Alfentanil

From Wikipedia, the free encyclopedia

Alfentanil
Systematic (IUPAC) name
N-[1-[2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl]- 4-(methoxymethyl)-4-piperidyl]-N-phenyl-propanamide
Identifiers
CAS number	71195-58-9
ATC code	N01AH02
PubChem	189496
DrugBank	APRD00726
Chemical data
Formula	C21H32N6O3
Mol. mass	416.517 g/mol
SMILES	eMolecules & PubChem
Physical data
Melt. point	140.8 °C (285 °F)
Pharmacokinetic data
Bioavailability	Not applicable
Protein binding	92%
Metabolism	Hepatic
Half life	90–111 minutes
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Class A(UK) Schedule II(US)
Routes	Intravenous

Alfentanil (trade name Alfenta) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with 10-20% the potency of fentanyl. It is an OP3 mu-agonist.

While alfentanil tends to cause less cardiovascular complications than other similar drugs such as fentanyl and remifentanil it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. Alfentanil is administered by the parenteral (injected) route for fast onset of effects and precise control of dosage.

Alfentanil is a restricted drug which is classified as Schedule II in the USA, according to the U.S. DEA website.^[1]

Alfentanil was discovered at Janssen Pharmaceutica in 1976.

[edit] References

[edit] External links

• some more info

v • d • e Analgesic products (N02A, N02B)
Opioids See also: Opioids template	Buprenorphine · Butorphanol · Codeine · Dextropropoxyphene · Diamorphine · Dihydrocodeine · Fentanyl · Hydrocodone · Hydromorphone · Ketobemidone · Levorphanol · Methadone · Morphine · Nalbuphine · Nicomorphine · Opium · Oxycodone · Oxymorphone · Pethidine · Tramadol · Tapentadol
Salicylic acid and derivatives	Aspirin (Acetylsalicylic Acid) · Benorylate · Diflunisal · Ethenzamide · Salicin · Salicylamide · See also: NSAIDs
Pyrazolones	Ampyrone/Aminophenazone · Metamizole · Phenazone
Cannabinoids	Cannabis · Tetrahydrocannabinol · AM404
Anilides	Paracetamol (acetaminophen) · Phenacetin
Others	Bicifadine · Diclofenac · Diflunisal · Duloxetine · Flurbiprofen · Gabapentin · Ibuprofen · Indometacin · Ketorolac · Ketoprofen · Mefenamic acid · Meloxicam · Naproxen · Nefopam · Piroxicam · Ziconotide

