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 2001;93:811–6.

Competing interests: None declared

RESEARCH:
Interventions to promote walking: systematic review
Ogilvie et al. (9 June 2007) [Abstract] [Full text] [PDF]
Interventions to promote walking: systematic review
Inactivity in Secondary Care Doctors
10 October 2007
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Amy L Chue,
Foundation Year Two
Sandwell Hospital, West Bromwich,
Kiran C. Patel, Rajai A. Ahmad, Patrick J. Cadigan, Derek L. Connolly, Russell C. Davis

Send response to journal:
Re: Inactivity in Secondary Care Doctors

The interventions suggested by Ogilvie et al to increase the amount of walking by individuals can, and perhaps should, be applied to secondary care doctors.(1)

The epidemic of obesity driven by inactivity is accentuated by obstacles in the workplace such as calorie-saving lifts and escalators. Hospitals are not exempt from such temptations and doctors as a profession face challenges to maintain adequate levels of physical activity. Physical activity is essential for long-term weight control and avoiding the phenomenon of ‘middle-aged spread.’(2) Even the suggested daily thirty minutes of moderate physical activity recommended may be inadequate to control body weight in some cases. Thirty minutes of moderate physical activity uses approximately two-hundred kilocalories and equates to approximately 3000-4000 steps.(3)

We assessed whether all members of a hospital Cardiology team experienced similar levels of physical activity in the workplace, or whether seniority, which brings with it higher levels of sedentary sessions, predisposes to physical inactivity. Pedometers of the same brand and type were given to each member of the Cardiology team, comprising the House Officer, Senior House Officer, Clinical Fellow, Specialist Registrar and Consultant, in a Teaching Hospital, to be worn during the working day, for five days. In order of seniority, the most junior team member (39354 steps) amassed the greatest number of steps each day, and over the five day period was found to walk more than the senior house officer (21148), who walked more than the Clinical Fellow (18567), who walked more than the Registrar (14393), who walked more than the Consultant (7291).

In conclusion, there is a clear and significant trend towards decreased levels of activity with increasing seniority within the Cardiology team. Some would argue that it is not the role of the workplace to offer physical activity, yet many would argue that the workplace should encourage physical activity in all its members for the well-being of its workforce. Extra activities, where provided, should be encouraged, such as fitness classes and on-site recreational clubs, and more senior doctors should be encouraged to avoid lifts and use stairs. This may be one of the effective means of intervention in an attempt to increase physical activity amongst doctors, which will provide a leading example to the remainder of the population.

(1) Ogilvie D, Foster CE, Rothnie H, Cavill N, Hamilton V, Fitzsimons CF, et al. Interventions to promote walking: systematic review. BMJ 2007; Jun 9;334(7605):1204.

(2) Jakicic, J. M. & Otto, A. D. Physical activity considerations for the treatment and prevention of obesity. American Journal Of Clinical Nutrition 2005, 82(1), Supplement, S226-S229

(3) British Heart Foundation – Think Fit! Be Active! www.bhf.org.uk

Competing interests: None declared

RESEARCH:
Alarm symptoms in early diagnosis of cancer in primary care: cohort study using General Practice Research Database
Jones et al. (19 May 2007) [Abstract] [Full text] [PDF]
Alarm symptoms in early diagnosis of cancer in primary care: cohort study using...
Alarm symptoms in primary care: Further evidence
1 October 2007
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Knut A Holtedahl,
Professor of General Practice
Institute of Community Medicine, University of Tromsø, 9037 Tromsø, Norway

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Re: Alarm symptoms in primary care: Further evidence

Dear Editor

The article by Jones et al (1) in your 19 May issue of BMJ gives solid evidence for the low predictive value of single symptoms in relation to relevant forms of cancer. In line with this, I would like to draw attention to my around twenty-five year old studies about alarm symptoms in Norwegian general practice (2;3), mainly published in a non-Medline acknowledged journal and thus difficult to find to-day. Single symptoms, examplified by “the seven warning signals of cancer”, are poor diagnostic indicators of cancer, although not without validity, as suggested by an odds ratio of 1.9 in a prospective part of the study. However, considering single symptoms alone is artificial when considering possibilities in the consultation in general practice. The GP always has access to further information, modifying initial probabilities, as examplified in our study (4). In a previous study, published in Norwegian with an English summary, it was shown that such information is accessible through ordinary medical work including a good medical history and a focussed clinical examination and, slightly less important, an appropriate selection of laboratory tests and imaging (5). The individual symptoms were further analysed in two other articles, accessible in Medline (6;7). At the time, a manual of early cancer diagnosis for GPs was published as well (8). Like Jones et al., I was concerned in my studies not only about how the GP can contribute to earlier diagnosis, but also to how to avoid patient delay. Andersen & Cacioppo (9) have written an interesting article about this.

