| Game |
| Result | Moves |
Year | Event/Locale | Opening |
| 1. Vaganian vs Karpov |
  | 0-1 | 54 | 1969 | World Jr Ch qual | E14 Queen's Indian |
| 2. J Pavliutin vs Karpov |
| 0-1 | 30 | 1970 | Russian Championship | E14 Queen's Indian |
| 3. R Osterman vs Karpov |
| 0-1 | 45 | 1975 | Vidmar Memorial | E14 Queen's Indian |
| 4. A Pomar Salamanca vs Karpov |
| 0-1 | 92 | 1976 | 6th Torneo del Vino | E19 Queen's Indian, Old Main line, 9.Qxc3 |
| 5. Vaganian vs Karpov |
| 0-1 | 53 | 1976 | USSR Championship | E19 Queen's Indian, Old Main line, 9.Qxc3 |
| 6. Browne vs Karpov |
| 0-1 | 38 | 1977 | Las Palmas | E18 Queen's Indian, Old Main line, 7.Nc3 |
| 7. J Garcia Padron vs Karpov |
| 0-1 | 41 | 1977 | Las Palmas | E18 Queen's Indian, Old Main line, 7.Nc3 |
| 8. Spassky vs Karpov |
| 0-1 | 42 | 1979 | Montreal | E12 Queen's Indian |
| 9. Larsen vs Karpov |
| 0-1 | 23 | 1980 | Amsterdam IBM | E19 Queen's Indian, Old Main line, 9.Qxc3 |
| 10. K Langeweg vs Karpov |
| 0-1 | 41 | 1981 | Amsterdam IBM | E12 Queen's Indian |
| 11. E Torre vs Karpov |
| 0-1 | 57 | 1982 | Interpolis 6th | E15 Queen's Indian |
| 12. Gheorghiu vs Karpov |
| 0-1 | 63 | 1982 | Lucerne Olympiad | E15 Queen's Indian |
| 13. Kasparov vs Karpov |
| 0-1 | 70 | 1984 | Karpov - Kasparov World Championship Match 1984/85 | E15 Queen's Indian |
| 14. Kasparov vs Karpov |
| 0-1 | 58 | 1986 | Kasparov - Karpov World Championship Rematch | E12 Queen's Indian |
| 15. Portisch vs Karpov |
| 0-1 | 61 | 1986 | Interpolis 10th | E17 Queen's Indian |
| 16. Timman vs Karpov |
| 0-1 | 38 | 1987 | SWIFT Blitz | E15 Queen's Indian |
| 17. Adianto vs Karpov |
| 0-1 | 38 | 1988 | ? | E15 Queen's Indian |
| 18. L Winants vs Karpov |
| 0-1 | 43 | 1988 | Brussels World Cup | E15 Queen's Indian |
| 19. Timman vs Karpov |
| 0-1 | 45 | 1988 | Interpolis 12th | E12 Queen's Indian |
| 20. S Agdestein vs Karpov |
| 0-1 | 49 | 1991 | Agdestein-Karpov Match | E15 Queen's Indian |
| 21. Bareev vs Karpov |
| 0-1 | 24 | 1991 | Interpolis 15th | E15 Queen's Indian |
| 22. Polugaevsky vs Karpov |
| 0-1 | 59 | 1992 | Melody Amber Rapid | E14 Queen's Indian |
| 23. Ivanchuk vs Karpov |
| 0-1 | 39 | 1992 | Melody Amber Blitz | E12 Queen's Indian |
| 24. A Beliavsky vs Karpov |
| 0-1 | 44 | 1992 | Linares | E15 Queen's Indian |
| 25. Granda Zuniga vs Karpov |
| 0-1 | 41 | 1992 | Madrid | E15 Queen's Indian |
Kibitzing