v • d • e Opioid products (N02A)
Opiate derivatives	2,4-Dinitrophenylmorphine • 6-Ketonalbuphine • 6-Methyldihydromorphine • 6-Methylenedihydrodesoxymorphine • 14-Ethoxymetopon • 14-Methoxymetopon • Acetylcodeine • Acetyldihydrocodeine • Acetylmorphone • Apocodeine • Apomorphine • Azidocodeine • Azidomorphine • Benzylmorphine • β-4-morpholinylethylmorphine • Chloromorphide • Clocinnamox • Codeine • Codeine-N-Oxide • Codeinone • Codorphone • Codoxime • Desomorphine • Diacetyldihydromorphine • Dihydrocodeine • Dihydrocodeinone enol acetate • Dihydrohydroxycodeinone • Dihydrodesoxymorphine • Dihydroheroin • Dihydroisocodeine • Dihydromorphine • Dibutanoylmorphine • Dipropanoylmorphine • Ethyldihydromorphinone • Ethyldihydromorphine • Ethylmorphine • Heroin (Diamorphine) • Heroin-7,8-Oxide • Heterocodeine • Heteromorphine • Hydrocodone • Hydromorphinol • Hydromorphone • Isocodeine • Laudanum • Methyldesorphine • Methyldihydromorphine • Methylnaltrexone • Metopon • Monoacetylmorphine • Monobutanoylmorphine • Morphine • Morphine-3-glucuronide • Morphine-6-glucuronide • Morphine monohemisuccinate • Morphine-N-Oxide • Morphinone • Myrophine • Nalbuphine • Nalfurafine • Nalmefene • Nalodeine • Nalorphine • Naloxone • Naltrexone • Naltrindole • Narceine • Nicocodeine • Nicodicodeine • Nicomorphine • Norcodeine • Normorphine • Omnopon • Opium • Oripavine • Oxycodone • Oxymorphone • Pantopon • Papaveretum • Paregoric • Pholcodine • Pseudomorphine • Poppy straw • Poppy tea • Semorphone • Tetrapon • Thebacon • Thebaine
Morphinans	Aknadinine • Butorphanol • Cyclorphan • Cyprodime • Dextro-3-hydroxy-N-allylmorphinan • Dextromethorphan • Dextrorphan • Dimemorfan • Drotebanol • Levargorphan • Levallorphan • Levorphanol • Levorphan • Levophenacylmorphan • Levomethorphan • Norlevorphanol • Oxilorphan • Phenomorphan • Racemethorphan • Racemorphan • Salutaridine (Sinoacutine) • Sinococuline • Sinomenine (Cocculine)
Benzomorphans	5,9-DEHB • Bremazocine • Cogazocine • Cyclazocine • Dezocine • Eptazocine • Etazocine • Ethylketocyclazocine • Fluorophen • Ketazocine • Metazocine • Pentazocine • Phenazocine
4-Phenylpiperidines	Pethidines (Meperidines) Anileridine • Benzethidine • Carperidine • Difenoxin • Diphenoxylate • Etoxeridine (Carbetidine) • Furethidine • Hydroxypethidine (Bemidone) • Hydroxymethoxypethidine • Morpheridine • Oxpheneridine (Carbamethidine) • Meperidine-N-Oxide • Pethidine (Meperidine) • Pethidine Intermediate A • Pethidine Intermediate B (Norpethidine) • Pethidine Intermediate C (Pethidinic Acid) • Pheneridine • Phenoperidine • Piminodine • Properidine (Ipropethidine) • Sameridine • WIN-7681 Prodines Allylprodine • α-meprodine • α-prodine • β-meprodine • β-prodine • Isopromedol • Meprodine • MPPP • PEPAP • Prodine • Prosidol • Trimeperidine (Promedol) Ketobemidones Acetoxyketobemidone • Ketobemidone • Methylketobemidone • Propylketobemidone Others Alvimopan • Loperamide • Picenadol
Open Chain Opioids	Amidones Dextromethadone • Dipipanone • Isomethadone • Levomethadone • Methadone • Methadone intermediate • Normethadone • Norpipanone • Phenadoxone  (Heptazone) • Pipidone Methadols Acetylmethadol • α-methadol • α-acetylmethadol • β-methadol • β-acetylmethadol • Dimepheptanol (Racemethadol) • Levo-α-acetylmethadol • Noracymethadol Moramides Dextromoramide • Levomoramide • Moramide intermediate • Racemoramide Thiambutenes Thiambutene • Diethylthiambutene • Dimethylthiambutene • Ethylmethylthiambutene • Tipepidine Phenalkoxams Dextropropoxyphene • Dimenoxadol • Dioxaphetyl Butyrate • Levopropoxyphene • Propoxyphene Ampromides Diampromide • Phenampromide • Propiram Others Lefetamine
Anilidopiperidines	3-Allylfentanyl • 3-Methylfentanyl • 3-Methylthiofentanyl • Alfentanil • α-methylacetylfentanyl • α-methylfentanyl • α-methylthiofentanyl • Benzylfentanyl • β-hydroxyfentanyl • β-hydroxythiofentanyl • β-methylfentanyl • Brifentanil • Carfentanil • Fentanyl • Lofentanil • Ohmefentanyl • Parafluorofentanyl • Phenaridine • Remifentanil • Sufentanil • Thenylfentanyl • Thiofentanyl • Trefentanil
Oripavine derivatives	7-PET • Acetorphine • Alletorphine • Buprenorphine • Cyprenorphine • Dihydroetorphine • Diprenorphine • Etorphine • N-cyclopropylmethyl-noretorphine • Nepenthone • Norbuprenorphine • Thevinone
Phenazepines	Ethoheptazine • Meptazinol • Metheptazine • Metethoheptazine • Proheptazine
Pirinitramides	Bezitramide • Piritramide
Benzimidazoles	Clonitazene • Etonitazene
Opioid Peptides	Casomorphin • DADLE • DALDA • DAMGO • Dermenkephalin • Dermorphin • Deltorphin • DPDPE • Dynorphin • Endomorphin • Endorphin • Enkephalin
Others	Akuammine • Ciramadol • Enadoline • Faxeladol • Herkinorin • Methopholine • Mitragynine • Noscapine/Narcotine • O-Desmethyltramadol • Salvinorin A • SNC-80 • Tapentadol • Tifluadom • Tilidine • Tramadol • Viminol • Zipeprol
Narcotic Antagonists	Cyclazocine • Diprenorphine • M5050 • Levallorphan • Nalmefene • Naloxone • Nalorphine • Naltrexone

v • d • e Anesthetic: General anesthetics (N01A)
Barbiturates	Hexobarbital, Methohexital, Narcobarbital, Thiopental
Ethers	Diethyl ether, Desflurane, Enflurane, Isoflurane, Methoxyflurane, Methoxypropane, Sevoflurane, Vinyl ether
Haloalkanes	Chloroform, Halothane, Trichloroethylene
Opioids	Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil
Others	Alfaxalone, Droperidol, Etomidate, gamma-Hydroxybutyric acid, Ketamine/Esketamine, Minaxolone, Nitrous oxide, Propanidid, Propofol, Xenon