p.t. Cherbourg, France 011007

Knut Holtedahl,
Institute of Community Medicine, University of Tromsø, 9037 Tromsø, Norway.
knutarne.holtedahl@ism.uit.no

Reference List

(1) Jones R, Latinovic R, Charlton J, Gulliford MC. Alarm symptoms in early diagnosis of cancer in primary care: cohort study using General Practice Research Database. BMJ 2007; 334(7602):1040. doi:10.1136/bmj.39171.637106.AE

(2) Holtedahl KA. A method of calculating diagnostic indexes for possible cancer symptoms in general practice. , 1990; 19: 74-79. Allgemeinmedizin 1990; 19:74-79.

(3) Holtedahl KA. More diagnostic indexes from general practice for some important forms of cancer. Allgemeinmedizin 1990; 19:80-85.

(4) Holtedahl KA. Probability revision in general practice: the cases of occult blood in stool in patients with indigestion, and daily smoking in patients who cough. Allgemeinmedizin 1990; 19:35-38.

(5) Holtedahl KA. [Diagnosis of cancer in general practice. I. Can diagnosis be made earlier?]. Tidsskr Nor Laegeforen 1980; 100(19-21):1219- 1223. English summary.

(6) Holtedahl KA. Inter-observer variation on registration of signals of cancer. Scand J Prim Health Care 1987; 5:133-139.

(7) Holtedahl KA. The value of warning signals of cancer in general practice. Scand J Prim Health Care 1987; 5:140-143.

(8) Holtedahl KA. Early diagnosis of cancer in general practice. A manual. Berlin: Springer Verlag 1990.

(9) Andersen BL, Cacioppo JT. Delay in seeking a cancer diagnosis: delay stages and psychophysiological processes. Br J Soc Psychol 1995; 34:33-52.

Competing interests: None declared

ANALYSIS:
Functional foods: the case for closer evaluation
de Jong et al. (19 May 2007) [Full text] [PDF]
Functional foods: the case for closer evaluation
Functional Foods: Already a feature of every-day practice
3 October 2007
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Ian R Wallace,
FTSTA in Endocrinology
Lagan Valley Hospital, Lisburn, Northern Ireland. BT28 7JP

Send response to journal:
Re: Functional Foods: Already a feature of every-day practice

Sales of functional foods or neutraceuticals account for billions of dollars annually worldwide. A number of recent articles in the BMJ have highlighted the case for scrutiny of this sector.1,2,3 I feel there are benefits and also dangers to the use of functional foods. I feel this sector requires scrutiny of marketing practices and monitoring of the long -term effects and possible interactions of ingestion of these substances.

In my own daily practice I am regularly encountering patients on various supplements and fortified foods. I now make a point of being thorough and asking about drug allergies, prescription medications, over- the-counter medications, illicit drug use and also about any dietary supplements they are taking.

A rapid response to the recent articles stated that functional foods can replace dietary deficiencies.4 They hence can be beneficial and we as doctors have been treating dietary deficiencies for years by prescribing iron, thiamine, Vitamin B12 and others. These are given to those with a clinical need and also have the benefit of years of monitoring and stringent production procedures. Functional foods by contrast are not prescribed by doctors and the patients are not reviewed for adverse effects.

My limited experience would suggest that it is not those who are deficient in nutrients who are taking functional foods. I do agree with Mr Vos that in the right subject groups functional foods replacing nutrients can assist in disease prevention.

I would like to close by raising a number of points.

1. Functional foods are in common usage and as clinicians we need to ask about them.

2. Marketing of these substances is aimed at a certain profitable sector of the market, which may not correspond to the sector which may gain benefit from these substances.

3. There are undoubted benefits to replacing nutritional deficiencies, but is an unregulated functional food market the way to do this. Would it not be better to have these foods manufactured to high standards and monitored over many years, along the lines of the pharmaceutical industry. Should we not be supportive of attempts by the European Union and FDA to apply controls to this sector.

4. The ingestion of functional foods may have unexpected effects.

References:

1. de Jong N, Verhagen H, Wolfs MCJ, Ocke MC, Klungel OH, Leufkens HGM. Functional foods: the case for closer evaluation. BMJ 2007; 334: 1037- 1039.

