Amyotrophic Lateral Sclerosis News
September 23, 2016
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September 23, 2016

How Mutations Disrupt ALS-Linked Protein

Aug. 18, 2016 — Structural biologists provide a new explanation for how ALS-associated genetic flaws interfere with the proper function and behavior of the protein ... read more

Differences in How ALS Affects Eye, Limb Muscles Act as Clue

June 2, 2016 — In an effort to better understand what happens during Amyotrophic Lateral Sclerosis (ALS), researchers have compared the impact of ALS on the eye and limb muscles. They have focused on specific ... read more

Second Gene Modifies Effect of Mutation in a Dog Model of ALS

May 16, 2016 — Canine Degenerative Myelopathy (DM) is a neurodegenerative disease in dogs with similarities to ALS in humans. Scientists have discovered a modifier gene that affects the risk of developing DM in ... read more

Resistant Neurons Point the Way to Protective Factors in ALS

May 16, 2016 — The growth factor IGF-2 can prevent the death of human nerve cells in the incurable disease ALS, according to a new study. The work demonstrates that degeneration-resistant oculomotor neurons can be ... read more

Pesticide Exposure Linked to Increased Risk of ALS

May 9, 2016 — Survey data suggest reported cumulative pesticide exposure was associated with increased risk of amyotrophic lateral sclerosis (ALS), a progressive and fatal neurodegenerative disease, say ... read more

Aggregated Protein in Nerve Cells Can Cause ALS

May 4, 2016 — Persons with the serious disorder ALS, can have a genetic mutation that causes the protein SOD1 to aggregate in motor neurons in the brain and spinal cord. Researchers at have discovered that, when ... read more

Experimental Alzheimer's Drug Reverses Genetic Changes Thought to Spur the Disease

May 3, 2016 — When given to old rats, the drug, which is known to affect signaling by the neurotransmitter glutamate, reversed many age-related changes that occur in a brain region key to learning and memory. The ... read more

Unique Mouse Model for Studying ALS Developed

Apr. 21, 2016 — A unique mouse model has been developed that will allow researchers around the world to better study the genetic origins and potential treatments for a neurodegenerative brain disease that causes ... read more

Researchers Find That Immune Cells Play Unexpected Role in Lou Gehrig's Disease

Mar. 17, 2016 — Research scientists have found that immune cells in the brain play a direct role in the development of amyotrophic lateral sclerosis, or ALS, offering hope for new therapies to target the ... read more

Spasticity: Two Potential Therapeutic Avenues

Mar. 16, 2016 — Following spinal cord injury, most patients experience an exaggeration of muscle tone called spasticity, which frequently leads to physical disability. A team has just identified one of the molecular ... read more

Loss of MHCI in Motor Neurons Leads to ALS Astrocyte Toxicity

Feb. 29, 2016 — Until recently, the role of astrocytes, glial cells that normally support motor neurons, in motor neuron death has been a mystery, but new research sheds light on molecular mechanisms responsible for ... read more

Speech Disorder Called Apraxia Can Progress to Neurodegenerative Disease

Feb. 14, 2016 — It may start with a simple word you can't pronounce. Your tongue and lips stumble, and gibberish comes out. Misspeaking might draw a chuckle from family and friends. But, then, it keeps ... read more

Important Role of Nucleocytoplasmic Transport in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Feb. 12, 2016 — Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating adult-onset neurodegenerative disorders. No cure exists for these diseases. Ten percent of ALS patients ... read more

More Effective Speech Therapy Approach for Children With Down Syndrome

Feb. 5, 2016 — Children with Down syndrome who have motor speech deficits have been inadequately diagnosed, which could have a major impact on the interventions used by speech pathologists when treating patients, a ... read more

Targeting Upper Motor Neurons to Treat ALS

Feb. 1, 2016 — Scientists have demonstrated for the first time that it is possible to specifically modify gene expression in diseased upper motor neurons, brain cells that break down in ALS. The study provides ... read more

Research Discovers Potential New Therapeutic Target for ALS

Jan. 19, 2016 — New findings reveal another piece of the amyotrophic lateral sclerosis (ALS) puzzle. A research team identified a protein that can protect against the toxic degeneration of cells in diseases like ... read more

Revealing the Intra-Cellular Mechanism Underlying ALS

Jan. 19, 2016 — Proteins associated with cancer suppression and prevention of hypoxia have been identified by researchers as key players in the progression of amyotrophic lateral sclerosis ... read more

ALS Protein Dynamics Highlight Delicate Balance Between Self-Association and Aggregation

Jan. 6, 2016 — The ALS-related protein TDP-43 takes the first steps toward pathologic aggregation as part of its normal function, according to a new study. The study supports the emerging idea that protein ... read more

Study Opens New Door for ALS Drug Discovery

Dec. 28, 2015 — Researchers have discovered the first-ever evidence-based description of the neuronal protein clumps thought to be important in Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's ... read more

Possible New Explanation for ALS

Oct. 29, 2015 — Researchers are proposing a new way of understanding Amyotrophic Lateral Sclerosis (ALS), the devastating and incurable neurological disease. Their findings could be a major milestone on the path to ... read more
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