2. Lang T. Functional foods: Their long term impact and marketing needs to be monitored. BMJ 2007; 334: 1015-1016.

3. Katan MB. Health claims for functional foods. BMJ 2004; 328: 180- 181.

4. Vos E. Re: Drugs or Functional Foods? eBMJ 2007; Rapid Responses. www.bmj.com/cgi/eletters/334/7602/1037

Competing interests: None declared

VIEWS & REVIEWS:
Addiction in America: in search of a fix
Veltman (31 March 2007) [Full text] [PDF]
Addiction in America: in search of a fix
Addiction: Imaginary Gains and Real Losses
3 October 2007
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Hugh Mann,
Physician
Eagle Rock, MO 65641 USA

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Re: Addiction: Imaginary Gains and Real Losses

Addiction is a bad bargain. The addict pursues imaginary gains, but suffers real losses. The imaginary gain of addiction is euphoria, which is a false heightened sense of well-being. The real loss of addiction is sickness.

Each addictive substance creates its own unique type of euphoria and sickness. For each addictive substance, the unique type of euphoria and sickness are polar opposites. For example:

1)  Alcohol creates the euphoria of confidence and relaxation, while at the same time, alcohol creates the sickness of poor judgment and anxiety.
2)  Tobacco creates the euphoria of easy breathing, while at the same time, tobacco creates the sickness of suffocation.
3)  Coffee and tea create the euphoria of mental energy, while at the same time, coffee and tea create the sickness of mental lethargy.
4)  Cola creates the euphoria of thirst-quenching, while at the same time, cola creates the sickness of dehydration.
5)  Chocolate creates the euphoria of feeling loved, while at the same time, chocolate creates the sickness of being love-starved.
6)  Honey and sugar create the euphoria of sweetness and peace, while at the same time, honey and sugar create the sickness of bitterness and anger.
7)  Marijuana creates the euphoria of wisdom, while at the same time, marijuana creates the sickness of confusion.
8)  Methamphetamine creates the euphoria of energy and strength, while at the same time, methamphetamine creates the sickness of exhaustion and weakness.
9)  Pain medicine creates the euphoria of feeling healthy and pain-free, while at the same time, pain medicine creates the sickness of being fragile and hypersensitive to pain.

The imaginary gain (euphoria) and the real loss (sickness) of addiction reinforce each other. Euphoria lures you into and blinds you to sickness. And sickness increases your craving for euphoria. Ironically, addictive substances cause and aggravate the very sickness they seem to cure. For example:

1)  The sickness created by alcohol (poor judgment and anxiety) increases your craving for the euphoria created by alcohol (confidence and relaxation).
2)  The sickness created by tobacco (suffocation) increases your craving for the euphoria created by tobacco (easy breathing).
3)  The sickness created by coffee and tea (mental lethary) increases your craving for the euphoria created by coffee and tea (mental energy).
4)  The sickness created by cola (dehydration) increases your craving for the euphoria created by cola (thirst-quenching).
5)  The sickness created by chocolate (love-starvation) increases your craving for the euphoria created by chocolate (feeling loved).
6)  The sickness created by honey and sugar (bitterness and anger) increases your craving for the euphoria created by honey and sugar (sweetness and peace).
7)  The sickness created by marijuana (confusion) increases your craving for the euphoria created by marijuana (wisdom).
8)  The sickness created by methamphetamine (exhaustion and weakness) increases your craving for the euphoria created by methamphetamine (energy and strength).
9)  The sickness created by pain medicine (being fragile and hypersensitive to pain) increases your craving for the euphoria created by pain medicine (feeling healthy and pain-free).

The euphoria of addiction is a false heaven. The sickness of addiction is a real hell. Addictive substances are a deadly paradox. The more you know them, the more they fool you. The more you use them, the more they control you. The more you enjoy them, the more they hurt you. Addiction is a funeral, not fun.

Competing interests: None declared

RESEARCH:
Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials
Walter et al. (10 March 2007) [Abstract] [Full text] [PDF]
Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis...
Importance of calculation of absorbed dose in radioiodine treatment in patients pre-treated with antithyroid drugs
12 October 2007
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Gertrud Berg,
ass professor
Department of Oncology, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden

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Re: Importance of calculation of absorbed dose in radioiodine treatment in patients pre-treated with antithyroid drugs

There is a disagreement about the influence of antithyroid drugs on radioiodine treatment. In the systematic review and meta-analysis of randomised controlled trials it was concluded that antithyroid drugs increase rates of failure and reduce rate of hypothyroidism if they are given in the week before or after radioiodine treatment (Walter et al 2007). I believe that one explanation for failure is the fact that antithyroid drugs simply affects the uptake and residence time of radioiodine. There is a risk in these cases that the thyroid receives a smaller absorbed dose from radioiodine if dose calculation including estimation of effective half-life of the radioiodine is not performed. If a dose calculation is performed, the outcome will be the same in patients treated with antithyroid drugs as in those without pre-treatment.

In Sweden the authorities recommend to use individual dose calculations for radioiodine treatment of patients with hyperthyroidism. We have thus for many years used a protocol where a test dose is given in order to calculate the amount of radioactivity (MBq) needed to obtain the absorbed dose (Gy) aimed at. We have shown that when we aim at an absorbed dose of 120 Gy we only have a failure of 7 % (Berg et al 96 b). The individual dose calculation takes into account the thyroid volume, the iodine uptake after 24 hours and the effective half -life of the radioiodine. We have reported about the special significance of the effective half-life (residence time of the radioisotope) in these measurements (Berg 1996a). We thus showed that the effective half-life can vary between 2 and 8 days where the mean half-life for patients with Graves’ disease was 5.3 days without pre medication with antithyroid drugs whereas patients with medication up to 7 days before treatment had a mean effective half-life of 4.4%. Thus if the half-life is not considered it is likely that the patients with prior antithyroid drugs will receive a lower absorbed dose than prescribed. The shorter period without medication the more impact on the half-life can be expected.

One explanation for the reduced half-life is that antithyroid drugs reduce the protein binding of iodine to thyroglobulin at the apical part of the thyrocytes. The radioiodine will thus reside shorter in the gland.

We often see a high uptake and a short half-life in patients with prior antithyroid drug treatment. It is our experience however that when an individual dose calculation is performed the treatment failure is in the same order for patients with and without prior medication. If individual dose calculation is not performed and standard activities are used it is likely that patients with prior antithyroid drugs receive a lower absorbed dose to the thyroid than wanted. A dose of eg 90 Gy is simply more unlikely to cure than the aimed dose of 120 Gy.

Berg G, Michanek A, Holmberg E, Nyström E. Clinical outcome of radioiodine treatment of hyperthyroidism: a follow up study. J Int Med 1996; 239:165-71.

Berg G, Michanek A, Holmberg E, Fink M. Iodine-131 treatment of hyperthyroidism: significance of effective half-life measurements. J Nucl Med 1996; 37: 228-32

Competing interests: None declared

RESEARCH:
Effectiveness of community physiotherapy and enhanced pharmacy review for knee pain in people aged over 55 presenting to primary care: pragmatic randomised trial
Hay et al. (11 November 2006) [Abstract] [Full text] [PDF]
Effectiveness of community physiotherapy and enhanced pharmacy review for knee pain...
Re: Rotational Field Quantum Magnetic Resonance
6 October 2007
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Sukhbindar S Sibia,
Consultant Physician
Ludhiana (India) 141001

Send response to journal:
Re: Re: Rotational Field Quantum Magnetic Resonance

Based on our experience of over one hundred osteoarthritis (OA) Knees treatment with Rotational Field Quantum Magnetic Resonance (RFQMR) we conclude that RFQMR has good result in most patients but the role of physiotherapy cannot be undermined even when there is evidence of increased thickness of joint cartilage. Also necessary is to take care of the patient's psychology as most of these patients having tried various treatments unsuccessfully and have some degree of depression and biased negativity against all therapy modes.

Competing interests: Using Cytotron to generate RFQMR since March 2006 to treat patients having Osteoarthritis and cancer.

REVIEWS:
Why are so many people dying on Everest?
Sutherland (26 August 2006) [Full text]
Why are so many people dying on Everest?
Damned if you treat, damned if you don’t.
3 October 2007
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Sean T Hudson,
GP and medical director expedition medicine
St Pauls Medical Centre, St Pauls Sq, Carlisle, Cumbria

Send response to journal:
Re: Damned if you treat, damned if you don’t.

Damned if you treat, damned if you don’t. The problem with treating Americans

The adventure travel market is undergoing an exponential growth, and UK companies are at the forefront of providing safe and well organized overseas ventures for people of all nationalities and in all environments.

The government recently recognized the need for standardization in this field and in 2007 released the BS8848 document which set the gold standard for providing support and care on organized trips outside of the UK. Part of this document covered the need to provide some level of medical support by a recognized medical practitioner, preferably in the field with the organization, especially in remote regions with limited access to medical facilities. UK companies were some of the first to provide medical cover on their expeditions, with doctors, nurses and paramedics often offering their skills in lieu of the opportunity to travel to exciting destinations, or going out of purely altruistic motives, to allow a population with disabilities and pre-existing conditions to participate in activities they would otherwise not be capable of. The situation seemed to be harmonious until the possible implication of providing medical cover to Americans, among others, was highlighted. The Defence Unions advise doctors, that although they are covered to treat Americans, they are not covered for any court case that arises in North America. (Americans obviously being at liberty to sue a doctor in America if they choose, independent of where the transgression occurred). The GMC advise all doctors not to participate in any activity without the appropriate cover.

The doctor is therefore left to decide if they are willing to take the risk, which is against the advice of the GMC. If however a doctor makes the decision not to provide medical cover for an American on an expedition, the American participant seems to be perfectly within their rights to sue for racial discrimination, bringing an action against the company organizing the trip and reporting the doctor to the GMC for improper conduct. The Defence Unions seem to escape any culpability in the eyes of the racial discrimination board as they are not discriminating against Americans but rather against any legal action taken in the US, whether it be by an American or a UK citizen. What about the American citizens that reside permanently in the UK? Or the dual nationals that retain their American status but are also UK citizens? At the moment they still fall into the same bracket so the advice to the doctor is the same.

How can this ludicrous, untenable situation be rectified? Does the solution lie in something as simple as a signed legal waiver, or will it be necessary for the defence unions to accept the risk? Whatever the solution it can not be allowed to continue as it is, with doctors risking being sued for treating or being sued for refusing to treat.

Competing interests: None declared

ANALYSIS AND COMMENT:
Do enforced bicycle helmet laws improve public health?
(25 March 2006) [Full text] [PDF]
Do enforced bicycle helmet laws improve public health?
What about motorcycle helmets?
3 October 2007
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Marcel Girodian,
Writer
US 90270

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Re: What about motorcycle helmets?

What a fascinating discussion. I wonder, do all of these points of view pertain equally to motorbike helmets and legal compulsion to wear them or just to the bicycle side of the issue?

Competing interests: None declared

ON THE CASE:
The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute
Lim et al. (24 December 2005) [Abstract] [Full text] [PDF]
The case of the disappearing teaspoons: longitudinal cohort study of the displacement...
Practical solution
6 October 2007
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Jennifer A Stillman,
Senior Lecturer
Massey University Albany,
Private Bag 102-904, North Shore MSC, Auckland, New Zealand.

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Re: Practical solution

Clearly Departmental budgets would be best served if, upon appointment, employees were issued with a personal teaspoon, etched with their name, and furnished with a key ring attachment via a hole in the handle. Alternatively the spoon could itself function as a key "ring". Lost spoons should be replaced at the owner's expense. Prominent individuals should be entitled to higher quality spoons, with gold ones given as momentoes when long-serving employees retire.

Competing interests: None declared

NEWS ROUNDUP:
GMC drops charges against paediatrician in Climbie case
Dyer (18 September 2004) [Full text]
GMC drops charges against paediatrician in Climbie case
Mellor's dilemma
8 October 2007
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Jonathan Gornall,
Freelance journalist
London

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Re: Mellor's dilemma

I thank Mrs Mellor for drawing attention to my website, www.gornall.info, which serves as a repository of published articles I have written about the ongoing campaign against child professionals in this country and also contains links to many documents, papers, judgments and news stories relevant to the subject of unexpected infant death.

I am also grateful for her lecture on the workings of the criminal appeal system, with which she is, of course, very familiar.

I am not sure, however, why she has chosen to enter this particular fray, other than for the purpose of attacking me. She appears to agree that Victoria Climbie was the victim of abuse and not, as Michael Innis insists, of an undiagnosed case of Kawasaki Disease.

It will come as no surprise to followers of Mrs Mellor's pronouncements to learn that she is privileged to have "inside knowledge" of the Climbie case. How fascinating - and what a shame that apparently she feels bound by some commitment to confidentiality not to share this knowledge with the rest of us.

Mrs Mellor's reluctance to endorse Mr Innis's theory appears at first to be out of character, but might have something to do with the fact that she has in the past suggested that Victoria Climbie died because nasty old paediatricians were far too busy hunting down imaginary cases of Munchausen syndrome by proxy to notice the young girl being abused to death before their eyes.

What a dilemma for Mellor. Although she must be sorely attempted to back Innis and the "falsely accused", to do so would mean letting a paediatrician off the hook, and that would never do. But that's the trouble with conspiracy theories - they don't always complement each other.

On May 7, 2006, Mrs Mellor posted the following on the website Mothers against Munchausen allegations:

"May I remind everyone about what I uncovered a couple of years ago, an MSbP allegation does-it isn't speculation it is a fact-whilst Dr Mary Rossiter was "chasing bits of information" on "potential" MSbP cases, Victoria Climbie was stood before her, the abused and battered child, the evidence all over her innocent little body and she failed to spot it, because she was too busy looking for the invisible-it really doesn't get any worse than this."[1]

Her conclusion: "There you have it MSbP kills-it kills other children."

This was a distortion of the truth - and, of course, Mellor had "uncovered" nothing. All she had done was misrepresent a statement made during the Laming inquiry that was there in the public domain, online, for anyone to read.

On December 10, 2001, Petra Kitchman, a child protection advisor employed by Haringey council, was explaining to the inquiry her reaction to a letter from a paediatrician, Dr Mary Rossiter, who had written about Victoria: "I have enormous concerns about this child who is now lost to follow-up somewhere in Haringey. What are you going to do?"

It is worth quoting Ms Kitchman in full here, because to do so exposes fully Mrs Mellor's manipulation of the truth:

"What I would say about Mary is that she has a lot of experience and despite that I would not say that she sort of lost her compassion at all, she is often very worried about a lot of cases, certainly that I speak to her about. This would not have been an unusual thing for her to say. She really does care about children that she actually works with and I think that she was worried about Victoria but that was not unusual for Mary, she was often worried about a lot of cases which I spoke to her about. So this would not have made me ring more alarm bells than normal. And the same for the 'very worrying case' thing. She often - I mean I said to you earlier that at the time I think we were dealing with about three potential Munchausen syndrome cases, which is very unusual, and she was working very hard chasing bits of information about them and she was equally very worried about those children because she is a paediatrician who I believe genuinely cares about the children that she sees."[2]

The suggestion that Victoria Climbie died because Dr Rossiter was "too busy looking for the invisible" may well have served Mrs Mellor's campaign against MSBP/FII, but it was a slur. Perhaps she and Mr Innis would like to get together and get their stories straight.

1 http://www.msbp.com/forum/viewtopic.php?t=1399&highlight;=rossiter

2 http://www.victoria-climbie-inquiry.org.uk/Evidence/Archive/Dec01/101201latestp6.htm

Competing interests: None declared

GMC drops charges against paediatrician in Climbie case
Kawasaki Disease - Misdiagnosed.
2 October 2007
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Michael D Innis,
Emeritus Consultant Haematologist
Home 4575

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Re: Kawasaki Disease - Misdiagnosed.

Editor,

Dr Adjaye's response to my claim that Victoria Climbie died from Kawasaki Disease raises several points which require answering.

Regarding Dr Adjaye’s advice to “consider the DIFFERENTIAL DIAGNOSIS in all presenting symptoms,” I would like to inform her that I have devised and patented a Computer Diagnostic Program based on a unique Inference Mechanism – the Intersection of a Set and its Complement is Not an Empty Set which does just that – it lists the possibilities of a particular combination of signs and symptoms as a differential diagnosis.

Clinical Problem Solving – the role of expert laboratory systems (Med Inform 1997;22 -251-256) describes the DIFFERENTIAL DIAGNOSTIC ABILITY of the program which has been recording material for the past 20 years.

In Victoria’s case the numerous pleomorphic skin lesions of varying age, redness of the eyes, mucosal lesions at the angles of the mouth and lesions on the hands are diagnostic of Kawasaki Disease. Rocky Mountain Spotted fever, Scarlet fever, Stevens-Johnson syndrome, Drug reaction and Juvenile Rheumatoid Arthritis have some similar features but only Kawasaki Disease includes all of them.

“Dr Innis has taken the signs he describes out of context”. Would Dr Adjaye prefer them to be taken in the context of Lord Laming’s report – “ Victoria spent the cold winter months, bound hand and foot, in an unheated bathroom, lying in the cold bath in a plastic bag in her own urine and faeces and having to eat what food she could get by pressing her face onto the plate of whatever was put in the bath beside her.”

Lord Laming does not say who OBSERVED Victoria bound hand and foot. What has not been observed is imagined, and what is imagined has no place in a scientific discussion.

“I have yet to see a child with Kawasaki disease who is not miserable ..” says Dr Adjaye. In that case one must conclude the good doctor did not see Victoria “in a plastic bag in her own urine and faeces” for surely that must make anyone miserable.

Fairly constant features of Kawasaki Disease are an increase in the levels of the hepatic transaminases, the C Reactive Protein and ESR. Lymphopenia and neutrophilia with an increased number of immature forms is another constant feature [1]. These blood tests should have been done while Victoria was in Hospital and should be available for inspection.

No amount of beating a child will account for these changes and one hopes the Laboratory results have not “gone missing” as they will help to support my diagnosis and perhaps set the prisoners free.

British Justice is on Trial – again. Sally was not the last.

Michael D Innis MBBS; DTM&H; FRCPA; FRCPath.

Reference

1. Rowley AH, Shulman ST. Kawasaki Disease In Nelson’s Textbook of Pediatrics 17th Edition pp 823-826 Eds Behram RE, Kliegman RM, Jenson HB Publisher Saunders

Competing interests: I have given my opinion in a similar case which was misdiagnosed by the prosecution.

GMC drops charges against paediatrician in Climbie case
Re: Or was she raygunned?
2 October 2007
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Penny Mellor,
Campaigner/research false allegations
Home WV9 5HX

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Re: Re: Or was she raygunned?

Mr Gornall, you failed to declare that you have set up a website that campaigns on behalf of Dr David Southall and other doctors who you deem to be victims of an "orchestrated campaign to destroy child protection". [1]

Mr Gornall states with some conviction " It is usual in these cases for campaigners to focus on a single medical feature of the evidence against those found guilty of abuse and there is never any shortage of experts prepared to propose an alternative theory as to cause. Of course, as is also usual in these cases, there was rather more to the evidence against the accused in the Climbie case than the single medical diagnosis that Mr Innis appears to suggest may have led to their unjust imprisonment."

Err no, I think Mr Gornall fails to understand the basic rules of thumb reating to how the court of appeal works. Lawyers can submit several new grounds for appeal covering several areas of medicine, it is the courts that decide what has sufficient merit to go through, not the lawyers, campaigners or defence experts.

Sometimes the Court of Appeal, to save time and thus money will pick on just one very strong new ground (which legally is all you need) of appeal to be heard, that would take up the court's time for just a day rather than set down several days to hear all the new grounds, at the point they grant the appeal, they then give leave for all the new grounds to be heard. When that appeal finally comes to court, the judges may just read the new evidence and accept it and only hear from experts in relation to disputed new medical evidence, that does not mean that there is only a "single medical feature".

You're wrong Mr Gornall, you do not have access to any of grounds of appeal submitted in any of the cases that I, as one of "those campaigners" have been involved in and I can tell you now as a matter of fact and not speculation, that there are always several medical anomolies that are submitted for review to the courts.

Kai Whiteind's second appeal is now being prepared with several ( that would be more than one Mr Gornall ) new ground relating to medical evidence not available at the trial.

For the avoidance of doubt, I have no doubt that Victoria Climbie was subjected to appalling abuse leading to her death, I am priveleged to have inside knowledge of this case.

[1] www.gornall.info

Competing interests: I am a campaigner against false allegations of child abuse

GMC drops charges against paediatrician in Climbie case
Kawasaki Disease and Victoria Climbie
1 October 2007
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Nellie T Adjaye,
Consultant Community Paediatrician
Birling Ward, Preston Hall Hospital, Maidstone Kent ME 20 7NJ

Send response to journal:
Re: Kawasaki Disease and Victoria Climbie

My attention is drawn to Dr Michael Innis' comment,"Kawasaki disease Unrecognised" BMJ2007 334: 7584.

He asserts that the doctors involved in Vicotria's case missed a case of Kawasaki disease on presentation of Victoria to the Central Middlesex Hospital, and that Vitoria died of that disease, which went unrecognised. So he claims thatVictoria did not die of child abuse .He bases his assertion on the bloodshot eyes , the oozing pus from Victoria's fingers and multiple scars of various ages and sizes including the marks around the wrists found by the pathologist...all being typical presentation of Kawasaki disease.

Dr Innis is wrong. Victoria died of Physical Abuse inflicted on her by her carers. The evidence is all there in the Laming report.Dr Innis has taken the signs he describes out of context.I am sure the good doctor is aware of the fundamentals of clinical practice of medicine in which we all taught . Consider the DIFFERENTIAL DIAGNOSES in all presenting symptoms. Kawasaki disease may present with blood shot eyes etc but has got to be seen in the context of the history. In Victoira's case she was described as "jolly child" who was not unduly distressed by what was happening to her. I have yet to see a child with Kawasaki disease who is not miserable.. ( I have diagnosed a few in my 30 years of paediatric practice)

May I refer the good doctor to the Laming Report 2003(The Victoria Climbie Inquiry, Report of an Inquiry by Lord Laming presented to Parliament Jan 2003 Cm5730) pages 239-254.

I would suggest that the good doctor Innis enters child physical abuse into his differential diagnoses next time he makes a case for Kawasaki disease.He might be saving a few chioldren from the horrors of child abuse.

Nellie Adjaye Competing interest.. Medical Assessor on Laming Iquiry

Competing interests: Medical Assessor to Lord Laming on the Victoria Climbie Inquiry 2003

EDITORIALS:
What's a good doctor, and how can you make one?
Hurwitz and Vass (28 September 2002) [Full text] [PDF]
What's a good doctor, and how can you make one?
Re: its multifactorial
6 October 2007
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Hammad Akram,
Graduate Research Assistant
The University of Oklahoma Health Sciences Center , OK 73104

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Re: Re: its multifactorial

its addition to my previous reponse, being a public health student and a physician I think a good physician is one who consider aaplication of health care on the basis of not only individual clinical aspects but also preventive community based point of views.

Competing interests: None declared

NEWS:
Withdrawal from paroxetine can be severe, warns FDA
Tonks (2 February 2002) [Full text] [PDF]
Withdrawal from paroxetine can be severe, warns FDA
Re: Paroxetine
7 October 2007
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E Lynn Alexander,
Retired
Housewife,
47960

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Re: Re: Paroxetine

I am so glad I found this help for me. I am a 61 year old woman and have been on Paroxetine for 12 years because of home problems and going through the change of life. A week ago I decided to go cold turkey on this med. Each day seems to be getting worse for me. It is now 4:00 am in the morning and I just woke up from a severe nightmare of leaving my husband of 42 years and how I would go about it. In the last week I thought I was getting the flu back that I just got over about 3 weeks previous. Thanks to all of this information I am going back on my med and try weaning myself off of it very slowly. The dizzy spells are dibilating. I cannot think at all and each day seems to get worse for me. My children were happy that i was going to try this but now I will share this information and explain how it will work. I have always been a softspoken person but am now hearing myself yelling..the nausa is also a problem. Severe headaches for no reason. I have became very abrasive in the last few days and thoughts of life ending have been entering my mind which have never before. I so much to live for and could not fathom why this was happening. I am so glad I found these facts so I now know I am not going crazy and losing my mind. I am a game player on the internet and cards with friends; I could no longer do this as I could not concentrate long enough to do so. Once again I am so grateful for this information...It very likely has saved a life.....

Competing interests: None declared

SOUNDINGS:
The value of life
Farrell (12 September 1998) [Full text] [PDF]
The value of life
I believe in insulin
30 September 2007
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Neil \ Kirk\,
customer service
51534,
Liam Farrell

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Re: I believe in insulin

Although no difference in oral medicines or insulin has been stated in these articles, I can attest to the fact, insulin makes life a lot easier. Without adequate insulin, the slightest error in food consumption leaves the diabetic with high glucose for 12-24 hours, and that is not a good thing. I have the best reports using insulin only. I find with exercise, I can return a spike to normal within 15 minutes, if I have adequate insulin in the system. On the contrary, the insufficient insulin combined with exercise will run my glucose very high. I sing the praises everyday for the short acting insulin. That is all I use and life has turned into real joy. I have been using insulin only for the past 24 months and would refuse pill therapy if offered again. I exercise 90 minutes at one time and add 5 10 minute workouts throughout the day -- before work, break, lunch and second break. The last short exercise burst come after work. I drive 45 minutes to the gym and do 90 minutes on the aerobic eliptical machine. I get lots of nitric oxide, dompamine well controlled glucose and a euphoric sense of life. I love my new life, I hated life on pills -- that was not life but an existence counting the days till death. I now plan to live to be age 100. Neil Kirk nkirk50@earthlink.net. Glenwood, Iowa 51534 712-527-4127

Competing interests: None declared

PAPERS:
Genetic influences on osteoarthritis in women: a twin study
Spector et al. (13 April 1996) [Abstract] [Full text]
Genetic influences on osteoarthritis in women: a twin study
Possible Incorrect Citation
3 October 2007
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Madeline C Walsh,
student
Australia

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Re: Possible Incorrect Citation

To the authors,

Please note citation 30 of your article which shows as follows:

"Sandland G. On correcting for misclassification in twin studies and other matched pair studies. Stat Med 1989;8:825-9. [Medline]"

I had a little difficulty finding this article considering the authors' correct name is in fact 'Greenland S' (Division of Epidemiology, UCLA School of Public Health).

Please consider the above.

Regards, Madeline Walsh

Competing interests: None declared